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  1. Article ; Online: Cannabidiol (CBD) use in psychiatric disorders: A systematic review.

    Bonaccorso, Stefania / Ricciardi, Angelo / Zangani, Caroline / Chiappini, Stefania / Schifano, Fabrizio

    Neurotoxicology

    2019  Volume 74, Page(s) 282–298

    Abstract: Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different activity compared with the psychotomimetic THC. Most typically, CBD is reported to be used ...

    Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different activity compared with the psychotomimetic THC. Most typically, CBD is reported to be used in some medical conditions, including chronic pain. Conversely, the main aim of this systematic review is to assess and summarise the available body of evidence relating to both efficacy and safety of CBD as a treatment for psychiatric disorders, alone and/or in combination with other treatments. Eligible studies included randomized controlled trials (RCT) assessing the effect of CBD in a range of psychopathological conditions, such as substance use; psychosis, anxiety, mood disturbances, and other psychiatric (e.g., cognitive impairment; sleep; personality; eating; obsessive-compulsive; post-traumatic stress/PTSD; dissociative; and somatic) disorders. For data gathering purposes, the PRISMA guidelines were followed. The initial search strategy identified some n = 1301 papers; n = 190 studies were included after the abstract's screening and n = 27 articles met the inclusion criteria. There is currently limited evidence regarding the safety and efficacy of CBD for the treatment of psychiatric disorders. However, available trials reported potential therapeutic effects for specific psychopathological conditions, such as substance use disorders, chronic psychosis, and anxiety. Further large-scale RCTs are required to better evaluate the efficacy of CBD in both acute and chronic illnesses, special categories, as well as to exclude any possible abuse liability.
    MeSH term(s) Anxiety/drug therapy ; Cannabidiol/therapeutic use ; Humans ; Mental Disorders/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2019-08-11
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2019.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of the Effects of Heteroaryl Ethylene Molecules in Combination with Antibiotics: A Preliminary Study on Control Strains.

    Bonomo, Carmelo / Bonacci, Paolo Giuseppe / Bivona, Dalida Angela / Mirabile, Alessia / Bongiorno, Dafne / Nicitra, Emanuele / Marino, Andrea / Bonaccorso, Carmela / Consiglio, Giuseppe / Fortuna, Cosimo Gianluca / Stefani, Stefania / Musso, Nicolò

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: The discovery of compounds with antibacterial activity is crucial in the ongoing battle against antibiotic resistance. We developed two QSAR models to design six novel heteroaryl drug candidates and assessed their antibacterial properties against nine ... ...

    Abstract The discovery of compounds with antibacterial activity is crucial in the ongoing battle against antibiotic resistance. We developed two QSAR models to design six novel heteroaryl drug candidates and assessed their antibacterial properties against nine ATCC strains, including
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081308
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  3. Article ; Online: Prevalence of smoking habits, attitudes and knowledge on counteractive strategies among a sample of healthcare employees: results of the smoking-free health environments project in the province of Palermo, Italy.

    Costantino, Claudio / Bonaccorso, Nicole / Minutolo, Giuseppa / Sciortino, Martina / Ripoli, Giovanna / Berardi, Marco / Gallo, Maurizio / Nastasi, Stefania / Serra, Stefano / Trapani, Elisa / Busalacchi, Eugenio / Ficano, Provvidenza / Siciliano, Salvatore / Immordino, Palmira / Mazzucco, Walter / Restivo, Vincenzo / Vitale, Francesco / Casuccio, Alessandra

    Frontiers in public health

    2024  Volume 12, Page(s) 1335937

    Abstract: Introduction: Tobacco use is responsible for over 7 million deaths annually, making smoking the leading cause of preventable mortality globally. Over the last two decades in Italy, the prevalence of smoking among physicians has consistently decreased, ... ...

    Abstract Introduction: Tobacco use is responsible for over 7 million deaths annually, making smoking the leading cause of preventable mortality globally. Over the last two decades in Italy, the prevalence of smoking among physicians has consistently decreased, while it remains higher and is gradually decreasing among non-physician healthcare workers. The aim of this study was to investigate the Prevalence of smoking habits, attitudes, and knowledge on counteractive strategies among employees in the Primary Healthcare Facilities in the Province of Palermo, Italy.
    Methods: A cross-sectional survey was conducted between June 2020 and December 2020 through a previously validated anonymous questionnaire structured in four sections including 34 items. Data were analyzed using Stata/MP 12.1 statistical software.
    Results: Overall, 2,645 participants answered the questionnaire. The prevalence of either current or former smokers was 18.6%. Based on the multivariable analysis conducted, a significantly higher frequency of current smokers was observed among male participants (AdjOR: 1.29; CI95%: 1.02-1.64) and those belonging to the Surgical Unit (AdjOR: 1.92; CI95%: 1.27-2.90). Conversely, the prevalence of current smokers was significantly lower among those with at least one child (AdjOR: 0.67; CI95%: 0.49-0.91), with an educational qualification equal to or greater than a graduation degree (AdjOR: 0.56; CI95%: 0.43-0.73), those who considered second-hand smoke harmful (AdjOR: 0.06; CI95%: 0.008-0.60), those who had observed smoking or detected the smell of smoke in their workplace (AdjOR: 0.64; CI95%: 0.45-0.91). Furthermore, the prevalence of current smokers was significantly lower among participants who believed that healthcare professionals could play a crucial role in influencing their patients' lifestyles (AdjOR: 0.67; CI95%: 0.50-0.90) and among those who recommend their patients to quit smoking (AdjOR: 0.35; CI95%: 0.24-0.51).
    Discussion: The results of the current research demonstrate that, despite the decline in smoking prevalence among physicians, the rate of smokers among healthcare facility employees remains unacceptably high. This underscores the need to re-evaluate current anti-tobacco strategies in the workplace.
    MeSH term(s) Child ; Humans ; Male ; Prevalence ; Cross-Sectional Studies ; Smoking Cessation/methods ; Health Knowledge, Attitudes, Practice ; Health Personnel ; Smoking/epidemiology ; Italy/epidemiology
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1335937
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  4. Article: Heteroaryl-Ethylenes as New Effective Agents for High Priority Gram-Positive and Gram-Negative Bacterial Clinical Isolates.

    Bivona, Dalida Angela / Mirabile, Alessia / Bonomo, Carmelo / Bonacci, Paolo Giuseppe / Stracquadanio, Stefano / Marino, Andrea / Campanile, Floriana / Bonaccorso, Carmela / Fortuna, Cosimo Gianluca / Stefani, Stefania / Musso, Nicolò / Bongiorno, Dafne

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: The World Health Organization has identified antimicrobial resistance as a public health emergency and developed a global priority pathogens list of antibiotic-resistant bacteria that can be summarized in the acronym ESKAPE ( ...

    Abstract The World Health Organization has identified antimicrobial resistance as a public health emergency and developed a global priority pathogens list of antibiotic-resistant bacteria that can be summarized in the acronym ESKAPE (
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11060767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report.

    Bonaccorso, Stefania / Ricciardi, Angelo / Ouabbou, Sophie / Theleritis, Christos / Ross-Michaelides, Arabella / Metastasio, Antonio / Stewart, Neil / Mohammed, Marwa / Schifano, Fabrizio

    Brain, behavior, & immunity - health

    2021  Volume 13, Page(s) 100212

    Abstract: Background: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, clinicians raised concerns ... ...

    Abstract Background: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, clinicians raised concerns regarding continuation of antipsychotic treatment, and specifically of clozapine, in patients with coronavirus disease. We aimed here at providing a short report focusing on the association between neutropenia and clozapine in a case series of psychiatric inpatients diagnosed with COVID-19.
    Patients & methods: We retrospectively inspected data of 10 patients on clozapine, admitted to Highgate Mental Health Centre, Camden & Islington NHS Foundation Trust, between March and July 2020; selection was based on their COVID-19 positive PCR test. We used a linear regression model to estimate whether there was a significant drop in the neutrophil count during SARS-CoV-2 infection.The analysis was done in R using a linear regression to the origin.
    Results: Data were collected on 10 patients, of which 7 were males. During COVID-19 infection, neutrophils' count (ANC) was 4.13 ​× ​10
    Conclusions: Clinicians should bear in mind that a significant drop in neutrophils' count may occur in patients taking clozapine and affected from a SARS-CoV-2 infectionand that this drop is only transitory.
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2021.100212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heteroaryl-Ethylenes as New Lead Compounds in the Fight against High Priority Bacterial Strains.

    Bongiorno, Dafne / Musso, Nicolò / Bonacci, Paolo G / Bivona, Dalida A / Massimino, Mariacristina / Stracquadanio, Stefano / Bonaccorso, Carmela / Fortuna, Cosimo G / Stefani, Stefania

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: The widespread use of antibiotics has led to a gradual increase in drug-resistant bacterial infections, which severely weakens the clinical efficacy of antibacterial therapies. In recent decades, stilbenes aroused great interest because of their high ... ...

    Abstract The widespread use of antibiotics has led to a gradual increase in drug-resistant bacterial infections, which severely weakens the clinical efficacy of antibacterial therapies. In recent decades, stilbenes aroused great interest because of their high bioavailability, as well as their manifold biological activity. Our research efforts are focused on synthetic heteroaromatic stilbene derivatives as they represent a potentially new type of antibiotic with a wide antibacterial spectrum. Herein, a preliminary molecular modeling study and a versatile synthetic scheme allowed us to define eight heteroaromatic stilbene derivatives with potential antimicrobial activity. In order to evaluate our compound's activity spectrum and antibacterial ability, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests have been performed on Gram-positive and Gram-negative ATCC strains. Compounds PB4, PB5, PB7, and PB8 showed the best values in terms of MIC and were also evaluated for MBC, which was found to be greater than MIC, confirming a bacteriostatic activity. For all compounds, we evaluated toxicity on colon-rectal adenocarcinoma cells tumor cells (CaCo2), once it was established that the whole selected set was more active than 5-Fluorouracil in reducing CaCo-2 cells viability. To the best of our knowledge, the biological assays have shown for these derivatives an excellent bacteriostatic activity, compared to similar molecular structures previously reported, thus paving the way for a new class of antibiotic compounds.
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10091034
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  7. Article ; Online: Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes.

    Şen, Özlem / Emanet, Melis / Mazzuferi, Martina / Bartolucci, Martina / Catalano, Federico / Prato, Mirko / Moscato, Stefania / Marino, Attilio / De Pasquale, Daniele / Pugliese, Giammarino / Bonaccorso, Francesco / Pellegrini, Vittorio / Castillo, Antonio Esau Del Rio / Petretto, Andrea / Ciofani, Gianni

    ACS applied materials & interfaces

    2023  Volume 15, Issue 50, Page(s) 58260–58273

    Abstract: Microglial cells play a critical role in glioblastoma multiforme (GBM) progression, which is considered a highly malignant brain cancer. The activation of microglia can either promote or inhibit GBM growth depending on the stage of the tumor development ... ...

    Abstract Microglial cells play a critical role in glioblastoma multiforme (GBM) progression, which is considered a highly malignant brain cancer. The activation of microglia can either promote or inhibit GBM growth depending on the stage of the tumor development and on the microenvironment conditions. The current treatments for GBM have limited efficacy; therefore, there is an urgent need to develop novel and efficient strategies for drug delivery and targeting: in this context, a promising strategy consists of using nanoplatforms. This study investigates the microglial response and the therapeutic efficacy of dual-cell membrane-coated and doxorubicin-loaded hexagonal boron nitride nanoflakes tested on human microglia and GBM cells. Obtained results show promising therapeutic effects on glioma cells and an M2 microglia polarization, which refers to a specific phenotype or activation state that is associated with anti-inflammatory and tissue repair functions, highlighted through proteomic analysis.
    MeSH term(s) Humans ; Microglia ; Proteomics ; Glioblastoma/pathology ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Brain Neoplasms/pathology ; Cell Membrane/pathology ; Tumor Microenvironment/physiology ; Cell Line, Tumor
    Chemical Substances boron nitride (2U4T60A6YD) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c17097
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  8. Article ; Online: Two Versus One High-Frequency Repetitive Transcranial Magnetic Stimulation Session per Day for Treatment-Resistant Depression: A Randomized Sham-Controlled Trial. Response to Andrade and Colleagues.

    Theleritis, Christos / Sakkas, Pavlos / Paparrigopoulos, Thomas / Vitoratou, Silia / Tzavara, Chara / Bonaccorso, Stefania / Politis, Antonios / Soldatos, Constantin R / Psarros, Constantin

    The journal of ECT

    2017  Volume 33, Issue 2, Page(s) 143

    MeSH term(s) Depression ; Depressive Disorder, Major ; Depressive Disorder, Treatment-Resistant ; Double-Blind Method ; Electroconvulsive Therapy ; Humans ; Prefrontal Cortex ; Transcranial Magnetic Stimulation ; Treatment Outcome
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1426385-3
    ISSN 1533-4112 ; 1095-0680
    ISSN (online) 1533-4112
    ISSN 1095-0680
    DOI 10.1097/YCT.0000000000000412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Two Versus One High-Frequency Repetitive Transcranial Magnetic Stimulation Session per Day for Treatment-Resistant Depression: A Randomized Sham-Controlled Trial.

    Theleritis, Christos / Sakkas, Pavlos / Paparrigopoulos, Thomas / Vitoratou, Silia / Tzavara, Chara / Bonaccorso, Stefania / Politis, Antonios / Soldatos, Constantin R / Psarros, Costantin

    The journal of ECT

    2017  Volume 33, Issue 3, Page(s) 190–197

    Abstract: Objectives: High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has proven antidepressant effects, but the optimal frequency of sessions remains unclear.: Methods: We conducted a 3-week, sham-controlled trial to assess the ... ...

    Abstract Objectives: High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has proven antidepressant effects, but the optimal frequency of sessions remains unclear.
    Methods: We conducted a 3-week, sham-controlled trial to assess the antidepressant efficacy of 1 active HF-rTMS session per day (A1 group) compared with 2 per day (A2 group) and equivalent sham sessions (once a day, S1 group; twice a day, S2 group) in patients with treatment-resistant major depression with a subsequent 2-week follow-up period. One hundred seventy-seven patients were screened, of whom 105 met eligibility criteria and 98 consented and were randomized. The HF-rTMS (20 Hz) was targeted to the left prefrontal cortex in sessions of approximately 40 trains (2 seconds each) at 100% resting motor threshold with an intertrain interval of 1 minute. Treatment response was defined as a 50% or greater decrease in the Hamilton Depression Rating Scale (HDRS) score and/or Clinician Global Impressions-Severity of Illness (CGI-S) score of 3 or less. Remission was defined as HDRS score less than 8 and/or CGI-S score of 2 or less.
    Results: Practically none of the subjects in either sham groups achieved remission. Increased odds of remission were present for CGI-S by stimulating twice rather than once per day (odds ratio [OR] = 1.5, P = 0.018), whereas there was a marginal result for HDRS (OR = 3.9, P = 0.066). Patients who had lower baseline HDRS (OR = 0.75, P = 0.014) and CGI-S scores (OR = 0.18, P = 0.001) were more likely to achieve remission.
    Conclusions: Twice per day active HF-rTMS might be more effective than once per day active HF-rTMS or sham stimulation.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1426385-3
    ISSN 1533-4112 ; 1095-0680
    ISSN (online) 1533-4112
    ISSN 1095-0680
    DOI 10.1097/YCT.0000000000000387
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  10. Article: Prediction of long-term metabolic effects of olanzapine and risperidone treatment from baseline body mass index in schizophrenia and bipolar disorder.

    Bobo, William Victor / Bonaccorso, Stefania / Jayathilake, Karuna / Meltzer, Herbert Yale

    Psychiatry research

    2011  Volume 189, Issue 2, Page(s) 200–207

    Abstract: Baseline body mass index (BMI), baseline BMI status (normal, overweight, obese) and early (1 month) BMI increases were tested as predictors of 6- and 12-month increases in glucose and lipid measures in 82 olanzapine (OLZ)- and 78 risperidone (RIS)- ... ...

    Abstract Baseline body mass index (BMI), baseline BMI status (normal, overweight, obese) and early (1 month) BMI increases were tested as predictors of 6- and 12-month increases in glucose and lipid measures in 82 olanzapine (OLZ)- and 78 risperidone (RIS)-treated patients with schizophrenia, schizoaffective disorder, or bipolar disorder who participated in a 12-month randomized, prospective metabolic effects study. Baseline BMI predicted greater fasting glucose and HgbA1c levels at 12 months for both treatments. Early BMI change predicted fasting glucose levels at 6 months, but not HgbA1c or BMI, at either time point. For patients who received no concomitant mood stabilizers, early BMI change predicted 12 month HgbA1c values in the OLZ group, and 6- (but not 12-) month fasting glucose and HgbA1c values in the RIS group. Neither baseline BMI nor early BMI change consistently predicted increases in lipids with either drug. OLZ-treated patients with normal baseline BMI had greater increases in total cholesterol, triglycerides, and non-HDL-cholesterol than those who were overweight or obese. In conclusion, higher baseline BMI predicted adverse glycemic changes after 12 months with OLZ and RIS. Individuals with normal baseline BMI may be most susceptible to OLZ-induced hyperlipidosis. Frequency of metabolic screening should be independent of baseline BMI or rapid increases in BMI.
    MeSH term(s) Adolescent ; Adult ; Anthropometry ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/pharmacology ; Benzodiazepines/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/metabolism ; Blood Glucose/drug effects ; Body Mass Index ; Fasting ; Female ; Humans ; Lipid Metabolism/drug effects ; Longitudinal Studies ; Male ; Middle Aged ; Olanzapine ; Predictive Value of Tests ; Retrospective Studies ; Risperidone/pharmacology ; Risperidone/therapeutic use ; Schizophrenia/drug therapy ; Schizophrenia/metabolism ; Time Factors ; Young Adult
    Chemical Substances Antipsychotic Agents ; Blood Glucose ; Benzodiazepines (12794-10-4) ; Risperidone (L6UH7ZF8HC) ; Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2011-07-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0165-1781 ; 0925-4927
    DOI 10.1016/j.psychres.2011.07.008
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