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Article: An Improved Scalable Process for the Synthesis of (S,S)-DACH-Ph Trost Ligand

Zhang, Yongda / Chong, Eugene / White, Jada A. H. / Radomkit, Suttipol / Xu, Yibo / Kosnik, Stephanie C. / Lorenz, Jon C.

Synlett

2022 Volume 33, Issue 13, Page(s) 1287–1289

Abstract: An improved chemical process has been developed for the synthesis of ( S S )-DACH-Ph Trost ligand ... The amidation of 2-diphenylphosphinylbenzoic acid and ( S S )-diaminocyclohexane is promoted by stoichiometric ... CDI and catalytic imidazole hydrochloride. The resulting product, ( S S )-DACH-Ph Trost ligand, is ...

Abstract	An improved chemical process has been developed for the synthesis of ( S S )-DACH-Ph Trost ligand. The amidation of 2-diphenylphosphinylbenzoic acid and ( S S )-diaminocyclohexane is promoted by stoichiometric CDI and catalytic imidazole hydrochloride. The resulting product, ( S S )-DACH-Ph Trost ligand, is isolated as a white solid in 80% yield with >99% ee by simple filtration without column chromatography. The current facile process is also demonstrated on kilogram scale.
Keywords	Trost ligand ; DACH-Ph ; coupling ; 2-diphenylphosphinylbenzoic acid ; chiral diaminocyclohexane ; CDI ; imidazole hydrochloride ; kilogram
Language	English
Publishing date	2022-05-23
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/s-0041-1738371
Database	Thieme publisher's database

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Article ; Online: Website Usability Analysis of U.S. Military Residency Programs.

Chong, Paul / Grob, Patrizia / DiMattia, Gina / Calvano, Joshua / Swanson, Karl / He, Shuhan / Gubler, K Dean / LaPorta, Anthony

Military medicine

2022

Abstract: ... Scholarship Program through the U.S. Army, Air Force, and Navy. To evaluate and compare military residency ... for Graduate Medical Education U.S. Military residency program websites was compiled. Of these, 96 programs and 106 websites were ...

Abstract	Introduction: The Military Match is the residency matching system for medical students attending the Uniformed Services University of Health Sciences, and the students were funded by the Health Professions Scholarship Program through the U.S. Army, Air Force, and Navy. To evaluate and compare military residency programs, students use residency program websites. Often, the residency program's website serves as a key source, or the only point of reference, when considering residency options, especially during times when face-to-face interactions are limited.This report aims to provide a systematic evaluation of military residency programs and their websites. Materials and methods: Utilizing a previously published website usability scoring system, military residency programs were categorized to objectively and quantitatively analyze their websites. Usability was divided into four categories for quantifiable analysis: accessibility, marketing, content quality, and technology. The methodology for this analysis was replicated from published reports that have examined healthcare website usability. Each website was analyzed and scored in four categories: accessibility, content quality, marketing, and technology. A "General Usability" score was calculated for each website using a composite of the key factors within the four categories. An overall score was generated utilizing the weighted percentage across all four categories. To address deficiencies of the original methodology, a secondary analysis was performed on the listed websites utilizing an automated methodology for website usability. Results: A comprehensive list of 125 Accreditation Council for Graduate Medical Education U.S. Military residency program websites was compiled. Of these, 96 programs and 106 websites were evaluated. The primary analysis employing usability methodology identified technology as the highest ranked category with a score of 0.749 (SD ± 0.039) (SE 0.005) (P < .05). Marketing and content quality were the lowest scoring categories with mean scores of 0.414 (SD ± 0.054) (SE 0.006) and 0.428 (SD ± 0.229) (SE 0.027), respectively (P < .05). There was no significant difference in overall usability rankings or scores among the 96 residency program websites across the three branches (P < .05).Secondary analysis with the new usability methodology demonstrated military residency websites to exhibit more external backlinking compared to internal backlinking (P < 0.05) and no social media backlinking to any of the 106 analyzed websites. When comparing the three services, the Army had significantly lower external backlinking ranking 43.4 (P < .05) and overall backlinking ranking 56.4 (P < 0.05) when compared to the Navy (mean 48.8 and 71.7, and 43.4). There were no other differences in backlinking rankings across the three branches. Conclusions: Residency websites have become a primary way to communicate information to applicants. By assessing the overall usability of the various military residency websites, we determined the effectiveness of these websites to relay information to prospective students interested in applying for military residency. We predict that by improving website accessibility, residency programs increase their effectiveness at communicating information to potential applicants and increase interest in military residency programs.
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usac290
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Article ; Online: S-TiO

Li, Yu-Xuan / Wang, Xun / Wang, Chong-Chen / Fu, Huifen / Liu, Yanbiao / Wang, Peng / Zhao, Chen

Journal of hazardous materials

2020 Volume 399, Page(s) 123085

Abstract: Series sulfur-doped ... ...

Abstract	Series sulfur-doped TiO
Language	English
Publishing date	2020-06-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.123085
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Book ; Online: S-Cyc

Liu, Shiyu / Tan, Chong Min John / Motani, Mehul

A Learning Rate Schedule for Iterative Pruning of ReLU-based Networks

2021

Abstract: ... called S-Cyclical (S-Cyc) which adapts the conventional cyclical LR schedule by gradually increasing ... the LR upper bound (max_lr) in an S-shape as the network is iteratively pruned.We highlight that S-Cyc is ... the performance of the proposed S-Cyc and compare it to four LR schedule benchmarks. Our experimental results ...

Abstract	We explore a new perspective on adapting the learning rate (LR) schedule to improve the performance of the ReLU-based network as it is iteratively pruned. Our work and contribution consist of four parts: (i) We find that, as the ReLU-based network is iteratively pruned, the distribution of weight gradients tends to become narrower. This leads to the finding that as the network becomes more sparse, a larger value of LR should be used to train the pruned network. (ii) Motivated by this finding, we propose a novel LR schedule, called S-Cyclical (S-Cyc) which adapts the conventional cyclical LR schedule by gradually increasing the LR upper bound (max_lr) in an S-shape as the network is iteratively pruned.We highlight that S-Cyc is a method agnostic LR schedule that applies to many iterative pruning methods. (iii) We evaluate the performance of the proposed S-Cyc and compare it to four LR schedule benchmarks. Our experimental results on three state-of-the-art networks (e.g., VGG-19, ResNet-20, ResNet-50) and two popular datasets (e.g., CIFAR-10, ImageNet-200) demonstrate that S-Cyc consistently outperforms the best performing benchmark with an improvement of 2.1% - 3.4%, without substantial increase in complexity. (iv) We evaluate S-Cyc against an oracle and show that S-Cyc achieves comparable performance to the oracle, which carefully tunes max_lr via grid search. Comment: 7 pages main paper with 5 pages appendix
Keywords	Computer Science - Machine Learning ; Computer Science - Neural and Evolutionary Computing
Subject code	006
Publishing date	2021-10-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Utilizing productivity and health breeding-to-market information along with disease diagnostic data to identify pig mortality risk factors in a U.S. swine production system.

Magalhães, Edison S / Zimmerman, Jeff J / Thomas, Pete / Moura, Cesar A A / Trevisan, Giovani / Schwartz, Kent J / Burrough, Eric / Holtkamp, Derald J / Wang, Chong / Rademacher, Christopher J / Silva, Gustavo S / Linhares, Daniel C L

Frontiers in veterinary science

2024 Volume 10, Page(s) 1301392

Abstract: Aggregated diagnostic data collected over time from swine production systems is an important data source to investigate swine productivity and health, especially when combined with records concerning the pre-weaning and post-weaning phases of production. ...

Abstract	Aggregated diagnostic data collected over time from swine production systems is an important data source to investigate swine productivity and health, especially when combined with records concerning the pre-weaning and post-weaning phases of production. The combination of multiple data streams collected over the lifetime of the pigs is the essence of the whole-herd epidemiological investigation. This approach is particularly valuable for investigating the multifaceted and ever-changing factors contributing to wean-to-finish (W2F) swine mortality. The objective of this study was to use a retrospective dataset ("master table") containing information on 1,742 groups of pigs marketed over time to identify the major risk factors associated with W2F mortality. The master table was built by combining historical breed-to-market performance and health data with disease diagnostic records (Dx Codes) from marketed groups of growing pigs. After building the master table, univariate analyses were conducted to screen for risk factors to be included in the initial multivariable model. After a stepwise backward model selection approach, 5 variables and 2 interactions remained in the final model. Notably, the diagnosis variable significantly associated with W2F mortality was porcine reproductive and respiratory syndrome virus (PRRSV). Closeouts with clinical signs suggestive of
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1301392
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Article ; Online: Diamide-linked imidazolyl Poly(dicationic ionic liquid)s for the conversion of CO

Zou, Yizhen / Amuti, Qimanguli / Zou, Zhongwei / Xu, Yuping / Yan, Chong / Cheng, Guoe / Ke, Hanzhong

Journal of colloid and interface science

2023 Volume 656, Page(s) 47–57

Abstract: The ionic active centers and hydrogen-bond donors (HBDs) in heterogeneous catalytic materials are highly beneficial for enhancing the interaction between solid-liquid-gas three-phase interfaces and promoting effective fixation of carbon dioxide ( ... ...

Abstract	The ionic active centers and hydrogen-bond donors (HBDs) in heterogeneous catalytic materials are highly beneficial for enhancing the interaction between solid-liquid-gas three-phase interfaces and promoting effective fixation of carbon dioxide (CO
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.11.084
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Article ; Online: Anti-S Antibodies Against SARS-CoV-2 Infection Among Four Types of Vaccines in Malaysia.

Lodz, Noor Aliza / Mat Tamizi, Nurdiyana Farhana / Abd Mutalip, Mohd Hatta / Ganapathy, Shubash Shander / Lin, Chong Zhuo / Ismail, Rohani / Ahmad, Noor Ani

Asia-Pacific journal of public health

2024 Volume 36, Issue 1, Page(s) 96–103

Abstract: ... inform decisions about vaccination and public health measures. Anti-S may be useful as an indicator ... S antibodies against SARS-CoV-2 for all the vaccine types over time among adult recipients ... from the initial vaccine dose (baseline). We found that the anti-S antibody generally increased for all vaccine ...

Abstract	Monitoring SARS-CoV-2 antibody levels can provide insights into a person's immunity to COVID-19 and inform decisions about vaccination and public health measures. Anti-S may be useful as an indicator of an effective immune response. Thus, we conducted this study that aimed to determine the immune response of anti-S antibodies against SARS-CoV-2 for all the vaccine types over time among adult recipients in Malaysia and to determine the associated factors. This study was a cohort that recruited 2513 respondents aged 18 years and above from June to December 2021. Each participant was followed-up for 1-year period from the initial vaccine dose (baseline). We found that the anti-S antibody generally increased for all vaccine types and peaked at two weeks after the second dose vaccination, with Pfizer recipients having the highest median of 100 (100.00-100.00). During the third-month follow-up, the seropositivity of anti-S antibody and the median level decreased for all vaccines. We found that type of vaccines, comorbid status, infection, and booster status were significantly associated with the anti-S antibody level after one year.
MeSH term(s)	Adult ; Humans ; COVID-19/prevention & control ; Malaysia/epidemiology ; SARS-CoV-2 ; Vaccines ; Vaccination
Chemical Substances	Vaccines
Language	English
Publishing date	2024-01-02
Publishing country	China
Document type	Journal Article
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/10105395231223332
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Article ; Online: Alveoli-Inspired Carbon Cathodes with Interconnected Porous Structure and Asymmetric Coordinated Vanadium Sites for Superior Li-S Batteries.

Yan, Rui / Zhao, Zhenyang / Zhu, Ran / Wu, Min / Liu, Xu / Adeli, Mohsen / Yin, Bo / Cheng, Chong / Li, Shuang

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202404019

Abstract: ... paradigm for effective Li-S batteries. Although nitrogen-coordinated metal single-atom (M-N4) catalysts ... stable Li-S batteries. The enzyme-mimetic V-S1N3 shows asymmetric electronic distribution and high ... results reveal that the high charge asymmetry degree and large atom radius of S in V-S1N3 result ...

Abstract	Accelerating sulfur conversion catalysis to alleviate the shuttle effect has become a novel paradigm for effective Li-S batteries. Although nitrogen-coordinated metal single-atom (M-N4) catalysts have been investigated, further optimizing its utilization rate and catalytic activities is urgently needed for practical applications. Inspired by the natural alveoli tissue with interconnected structure and well-distributed enzyme catalytic sites on the wall for the simultaneously fast diffusion and in-situ catalytic conversion of substrates, here, we proposed the controllable synthesis of bioinspired carbon cathode with interconnected porous structure and asymmetric coordinated V-S1N3 sites for efficient and stable Li-S batteries. The enzyme-mimetic V-S1N3 shows asymmetric electronic distribution and high tunability, therefore enhancing in-situ polysulfide conversion activities. Experimental and theoretical results reveal that the high charge asymmetry degree and large atom radius of S in V-S1N3 result in sloping adsorption for polysulfide, thereby exhibiting low thermodynamic energy barriers and long-range stability (0.076% decay over 600 cycles).
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202404019
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Article ; Online: Association of acylcarnitines with maternal cardiometabolic risk factors is defined by chain length: the S-PRESTO study.

Chen, Li / Goh, Xue Ping / Bendt, Anne K / Tan, Karen Mei-Ling / Leow, Melvin Khee-Shing / Tan, Kok Hian / Chan, Jerry K Y / Chan, Shiao-Yng / Chong, Yap Seng / Gluckman, Peter D / Eriksson, Johan G / Wenk, Markus R / Mir, Sartaj Ahmad

The Journal of clinical endocrinology and metabolism

2024

Abstract: ... PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort study.: Results: Plasma ...

Abstract	Context: Due to the essential role of carnitine as an intermediary in amino acid, carbohydrate and lipid metabolism, a detailed characterization of circulating and urinary carnitine concentrations will aid in elucidating the molecular basis of impaired maternal metabolic flexibility and facilitating timely intervention for expectant mothers. Objective: To investigate the association of maternal plasma and urinary free carnitine and acylcarnitines with cardiometabolic risk factors. Methods: LC-MS/MS-based quantification of free carnitine and acylcarnitines (C2-C18) was performed on 765 plasma and 702 urine samples collected at preconception, 26-28 weeks' pregnancy, and three months postpartum in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort study. Results: Plasma concentrations of free carnitine and acylcarnitines decreased coupled with increased renal clearance in pregnancy compared to preconception and postpartum. Renal clearance of carnitine increased with an increase in pre-pregnancy body mass index (ppBMI) and gestational weight gain. Plasma short-chain acylcarnitines were positively associated with ppBMI, irrespective of the physiological state, while medium- and long-chain acylcarnitines were negatively associated with ppBMI at preconception and postpartum but showed a positive association in pregnancy. Similarly, plasma short-chain acylcarnitines were positively associated with HOMA-IR whereas medium- and long-chain acylcarnitines were negatively associated with HOMA-IR at preconception and in pregnancy. Mothers who developed gestational diabetes mellitus during pregnancy had ∼10% higher plasma propionylcarnitine concentration and ∼18% higher urine tiglylcarnitine concentration compared to mothers with normal glucose metabolism at preconception. Conclusions: This study provides the metabolic and physiological basis of maternal carnitine homeostasis, which can be used in assessment of maternal cardiometabolic health at preconception to improve pregnancy outcomes.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae255
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Article ; Online: Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

Hendrickx, Diana / An, Ran / Boeren, Sjef / Mutte, Sumanth / Chatchatee, Pantipa / Nowak-Wegrzyn, Anna / Lange, Lars / Benjaponpitak, Suwat / Wee Chong, Kok / Sangsupawanich, Pasuree / van Ampting, Marleen / Oude Nijhuis, Manon / Harthoorn, Lucien / Langford, Jane / Knol, Jan / Knipping, Karen / Garssen, Johan / Trendelenburg, Valerie / Pesek, Robert /

Davis, Carla / Muraro, Antonella / Erlewyn-Lajeunesse, Mich / Fox, Adam / Michaelis, Louise / Beyer, Kirsten / Noimark, Lee / Stiefel, Gary / Schauer, Uwe / Hamelmann, Eckard / Peroni, Diego / Boner, Attilio / Lambert, Jolanda / Belzer, Clara

Scientific Reports

2023 Volume 13, Issue 1

Abstract: ... infants diagnosed with cow’s milk allergy (CMA) when entering the study. Some of the infants showed ...

Abstract	Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome functionality (metaproteomics) in a cohort of 40 infants diagnosed with cow’s milk allergy (CMA) when entering the study. Some of the infants showed outgrowth of CMA after 12 months, while others did not. Faecal microbiota composition of infants was analysed directly after CMA diagnosis (baseline) as well as 6 and 12 months after entering the study. The aim was to gain insight on gut microbiome parameters in relation to outgrowth of CMA. The results of this study show that microbiome differences related to outgrowth of CMA can be mainly identified at the taxonomic level of the 16S rRNA gene, and to a lesser extent at the protein-based microbial taxonomy and functional protein level. At the 16S rRNA gene level outgrowth of CMA is characterized by lower relative abundance of Lachnospiraceae at baseline and lower Bacteroidaceae at visit 12 months.
Keywords	Life Science
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2615211-3
ISSN	2045-2322
ISSN	2045-2322
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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