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  1. Article ; Online: m

    Alvizi, Lucas / Brito, Luciano Abreu / Kobayashi, Gerson Shigeru / Bischain, Bárbara / da Silva, Camila Bassi Fernandes / Ramos, Sofia Ligia Guimaraes / Wang, Jaqueline / Passos-Bueno, Maria Rita

    Epigenetics

    2022  Volume 17, Issue 13, Page(s) 2278–2295

    Abstract: Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human craniofacial malformation, is a complex disorder given its genetic heterogeneity and multifactorial component revealed by genetic, epidemiological, and epigenetic ... ...

    Abstract Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human craniofacial malformation, is a complex disorder given its genetic heterogeneity and multifactorial component revealed by genetic, epidemiological, and epigenetic findings. Epigenetic variations associated with NSCLP have been identified; however, functional investigation has been limited. Here, we combined a reanalysis of NSCLP methylome data with genetic analysis and used both
    MeSH term(s) Animals ; Humans ; Cleft Lip/genetics ; Cleft Palate/genetics ; Zebrafish/genetics ; Genetic Predisposition to Disease ; DNA Methylation ; Hypoxia/genetics ; Polymorphism, Single Nucleotide ; MicroRNAs/genetics
    Chemical Substances MIRN152 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2022.2115606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis.

    Imajo, Kento / Saigusa, Yusuke / Kobayashi, Takashi / Nagai, Koki / Nishida, Shinya / Kawamura, Nobuyoshi / Doi, Hiroyoshi / Iwaki, Michihiro / Nogami, Asako / Honda, Yasushi / Kessoku, Takaomi / Ogawa, Yuji / Kirikoshi, Hiroyuki / Yasuda, Satoshi / Toyoda, Hidenori / Hayashi, Hideki / Kokubu, Shigehiro / Utsunomiya, Daisuke / Takahashi, Hirokazu /
    Aishima, Shinichi / Kim, Beom Kyung / Tamaki, Nobuharu / Saito, Satoru / Yoneda, Masato / Loomba, Rohit / Nakajima, Atsushi

    Hepatology research : the official journal of the Japan Society of Hepatology

    2023  Volume 53, Issue 9, Page(s) 844–856

    Abstract: ... CAST) and MRE-based LSM followed by PDFF with AST (M-PAST)-and compared with FibroScan-AST (FAST) and ... 826) and M-PAST (0.832) were significantly higher than those of FAST (0.744, p = 0.004) and MAST (0 ... 710, p < 0.001). Following the rule-in criteria, positive predictive values of F-CAST (81.8%) and M ...

    Abstract Background: Clinical trials enroll patients with active fibrotic nonalcoholic steatohepatitis (NASH) (nonalcoholic fatty liver disease [NAFLD] activity score ≥ 4) and significant fibrosis (F ≥ 2); however, screening failure rates are high following biopsy. We developed new scores to identify active fibrotic NASH using FibroScan and magnetic resonance imaging (MRI).
    Methods: We undertook prospective primary (n = 176), retrospective validation (n = 169), and University of California San Diego (UCSD; n = 234) studies of liver biopsy-proven NAFLD. Liver stiffness measurement (LSM) using FibroScan or magnetic resonance elastography (MRE), controlled attenuation parameter (CAP), or proton density fat fraction (PDFF), and aspartate aminotransferase (AST) were combined to develop a two-step strategy-FibroScan-based LSM followed by CAP with AST (F-CAST) and MRE-based LSM followed by PDFF with AST (M-PAST)-and compared with FibroScan-AST (FAST) and MRI-AST (MAST) for diagnosing active fibrotic NASH. Each model was categorized using rule-in and rule-out criteria.
    Results: Areas under receiver operating characteristic curves (AUROCs) of F-CAST (0.826) and M-PAST (0.832) were significantly higher than those of FAST (0.744, p = 0.004) and MAST (0.710, p < 0.001). Following the rule-in criteria, positive predictive values of F-CAST (81.8%) and M-PAST (81.8%) were higher than those of FAST (73.5%) and MAST (70.0%). Following the rule-out criteria, negative predictive values of F-CAST (90.5%) and M-PAST (90.9%) were higher than those of FAST (84.0%) and MAST (73.9%). In the validation and UCSD cohorts, AUROCs did not differ significantly between F-CAST and FAST, but M-PAST had a higher diagnostic performance than MAST.
    Conclusions: The two-step strategy, especially M-PAST, showed reliability of rule-in/-out for active fibrotic NASH, with better predictive performance compared with MAST. This study is registered with ClinicalTrials.gov (number, UMIN000012757).
    Language English
    Publishing date 2023-06-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1387041-5
    ISSN 1386-6346 ; 0928-4346
    ISSN 1386-6346 ; 0928-4346
    DOI 10.1111/hepr.13927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vibrational analysis of acetylcholine binding to the M

    Suzuki, Kohei / Katayama, Kota / Sumii, Yuji / Nakagita, Tomoya / Suno, Ryoji / Tsujimoto, Hirokazu / Iwata, So / Kobayashi, Takuya / Shibata, Norio / Kandori, Hideki

    RSC advances

    2021  Volume 11, Issue 21, Page(s) 12559–12567

    Abstract: The M ...

    Abstract The M
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra01030a
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  4. Article ; Online: Author Correction: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

    Nechama, Morris / Kwon, Jeahoo / Wei, Shuo / Tun-Kyi, Adrian / Welner, Robert S / Ben-Dov, Iddo Z / Arredouani, Mohamed S / Asara, John M / Chen, Chun-Hau / Tsai, Cheng-Yu / Nelson, Kyle F / Kobayashi, Koichi S / Israel, Elliot / Zhou, Xiao Zhen / Nicholson, Linda K / Lu, Kun Ping

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3622

    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39297-5
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  5. Article ; Online: Role of the M point phonons for the dynamical stability of B2 compounds.

    Ono, Shota / Kobayashi, Daigo

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7258

    Abstract: ... in whether the lowest frequency phonons around the M point in the Brillouin zone are endowed with a positive frequency ...

    Abstract Although many binary compounds have the B2 (CsCl-type) structure in the thermodynamic phase diagram, an origin of the dynamical stability is not understood well. Here, we focus on 416 compounds in the B2 structure extracted from the Materials Project, and study the dynamical stability of those compounds from first principles. We demonstrate that the dynamical stability of the B2 compounds lies in whether the lowest frequency phonons around the M point in the Brillouin zone are endowed with a positive frequency, except for VRu. We show that the interatomic interactions up to the fourth nearest neighbor atoms are necessary for stabilizing such phonon modes, which should determine the minimum cutoff radius for constructing the interatomic potentials of binary compounds with guaranteed accuracy.
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10658-2
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  6. Article ; Online: Vibrational spectroscopy analysis of ligand efficacy in human M

    Katayama, Kota / Suzuki, Kohei / Suno, Ryoji / Kise, Ryoji / Tsujimoto, Hirokazu / Iwata, So / Inoue, Asuka / Kobayashi, Takuya / Kandori, Hideki

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 1321

    Abstract: ... dependent conformational changes in the human M ...

    Abstract The intrinsic efficacy of ligand binding to G protein-coupled receptors (GPCRs) reflects the ability of the ligand to differentially activate its receptor to cause a physiological effect. Here we use attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to examine the ligand-dependent conformational changes in the human M
    MeSH term(s) Humans ; Ligands ; Receptor, Muscarinic M2/chemistry ; Spectrum Analysis
    Chemical Substances CHRM2 protein, human ; Ligands ; Receptor, Muscarinic M2
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-02836-1
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  7. Article ; Online: Structural insights into the subtype-selective antagonist binding to the M

    Suno, Ryoji / Lee, Sangbae / Maeda, Shoji / Yasuda, Satoshi / Yamashita, Keitaro / Hirata, Kunio / Horita, Shoichiro / Tawaramoto, Maki S / Tsujimoto, Hirokazu / Murata, Takeshi / Kinoshita, Masahiro / Yamamoto, Masaki / Kobilka, Brian K / Vaidehi, Nagarajan / Iwata, So / Kobayashi, Takuya

    Nature chemical biology

    2018  Volume 14, Issue 12, Page(s) 1150–1158

    Abstract: Human muscarinic receptor M ...

    Abstract Human muscarinic receptor M
    MeSH term(s) Binding Sites ; Crystallography, X-Ray ; Enzyme Stability ; Humans ; Molecular Dynamics Simulation ; Muscarinic Antagonists/chemistry ; Muscarinic Antagonists/metabolism ; Mutation ; N-Methylscopolamine/chemistry ; N-Methylscopolamine/metabolism ; Pirenzepine/analogs & derivatives ; Pirenzepine/chemistry ; Pirenzepine/metabolism ; Receptor, Muscarinic M2/antagonists & inhibitors ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/metabolism
    Chemical Substances Muscarinic Antagonists ; Receptor, Muscarinic M2 ; AFDX 384 (118290-27-0) ; Pirenzepine (3G0285N20N) ; N-Methylscopolamine (VDR09VTQ8U)
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-018-0152-y
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    Zs.A 6251: Show issues Location:
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    Zs.MG 90: Show issues

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  8. Article ; Online: Intermetallic Compound TiM (M=Co, Fe) with a Layered Structure Prepared by Deoxidizing Ilmenite-type Oxides in Molten LiCl-CaH

    Kobayashi, Yasukazu / Nagaura, Tomota / Alowasheeir, Azhar / Tada, Shohei / Yamauchi, Yusuke

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 32, Page(s) e202300194

    Abstract: CsCl-type intermetallic compounds TiM (M=Co, Fe) were obtained by deoxidizing trigonal ilmenite ...

    Abstract CsCl-type intermetallic compounds TiM (M=Co, Fe) were obtained by deoxidizing trigonal ilmenite-type MTiO
    MeSH term(s) Oxides/chemistry ; Iron/chemistry ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Lithium
    Chemical Substances ilmenite (12168-52-4) ; Oxides ; Iron (E1UOL152H7) ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202300194
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  9. Article ; Online: Glycation of HDL Polymerizes Apolipoprotein M and Attenuates Its Capacity to Bind to Sphingosine 1-Phosphate.

    Kobayashi, Tamaki / Kurano, Makoto / Nanya, Mai / Shimizu, Tomo / Ohkawa, Ryunosuke / Tozuka, Minoru / Yatomi, Yutaka

    Journal of atherosclerosis and thrombosis

    2021  Volume 28, Issue 7, Page(s) 730–741

    Abstract: ... lipoprotein (HDL) are attributed to sphingosine 1-phosphate (S1P), which rides on HDL via apolipoprotein M ...

    Abstract Aim: Recently, it has been established that most of the pleiotropic effects of high-density lipoprotein (HDL) are attributed to sphingosine 1-phosphate (S1P), which rides on HDL via apolipoprotein M (ApoM). In subjects with diabetes mellitus, both the pleiotropic effects of HDL and its role in reverse cholesterol transport are reported to be impaired. To elucidate the mechanisms underlying the impaired pleiotropic effects of HDL in subjects with diabetes, from the aspects of S1P and ApoM.
    Methods: The incubation of HDL in a high-glucose condition resulted in the dimerization of ApoM. Moreover, the treatment of HDL with methylglyoxal resulted in the modulation of the ApoM structure, as suggested by the results of western blot analysis, isoelectric focusing electrophoresis, and two-dimensional gel electrophoresis, which was reversed by treatment with anti-glycation reagents.
    Results: The glycation of HDL resulted in impaired binding of the glycated HDL to S1P, and the S1P on glycated HDL degraded faster. In the case of human subjects, on the other hand, although both the serum ApoM levels and the ApoM content in HDL were lower in subjects with diabetes, we did not observe the polymerization of ApoM.
    Conclusions: Modulation of the quantity and quality of ApoM might explain, at least in part, the impaired functions of HDL in subjects with diabetes mellitus. ApoM might be a useful target for laboratory testing and/or the treatment of diabetes mellitus.
    MeSH term(s) Apolipoproteins M/metabolism ; Biological Transport/drug effects ; Biological Transport/physiology ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; Drug Discovery ; Electrophoresis, Gel, Two-Dimensional/methods ; Humans ; Isoelectric Focusing/methods ; Lipoproteins, HDL/analysis ; Lipoproteins, HDL/metabolism ; Lysophospholipids/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
    Chemical Substances Apolipoproteins M ; Lipoproteins, HDL ; Lysophospholipids ; glycated lipoproteins, HDL ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2021-01-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.55699
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    Zs.A 5192: Show issues Location:
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  10. Article ; Online: Autoimmune haemolytic anaemia caused by anti-M antibody in a patient with Kawasaki disease.

    Shimomura, Masaki / Okura, Yuka / Ohta, Osamu / Takahashi, Yutaka / Kobayashi, Ichiro

    Modern rheumatology case reports

    2019  Volume 4, Issue 1, Page(s) 99–101

    Abstract: ... Although both direct and indirect antiglobulin tests and anti-M antibodies were positive in his blood obtained after ... the onset of HA, indirect antiglobulin tests and anti-M antibodies were negative either in the blood sample ... This is, to our knowledge, the first report of autoimmune HA caused by anti-M autoantibodies after IVIG ...

    Abstract Intravenous immunoglobulin (IVIG) is a standard therapy for Kawasaki disease (KD), because it prevents formation of coronary artery aneurysm, a major complication of KD. Herein, we report a 3-year-old boy with KD complicated by haemolytic anaemia (HA) which developed following two courses of IVIG. Although both direct and indirect antiglobulin tests and anti-M antibodies were positive in his blood obtained after the onset of HA, indirect antiglobulin tests and anti-M antibodies were negative either in the blood sample before the treatment or the same lot of IVIG products as those used for the therapy, suggesting autoimmune mechanism. This is, to our knowledge, the first report of autoimmune HA caused by anti-M autoantibodies after IVIG therapy in KD.
    MeSH term(s) Anemia, Hemolytic, Autoimmune/diagnosis ; Anemia, Hemolytic, Autoimmune/etiology ; Anemia, Hemolytic, Autoimmune/therapy ; Autoantibodies/immunology ; Autoimmunity ; Child, Preschool ; Coombs Test ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/immunology ; Treatment Outcome
    Chemical Substances Autoantibodies ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2019-11-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1080/24725625.2019.1681654
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