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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China.

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Functional & integrative genomics

2023 Volume 23, Issue 2, Page(s) 85

Abstract: ... among different populations. However, there is little pharmacogenomic information about the Chinese Hui population ... Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical ... foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment ...

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ
MeSH term(s)	Humans ; Pharmacogenetics ; Cytochrome P-450 CYP2D6/genetics ; Cyclooxygenase 2/genetics ; Ethnicity/genetics ; Polymorphism, Single Nucleotide ; Genotype ; China ; Arylamine N-Acetyltransferase/genetics
Chemical Substances	Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; NAT2 protein, human (EC 2.3.1.5) ; Arylamine N-Acetyltransferase (EC 2.3.1.5)
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
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Article ; Online: Interpreting regional ecological security from perspective of ecological networks: a case study in Ningxia Hui Autonomous Region, China.

Ji, Xianglin / Wu, Dan / Yan, Yueguan / Guo, Wei / Li, Kai

Environmental science and pollution research international

2023 Volume 30, Issue 24, Page(s) 65412–65426

Abstract: ... This study proposes a multimodel coupling framework to explore the ecological security status of Ningxia Hui ...

Abstract	The rapid economic development and intense human activities have seriously restricted the sustainable development of ecology and the maintenance of ecosystem services. Ecological network can effectively connect fragmented habitats and is an important way to couple landscape structure, ecological process, and function. This study proposes a multimodel coupling framework to explore the ecological security status of Ningxia Hui Autonomous Region (NHAR) under different development scenarios from the perspective of ecological networks. The conclusions are as follows: (1) From 2000 to 2030, grassland and arable land were the main land types of NHAR. Grassland is the main expansion land type under the ecological land protection (ELP) scenario, while construction land is the main expansion land type in two other scenarios. (2) The main gather and change of the ecological sources occurred in the central region, and the ecological expansion should develop from the middle to the south. (3) The average area of ecological sources under BAU and RED scenarios is smaller than that under ELP scenario, and more ecological corridors are needed to connect. (4) The centrality of the ecological sources under the BAU scenario is generally high, but the ecological sources under ELP and RED scenarios have undergone spatial migration. In addition, the urbanization trend of NHAR is different under different scenarios, and more attention should be paid to the maintenance and protection of ecological networks in typical areas. This study can provide important reference for NHAR's ecological space planning and ecological protection policy formulation.
MeSH term(s)	Humans ; Ecosystem ; Ecology ; Conservation of Natural Resources ; Urbanization ; China
Language	English
Publishing date	2023-04-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26997-0
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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Funct Integr Genomics. 2023 June, v. 23, no. 2 p.85-85

2023

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ² test. The genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in PTGS2 (rs20417), NAT2 (rs1801280), NAT2 (rs1208), ACE (rs4291), and CYP2D6 (rs1065852) were considerably different in the Hui population compared with those in the other 26 populations. Besides, using the PharmGKB database, we identified several VIP variants that may alter the drug metabolism of ibuprofen, rofecoxib (PTGS2), captopril (ACE), citalopram, and escitalopram (CYP2D6). We also discovered other variants associated with adverse reactions to cisplatin and cyclophosphamide (NAT2). Our study indicated that the loci of PTGS2 (rs20417), NAT2 (rs1801280 and rs1208), ACE (rs4291), and CYP2D6 (rs1065852) in the Hui population were obviously different from those in the other 26 populations, which provides reliable information for predicting drug efficacy. Besides, it supplements the pharmacogenomic knowledge of the Hui population and lays the foundation for the individualized treatment for the Hui population.
Keywords	alleles ; cisplatin ; cyclophosphamide ; databases ; genotype ; ibuprofen ; pharmacogenomics ; pharmacokinetics ; China
Language	English
Dates of publication	2023-06
Size	p. 85.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occurrence of Trichophyton verrucosum in cattle in the Ningxia Hui autonomous region, China.

Guo, Yanan / Ge, Song / Luo, Haifeng / Rehman, Atif / Li, Yong / He, Shenghu

BMC veterinary research

2020 Volume 16, Issue 1, Page(s) 187

Abstract: Background: Ningxia Hui Autonomous Region is an important cattle breeding area in China, and ...

Abstract	Background: Ningxia Hui Autonomous Region is an important cattle breeding area in China, and cattle breeding bases are located in this area. In Ningxia, dermatophytes have not been paid attention to, so dermatophytosis is becoming more and more serious. For effective control measures, it is important to determine the disease prevalence and isolate and identify the pathogenic microorganism. Results: The study showed the prevalence of dermatophytes was 15.35% (74/482). The prevalence in calf was higher than adult cattle (p < 0.05). The morbidity was the highest in winter compared with autumn (p < 0.0001), summer (p < 0.05) and spring (p < 0.0001). The prevalence in Guyuan was the highest compared with Yinchuan (p < 0.05) and Shizuishan (p < 0.05). The incidence of lesions on the face, head, neck, trunk and whole body was 20.43, 38.71, 20.43, 10.75 and 9.68%, respectively. From all samples, the isolation rate of Trichophyton was highest (61.1%). The phylogenetic tree constructed showed that the 11 pathogenic fungi were on the same branch as Trichophyton verrucosum. Conclusions: This study reports, for the first time, the presence of Trichophyton verrucosum in cattle in Ningxia and showed that the incidence of dermatophytosis is related to different regions, ages and seasons. A better knowledge of the prevalence of dermatophytosis of cattle may allow the adoption of more efficient control measures and prophylaxis.
MeSH term(s)	Age Factors ; Animals ; Arthrodermataceae/isolation & purification ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/microbiology ; China/epidemiology ; Phylogeny ; Prevalence ; Seasons ; Tinea/epidemiology ; Tinea/veterinary
Language	English
Publishing date	2020-06-10
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-020-02403-6
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Article ; Online: The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome.

Wang, Chuan-Chao / Lu, Yan / Kang, Longli / Ding, Huiqian / Yan, Shi / Guo, Jianxin / Zhang, Qun / Wen, Shao-Qing / Wang, Ling-Xiang / Zhang, Manfei / Tong, Xinzhu / Huang, Xiufeng / Nie, Shengjie / Deng, Qiongying / Zhu, Bofeng / Jin, Li / Li, Hui

American journal of physical anthropology

2019 Volume 169, Issue 2, Page(s) 341–347

Abstract: Objectives: The Hui people are the adherents of Muslim faith and distributing throughout China ... There are two contrasting hypotheses about the origin and diversification of the Hui people, namely ... methods: We collected 621 unrelated male individuals from 23 Hui populations all over China ...

Abstract	Objectives: The Hui people are the adherents of Muslim faith and distributing throughout China. There are two contrasting hypotheses about the origin and diversification of the Hui people, namely, the demic diffusion involving the mass movement of people or simple cultural diffusion. Materials and methods: We collected 621 unrelated male individuals from 23 Hui populations all over China. We comprehensively genotyped more than 100 informative Y-chromosomal single nucleotide polymorphisms and 17 Y-chromosomal short tandem repeats (STRs) on those samples. Results: Co-analyzed with published worldwide populations, our results suggest the origin of Hui people has involved massive assimilation of indigenous East Asians with about 70% in total of the paternal ancestry could be traced back to East Asia and the left 30% to various regions in West Eurasia. Discussion: The genetic structure of the extant Hui populations was primarily shaped by the indigenous East Asian populations as they contribute the majority part of the paternal lineages of Hui people. The West Eurasian admixture was probably a sex-biased male-driven process since we have not found such a high proportion of West Eurasian gene flow on autosomal STRs and maternal mtDNA.
MeSH term(s)	Anthropology, Physical ; Asian Continental Ancestry Group/genetics ; China ; Chromosomes, Human, Y/genetics ; Ethnic Groups/genetics ; Gene Flow/genetics ; Genetics, Population ; Humans ; Islam ; Male ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.23823
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Article: Male-Dominated Migration and Massive Assimilation of Indigenous East Asians in the Formation of Muslim Hui People in Southwest China.

Wang, Qiyan / Zhao, Jing / Ren, Zheng / Sun, Jin / He, Guanglin / Guo, Jianxin / Zhang, Hongling / Ji, Jingyan / Liu, Yubo / Yang, Meiqing / Yang, Xiaomin / Chen, Jinwen / Zhu, Kongyang / Wang, Rui / Li, Yingxiang / Chen, Gang / Huang, Jiang / Wang, Chuan-Chao

Frontiers in genetics

2021 Volume 11, Page(s) 618614

Abstract: The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion ... single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest ...

Abstract	The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion is a long-going debate. We here generated genome-wide data at nearly 700,000 single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest China. We applied principal component analysis (PCA), ADMIXTURE,
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.618614
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Article: [Summary of Hui prescriptions for stroke].

Li, Ting-Ting / Dong, Lin / Chen, Guo-Ting / Chen, Jing / Fu, Xue-Yan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2013 Volume 38, Issue 14, Page(s) 2412–2415

Abstract: Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent ... names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having ... collected and screened out 101 Hui prescriptions for stroke, the author further studied some of their names ...

Abstract	Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having collected and screened out 101 Hui prescriptions for stroke, the author further studied some of their names in literatures, in order to facilitate clinical application of these prescriptions (i. e. unification of their Arabic and Chinese names, and textual research of identical drugs with different Arabic names). This lays a foundation for the clinical application of Hui prescriptions and the analysis on compatibility regulatory, and provides scientific basis for studies on new Hui medicines.
MeSH term(s)	Asian Continental Ancestry Group ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Arabic ; Medicine, Chinese Traditional/methods ; Plant Extracts/therapeutic use ; Stroke/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Plant Extracts
Language	Chinese
Publishing date	2013-07
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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Article ; Online: Multi-locus sequence typing of Mycoplasma bovis to assess its genetic diversity from 2009 to 2018 in Ningxia Hui Autonomous Region, China.

Guo, Yanan / Luo, Haifeng / Guo, Shuqiang / Lei, Yuanyuan / Li, Yong / He, Shenghu

BMC veterinary research

2020 Volume 16, Issue 1, Page(s) 454

Abstract: ... and especially in Ningxia Hui Autonomous Region in China.: Results: Two types of ST, ST10and ST134 ... were identified in Ningxia Hui Autonomous Region. Thirty-seven strains belonged to ST10 and 28 strains ... in Ningxia Hui Autonomous Region at present. The M. bovis ST10 was widely spread in many provinces in China and ...

Abstract	Background: Mycoplasma bovis (M. bovis) is a highly contagious cattle pathogen spreading worldwide and especially in Ningxia Hui Autonomous Region in China. Results: Two types of ST, ST10and ST134, were identified in Ningxia Hui Autonomous Region. Thirty-seven strains belonged to ST10 and 28 strains belonged to ST134. ST134 was a new ST and first found in 2009 and was only widely distributed in Ningxia Hui Autonomous Region at present. The M. bovis ST10 was widely spread in many provinces in China and was widespread in Ningxia Hui Autonomous Region since 2010. It is speculated that the prevalence of M. bovis ST10 in Ningxia Hui Autonomous Region began in 2010. Conclusions: This study is the first report on the genetic diversity of M. bovis from 2009 to 2018 in Ningxia Hui Autonomous Region and provides the epidemiological information. These results may help further our understanding of the evolution of M. bovis and provide information that may be useful for the development of novel vaccines.
MeSH term(s)	Animals ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/microbiology ; China/epidemiology ; Genetic Variation ; Multilocus Sequence Typing/veterinary ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/veterinary ; Mycoplasma bovis/genetics ; Polymerase Chain Reaction/veterinary
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-020-02668-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Spatial-temporal distribution of human brucellosis and its correlation with the number of livestock in Ningxia Hui Autonomous Region, 2012-2018].

Zhao, Y / Guo, Z Q / Zhao, J H / Liang, P F

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2020 Volume 41, Issue 6, Page(s) 872–876

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Brucellosis/epidemiology ; Cattle ; China/epidemiology ; Humans ; Incidence ; Livestock ; Sheep ; Spatio-Temporal Analysis ; Swine
Language	Chinese
Publishing date	2020-06-21
Publishing country	China
Document type	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20190925-00701
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Article ; Online: The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing.

Chen, Chong / Li, Yuchun / Tao, Ruiyang / Jin, Xiaoye / Guo, Yuxin / Cui, Wei / Chen, Anqi / Yang, Yue / Zhang, Xingru / Zhang, Jingyi / Li, Chengtao / Zhu, Bofeng

Genes

2020 Volume 11, Issue 11

Abstract: ... provides a pivotal way for us to investigate the formation histories of populations. The Hui minority ... the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results ... demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different ...

Abstract	Mitochondrial DNA (mtDNA), coupled with maternal inheritance and relatively high mutation rates, provides a pivotal way for us to investigate the formation histories of populations. The Hui minority with Islamic faith is one of the most widely distributed ethnic groups in China. However, the exploration of Hui's genetic architecture from the complete mitochondrial genome perspective has not been detected yet. Therefore, in this study, we employed the complete mitochondrial genomes of 98 healthy and unrelated individuals from Northwest China, as well as 99 previously published populations containing 7274 individuals from all over the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different regions, which was largely attributable to the widespread of haplogroups D4, D5, M7, B4, and F1 in these populations. The demographic expansion of Hui group might occur during the Late Pleistocene. Finally, we also found that Hui group might have gene exchanges with Uygur, Tibetan, and Tajik groups in different degrees and retained minor genetic imprint of European-specific lineages, therefore, hinting the existence of multi-ethnic integration events in shaping the genetic landscape of Chinese Hui group.
MeSH term(s)	Asian People/genetics ; China/ethnology ; DNA, Mitochondrial/genetics ; Ethnicity/genetics ; Genetic Variation ; Genetics, Population ; Genome, Mitochondrial ; Haplotypes ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Population Dynamics ; Principal Component Analysis
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2020-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11111352
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