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  1. Article ; Online: Nonvolatile resistive switching and synaptic characteristics of lead-free all-inorganic perovskite-based flexible memristive devices for neuromorphic systems.

    Siddik, Abubakkar / Haldar, Prabir Kumar / Paul, Tufan / Das, Ujjal / Barman, Arabinda / Roy, Asim / Sarkar, Pranab Kumar

    Nanoscale

    2021  Volume 13, Issue 19, Page(s) 8864–8874

    Abstract: Recently, several types of lead halide perovskites have been actively researched for resistive switching (RS) memory or artificial synaptic devices due to their current-voltage hysteresis along with the feasibility of fabrication, low-temperature ... ...

    Abstract Recently, several types of lead halide perovskites have been actively researched for resistive switching (RS) memory or artificial synaptic devices due to their current-voltage hysteresis along with the feasibility of fabrication, low-temperature processability and superior charge mobility. However, the toxicity and environmental pollution potential of lead halide perovskites severely restrict their large-scale commercial prospects. In the present work, the environmentally friendly and uniform CsSnCl
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d0nr08214g
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  2. Article ; Online: Early lessons from a second COVID-19 lockdown in Leicester, UK.

    Nazareth, Joshua / Minhas, Jatinder S / Jenkins, David R / Sahota, Amandip / Khunti, Kamlesh / Haldar, Pranab / Pareek, Manish

    Lancet (London, England)

    2020  Volume 396, Issue 10245, Page(s) e4–e5

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Communication ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31490-2
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  3. Article: Predictors of adverse outcome in the first and second waves of the COVID-19 pandemic: results from a UK centre.

    Martin, Christopher A / Pan, Daniel / Hills, George / Modha, Deborah / Patel, Prashanth / Gray, Laura J / Jenkins, David R / Barton, Linda / Jones, William / Brunskill, Nigel J / Haldar, Pranab / Khunti, Kamlesh / Pareek, Manish

    Therapeutic advances in infectious disease

    2022  Volume 9, Page(s) 20499361221074569

    Abstract: Background/aims: Data concerning differences in demographics/disease severity between the first and second waves of COVID-19 are limited. We aimed to examine prognosis in patients presenting to hospital with COVID-19 amongst different ethnic groups ... ...

    Abstract Background/aims: Data concerning differences in demographics/disease severity between the first and second waves of COVID-19 are limited. We aimed to examine prognosis in patients presenting to hospital with COVID-19 amongst different ethnic groups between the first and second waves in the UK.
    Methods: In this retrospective cohort study, we included 1763 patients presenting to a regional hospital centre in Leicester (UK) and compared those in the first (
    Results: Thirty-day mortality risk in second wave patients was approximately half that of first wave patients [adjusted hazard ratio (aHR) 0.55, 95% confidence interval (CI) 0.40-0.75]. In the second wave, Black patients were at higher risk of 30-day mortality than White patients (4.73, 1.56-14.3).
    Conclusion: We found that disporportionately higher risks of death in patients from ethnic minority groups were not equivalent across consecutive waves of the pandemic. This suggests that risk factors for death in those from ethnic minority groups are malleable and potentially reversible. Our findings need urgent investigation in larger studies.
    Language English
    Publishing date 2022-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361221074569
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  4. Article: Early lessons from a second COVID-19 lockdown in Leicester, UK

    Nazareth, Joshua / Minhas, Jatinder S / Jenkins, David R / Sahota, Amandip / Khunti, Kamlesh / Haldar, Pranab / Pareek, Manish

    Lancet

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #633438
    Database COVID19

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  5. Article: Dirhodium Tetraacetate: An Effective Catalyst in Organic Synthesis

    Haldar, Pranab

    Synlett

    2005  Volume 2005, Issue 20, Page(s) 3169–3170

    Language English
    Publishing date 2005-11-28
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-2005-922755
    Database Thieme publisher's database

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  6. Article ; Online: Early lessons from a second COVID-19 lockdown in Leicester, UK

    Nazareth, Joshua / Minhas, Jatinder S / Jenkins, David R / Sahota, Amandip / Khunti, Kamlesh / Haldar, Pranab / Pareek, Manish

    The Lancet

    2020  Volume 396, Issue 10245, Page(s) e4–e5

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31490-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Hydrocarbon Chain-Length Dependence of Solvation Dynamics in Alcohol-Based Deep Eutectic Solvents: A Two-Dimensional Infrared Spectroscopic Investigation.

    Chatterjee, Srijan / Ghosh, Deborin / Haldar, Tapas / Deb, Pranab / Sakpal, Sushil S / Deshmukh, Samadhan H / Kashid, Somnath M / Bagchi, Sayan

    The journal of physical chemistry. B

    2019  Volume 123, Issue 44, Page(s) 9355–9363

    Abstract: Deep eutectic solvents (DESs) have gained popularity in recent years as an environmentally benign, inexpensive alternative to organic solvents for diverse applications in chemistry and biology. Among them, alcohol-based DESs serve as useful media in ... ...

    Abstract Deep eutectic solvents (DESs) have gained popularity in recent years as an environmentally benign, inexpensive alternative to organic solvents for diverse applications in chemistry and biology. Among them, alcohol-based DESs serve as useful media in various applications due to their significantly low viscosity as compared to other DESs. Despite their importance as media, little is known how their solvation dynamics change as a function of the hydrocarbon chain length of the alcohol constituent. In order to obtain insights into the chain-length dependence of the solvation dynamics, we have performed two-dimensional infrared spectroscopy on three alcohol-based DESs by systematically varying the hydrocarbon chain length. The results reveal that the solvent dynamics slows down monotonically with an increase in the chain length. This increase in the dynamic timescales also shows a strong correlation with the concomitant increase in the viscosity of DESs. In addition, we have performed molecular dynamics simulations to compare with the experimental results, thereby testing the capacity of simulations to determine the amplitudes and timescales of the structural fluctuations on fast timescales under thermal equilibrium conditions.
    Language English
    Publishing date 2019-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.9b08954
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  8. Article ; Online: A validated chiral LC method for enantiomeric separation of nebivolol stereoisomers in bulk drugs and dosage forms on amylose-based stationary phase.

    Visweswara Rao, Karri / Padmaja Reddy, Kesareddy / Haldar, Pranab

    Journal of chromatographic science

    2014  Volume 52, Issue 9, Page(s) 1051–1058

    Abstract: A novel and reproducible isocratic normal phase liquid chromatographic method was developed for the quantitative determination of 10 stereoisomers of Nebivolol in pharmaceutical bulk drugs and dosage forms. The method was developed using an amylose-based ...

    Abstract A novel and reproducible isocratic normal phase liquid chromatographic method was developed for the quantitative determination of 10 stereoisomers of Nebivolol in pharmaceutical bulk drugs and dosage forms. The method was developed using an amylose-based chiral stationary phase, Chiralpak AD-3 (250 × 4.6 mm, 3 μm) column with mobile phase containing n-hexane-ethanol-isopropanol-diethanolamine in the ratio 42:45:13:0.1 (v/v/v/v). The eluted compounds were monitored at 280 nm. Ten stereoisomers of Nebivolol were well separated with resolution >2.0 for all pair of components. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, linearity (R(2) value >0.999), limit of detection, limit of quantification, accuracy (recovery range 95.8-103.2%), precision (relative standard deviation, RSD, <2.5%) and robustness. Nebivolol sample solutions were found to be stable when characterized over a period of 48 h. Forced degradation studies were also performed to demonstrate the stability-indicating power of the developed HPLC method. The method was found to be rugged and robust.
    MeSH term(s) Amylose/analogs & derivatives ; Amylose/chemistry ; Benzopyrans/analysis ; Benzopyrans/isolation & purification ; Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/methods ; Dosage Forms ; Ethanolamines/analysis ; Ethanolamines/chemistry ; Ethanolamines/isolation & purification ; Hexanes/chemistry ; Limit of Detection ; Nebivolol ; Phenylcarbamates/chemistry ; Reproducibility of Results ; Stereoisomerism
    Chemical Substances Benzopyrans ; Dosage Forms ; Ethanolamines ; Hexanes ; Phenylcarbamates ; Nebivolol (030Y90569U) ; Chiralpak AD (138361-09-8) ; n-hexane (2DDG612ED8) ; Amylose (9005-82-7) ; diethanolamine (AZE05TDV2V)
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80141-0
    ISSN 1945-239X ; 0021-9665
    ISSN (online) 1945-239X
    ISSN 0021-9665
    DOI 10.1093/chromsci/bmt158
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  9. Article ; Online: Pick and Choose the Spectroscopic Method to Calibrate the Local Electric Field inside Proteins.

    Haldar, Tapas / Kashid, Somnath M / Deb, Pranab / Kesh, Sandeep / Bagchi, Sayan

    The journal of physical chemistry letters

    2016  Volume 7, Issue 13, Page(s) 2456–2460

    Abstract: Electrostatic interactions in proteins play a crucial role in determining the structure-function relation in biomolecules. In recent years, fluorescent probes have been extensively employed to interrogate the polarity in biological cavities through ... ...

    Abstract Electrostatic interactions in proteins play a crucial role in determining the structure-function relation in biomolecules. In recent years, fluorescent probes have been extensively employed to interrogate the polarity in biological cavities through dielectric constants or semiempirical polarity scales. A choice of multiple spectroscopic methods, not limited by fluorophores, along with a molecular level description of electrostatics involving solute-solvent interactions, would allow more flexibility to pick and choose the experimental technique to determine the local electrostatics within protein interiors. In this work we report that ultraviolet/visible-absorption, infrared-absorption, or (13)C NMR can be used to calibrate the local electric field in both hydrogen bonded and non-hydrogen bonded protein environments. The local electric field at the binding site of a serum protein has been determined using the absorption wavelength as well as the carbonyl stretching frequency of its natural steroid substrate, testosterone. Excellent agreement is observed in the results obtained from two independent spectroscopic techniques.
    Language English
    Publishing date 2016-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.6b00852
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  10. Article ; Online: No cases of asymptomatic SARS-CoV-2 infection among healthcare staff in a city under lockdown restrictions: lessons to inform 'Operation Moonshot'.

    Martin, Christopher A / Jenkins, David R / Patel, Prashanth / Goss, Charles / Price, Arthur / Barton, Linda / Gupta, Pankaj / Zaccardi, Francesco / Brunskill, Nigel J / Haldar, Pranab / Khunti, Kamlesh / Pareek, Manish

    Journal of public health (Oxford, England)

    2020  Volume 44, Issue 2, Page(s) 255–258

    Abstract: Background: Leicester was the first city in the UK to have 'local lockdown' measures imposed in response to high community rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. As part of this response, a directive was ... ...

    Abstract Background: Leicester was the first city in the UK to have 'local lockdown' measures imposed in response to high community rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. As part of this response, a directive was issued by NHS England to offer testing of asymptomatic healthcare workers (HCWs) at University Hospitals of Leicester NHS Trust (UHL) for SARS-CoV-2 infection.
    Methods: Between 20 July and 14 August 2020, we invited all HCWs at UHL to attend for SARS-CoV-2 testing by nucleic acid amplification (NAAT). We combined the result of this assay with demographic information from the electronic staff record.
    Results: A total of 1150 staff (~8% of the workforce) volunteered. The median age was 46 years (IQR 34-55), 972 (84.5%) were female; 234 (20.4%) were of South Asian and 58 (5.0%) of Black ethnicity; 564 (49.0%) were nurses/healthcare assistants. We found no cases of asymptomatic infection. In comparison, average community test positivity rate in Leicester city was 2.6%.
    Conclusions: Within the context of local lockdowns due to high community transmission rates, voluntary testing of asymptomatic staff has low uptake and low yield and thus its premise and cost-effectiveness should be re-considered.
    MeSH term(s) COVID-19/epidemiology ; COVID-19 Testing ; Communicable Disease Control ; Delivery of Health Care ; Female ; Health Personnel ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; Male ; Middle Aged ; SARS-CoV-2
    Language English
    Publishing date 2020-12-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdaa237
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