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Article ; Online: Low vaccination coverage for human papillomavirus disease among young men who have sex with men, France, 2019.

Ortu, Giuseppina / Barret, Anne-Sophie / Danis, Kostas / Duchesne, Lucie / Levy-Bruhl, Daniel / Velter, Annie

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 50

Abstract: BackgroundIn France, human papillomavirus (HPV) vaccination has been recommended in 2016 for men who have sex with men (MSM) up to age 26 years.AimWe aimed to estimate HPV vaccine coverage in 18-28 year-old MSM and identify uptake determinants.MethodsWe ... ...

Abstract	BackgroundIn France, human papillomavirus (HPV) vaccination has been recommended in 2016 for men who have sex with men (MSM) up to age 26 years.AimWe aimed to estimate HPV vaccine coverage in 18-28 year-old MSM and identify uptake determinants.MethodsWe collected data on socio-demographic characteristics, sexual behaviour, sexually transmitted diseases (STI) screening and vaccination uptake using a voluntary cross-sectional online survey conducted in 2019 targeting MSM. We calculated coverage of at least one dose of HPV vaccine and prevalence ratios (PR) of determinants with 95% confidence intervals (CI) using Poisson regression.ResultsOf 9,469 respondents (age range: 18-28 years), 15% (95% CI: 14-16) reported being vaccinated for HPV. Coverage was significantly higher among MSM < 24 years (PR: 1.25; 95% CI: 1.13-1.39), with education level below university degree (PR: 1.12; 95% CI: 1.08-1.32), living in rural areas (PR: 1.21; 95% CI: 1.08-1.36), attending sex parties (PR: 1.12; 95% CI: 1.03-1.33), using HIV-related biomedical prevention methods (PR: 1.31; 95% CI: 1.12-1.54), with STI diagnosis (PR: 1.22; 95% CI: 1.08-1.38) and with hepatitis A or B vaccination (PR: 4.56; 95% CI: 3.63-5.81 vs PR: 3.35; 95% CI: 2.53-4.44).ConclusionsThe HPV vaccination uptake among MSM in France was not satisfactory. It was higher among MSM benefitting from other vaccinations and biomedical preventive methods against HIV, suggesting a synergistic effect of the national preventive sexual health recommendations for MSM. Further efforts to improve HPV vaccination coverage targeting MSM are warranted.
MeSH term(s)	Adolescent ; Adult ; Alphapapillomavirus ; Cross-Sectional Studies ; France/epidemiology ; Homosexuality, Male ; Humans ; Male ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines ; Patient Acceptance of Health Care ; Sexual Behavior ; Sexual and Gender Minorities ; Vaccination ; Vaccination Coverage ; Young Adult
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2021-12-17
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.50.2001965
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Zs.A 5066: Show issues

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Article ; Online: Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014-16 Ebola outbreak in Bo District, Sierra Leone.

Caleo, Grazia / Lokuge, Kamalini / Kardamanidis, Katina / Greig, Jane / Belava, Jaroslava / Kilbride, Emer / Sayui Turay, Alhaji / Saffa, Gbessay / Kremer, Ronald / Grandesso, Francesco / Danis, Kostas / Sprecher, Armand / Luca Di Tanna, Gian / Baker, Holly / Weiss, Helen A

Global health action

2024 Volume 17, Issue 1, Page(s) 2331291

Abstract: Background: There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operational utility of ... ...

Abstract	Background: There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operational utility of mortality estimated from cluster-sampled studies when the DEFF is high. Objectives: The objectives of this paper are to report EVD mortality rate and DEFF estimates, and discuss the methodological limitations of cluster surveys when data are highly clustered such as during an EVD outbreak. Methods: We analysed the outputs of two independent population-based surveys conducted at the end of the 2014-2016 EVD outbreak in Bo District, Sierra Leone, in urban and rural areas. In each area, 35 clusters of 14 households were selected with probability proportional to population size. We collected information on morbidity, mortality and changes in household composition during the recall period (May 2014 to April 2015). Rates were calculated for all-cause, all-age, under-5 and EVD-specific mortality, respectively, by areas and overall. Crude and adjusted mortality rates were estimated using Poisson regression, accounting for the surveys sample weights and the clustered design. Results: Overall 980 households and 6,522 individuals participated in both surveys. A total of 64 deaths were reported, of which 20 were attributed to EVD. The crude and EVD-specific mortality rates were 0.35/10,000 person-days (95%CI: 0.23-0.52) and 0.12/10,000 person-days (95%CI: 0.05-0.32), respectively. The DEFF for EVD mortality was 5.53, and for non-EVD mortality, it was 1.53. DEFF for EVD-specific mortality was 6.18 in the rural area and 0.58 in the urban area. DEFF for non-EVD-specific mortality was 1.87 in the rural area and 0.44 in the urban area. Conclusion: Our findings demonstrate a high degree of clustering; this contributed to imprecise mortality estimates, which have limited utility when assessing the impact of disease. We provide DEFF estimates that can inform future cluster surveys and discuss design improvements to mitigate the limitations of surveys for highly clustered data.
MeSH term(s)	Humans ; Sierra Leone/epidemiology ; Hemorrhagic Fever, Ebola/mortality ; Hemorrhagic Fever, Ebola/epidemiology ; Disease Outbreaks ; Retrospective Studies ; Adult ; Female ; Adolescent ; Child, Preschool ; Male ; Middle Aged ; Young Adult ; Cluster Analysis ; Child ; Infant ; Rural Population/statistics & numerical data ; Urban Population ; Surveys and Questionnaires
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540569-X
ISSN	1654-9880 ; 1654-9880
ISSN (online)	1654-9880
ISSN	1654-9880
DOI	10.1080/16549716.2024.2331291
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Article ; Online: Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV.

Delestrain, Céline / Danis, Kostas / Hau, Isabelle / Behillil, Sylvie / Billard, Marie-Noëlle / Krajten, Leyla / Cohen, Robert / Bont, Louis / Epaud, Ralph

Pediatric pulmonology

2021 Volume 56, Issue 12, Page(s) 3669–3673

Abstract: Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV).: Methods: We analyzed French national data from three networks: ... ...

Abstract	Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV). Methods: We analyzed French national data from three networks: emergency departments (ED) of French hospitals, general practitioners (GP), and hospital laboratories. We compared the number of ED or GP visits for bronchiolitis in children <2 years of age, and the percentage of RSV positive tests in the 2020 to 2021 season with those of the two previous seasons (2018-2019 and 2019-2020). We used time series of the previous 5 years to calculate epidemic thresholds. Results: During the 2020-2021 season, the epidemic begun in February (Week 05) in the Ile de France (Paris and suburbs) region, 12 weeks later compared with the previous seasons and progressively spread across all the French metropolitan regions. The highest number of bronchiolitis cases in 2021 (Week 12) occurred 10-12 weeks after the previous seasonal peaks of previous seasons, but the number of cases remained lower than in the previous seasonal peaks. Conclusion: We identified a delayed RSV epidemic in the period that usually corresponds at the end of the epidemic season, raising concerns for the burden of RSV in the already strained healthcare systems during the COVID-19 pandemic.
MeSH term(s)	COVID-19 ; Child ; Communicable Disease Control ; Disease Outbreaks ; France/epidemiology ; Humans ; Infant ; Pandemics ; Physical Distancing ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human ; SARS-CoV-2 ; Seasons
Language	English
Publishing date	2021-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.25644
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Zs.A 2143: Show issues

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Article ; Online: Socioeconomic disparities associated with 29 common infectious diseases in Sweden, 2005-14: an individually matched case-control study.

Pini, Alessandro / Stenbeck, Magnus / Galanis, Ilias / Kallberg, Henrik / Danis, Kostas / Tegnell, Anders / Wallensten, Anders

The Lancet. Infectious diseases

2018 Volume 19, Issue 2, Page(s) 165–176

Abstract: Background: Although the association between low socioeconomic status and non-communicable diseases is well established, the effect of socioeconomic factors on many infectious diseases is less clear, particularly in high-income countries. We examined ... ...

Abstract	Background: Although the association between low socioeconomic status and non-communicable diseases is well established, the effect of socioeconomic factors on many infectious diseases is less clear, particularly in high-income countries. We examined the associations between socioeconomic characteristics and 29 infections in Sweden. Methods: We did an individually matched case-control study in Sweden. We defined a case as a person aged 18-65 years who was notified with one of 29 infections between 2005 and 2014, in Sweden. Cases were individually matched with respect to sex, age, and county of residence with five randomly selected controls. We extracted the data on the 29 infectious diseases from the electronic national register of notified infections and infectious diseases (SmiNet). We extracted information on country of birth, educational and employment status, and income of cases and controls from Statistics Sweden's population registers. We calculated adjusted matched odds ratios (amOR) using conditional logistic regression to examine the association between infections or groups of infections and place of birth, education, employment, and income. Findings: We included 173 729 cases notified between Jan 1, 2005, and Dec 31, 2014 and 868 645 controls. Patients with invasive bacterial diseases, blood-borne infectious diseases, tuberculosis, and antibiotic-resistant infections were more likely to be unemployed (amOR 1·59, 95% CI 1·49-1·70; amOR 3·62, 3·48-3·76; amOR 1·88, 1·65-2·14; and amOR 1·73, 1·67-1·79, respectively), to have a lower educational attainment (amOR 1·24, 1·15-1·34; amOR 3·63, 3·45-3·81; amOR 2·14, 1·85-2·47; and amOR 1·07, 1·03-1·12, respectively), and to have a lowest income (amOR 1·52, 1·39-1·66; amOR 3·64, 3·41-3·89; amOR 3·17, 2·49-4·04; and amOR 1·2, 1·14-1·25, respectively). By contrast, patients with food-borne and water-borne infections were less likely than controls to be unemployed (amOR 0·74, 95% CI 0·72-0·76), to have lower education (amOR 0·75, 0·73-0·77), and lowest income (amOR 0·59, 0·58-0·61). Interpretation: These findings indicate persistent socioeconomic inequalities in infectious diseases in an egalitarian high-income country with universal health care. We recommend using these findings to identify priority interventions and as a baseline to monitor programmes addressing socioeconomic inequalities in health. Funding: The Public Health Agency of Sweden.
MeSH term(s)	Adolescent ; Adult ; Aged ; Case-Control Studies ; Communicable Diseases/epidemiology ; Female ; Healthcare Disparities/trends ; Humans ; Income ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Socioeconomic Factors ; Sweden/epidemiology ; Unemployment ; Young Adult
Language	English
Publishing date	2018-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(18)30485-7
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Zs.A 5743: Show issues

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Article ; Online: Coronavirus Disease 2019 in French Residential Care Facilities: A Nationwide Study.

Belmin, Joël / Georges, Scarlett / Franke, Florian / Daniau, Come / Cochet, Amandine / Durand, Cécile / Noury, Ursula / Gomes do Espirito Santo, Maria Eugênia / Fonteneau, Laure / Pariel, Sylvie / Lafuente-Lafuente, Carmelo / Danis, Kostas

Journal of the American Medical Directors Association

2021 Volume 22, Issue 6, Page(s) 1142–1145

Abstract: Objectives: The Coronavirus 2019 (COVID-19) pandemic caused a considerable mortality in long-term care facilities (LTCFs), including residential care setting and nursing homes. This study aimed to estimate COVID-19 incidence and mortality in residential ...

Abstract	Objectives: The Coronavirus 2019 (COVID-19) pandemic caused a considerable mortality in long-term care facilities (LTCFs), including residential care setting and nursing homes. This study aimed to estimate COVID-19 incidence and mortality in residential care facilities and to compare them with those recorded in nursing homes. Design: Nationwide observational study conducted by French health authorities. Settings and participants: Since March 1, 2020, all LTCFs in France reported all COVID-19 cases and COVID-19-related deaths among their residents. Methods: Possible cases were those with COVID-19-related symptoms without laboratory confirmation and confirmed cases those with a reverse transcriptase polymerase chain reaction test or serology positive for SARS-CoV-2. We included facilities with at least 1 confirmed case of COVID-19 and estimated the cumulative incidence of COVID-19 cases and mortality due to COVID-19 reported until June 30, 2020, using the maximum bed capacity as a denominator. Results: Of the 2288 residential care facilities, 310 (14%) and, of the 7688 nursing homes, 3110 (40%) reported COVID-19 cases among residents (P < .001). The cumulative incidence of COVID-19 was significantly lower in residential care facilities as compared with nursing homes (1.10 vs 9.97 per 100 beds, P < .001). Mortality due to COVID-19 was also lower in residential care facilities compared with nursing homes (0.07 vs 1.29 per 100 beds, P < .001). Case fatality was lower in residential care facilities (6.49% vs 12.93%, P < .001). Conclusion and implications: French residential care facilities experienced a much lower burden from COVID-19 than nursing homes. Our findings may inform the implementation of better infection control practices in these settings.
MeSH term(s)	COVID-19/epidemiology ; France/epidemiology ; Humans ; Nursing Homes ; Pandemics ; Residential Facilities ; SARS-CoV-2
Language	English
Publishing date	2021-03-20
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2021.03.013
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Zs.A 5971: Show issues

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Article ; Online: Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease.

Benadji, Amine / Duval, Xavier / Danis, Kostas / Hoen, Bruno / Page, Bernard / Béraud, Guillaume / Vernet-Garnier, Véronique / Strady, Christophe / Brieu, Nathalie / Maulin, Laurence / Roy, Carine / Ploy, Marie-Cécile / Gaillat, Jacques / Varon, Emmanuelle / Tubiana, Sarah

Infection

2021 Volume 50, Issue 1, Page(s) 223–233

Abstract: Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from ... ...

Abstract	Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015. Methods: This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression. Results: Among the 771 enrolled patients (median age 66 years, IQR [52.0-79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines. Conclusion: We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients. Clinical trial: ClinicalTrial. Gov identification number: NCT01730690.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cohort Studies ; Humans ; Infant ; Meningitis, Pneumococcal/epidemiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae
Chemical Substances	Pneumococcal Vaccines
Language	English
Publishing date	2021-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-021-01688-5
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association of Nonpharmaceutical Interventions During the COVID-19 Pandemic With Invasive Pneumococcal Disease, Pneumococcal Carriage, and Respiratory Viral Infections Among Children in France.

Rybak, Alexis / Levy, Corinne / Angoulvant, François / Auvrignon, Anne / Gembara, Piotr / Danis, Kostas / Vaux, Sophie / Levy-Bruhl, Daniel / van der Werf, Sylvie / Béchet, Stéphane / Bonacorsi, Stéphane / Assad, Zein / Lazzati, Andréa / Michel, Morgane / Kaguelidou, Florentia / Faye, Albert / Cohen, Robert / Varon, Emmanuelle / Ouldali, Naïm

JAMA network open

2022 Volume 5, Issue 6, Page(s) e2218959

Abstract: Importance: An association between pneumococcal nasopharyngeal carriage and invasive pneumococcal disease (IPD) has been previously established. However, it is unclear whether the decrease in IPD incidence observed after implementation of ... ...

Abstract	Importance: An association between pneumococcal nasopharyngeal carriage and invasive pneumococcal disease (IPD) has been previously established. However, it is unclear whether the decrease in IPD incidence observed after implementation of nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic was associated with concomitant changes in pneumococcal carriage and respiratory viral infections. Objective: To assess changes in IPD incidence after the implementation of NPIs during the COVID-19 pandemic and examine their temporal association with changes in pneumococcal carriage rate and respiratory viral infections (specifically respiratory syncytial virus [RSV] and influenza cases) among children in France. Design, setting, and participants: This cohort study used interrupted time series analysis of data from ambulatory and hospital-based national continuous surveillance systems of pneumococcal carriage, RSV and influenza-related diseases, and IPD between January 1, 2007, and March 31, 2021. Participants included 11 944 children younger than 15 years in France. Exposures: Implementation of NPIs during the COVID-19 pandemic. Main outcomes and measures: The estimated fraction of IPD change after implementation of NPIs and the association of this change with concomitant changes in pneumococcal carriage rate and RSV and influenza cases among children younger than 15 years. The estimated fraction of change was analyzed using a quasi-Poisson regression model. Results: During the study period, 5113 children (median [IQR] age, 1.0 [0.6-4.0] years; 2959 boys [57.9%]) had IPD, and 6831 healthy children (median [IQR] age, 1.5 [0.9-3.9] years; 3534 boys [51.7%]) received a swab test. Data on race and ethnicity were not collected. After NPI implementation, IPD incidence decreased by 63% (95% CI, -82% to -43%; P < .001) and was similar for non-13-valent pneumococcal conjugate vaccine serotypes with both high disease potential (-63%; 95% CI, -77% to -48%; P < .001) and low disease potential (-53%; 95% CI, -70% to -35%; P < .001). The overall pneumococcal carriage rate did not significantly change after NPI implementation (-12%; 95% CI, -37% to 12%; P = .32), nor did the carriage rate for non-PCV13 serotypes with high disease potential (-26%; 95% CI, -100% to 52%; P = .50) or low disease potential (-7%; 95% CI, -34% to 20%; P = .61). After NPI implementation, the estimated number of influenza cases decreased by 91% (95% CI, -74% to -97%; P < .001), and the estimated number of RSV cases decreased by 74% (95% CI, -55% to -85%; P < .001). Overall, the decrease in influenza and RSV cases accounted for 53% (95% CI, -28% to -78%; P < .001) and 40% (95% CI, -15% to -65%; P = .002) of the decrease in IPD incidence during the NPI period, respectively. The decrease in IPD incidence was not associated with pneumococcal carriage, with carriage accounting for only 4% (95% CI, -7% to 15%; P = .49) of the decrease. Conclusions and relevance: In this cohort study of data from multiple national continuous surveillance systems, a decrease in pediatric IPD incidence occurred after the implementation of NPIs in France; this decrease was associated with a decrease in viral infection cases rather than pneumococcal carriage rate. The association between pneumococcal carriage and IPD was potentially modified by changes in the number of RSV and influenza cases, suggesting that interventions targeting respiratory viruses, such as immunoprophylaxis or vaccines for RSV and influenza, may be able to prevent a large proportion of pediatric IPD cases.
MeSH term(s)	COVID-19/epidemiology ; Child ; Cohort Studies ; Humans ; Infant ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Male ; Pandemics ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Streptococcus pneumoniae ; Viruses
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.18959
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Article ; Online: Emerging Shiga-toxin-producing Escherichia coli serogroup O80 associated hemolytic and uremic syndrome in France, 2013-2016: Differences with other serogroups.

Ingelbeen, Brecht / Bruyand, Mathias / Mariani-Kurkjian, Patricia / Le Hello, Simon / Danis, Kostas / Sommen, Cécile / Bonacorsi, Stéphane / de Valk, Henriette

PloS one

2018 Volume 13, Issue 11, Page(s) e0207492

Abstract: To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or ... ...

Abstract	To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013-16. STEC was isolated from 153/521 (30%) reported HUS cases: 45 serogroup O80, 46 O157 and 62 other serogroups. Median ages were 1.1 years, 4.0 years and 1.8 years, respectively. O80 infected patients were less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0.14 95% CI [Confidence Interval] 0.02-0.80) or previous contact with a person with diarrhea or HUS (aOR 0.13 95%CI 0.02-0.78) than patients infected with STEC O157. They were also less likely to report previous contact with a person presenting with diarrhea/HUS than patients infected with other serogroups (aOR 0.13 95%CI 0.02-0.78). STEC O80 spread all over France among young children less exposed to known risk factors of O157 or other STEC infections, suggesting the existence of different reservoirs and transmission patterns.
MeSH term(s)	Child, Preschool ; Diarrhea/epidemiology ; Diarrhea/microbiology ; Female ; France/epidemiology ; Hemolytic-Uremic Syndrome/epidemiology ; Hemolytic-Uremic Syndrome/microbiology ; Humans ; Infant ; Male ; Red Meat/microbiology ; Retrospective Studies ; Serogroup ; Shiga-Toxigenic Escherichia coli
Language	English
Publishing date	2018-11-12
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0207492
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Article ; Online: New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.

Teirlinck, Anne C / Johannesen, Caroline K / Broberg, Eeva K / Penttinen, Pasi / Campbell, Harry / Nair, Harish / Reeves, Rachel M / Bøås, Håkon / Brytting, Mia / Cai, Wei / Carnahan, AnnaSara / Casalegno, Jean-Sebastien / Danis, Kostas / De Gascun, Cillian / Ellis, Joanna / Emborg, Hanne-Dorthe / Gijon, Manuel / Guiomar, Raquel / Hirve, Siddhivinayak S /

The European respiratory journal

2023 Volume 61, Issue 4

MeSH term(s)	Humans ; Pandemics ; COVID-19/epidemiology ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Tract Infections/epidemiology
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01569-2022
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Zs.MO 292: Show issues

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Article ; Online: Clinical and epidemiological performance of WHO Ebola case definitions: a systematic review and meta-analysis.

Caleo, Grazia / Theocharaki, Foivi / Lokuge, Kamalini / Weiss, Helen A / Inamdar, Leena / Grandesso, Francesco / Danis, Kostas / Pedalino, Biagio / Kobinger, Gary / Sprecher, Armand / Greig, Jane / Di Tanna, Gian Luca

The Lancet. Infectious diseases

2020 Volume 20, Issue 11, Page(s) 1324–1338

Abstract: Background: Ebola virus disease case definition is a crucial surveillance tool to detect suspected cases for referral and as a screening tool for clinicians to support admission and laboratory testing decisions at Ebola health facilities. We aimed to ... ...

Abstract	Background: Ebola virus disease case definition is a crucial surveillance tool to detect suspected cases for referral and as a screening tool for clinicians to support admission and laboratory testing decisions at Ebola health facilities. We aimed to assess the performance of the WHO Ebola virus disease case definitions and other screening scores. Methods: In this systematic review and meta-analysis, we searched PubMed, Scopus, Embase, and Web of Science for studies published in English between June 13, 1978, and Jan 14, 2020. We included studies that estimated the sensitivity and specificity of WHO Ebola virus disease case definitions, clinical and epidemiological characteristics (symptoms at admission and contact history), and predictive risk scores against the reference standard (laboratory-confirmed Ebola virus disease). Summary estimates of sensitivity and specificity were calculated using bivariate and hierarchical summary receiver operating characteristic (when four or more studies provided data) or random-effects meta-analysis (fewer than four studies provided data). Findings: We identified 2493 publications, of which 14 studies from four countries (Sierra Leone, Guinea, Liberia, and Angola) were included in the analysis. 12 021 people with suspected disease were included, of whom 4874 were confirmed as positive for Ebola virus infection. Six studies explored the performance of WHO case definitions in non-paediatric populations, and in all of these studies, suspected and probable cases were combined and could not be disaggregated for analysis. The pooled sensitivity of the WHO Ebola virus disease case definitions from these studies was 81·5% (95% CI 74·1-87·2) and pooled specificity was 35·7% (28·5-43·6). History of contact or epidemiological link was a key predictor for the WHO case definitions (seven studies) and for risk scores (six studies). The most sensitive symptom was intense fatigue (79·0% [95% CI 74·4-83·0]), assessed in seven studies, and the least sensitive symptom was pain behind the eyes (1·0% [0·0-7·0]), assessed in three studies. The performance of fever as a symptom varied depending on the cutoff used to define fever. Interpretation: WHO Ebola virus disease case definitions perform suboptimally to identify cases at both community level and during triage at Ebola health facilities. Inclusion of intense fatigue as a key symptom and contact history could improve the performance of case definitions, but implementation of these changes will require effective collaboration with, and trust of, affected communities. Funding: Médecins sans Frontières.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angola/epidemiology ; Child ; Child, Preschool ; Diagnostic Techniques and Procedures ; Diarrhea/diagnosis ; Disease Outbreaks ; Ebolavirus ; Epidemiological Monitoring ; Fatigue/diagnosis ; Female ; Fever/diagnosis ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/diagnosis ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/physiopathology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Infant ; Infant, Newborn ; Liberia/epidemiology ; Male ; Middle Aged ; ROC Curve ; Sensitivity and Specificity ; Sierra Leone/epidemiology ; Young Adult
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(20)30193-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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