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  1. Book ; Online ; E-Book: Biologische Sicherheit im Labor

    Binz, Thomas

    ein kompakter Überblick für Studierende und Technische Assistenzen

    (essentials)

    2018  

    Author's details Thomas Binz
    Series title essentials
    Keywords Biologische Sicherheit ; Biosicherheit ; Biotechnologie ; EU-Richtlinie ; Einschließung ; GVO ; Gentechnologie ; Geschlossenes System ; Mikroorganismen ; Risikobewertung ; Sicherheitsmaßnahmen ; TAs ; Technische Assistenten ; Technische Assistenzen
    Language German
    Size 1 Online-Ressource (IX, 44 Seiten)
    Publisher Springer Spektrum
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019751147
    ISBN 978-3-658-22895-8 ; 9783658228941 ; 3-658-22895-4 ; 3658228946
    DOI 10.1007/978-3-658-22895-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Botulinum neurotoxins

    Rummel, Andreas / Binz, Thomas

    (Current topics in microbiology and immunology ; 364)

    2013  

    Author's details Andreas Rummel ; Thomas Binz, ed
    Series title Current topics in microbiology and immunology ; 364
    Collection
    Keywords Botulinustoxin ; Arzneimittel
    Subject Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge ; Botulin ; Botulinumtoxin ; Botulinustoxine ; EC 3.4.24.69
    Language English
    Size VIII, 321 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017516495
    ISBN 978-3-642-33569-3 ; 3-642-33569-1 ; 9783642335709 ; 3642335705
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -364- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Ability of human SNAP-23 to generate high molecular weight SDS-resistant ternary SNARE complexes is influenced by C-terminal coil content.

    Vaidyanathan, Vadakkanchery V / Binz, Thomas

    Biochemistry and biophysics reports

    2021  Volume 28, Page(s) 101150

    Abstract: ... ...

    Abstract Using
    Language English
    Publishing date 2021-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2021.101150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Charakterisierung der Interaktion von Botulinum Neurotoxin und seinem nicht toxischen nicht hämagglutinierenden Protein NTNHA im proteaseresistenten 290 kDa minimalen Komplex (M-PTC)

    Rumpel, Catherin Sophie / Bigalke, Hans / Rummel, Andreas / Binz, Thomas

    2018  

    Institution Medizinische Hochschule Hannover
    Medizinische Hochschule Hannover / Institut für Toxikologie
    Author's details vorgelegt von Catherin Sophie Rumpel
    Language German
    Size XII, 127 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2018
    HBZ-ID HT020106715
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 E 571 order for loan Magazin

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  5. Article ; Online: Accuracy and Safety of Non-Image Guided Trigger Finger Injections: A Cadaveric Study.

    Binz, Daniel D / Mitchell, Thomas W / Mitchell, Scott A

    Hand (New York, N.Y.)

    2022  Volume 18, Issue 8, Page(s) 1349–1356

    Abstract: Background: Stenosing flexor tenosynovitis is commonly treated by injection of corticosteroids into the flexor tendon sheath. However, there is no consensus in the literature regarding the optimal technique, specifically when not utilizing ultrasound ... ...

    Abstract Background: Stenosing flexor tenosynovitis is commonly treated by injection of corticosteroids into the flexor tendon sheath. However, there is no consensus in the literature regarding the optimal technique, specifically when not utilizing ultrasound guidance. Here, we present a cadaver study in which 3 common techniques of flexor sheath injection were compared with regard to their accuracy and safety profiles.
    Methods: Fifteen fresh-frozen cadaver hands (60 digits) were evenly divided into 3 groups (20 digits per group). Digits in each group were injected with methylene blue dye using 1 of the 3 techniques (palmar-to-bone, palmar supra-tendinous, and mid-axial). The fingers were then dissected and were inspected for location of dye, as well as injury to tendon or digital nerves.
    Results: The mid-axial technique demonstrated the greatest accuracy with the highest rate of all intra-sheath injection, 15 of 20 digits (75%), while the palmar-to-bone technique produced the most combined intra- and extra-sheath injections, 13 of 20 digits, (65%) and the palmar supra-tendinous technique resulted in the most all extra-sheath injections, 9 of 20 digits (45%). The difference in rates of all intra-sheath injection was significant (
    Conclusions: Compared to other common non-image guided flexor tendon sheath injection techniques, the mid-axial injection technique was found to be the most accurate in producing all intra-sheath injection and least likely to result in intra-tendinous injection.
    MeSH term(s) Humans ; Trigger Finger Disorder/drug therapy ; Injections/methods ; Tendons ; Fingers ; Cadaver
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277325-3
    ISSN 1558-9455 ; 1558-9447
    ISSN (online) 1558-9455
    ISSN 1558-9447
    DOI 10.1177/15589447221093676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6820: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: Theorie und Praxis der Unternehmerfamilie und des Familienunternehmens - Theory and Practice of Business Families and Family Businesses : Festschrift für Arist von Schlippe - Commemorative Publication for Arist von Schlippe (Edition 1)

    Rüsen, Tom A. / Hack, Andreas / Thomas, Adrian / Simon, Fritz B. / von Hertel, Anita / Astrachan Binz, Claudia / Brundin, Ethel / Spitzley, Dinah / Pieper, Torsten / Kriz, Jürgen / Rauschendorfer, Natalie / Mittelsten Scheid, Jörg / Frank, Hermann / Schreiber, Christoph / Wimmer, Rudolf / Groth, Torsten / Sharma, Pramodita / Scheffler, Marc André / Rau, Sabine /
    Steinhübel, Andreas / Zellweger, Thomas / Kirchdörfer, Rainer / Gimeno, Alberto / Plate, Markus / Prügl, Reinhard

    2021  

    Keywords Biography: general ; Biography & Autobiography ; Social Scientists & Psychologists
    Size 1 Online-Ressource
    Publisher Vandenhoeck and Ruprecht
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021047144
    ISBN 9783666454196 ; 3666454194
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Ability of human SNAP-23 to generate high molecular weight SDS-resistant ternary SNARE complexes is influenced by C-terminal coil content

    Vadakkanchery V. Vaidyanathan / Thomas Binz

    Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101150- (2021)

    2021  

    Abstract: Using in vitro protein complex formation assay, ability of SNAP-25 isoforms to generate SDS-resistant ternary SNARE complexes with Syntaxin-1 and VAMP-2 was investigated. Major SNAP-25 family proteins were found to generate heat-resistant ternary ... ...

    Abstract Using in vitro protein complex formation assay, ability of SNAP-25 isoforms to generate SDS-resistant ternary SNARE complexes with Syntaxin-1 and VAMP-2 was investigated. Major SNAP-25 family proteins were found to generate heat-resistant ternary complexes with varying efficiency. Compared to human SNAP-25, its non-neuronal counterparts SNAP-23 and SNAP-29 formed lower amounts of ternary complexes. Changing Pro182 in human SNAP-23 to Arg182 (SNAP-23 P182R) improved its ability to bind partners and form complexes. In silico analysis of C-terminal helical content in various SNAP-25 family members showed that except human SNAP-23, all others displayed secondary α-helical conformation. We also report that human SNAP-29 is resistant to the proteolytic action of botulinum neurotoxin A even when applied at large concentration.
    Keywords SNAP-25 and SNAP-23 proteins ; SDS-Resistant ternary SNARE complexes ; C-terminal coiled-coil content ; Botulinum neurotoxin cleavage ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method including 25 novel synthetic opioids in hair and subsequent analysis of a Swiss opioid consumer cohort.

    Polke, Max / Concheiro, Marta / Cooper, Gail / Bogdal, Christian / Baumgartner, Markus R / Krämer, Thomas / Binz, Tina M

    Drug testing and analysis

    2024  

    Abstract: Major public health concern is raised by the evidence that common drugs like heroin are now frequently laced or replaced with highly potent novel synthetic opioids (NSOs). The objective of this study was to explore the prevalence and patterns of NSOs in ... ...

    Abstract Major public health concern is raised by the evidence that common drugs like heroin are now frequently laced or replaced with highly potent novel synthetic opioids (NSOs). The objective of this study was to explore the prevalence and patterns of NSOs in a cohort of Swiss opioid users by hair analysis. Hair analysis is considered an ideal tool for retrospective consumption monitoring. Hair samples from 439 opioid users in Zurich were analyzed. Study inclusion required a previous positive hair test result for heroin metabolites, oxycodone, fentanyl, methadone, or tramadol. The samples were extracted with a two-step extraction procedure, followed by a targeted LC-MS/MS (QTRAP® 6500+) analysis in multiple reaction monitoring mode for a total of 25 NSOs. The method underwent full validation and demonstrated good selectivity and sensitivity with limits of detection (LOD) as low as 0.1 pg/mg. The analyzed sample cohort demonstrated a positivity rate for NSOs of 2.5%, including the following NSOs: butyrylfentanyl, acrylfentanyl, furanylfentanyl, methoxyacetylfentanyl, ocfentanil, U-47700, isobutyrylfentanyl and benzylfentanyl. Furthermore, we were able to identify specific consumption patterns among drug users. The results indicate that hair analysis is a valuable tool for investigating the prevalence of NSOs in drug-using populations, which seems to be low in the case of Swiss opioid users. Nevertheless, the results highlight the need for sensitive analytical detection methods in forensic toxicology to identify and monitor substance distribution in different populations.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Single sample preparation for the simultaneous extraction of drugs, pharmaceuticals, cannabinoids and endogenous steroids in hair.

    Scholz, Clementine / Baumgartner, Markus R / Kraemer, Thomas / Binz, Tina M

    Analytical methods : advancing methods and applications

    2022  Volume 14, Issue 44, Page(s) 4583–4591

    Abstract: Recently, we published a multi-analyte method for the simultaneous analysis of 116 drugs and pharmaceuticals including different substance groups like opioids, stimulants, benzodiazepines, z-drugs, antidepressants and neuroleptics based on a single ... ...

    Abstract Recently, we published a multi-analyte method for the simultaneous analysis of 116 drugs and pharmaceuticals including different substance groups like opioids, stimulants, benzodiazepines, z-drugs, antidepressants and neuroleptics based on a single sample workup followed by a single analytical measurement with LC-MS/MS. However, in some cases, additional analysis of further substance groups, such as cannabinoids and endogenous steroids, is required, which are analyzed in our laboratory using separate sample preparation and separate analytical methods. The goal of this study was to use the knowledge from the different sample preparations and combine them into a single sample preparation and extraction workflow for the simultaneous extraction of drugs, pharmaceuticals, cannabinoids, and endogenous steroids to be analyzed with the appropriate analytical methods. A partial validation of selected parameters such as selectivity, linearity, limit of quantification (LOQ), accuracy, precision and robustness for the different analytical methods was carried out and revalidated. In addition, comparative measurements of quality controls and authentic pools were performed and statistically evaluated using the unpaired
    MeSH term(s) Chromatography, Liquid/methods ; Cannabinoids/analysis ; Tandem Mass Spectrometry/methods ; Hair/chemistry ; Steroids ; Pharmaceutical Preparations
    Chemical Substances Cannabinoids ; Steroids ; Pharmaceutical Preparations
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d2ay01325h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clostridial neurotoxin light chains: devices for SNARE cleavage mediated blockade of neurotransmission.

    Binz, Thomas

    Current topics in microbiology and immunology

    2013  Volume 364, Page(s) 139–157

    Abstract: Seven serologically distinct botulinum neurotoxins and tetanus neurotoxin which cause the diseases botulism and tetanus constitute the clostridial neurotoxin family. Like many other bacterial protein toxins they exhibit a modular structure. One domain ... ...

    Abstract Seven serologically distinct botulinum neurotoxins and tetanus neurotoxin which cause the diseases botulism and tetanus constitute the clostridial neurotoxin family. Like many other bacterial protein toxins they exhibit a modular structure. One domain mediates highly specific binding to target cells and endocytosis, while the second translocates the third, a catalytic domain across the endosomal membrane to the target cell cytosol. In case of Clostridial neurotoxins (CNT), the latter acts as extremely specific Zn(2+)-dependent metalloproteinase. The various serotypes proteolyze each one particular peptide bond in one of the three SNARE proteins, which are the core of the membrane fusion apparatus for synaptic vesicles. SNARE cleavage causes the blockade of neurotransmitter release. This chapter details the molecular basis for the highly selective substrate recognition and cleavage mechanism of CNT.
    MeSH term(s) Amino Acid Sequence ; Animals ; Catalytic Domain ; Clostridium/metabolism ; Endocytosis ; Enzyme Activation ; Exocytosis ; Humans ; Hydrolysis ; Molecular Sequence Data ; Neurons/metabolism ; Neurotransmitter Uptake Inhibitors/metabolism ; Protein Binding ; Protein Transport ; Proteolysis ; SNARE Proteins/metabolism ; Sequence Homology, Amino Acid ; Substrate Specificity ; Synaptic Membranes/metabolism ; Synaptic Transmission ; Synaptic Vesicles/metabolism ; Tetanus Toxin/metabolism ; Zinc/metabolism
    Chemical Substances Neurotransmitter Uptake Inhibitors ; SNARE Proteins ; Tetanus Toxin ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2013
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-33570-9_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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