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Article ; Online: Impact of H

Yabuta, Keisho / Futamura, Haruka / Kawasaki, Koji / Sugiyama, Hirokazu

2020 Volume 109, Issue 9, Page(s) 2767–2773

Abstract: As part of manufacturing a sterile drug product, we quantified the impact of H ...

Abstract	As part of manufacturing a sterile drug product, we quantified the impact of H
MeSH term(s)	Decontamination ; Hydrogen Peroxide ; Models, Theoretical ; Pharmaceutical Preparations ; Polymers
Chemical Substances	Pharmaceutical Preparations ; Polymers ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2020.05.024
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Article ; Online: Biochemical analysis of H

Sugiyama, Tomohiko / Sanyal, Mahima R

DNA repair

2023 Volume 134, Page(s) 103617

Abstract: ... was exposed to H ...

Abstract	Reactive oxygen species (ROS) are a major threat to genomic integrity and believed to be one of the etiologies of cancers. Here we developed a cell-free system to analyze ROS-induced mutagenesis, in which DNA was exposed to H
MeSH term(s)	Hydrogen Peroxide ; Reactive Oxygen Species ; Mutation ; Mutagenesis ; DNA-Directed DNA Polymerase/genetics ; DNA ; DNA Damage
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Reactive Oxygen Species ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; DNA (9007-49-2)
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2023.103617
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Zs.A 5555: Show issues

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Article ; Online: Design-oriented regression models for H

Yabuta, Keisho / Futamura, Haruka / Kawasaki, Koji / Hirao, Masahiko / Sugiyama, Hirokazu

International journal of pharmaceutics

2018 Volume 548, Issue 1, Page(s) 466–473

Abstract: We developed regression models for designing rapid and effective H ...

Abstract	We developed regression models for designing rapid and effective H
MeSH term(s)	Decontamination/methods ; Drug Compounding ; Hydrogen Peroxide/chemistry ; Models, Theoretical ; Oxidants/chemistry ; Regression Analysis ; Sterilization
Chemical Substances	Oxidants ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2018-06-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2018.06.055
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Zs.A 1409: Show issues

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Article ; Online: Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer.

Inamori, Koji / Togashi, Yosuke / Fukuoka, Shota / Akagi, Kiwamu / Ogasawara, Kouetsu / Irie, Takuma / Motooka, Daisuke / Kobayashi, Yoichi / Sugiyama, Daisuke / Kojima, Motohiro / Shiiya, Norihiko / Nakamura, Shota / Maruyama, Shoichi / Suzuki, Yutaka / Ito, Masaaki / Nishikawa, Hiroyoshi

JCI insight

2021 Volume 6, Issue 9

Abstract: ... TCR) repertoire was observed in microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR ... impact on long-term prognosis in our MSI-H/dMMR CRC cohort (n = 130). We propose that regional LNs play ... an important role in antitumor immunity, particularly in MSI-H/dMMR CRCs with high TMB, requiring care to be ...

Abstract	Patients with colorectal cancers (CRCs) generally exhibit improved survival through intensive lymph node (LN) dissection. However, recent progress in cancer immunotherapy revisits the potential importance of regional LNs, where T cells are primed to attack tumor cells. To elucidate the role of regional LN, we investigated the immunological status of nonmetastatic regional LN lymphocytes (LNLs) in comparison with those of the tumor microenvironment (tumor-infiltrating lymphocytes; TILs) using flow cytometry and next-generation sequencing. LNLs comprised an intermediate level of the effector T cell population between peripheral blood lymphocytes (PBLs) and TILs. Significant overlap of the T cell receptor (TCR) repertoire was observed in microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) CRCs with high tumor mutation burden (TMB), although limited TCRs were shared between nonmetastatic LNs and primary tumors in microsatellite stable/MMR proficient (MSS/pMMR) CRC patients with low TMB. In line with the overlap of the TCR repertoire, an excessive LN dissection did not provide a positive impact on long-term prognosis in our MSI-H/dMMR CRC cohort (n = 130). We propose that regional LNs play an important role in antitumor immunity, particularly in MSI-H/dMMR CRCs with high TMB, requiring care to be taken regarding excessive nonmetastatic LN dissection in MSI-H/dMMR CRC patients.
MeSH term(s)	Aged ; CD4-Positive T-Lymphocytes/immunology ; Cohort Studies ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; DNA Mismatch Repair/genetics ; Female ; Flow Cytometry ; Forkhead Transcription Factors/immunology ; Humans ; Lymph Node Excision ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Memory T Cells/immunology ; Microsatellite Instability ; Middle Aged ; Programmed Cell Death 1 Receptor/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
Chemical Substances	FOXP3 protein, human ; Forkhead Transcription Factors ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.137365
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Article ; Online: Light-induced stomatal opening requires phosphorylation of the C-terminal autoinhibitory domain of plasma membrane H

Fuji, Saashia / Yamauchi, Shota / Sugiyama, Naoyuki / Kohchi, Takayuki / Nishihama, Ryuichi / Shimazaki, Ken-Ichiro / Takemiya, Atsushi

Nature communications

2024 Volume 15, Issue 1, Page(s) 1195

Abstract: Plasma membrane H ...

Abstract	Plasma membrane H
MeSH term(s)	Phosphorylation ; Light ; Plant Stomata/metabolism ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Cell Membrane/metabolism
Chemical Substances	Arabidopsis Proteins ; Proton-Translocating ATPases (EC 3.6.3.14)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45236-9
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Article ; Online: Modification of Poly(maleic anhydride)-Based Polymers with H

Jin, Zhicheng / Du, Liang / Zhang, Chengqi / Sugiyama, Yuya / Wang, Wentao / Palui, Goutam / Wang, Sisi / Mattoussi, Hedi

Bioconjugate chemistry

2019 Volume 30, Issue 3, Page(s) 871–880

Abstract: Reacting poly(maleic anhydride)-based polymers with H ...

Abstract	Reacting poly(maleic anhydride)-based polymers with H
MeSH term(s)	Electrophoresis, Polyacrylamide Gel ; Magnetic Resonance Spectroscopy/methods ; Maleic Anhydrides/chemistry ; Polymers/chemistry ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared ; Temperature
Chemical Substances	Maleic Anhydrides ; Polymers
Language	English
Publishing date	2019-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.9b00008
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Zs.A 3400: Show issues

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Article ; Online: Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H

Fujii, Tatsuya / Kitamura, Yoshiaki / Mizuguchi, Hiroyuki / Okamoto, Kentaro / Sanada, Nanae / Yamada, Takuya / Sugiyama, Manabu / Michinaga, Shotaro / Kitayama, Mika / Fukui, Hiroyuki / Takeda, Noriaki

Journal of pharmacological sciences

2018 Volume 138, Issue 1, Page(s) 54–62

Abstract: Narrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/ ... ...

Abstract	Narrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/cm
MeSH term(s)	Animals ; Apoptosis/radiation effects ; Dose-Response Relationship, Radiation ; Gene Expression/radiation effects ; HeLa Cells ; Humans ; Male ; Nasal Mucosa/pathology ; Nasal Mucosa/radiation effects ; Phototherapy ; RNA, Messenger/metabolism ; Rats ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/metabolism ; Rhinitis, Allergic/therapy ; Ultraviolet Rays ; Up-Regulation/radiation effects
Chemical Substances	RNA, Messenger ; Receptors, Histamine H1
Language	English
Publishing date	2018-09-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2018.08.011
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Zs.A 237: Show issues

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Article ; Online: The effect of tracheostomy performed within 72 h after traumatic brain injury.

Shibahashi, Keita / Sugiyama, Kazuhiro / Houda, Hidenori / Takasu, Yuichi / Hamabe, Yuichi / Morita, Akio

British journal of neurosurgery

2017 Volume 31, Issue 5, Page(s) 564–568

Abstract: ... The purpose of this study was to examine the effects of tracheostomy performed within 72 h after admission ... for intubation because of upper airway obstruction. Patients who underwent tracheostomy ≤72 h and >72 h after ... that the performance of tracheostomy within 72 h of admission may decrease the duration of mechanical ventilation and ...

Abstract	The optimal timing of tracheostomy in patients with traumatic brain injury (TBI) remains unclear. The purpose of this study was to examine the effects of tracheostomy performed within 72 h after admission. In this retrospective cohort study, the authors reviewed the data for a series of 120 consecutive patients who underwent tracheostomy after suffering TBI with an Abbreviated Injury Scale (AIS) score of ≥4. The exclusion criteria were as follows: age <18 years, severe chest injury with an AIS score of ≥4, and a requirement for intubation because of upper airway obstruction. Patients who underwent tracheostomy ≤72 h and >72 h after admission were classified into early group and control groups, respectively. The duration of mechanical ventilation, length of stay (LOS) in intensive care unit (ICU), incidence of pneumonia, adverse event rate, unnecessary tracheostomy and outcomes were compared between the two groups. Of the 120 patients, 29 were excluded from the study, 40 were classified into the early group, and 51 were classified into the control group. The duration of mechanical ventilation and LOS in ICU were significantly less in the early group than in the control group. The 30-day mortality rates were 3% and 8% for the early and control groups, respectively. There was no significant difference in the adverse event rate, incidence of pneumonia, unnecessary tracheostomy rate and the rate of favorable outcome between groups. The results of this study suggest that the performance of tracheostomy within 72 h of admission may decrease the duration of mechanical ventilation and LOS in ICU, with acceptable mortality and morbidity rates.
MeSH term(s)	Adult ; Aged ; Brain Injuries, Traumatic/surgery ; Critical Care/statistics & numerical data ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Pneumonia/etiology ; Postoperative Complications/etiology ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; Time-to-Treatment/statistics & numerical data ; Tracheostomy/methods ; Treatment Outcome
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2017.1302071
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Article ; Online: Crystallographic and mutational analyses of cystathionine β-synthase in the H

Matoba, Yasuyuki / Yoshida, Tomoki / Izuhara-Kihara, Hisae / Noda, Masafumi / Sugiyama, Masanori

Protein science : a publication of the Protein Society

2017 Volume 26, Issue 4, Page(s) 763–783

Abstract: ... physiological enzymes for the generation of hydrogen sulfide (H ...

Abstract	Cystathionine β-synthase (CBS) catalyzes the formation of l-cystathionine from l-serine and l-homocysteine. The resulting l-cystathionine is decomposed into l-cysteine, ammonia, and α-ketobutylic acid by cystathionine γ-lyase (CGL). This reverse transsulfuration pathway, which is catalyzed by both enzymes, mainly occurs in eukaryotic cells. The eukaryotic CBS and CGL have recently been recognized as major physiological enzymes for the generation of hydrogen sulfide (H
MeSH term(s)	Amino Acid Substitution ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Crystallography, X-Ray ; Cystathionine/metabolism ; Cystathionine beta-Synthase/chemistry ; Cystathionine beta-Synthase/genetics ; Cystathionine beta-Synthase/metabolism ; Hydrogen Sulfide/chemistry ; Hydrogen Sulfide/metabolism ; Hydrolases/genetics ; Hydrolases/metabolism ; Lactobacillus plantarum/enzymology ; Lactobacillus plantarum/genetics ; Multigene Family ; Mutation, Missense
Chemical Substances	Bacterial Proteins ; Cystathionine (375YFJ481O) ; Hydrolases (EC 3.-) ; homocysteinase (EC 3.3.1.-) ; Cystathionine beta-Synthase (EC 4.2.1.22) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2017-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.3123
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Zs.A 3407: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates.

Guo, Chuanxin / Asamitsu, Sefan / Kashiwazaki, Gengo / Sato, Shinsuke / Bando, Toshikazu / Sugiyama, Hiroshi

Chembiochem : a European journal of chemical biology

2017 Volume 18, Issue 2, Page(s) 166–170

Abstract: ... specific ICL agents are quite rare. In this study, H-pin imidazole-pyrrole polyamide 1-(chloromethyl)-2,3 ... and synthesized. Conjugates with H-pin polyamide and seco-CBI moieties were constructed to recognize ...

Abstract	Although DNA interstrand crosslinking (ICL) agents are widely used as antitumor drugs, DNA sequence-specific ICL agents are quite rare. In this study, H-pin imidazole-pyrrole polyamide 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-CBI) conjugates that produce sequence-specific DNA ICLs were designed and synthesized. Conjugates with H-pin polyamide and seco-CBI moieties were constructed to recognize a 7 bp DNA sequence, and their reactivity and selectivity in DNA alkylation were evaluated by using high-resolution denaturing gel electrophoresis and sequence-specific plasmid cleavage. One conjugate (6), which contained a chiral (S)-seco-CBI, exhibited greater sequence-specific ICL activity toward the target DNA sequence and was cytotoxic to a cancer cell line. Molecular modeling studies indicated that the greater activity of 6 resulted from the relative orientation of the cyclopropane group in the (S)-CBI unit.
MeSH term(s)	Alkylation ; Antineoplastic Agents, Alkylating/chemistry ; Antineoplastic Agents, Alkylating/toxicity ; Base Sequence ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA/chemistry ; DNA/metabolism ; Electrophoresis, Polyacrylamide Gel ; Humans ; Imidazoles/chemistry ; Indoles/chemistry ; Indoles/toxicity ; Intercalating Agents/chemistry ; Intercalating Agents/toxicity ; Plasmids/genetics ; Plasmids/metabolism ; Pyrroles/chemistry ; Stereoisomerism
Chemical Substances	Antineoplastic Agents, Alkylating ; Imidazoles ; Indoles ; Intercalating Agents ; Pyrroles ; imidazole (7GBN705NH1) ; DNA (9007-49-2)
Language	English
Publishing date	2017-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.201600425
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