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  1. Article ; Online: Salvia rosmarinus: a possible role in unmet therapeutic needs in the prevention and care of immunological disorders.

    Furci, Fabiana / Cicero, Nicola / Allegra, Alessandro / Gangemi, Sebastiano

    Natural product research

    2024  , Page(s) 1–5

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2338815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Exploring the Therapeutic Potential of

    Cancemi, Gabriella / Caserta, Santino / Gangemi, Sebastiano / Pioggia, Giovanni / Allegra, Alessandro

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal ... ...

    Abstract Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma.

    Allegra, Alessandro / Murdaca, Giuseppe / Mirabile, Giuseppe / Gangemi, Sebastiano

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as ...

    Abstract Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, lipids are essential to the development of cancer. Above all, the proper immune response of tumor cells depends on the control of lipid metabolism. Changes in metabolism can modify systems that regulate carcinogenesis, such as inflammation, oxidative stress, and angiogenesis. The dependence of various malignancies on lipid metabolism varies. This review delves into the modifications to lipid metabolism that take place in cancer, specifically focusing on multiple myeloma. The review illustrates how changes in different lipid pathways impact the growth, survival, and drug-responsiveness of multiple myeloma cells, in addition to their interactions with other cells within the tumor microenvironment. The phenotype of malignant plasma cells can be affected by lipid vulnerabilities, and these findings offer a new avenue for understanding this process. Additionally, they identify novel druggable pathways that have a major bearing on multiple myeloma care.
    Language English
    Publishing date 2024-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw.

    Caserta, Santino / Stagno, Fabio / Gangemi, Sebastiano / Allegra, Alessandro

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the ... ...

    Abstract Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the inflammatory pathway of receptor activator of nuclear factor NF-kB ligand and the macrophage colony-stimulating factor, essential for osteoclast precursors survival and proliferation and acting through its receptor c-Fms. Evidence has shown the role of non-coding RNAs in the pathogenesis of osteonecrosis of the jaw and this finding might be useful in diagnosis since these small RNAs could be considered as biomarkers of apoptotic activity in bone. Interestingly, it has been proved that miR-29 and miR-31-5p, acting on specific targets such as CALCR and RhoA, promote programmed-cell death and consequently the necrosis of bone tissue. Specific long non-coding RNAs, instead, have been detected both at reduced levels in patients with multiple myeloma and osteonecrosis, and associated with suppression of osteoblast differentiation, with consequences in the progression of mandible lesions. Among non-coding genic material, circular RNAs have the capability to modify the expression of specific mRNAs responsible for the inhibition of bisphosphonates activity on osteoclastogenesis.
    MeSH term(s) Humans ; Diphosphonates ; Osteonecrosis/metabolism ; Bone Density Conservation Agents ; Multiple Myeloma ; MicroRNAs/genetics
    Chemical Substances Diphosphonates ; Bone Density Conservation Agents ; MicroRNAs
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Retinal Vessel Analysis and Microvascular Abnormalities in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms.

    Roszkowska, Anna Maria / Leanza, Rossana / Aragona, Emanuela / Gargiulo, Ludovica / Alibrandi, Angela / Arrigo, Alessandro / Bottaro, Adele / Barone, Paola / Stagno, Fabio / Allegra, Alessandro

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies.

    Caserta, Santino / Genovese, Claudia / Cicero, Nicola / Gangemi, Sebastiano / Allegra, Alessandro

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Cinnamon is an evergreen and tropical plant of the ... ...

    Abstract Cinnamon is an evergreen and tropical plant of the family
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Aging and Age-Related Epigenetic Drift in the Pathogenesis of Leukemia and Lymphomas: New Therapeutic Targets.

    Allegra, Alessandro / Caserta, Santino / Mirabile, Giuseppe / Gangemi, Sebastiano

    Cells

    2023  Volume 12, Issue 19

    Abstract: One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-related epigenetic changes may partially explain the increased risk of cancer in the elderly is based on the observation that aging is also accompanied by ... ...

    Abstract One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-related epigenetic changes may partially explain the increased risk of cancer in the elderly is based on the observation that aging is also accompanied by comparable changes in epigenetic patterns. Lineage bias and decreased stem cell function are signs of hematopoietic stem cell compartment aging. Additionally, aging in the hematopoietic system and the stem cell niche have a role in hematopoietic stem cell phenotypes linked with age, such as leukemia and lymphoma. Understanding these changes will open up promising pathways for therapies against age-related disorders because epigenetic mechanisms are reversible. Additionally, the development of high-throughput epigenome mapping technologies will make it possible to identify the "epigenomic identity card" of every hematological disease as well as every patient, opening up the possibility of finding novel molecular biomarkers that can be used for diagnosis, prediction, and prognosis.
    MeSH term(s) Humans ; Aged ; Epigenomics ; Aging/genetics ; Epigenesis, Genetic ; Leukemia/metabolism ; Hematopoietic Stem Cells/metabolism ; Lymphoma/genetics ; Lymphoma/therapy ; Lymphoma/metabolism
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12192392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders.

    Cancemi, Gabriella / Cicero, Nicola / Allegra, Alessandro / Gangemi, Sebastiano

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant ... ...

    Abstract Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice.
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients.

    Allegra, Alessandro / Murdaca, Giuseppe / Mirabile, Giuseppe / Gangemi, Sebastiano

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Although immunotherapy is already a staple of cancer care, many patients may not benefit from these cutting-edge treatments. A crucial field of research now focuses on figuring out how to improve treatment efficacy and assess the resistance mechanisms ... ...

    Abstract Although immunotherapy is already a staple of cancer care, many patients may not benefit from these cutting-edge treatments. A crucial field of research now focuses on figuring out how to improve treatment efficacy and assess the resistance mechanisms underlying this uneven response. For a good response, immune-based treatments, in particular immune checkpoint inhibitors, rely on a strong infiltration of T cells into the tumour microenvironment. The severe metabolic environment that immune cells must endure can drastically reduce effector activity. These immune dysregulation-related tumour-mediated perturbations include oxidative stress, which can encourage lipid peroxidation, ER stress, and T regulatory cells dysfunction. In this review, we have made an effort to characterize the status of immunological checkpoints, the degree of oxidative stress, and the part that latter plays in determining the therapeutic impact of immunological check point inhibitors in different neoplastic diseases. In the second section of the review, we will make an effort to assess new therapeutic possibilities that, by affecting redox signalling, may modify the effectiveness of immunological treatment.
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Air Pollution and microRNAs: The Role of Association in Airway Inflammation.

    Furci, Fabiana / Allegra, Alessandro / Tonacci, Alessandro / Isola, Stefania / Senna, Gianenrico / Pioggia, Giovanni / Gangemi, Sebastiano

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, ... ...

    Abstract Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, including tobacco smoke. Various diseases are related to specific microRNA signatures, suggesting their potential role in pathophysiological processes; considering their association with environmental pollutants, they could become novel biomarkers of exposure. Therefore, the aim of the present work is to analyse data reported in the literature on the role of environmental stressors on microRNA alterations and, in particular, to identify specific alterations that might be related to the development of airway diseases so as to propose future preventive, diagnostic, and therapeutic strategies.
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13061375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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