LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 33

Search options

  1. Article ; Online: The real reason why ATP hydrolysis is spontaneous at pH > 7: It's (mostly) the proton concentration!

    Silverstein, Todd P

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2023  Volume 51, Issue 5, Page(s) 476–485

    Abstract: Common wisdom holds that ATP hydrolysis is spontaneous because of the weakness of its phosphoanhydride bonds, electrostatic repulsion within the polyanionic ... ...

    Abstract Common wisdom holds that ATP hydrolysis is spontaneous because of the weakness of its phosphoanhydride bonds, electrostatic repulsion within the polyanionic ATP
    MeSH term(s) Protons ; Hydrolysis ; Adenosine Triphosphate ; Hydrogen-Ion Concentration ; Phosphates/chemistry ; Thermodynamics
    Chemical Substances Protons ; Adenosine Triphosphate (8L70Q75FXE) ; Phosphates
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2039717-3
    ISSN 1539-3429 ; 1470-8175
    ISSN (online) 1539-3429
    ISSN 1470-8175
    DOI 10.1002/bmb.21745
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Lee's "Transmembrane Electrostatically-Localized Proton" model does NOT offer a better understanding of neuronal transmembrane potentials.

    Silverstein, Todd P

    Journal of neurophysiology

    2023  Volume 130, Issue 1, Page(s) 123–127

    Abstract: Recently, in a paper entitled "Protonic conductor: Better understanding [sic] neural resting and action potential," Lee applied his Transmembrane Electrostatically-Localized Protons (TELP) hypothesis to neuronal signaling. He stated that Hodgkin's cable ... ...

    Abstract Recently, in a paper entitled "Protonic conductor: Better understanding [sic] neural resting and action potential," Lee applied his Transmembrane Electrostatically-Localized Protons (TELP) hypothesis to neuronal signaling. He stated that Hodgkin's cable theory "could not fully explain the different conductive patterns in unmyelinated and myelinated nerves," whereas his TELP hypothesis "enables much better understanding of neural resting/action potential and [the biological significance of] axon myelination…" However, Lee's TELP hypothesis predicts that under resting conditions, the neuron "accumulat[es] excess negative charge (anions) inside," whereas resting chloride gradients actually feature excess Cl
    MeSH term(s) Male ; Humans ; Membrane Potentials ; Protons ; Chlorides ; Action Potentials ; Axons/physiology
    Chemical Substances Protons ; Chlorides
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00173.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.224: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Lee's transient protonic capacitor cannot explain the surface proton current observed in bacteriorhodopsin purple membranes.

    Silverstein, Todd P

    Biophysical chemistry

    2023  Volume 301, Page(s) 107096

    Abstract: ... support the surface proton current moving from the P side to the N side that was reported by Heberle et al ...

    Abstract Recently in this Journal, James Lee employed his transmembrane electrostatically localized proton (TELP) hypothesis and the notion of a transient protonic capacitor to explain the force holding protons at the surface of bacteriorhodopsin purple membrane fragments. Here we show that purple membrane fragments cannot maintain the requisite transient non-zero transmembrane potential, and even if they could, it would not support the surface proton current moving from the P side to the N side that was reported by Heberle et al. (Nature, 1994). Currently accepted models explain the force keeping protons at the membrane surface by invoking the unusual structure of water at the interface which serves to stabilize the proton (energy well) and/or raise the activation ∆G‡ (energy barrier) for release to the bulk phase. Any future invocations of TELP should be required to include experimental measurements carried out at the surfaces of lipid bilayer membranes and/or biological membranes.
    MeSH term(s) Bacteriorhodopsins ; Purple Membrane ; Protons ; Cell Membrane ; Lipid Bilayers
    Chemical Substances Bacteriorhodopsins (53026-44-1) ; Protons ; Lipid Bilayers
    Language English
    Publishing date 2023-08-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2023.107096
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1147: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Correction to: A critique of the capacitor-based "Transmembrane Electrostatically Localized Proton" hypothesis.

    Silverstein, Todd P

    Journal of bioenergetics and biomembranes

    2022  Volume 54, Issue 2, Page(s) 67

    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-022-09936-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A critique of the capacitor-based "Transmembrane Electrostatically Localized Proton" hypothesis.

    Silverstein, Todd P

    Journal of bioenergetics and biomembranes

    2022  Volume 54, Issue 2, Page(s) 59–65

    Abstract: In his Transmembrane Electrostatically Localized Proton hypothesis (TELP), James W. Lee has modeled the bioenergetic membrane as a simple capacitor. According to this model, the surface concentration of protons is completely independent of proton ... ...

    Abstract In his Transmembrane Electrostatically Localized Proton hypothesis (TELP), James W. Lee has modeled the bioenergetic membrane as a simple capacitor. According to this model, the surface concentration of protons is completely independent of proton concentration in the bulk phase, and is linearly proportional to the transmembrane potential. Such a proportionality runs counter to the results of experimental measurements, molecular dynamics simulations, and electrostatics calculations. We show that the TELP model dramatically overestimates the surface concentration of protons, and we discuss the electrostatic reasons why a simple capacitor is not an appropriate model for the bioenergetic membrane.
    MeSH term(s) Energy Metabolism ; Hydrogen-Ion Concentration ; Membrane Potentials ; Protons
    Chemical Substances Protons
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-022-09931-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: The Proton in Biochemistry: Impacts on Bioenergetics, Biophysical Chemistry, and Bioorganic Chemistry.

    Silverstein, Todd P

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 764099

    Abstract: ... in chemistry and biochemistry, starting with the definitions of pH and p ...

    Abstract The proton is the smallest atomic particle, and in aqueous solution it is the smallest hydrated ion, having only two waters in its first hydration shell. In this article we survey key aspects of the proton in chemistry and biochemistry, starting with the definitions of pH and p
    Language English
    Publishing date 2021-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.764099
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Enzyme free energy profiles: Can substrate binding be nonspontaneous? Can ground state interactions enhance catalysis?

    Silverstein, Todd P

    Biophysical chemistry

    2021  Volume 274, Page(s) 106606

    Abstract: Two influential enzymological theories were proposed in the late 1970s - that catalytic power stems only from transition state stabilization, while ground state interactions are either irrelevant or inhibitory; and enzyme substrate binding is ... ...

    Abstract Two influential enzymological theories were proposed in the late 1970s - that catalytic power stems only from transition state stabilization, while ground state interactions are either irrelevant or inhibitory; and enzyme substrate binding is nonspontaneous at low substrate concentrations ([S]
    MeSH term(s) Biocatalysis ; Enzymes/metabolism ; Thermodynamics
    Chemical Substances Enzymes
    Language English
    Publishing date 2021-04-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2021.106606
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1147: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: How enzymes harness highly unfavorable proton transfer reactions.

    Silverstein, Todd P

    Protein science : a publication of the Protein Society

    2021  Volume 30, Issue 4, Page(s) 735–744

    Abstract: Acid-base reactions that are exceedingly unfavorable under standard conditions can be catalytically important at enzyme active sites. For example, in triose phosphate isomerase, a glutamate side chain (nominal ... ...

    Abstract Acid-base reactions that are exceedingly unfavorable under standard conditions can be catalytically important at enzyme active sites. For example, in triose phosphate isomerase, a glutamate side chain (nominal pK
    MeSH term(s) Hydrogen Bonding ; Models, Molecular ; Protons ; Static Electricity
    Chemical Substances Protons
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3407: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Correction to "H

    Neils, Thomas L / Silverstein, Todd P / Schaertel, Stephanie

    Journal of chemical education

    2023  Volume 100, Issue 6, Page(s) 2479

    Abstract: This corrects the article DOI: 10.1021/acs.jchemed.3c00099.]. ...

    Abstract [This corrects the article DOI: 10.1021/acs.jchemed.3c00099.].
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 218164-2
    ISSN 1938-1328 ; 0021-9584
    ISSN (online) 1938-1328
    ISSN 0021-9584
    DOI 10.1021/acs.jchemed.3c00367
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1902: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: CoViD-19 epidemic follows the "kinetics" of enzymes with cooperative substrate binding.

    Silverstein, Todd P

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2020  Volume 48, Issue 5, Page(s) 452–459

    Abstract: The Hill equation, which models the cooperative ligand-receptor binding equilibrium, turns out to be useful in modeling the progression of infectious disease outbreaks such as CoViD-19. The equation fits well the data for total and daily case numbers, ... ...

    Abstract The Hill equation, which models the cooperative ligand-receptor binding equilibrium, turns out to be useful in modeling the progression of infectious disease outbreaks such as CoViD-19. The equation fits well the data for total and daily case numbers, allows tentative predictions for the half-point and end point of the epidemic, and presents a mathematical characterization of how social interventions "flatten the curve" of the disease progression.
    MeSH term(s) Biochemistry/education ; COVID-19/epidemiology ; Enzymes/chemistry ; Humans ; Kinetics ; Models, Chemical ; Pandemics ; SARS-CoV-2
    Chemical Substances Enzymes
    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 1539-3429
    ISSN (online) 1539-3429
    DOI 10.1002/bmb.21397
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top