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  1. Article ; Online: COVID-19 and Liver Transplantation: Early Reports and Recommendations.

    Giannis, Dimitrios / Moris, Dimitrios

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2020  Volume 21, Issue 3, Page(s) 286–287

    MeSH term(s) Humans ; COVID-19 ; Liver Transplantation/adverse effects ; SARS-CoV-2
    Language English
    Publishing date 2020-11-27
    Publishing country Turkey
    Document type Letter ; Comment
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2020.0229
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6632: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Diagnostic, Predictive and Prognostic Molecular Biomarkers in Pancreatic Cancer: An Overview for Clinicians.

    Giannis, Dimitrios / Moris, Dimitrios / Barbas, Andrew S

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and is associated with aggressive tumor behavior and poor prognosis. Most patients with PDAC present with an advanced disease stage and treatment-resistant tumors. The lack ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and is associated with aggressive tumor behavior and poor prognosis. Most patients with PDAC present with an advanced disease stage and treatment-resistant tumors. The lack of noninvasive tests for PDAC diagnosis and survival prediction mandates the identification of novel biomarkers. The early identification of high-risk patients and patients with PDAC is of utmost importance. In addition, the identification of molecules that are associated with tumor biology, aggressiveness, and metastatic potential is crucial to predict survival and to provide patients with personalized treatment regimens. In this review, we summarize the current literature and focus on newer biomarkers, which are continuously added to the armamentarium of PDAC screening, predictive tools, and prognostic tools.
    Language English
    Publishing date 2021-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implication of Thioredoxin 1 and Glutaredoxin 1 in H2O2-induced Phosphorylation of JNK and p38 MAP Kinases.

    Poulios, Efthymios / Roupaka, Vasiliki / Giaginis, Constantinos / Galaris, Dimitrios / Spyrou, Giannis

    Current molecular medicine

    2024  

    Abstract: Background: Aerobic organisms continuously generate small amounts of Reactive Oxygen Species (ROS), which are involved in the oxidation of sensitive cysteine residues in proteins, leading to the formation of disulfide bonds. Thioredoxin (Trx1) and ... ...

    Abstract Background: Aerobic organisms continuously generate small amounts of Reactive Oxygen Species (ROS), which are involved in the oxidation of sensitive cysteine residues in proteins, leading to the formation of disulfide bonds. Thioredoxin (Trx1) and Glutaredoxin (Grx1) represent key antioxidant enzymes reducing disulfide bonds.
    Objective: In this work, we have focused on the possible protective effect of Trx1 and Grx1 against oxidative stress-induced DNA damage and apoptosis-signaling, by studying the phosphorylation of MAP kinases.
    Methods: Trx1 and Grx1 were overexpressed or silenced in cultured H1299 non-small cell lung cancer epithelial cells. We examined cell growth, DNA damage, and the phosphorylation status of MAP kinases following treatment with H2O2.
    Results: Overexpression of both Trx1 and Grx1 had a significant impact on the growth of H1299 cells and provided protection against H2O2-induced toxicity, as well as acute DNA single-strand breaks. Conversely, silencing of these proteins exacerbated DNA damage. Furthermore, overexpression of Trx1 and Grx1 inhibited the rapid phosphorylation of JNK (especially at 360 min of treatment, ****p=0.004 and **p=0.0033 respectively) and p38 MAP kinases (especially at 360 min of treatment, ****p<0.0001 and ***p=0.0008 respectively) during H2O2 exposure, while their silencing had the opposite effect (especially at 360 min of treatment, ****p<0.0001).
    Conclusion: These results suggest that both Trx1 and Grx1 have protective roles against H2O2 induced toxicity, emphasizing their significance in mitigating oxidative stress-related cellular damage.
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064873-X
    ISSN 1875-5666 ; 1566-5240
    ISSN (online) 1875-5666
    ISSN 1566-5240
    DOI 10.2174/0115665240271103231127072635
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5580: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Letter in response to article in journal of infection: "Cardiovascular complications in COVID-19: A systematic review and meta-analysis".

    Giannis, Dimitrios / Ziogas, Ioannis A

    The Journal of infection

    2020  Volume 82, Issue 1, Page(s) 159–198

    MeSH term(s) Anticoagulants ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.074
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    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 48: Show issues

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  5. Article ; Online: Vascular thromboembolic events following COVID-19 hospital discharge: Incidence and risk factors.

    Spyropoulos, Alex C / Giannis, Dimitrios / Goldin, Mark

    Research and practice in thrombosis and haemostasis

    2021  Volume 5, Issue 5, Page(s) e12547

    Language English
    Publishing date 2021-06-27
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12547
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  6. Article ; Online: Anticoagulant therapy for COVID-19: What we have learned and what are the unanswered questions?

    Giannis, Dimitrios / Douketis, James D / Spyropoulos, Alex C

    European journal of internal medicine

    2021  Volume 96, Page(s) 13–16

    MeSH term(s) Anticoagulants ; COVID-19 ; Humans ; SARS-CoV-2 ; Thrombosis
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-11-11
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Costimulation Blockade in Vascularized Composite Allotransplantation.

    Giannis, Dimitrios / Moris, Dimitrios / Cendales, Linda C

    Frontiers in immunology

    2020  Volume 11, Page(s) 544186

    Abstract: Vascular composite allotransplantation (VCA) is a field under research and has emerged as an alternative option for the repair of severe disfiguring defects that result from infections or traumatic amputation in a selected group of patients. VCA is ... ...

    Abstract Vascular composite allotransplantation (VCA) is a field under research and has emerged as an alternative option for the repair of severe disfiguring defects that result from infections or traumatic amputation in a selected group of patients. VCA is performed in centers with appropriate expertise, experience and adequate resources to effectively manage the complexity and complications of this treatment. Lifelong immunosuppressive therapy, immunosuppression associated complications, and the effects of the host immune response in the graft are major concerns in VCA. VCA is considered a quality of life transplant and the risk-benefit ratio is dissimilar to life saving transplants. Belatacept seems a promising drug that prolongs patient and graft survival in kidney transplantation and it could also be an alternative approach to VCA immunosuppression. In this review, we are summarizing current literature about the role of costimulation blockade, with a focus on belatacept in VCA.
    MeSH term(s) Graft Rejection/immunology ; Graft Survival/immunology ; Humans ; Immunosuppression Therapy ; Transplantation Immunology ; Transplantation, Homologous ; Vascularized Composite Allotransplantation
    Language English
    Publishing date 2020-09-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.544186
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  8. Article: Hyponatremia as a marker of complicated appendicitis: A systematic review.

    Giannis, Dimitrios / Matenoglou, Evangelia / Moris, Dimitrios

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2020  Volume 18, Issue 5, Page(s) 295–304

    Abstract: Background: Acute appendicitis, the most common cause of acute surgical abdomen, is associated with intra-abdominal complications, such as perforation, that increase morbidity and mortality. Early and accurate preoperative diagnosis of complicated ... ...

    Abstract Background: Acute appendicitis, the most common cause of acute surgical abdomen, is associated with intra-abdominal complications, such as perforation, that increase morbidity and mortality. Early and accurate preoperative diagnosis of complicated appendicitis mandates the identification of new diagnostic markers. This systematic review summarizes current literature on the adoption of hyponatremia as an early diagnostic and predictive marker of complicated appendicitis.
    Methods: Pubmed, Cochrane Library, Scopus, Google Scholar, WHO Global Health Library, System for Information on Grey Literature, ISI Web of Science, EBSCOHost and Virtual Health Library were searched in accordance with the PRISMA guidelines in order to identify original human studies investigating the association between hyponatremia and the presence or development of complicated appendicitis.
    Results: A total of 7 studies conducted in 6 different countries were identified. A prospective diagnostic accuracy study reported a strong association between hyponatremia and complicated appendicitis in children. The largest sample size study performed in adults reported a significant association between hyponatremia and perforated or gangrenous appendicitis.
    Conclusions: The admission serum sodium level measurement, a routinely performed, low-cost test, should be taken into account in patients with clinical presentation compatible with acute appendicitis and suspicion of underlying complications. Future well-designed prospective diagnostic accuracy studies are required to further establish the association between hyponatremia and perforated appendicitis.
    MeSH term(s) Appendicitis/blood ; Appendicitis/complications ; Appendicitis/diagnosis ; Humans ; Hyponatremia/diagnosis ; Hyponatremia/etiology
    Language English
    Publishing date 2020-02-05
    Publishing country Scotland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2020.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: An optimized protocol for chromatin immunoprecipitation from murine inguinal white adipose tissue.

    Katsouda, Antonia / Valakos, Dimitrios / Vatsellas, Giannis / Thanos, Dimitris / Papapetropoulos, Andreas

    STAR protocols

    2023  Volume 4, Issue 4, Page(s) 102594

    Abstract: Chromatin immunoprecipitation (ChIP) protocols have been used to reveal protein-DNA interactions of various cell types and tissues; however, optimization is required for each specific type of sample. Here, we present a ChIP protocol from murine inguinal ... ...

    Abstract Chromatin immunoprecipitation (ChIP) protocols have been used to reveal protein-DNA interactions of various cell types and tissues; however, optimization is required for each specific type of sample. Here, we present a ChIP protocol from murine inguinal white adipose tissue. We describe steps for tissue harvesting, crosslinking, chromatin extraction, shearing, immunoprecipitation, and purification. We then detail procedures for analysis including library preparation, sequencing, and qRT-PCR validation. For complete details on the use and execution of this protocol, please refer to Antonia Katsouda et al. (2022).
    MeSH term(s) Animals ; Mice ; Chromatin Immunoprecipitation/methods ; Chromatin/genetics ; DNA ; Sequence Analysis, DNA/methods ; Adipose Tissue, White
    Chemical Substances Chromatin ; DNA (9007-49-2)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of coronavirus disease 2019 on healthcare workers: beyond the risk of exposure.

    Giannis, Dimitrios / Geropoulos, Georgios / Matenoglou, Evangelia / Moris, Demetrios

    Postgraduate medical journal

    2020  Volume 97, Issue 1147, Page(s) 326–328

    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Primary Health Care ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-137988
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    Ua VI Zs.340: Show issues Location:
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