Article ; Online: Serum IgG Concentrations in Adult Patients Experiencing Virus-Induced Severe Asthma Exacerbations.
The journal of allergy and clinical immunology. In practice
2019 Volume 7, Issue 5, Page(s) 1507–1513.e1
Abstract: Background: Patients experiencing severe asthma exacerbations have a poorer quality of life and an increase in morbidity and mortality. Viruses are frequently involved in asthma exacerbations.: Objective: To determine the value of measuring serum IgG ...
| Abstract | Background: Patients experiencing severe asthma exacerbations have a poorer quality of life and an increase in morbidity and mortality. Viruses are frequently involved in asthma exacerbations. Objective: To determine the value of measuring serum IgG concentrations in asthma exacerbations and assess their link with viral infections in patients hospitalized for asthma. Methods: Patients hospitalized for asthma exacerbation were included in an observational study from January 1, 2015, to December 31, 2015. Serum IgG concentrations on admission were compared between patients with a positive upper airway viral sample and those with a negative viral sample. Results: Among the 82 patients included, those with positive viral nasopharyngeal samples (n = 40) presented with lower serum IgG concentrations during exacerbation than those with a negative viral sample (n = 42) (10.1 ± 2.3 g/L vs 11.5 ± 3.6 g/L; P < .05). The median concentration of serum IgG was lower in patients hospitalized for more than 3 days compared with those hospitalized for less than 3 days (10.0 g/L [8.2-12.4] vs 11.4 g/L [10.1-12.8]; P < .05) and in patients who received oral corticosteroid therapy for more than 5 days compared with those treated with oral steroids for less than 5 days (10.1 g/L [8.3-12.2] vs 11.6 g/L [10.0-13.8]; P < .05). Conclusions: Serum IgG level was significantly lower when asthma exacerbations were associated with positive viral samples. The patients with lower serum IgG concentrations required longer hospitalizations and longer courses of steroids. |
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| MeSH term(s) | Administration, Oral ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/drug therapy ; Asthma/immunology ; Asthma/physiopathology ; Asthma/virology ; Coronavirus Infections/immunology ; Disease Progression ; Enterovirus Infections/immunology ; Female ; Hospitalization ; Humans ; Immunoglobulin G/immunology ; Influenza, Human/immunology ; Length of Stay ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Nasopharynx/virology ; Paramyxoviridae Infections/immunology ; Picornaviridae Infections/immunology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Tract Infections/immunology ; Severity of Illness Index ; Virus Diseases/immunology |
| Chemical Substances | Adrenal Cortex Hormones ; Immunoglobulin G |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2019-01-14 |
| Publishing country | United States |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2843237-X |
| ISSN | 2213-2201 ; 2213-2198 |
| ISSN (online) | 2213-2201 |
| ISSN | 2213-2198 |
| DOI | 10.1016/j.jaip.2018.12.028 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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