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  1. Article ; Online: High-dose insulin should be used before vasopressors/inotropes in calcium-channel blocker toxicity.

    Mégarbane, Bruno

    British journal of clinical pharmacology

    2023  Volume 89, Issue 4, Page(s) 1269–1274

    Abstract: High-dose insulin (HDI) therapy with adapted glucose supplementation to maintain euglycaemia has been suggested to treat calcium-channel blocker (CCB) poisonings. Its underlying mechanisms of action are now well documented. We present a narrative review ... ...

    Abstract High-dose insulin (HDI) therapy with adapted glucose supplementation to maintain euglycaemia has been suggested to treat calcium-channel blocker (CCB) poisonings. Its underlying mechanisms of action are now well documented. We present a narrative review of the published experimental studies, case reports and experts' opinions to support the effectiveness and safety of HDI in the treatment of CCB poisoning. Our review strongly encourages the use of HDI as first-line therapy in CCB-poisoned patients in the presence of cardiovascular compromise, especially if cardiac function impairment has been diagnosed, before, but without delaying, the administration of vasopressors/inotropic drugs.
    MeSH term(s) Humans ; Insulin/adverse effects ; Calcium Channel Blockers/therapeutic use ; Calcium ; Glucose ; Vasoconstrictor Agents
    Chemical Substances Insulin ; Calcium Channel Blockers ; Calcium (SY7Q814VUP) ; Glucose (IY9XDZ35W2) ; Vasoconstrictor Agents
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Statin Therapy to Improve Outcome of COVID-19 Patients: Useful or Not Useful?

    Mégarbane, Bruno

    Journal of personalized medicine

    2022  Volume 12, Issue 10

    Abstract: About one year ago, the journal published a large population-based cohort study from South Korea investigating the potential benefits associated with statins at preventing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or ... ...

    Abstract About one year ago, the journal published a large population-based cohort study from South Korea investigating the potential benefits associated with statins at preventing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or improving the outcome of hospitalized coronavirus disease-2019 (COVID-19) patients [...].
    Language English
    Publishing date 2022-10-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12101627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Time Has Come to Understand the Mechanisms by Which Comorbidities Contribute to COVID-19 Severity.

    Mégarbane, Bruno

    Journal of personalized medicine

    2022  Volume 12, Issue 2

    Abstract: A new coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been responsible for a worldwide pandemic for two years, resulting in almost 280 million infections and 5 [ ... ]. ...

    Abstract A new coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been responsible for a worldwide pandemic for two years, resulting in almost 280 million infections and 5 [...].
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12020123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Time Has Come to Understand the Mechanisms by Which Comorbidities Contribute to COVID-19 Severity

    Bruno Mégarbane

    Journal of Personalized Medicine, Vol 12, Iss 123, p

    2022  Volume 123

    Abstract: A new coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been responsible for a worldwide pandemic for two years, resulting in almost 280 million infections and 5 [.] ...

    Abstract A new coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been responsible for a worldwide pandemic for two years, resulting in almost 280 million infections and 5 [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Statin Therapy to Improve Outcome of COVID-19 Patients

    Bruno Mégarbane

    Journal of Personalized Medicine, Vol 12, Iss 1627, p

    Useful or Not Useful?

    2022  Volume 1627

    Abstract: About one year ago, the journal published a large population-based cohort study from South Korea investigating the potential benefits associated with statins at preventing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or ... ...

    Abstract About one year ago, the journal published a large population-based cohort study from South Korea investigating the potential benefits associated with statins at preventing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or improving the outcome of hospitalized coronavirus disease-2019 (COVID-19) patients [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution.

    Mégarbane, Bruno

    Clinical toxicology (Philadelphia, Pa.)

    2020  Volume 59, Issue 1, Page(s) 70–71

    MeSH term(s) COVID-19/drug therapy ; Chloroquine/adverse effects ; Chloroquine/therapeutic use ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country England
    Document type Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2020.1748194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Carbon monoxide intoxication in the 21st century: the battle to improve outcomes continues.

    Mégarbane, Bruno

    Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

    2019  Volume 31, Issue 5, Page(s) 300–301

    Title translation Intoxicación por monóxido de carbono en el siglo XXI: la lucha para conseguir un mejor resultado continúa.
    MeSH term(s) Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Carbon Monoxide Poisoning/complications ; Carbon Monoxide Poisoning/diagnosis ; Carbon Monoxide Poisoning/therapy ; Emergency Treatment/methods ; Humans ; Hyperbaric Oxygenation ; Oximetry/methods ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-10-17
    Publishing country Spain
    Document type Editorial
    ZDB-ID 2127173-2
    ISSN 2386-5857 ; 1137-6821
    ISSN (online) 2386-5857
    ISSN 1137-6821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intravenous Lipid Emulsion for treating Tramadol-Induced Seizures: Surprising but Worth Considering for Future Studies; a Letter to Editor.

    Mégarbane, Bruno / Gouda, Ahmed S

    Archives of academic emergency medicine

    2022  Volume 10, Issue 1, Page(s) e14

    Language English
    Publishing date 2022-02-09
    Publishing country Iran
    Document type Journal Article
    ISSN 2645-4904
    ISSN (online) 2645-4904
    DOI 10.22037/aaem.v10i1.1541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury.

    Vodovar, Dominique / Mégarbane, Bruno

    The New England journal of medicine

    2022  Volume 386, Issue 23, Page(s) 2250

    MeSH term(s) Acute Kidney Injury/therapy ; Humans ; Kidney ; Renal Replacement Therapy
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2204453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extracorporeal life support as a bridge to lung transplantation strategy in anti-MDA5+ rapidly progressive interstitial lung disease is life-saving but with persistent difficulties at the bedside.

    Comarmond, Cloé / Mégarbane, Bruno

    The European respiratory journal

    2022  Volume 60, Issue 1

    MeSH term(s) Autoantibodies ; Extracorporeal Membrane Oxygenation ; Humans ; Lung Diseases, Interstitial/therapy ; Lung Transplantation
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00817-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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