LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 164

Search options

  1. Article ; Online: The impacts of regional transport on anthropogenic source contributions of PM

    Liu, Huikun / Wang, Qiyuan / Wei, Peng / Zhang, Qian / Qu, Yao / Zhang, Yong / Tian, Jie / Xu, Hongmei / Zhang, Ningning / Shen, Zhenxing / Su, Hui / Han, Yongming / Cao, Junji

    The Science of the total environment

    2024  Volume 917, Page(s) 170038

    Abstract: ... ...

    Abstract PM
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Correction: Dynorphin / kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner.

    Yarur, Hector E / Casello, Sanne M / Tsai, Valerie S / Enriquez-Traba, Juan / Kore, Rufina / Wang, Huikun / Arenivar, Miguel / Tejeda, Hugo A

    Molecular psychiatry

    2023  Volume 28, Issue 11, Page(s) 4934

    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02368-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Source-specific light absorption and radiative effects decreases and indications due to the lockdown.

    Qu, Yao / Liu, Huikun / Zhang, Ting / Su, Hui / Wang, Nan / Zhou, Yue / Shi, Julian / Wang, Luyao / Wang, Qiyuan / Liu, Suixin / Zhu, Chongshu / Cao, Junji

    Journal of environmental management

    2024  Volume 356, Page(s) 120600

    Abstract: The 'extreme' emission abatement during the lockdown (from the end of 2019 to the early 2020) provided an experimental period to investigate the corresponding source-specific effects of aerosol. In this study, the variations of source-specific light ... ...

    Abstract The 'extreme' emission abatement during the lockdown (from the end of 2019 to the early 2020) provided an experimental period to investigate the corresponding source-specific effects of aerosol. In this study, the variations of source-specific light absorption (b
    MeSH term(s) Air Pollutants/analysis ; Environmental Monitoring/methods ; Coal ; Aerosols/analysis ; Biomass ; Particulate Matter/analysis ; China
    Chemical Substances Air Pollutants ; Coal ; Aerosols ; Particulate Matter
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120600
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Analysis of the Housing–Jobs Separation Characteristics of Different Village Types in the Mountainous and Hilly Region of Southwest China

    Huikun Hong / Ting Liu / Heping Liao / Zhicong Cai / Gang Wang

    Land, Vol 11, Iss 1990, p

    2022  Volume 1990

    Abstract: The economic and social transition toward modernization is characterized by a massive outflow of rural labor, which raises problems such as rural job–housing separation and rural decline. Few studies have used rural labor employment microdata to ... ...

    Abstract The economic and social transition toward modernization is characterized by a massive outflow of rural labor, which raises problems such as rural job–housing separation and rural decline. Few studies have used rural labor employment microdata to quantitatively analyze the degree of separation between housing and jobs in different types of villages, especially in ecologically fragile mountainous and hilly regions. This article is based on a 2021 survey of 6181 rural households in 158 villages of Chongqing, a mountainous and hilly region of China, and divides villages into city edge, suburban, and outer suburban villages. In this study, the separation degree of housing–jobs (SDHJ) measurement model was created in order to explore the degree of separation between rural jobs and housing in terms of space–time dimension separation in these areas, and the different job–housing separation characteristics under different village types were distinguished. The results show the following. (1) The county’s rural SDHJ has a clear regional differentiation law, and the degrees of separation between housing and jobs in all counties are in the following order: main urban area < northeast of Chongqing < southeast of Chongqing. The degree of separation between housing and jobs presents a spatial pattern of “medium–low perimeter high, local prominence” according to both the degree of temporal separation and the degree of spatial separation. (2) The degrees of separation between housing and jobs in various village types are in the following order: urban fringe villages < suburban villages < outer suburban villages. The distance effect was verified. The SDHJ is typically low in urban fringe villages and moderate in suburban villages, with distinct geographical disparities in labor distribution. The SDHJ is typically higher in the outer suburban villages, where laborers choose long-term long-distance employment. (3) This study proposes some countermeasures that could reduce the SDHJ for different types of villages. The ...
    Keywords housing–jobs separation ; rural labor ; rural sustainable development ; the hilly and mountainous region ; China ; Agriculture ; S
    Subject code 720
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Mechanisms and Kinetics Studies of Butylated Hydroxytoluene Degradation to Isobutene.

    Zhou, Junwei / Chen, Hongrui / Chen, Jianfa / Wan, Daihong / Zhang, Huikun / Wang, Rong / Xie, Daiqian / Mao, Chengli

    The journal of physical chemistry. A

    2022  Volume 126, Issue 20, Page(s) 3210–3218

    Abstract: 2,6-Di- ...

    Abstract 2,6-Di-
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c01961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Breast Cancer Patients With Positive Apical or Infraclavicular/Ipsilateral Supraclavicular Lymph Nodes Should Be Excluded in the Application of the Lymph Node Ratio System.

    Wang, Zhe / Chong, Wei / Zhang, Huikun / Liu, Xiaoli / Zhao, Yawen / Guo, Zhifang / Fu, Li / Ma, Yongjie / Gu, Feng

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 784920

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.784920
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: A Reference Architecture for Blockchain-based Traceability Systems Using Domain-Driven Design and Microservices

    Wang, Yanze / Li, Shanshan / Liu, Huikun / Zhang, He / Pan, Bo

    2023  

    Abstract: Traceability systems are important for solving problems due to the increasing scale of the global supply chain, such as food safety crises and market disorder. Blockchain, as an immutable and decentralized ledger, is able to optimize the traditional ... ...

    Abstract Traceability systems are important for solving problems due to the increasing scale of the global supply chain, such as food safety crises and market disorder. Blockchain, as an immutable and decentralized ledger, is able to optimize the traditional traceability system by ensuring the transparency and reliability of the system data. However, the use of blockchain technology may lead to a rapid increase in the complexity of system design and development. It is challenging to address widespread and complicated business, changeable processes, and massive data in practice, which are the main factors restricting the wide application of a blockchain-based traceability system (BTS). Therefore, in this paper, we reviewed relevant studies and proposed a reference architecture for BTSs. The proposed reference architecture can improve the cohesiveness, maintainability, and extensibility of BTSs through domain-driven design (DDD) and microservices. Considering the efficiency reduction caused by massive data and complicated data structure, we further changed the traditional single blockchain framework into multiple sub-chain networks, which could improve development efficiency and system performance. With the guidance of the architecture trade-off analysis method (ATAM), we evaluated our reference architecture and implemented a prototype in the salmon supply chain scenario. The results show that our solution is effective and adaptable to meet the requirements of BTSs.

    Comment: 10 pages, 6 figures, Asia Pacific Structural Engineering and Construction conference (APSEC) 2022
    Keywords Computer Science - Software Engineering
    Subject code 670
    Publishing date 2023-02-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: The multilevel extensive diversity across the cynomolgus macaque captured by ultra-deep adaptive immune receptor repertoire sequencing.

    Zhu, Yan / Tang, Haipei / Xie, Wenxi / Chen, Sen / Zeng, Huikun / Lan, Chunhong / Guan, Junjie / Ma, Cuiyu / Yang, Xiujia / Wang, Qilong / Wei, Lai / Zhang, Zhenhai / Yu, Xueqing

    Science advances

    2024  Volume 10, Issue 4, Page(s) eadj5640

    Abstract: The extent to which AIRRs differ among and within individuals remains elusive. Via ultra-deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques, respectively, we identified 84 and 114 novel IGHV and TRBV alleles, confirming 72 (85 ... ...

    Abstract The extent to which AIRRs differ among and within individuals remains elusive. Via ultra-deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques, respectively, we identified 84 and 114 novel IGHV and TRBV alleles, confirming 72 (85.71%) and 100 (87.72%) of them. The heterogeneous V gene usage patterns were influenced, in turn, by genetics, isotype (for BCRs only), tissue group, and tissue. A higher proportion of intragroup shared clones in the intestinal tissues than those in other tissues suggests a close intra-intestinal adaptive immunity network. Significantly higher mutation burdens in the public clones and the inter-tissue shared IgM and IgD clones indicate that they might target the shared antigens. This study reveals the extensive heterogeneity of the AIRRs at various levels and has broad fundamental and clinical implications. The data generated here will serve as an invaluable resource for future studies on adaptive immunity in health and diseases.
    MeSH term(s) Animals ; Adaptive Immunity/genetics ; Alleles ; Immunoglobulin Isotypes ; Macaca fascicularis/genetics ; Receptors, Immunologic
    Chemical Substances Immunoglobulin Isotypes ; Receptors, Immunologic
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adj5640
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry.

    Tejeda, Hugo A / Wang, Huikun / Flores, Rodolfo J / Yarur, Hector E

    Handbook of experimental pharmacology

    2021  Volume 271, Page(s) 223–253

    Abstract: Cortical circuits control a plethora of behaviors, from sensation to cognition. The cortex is enriched with neuropeptides and receptors that play a role in information processing, including opioid peptides and their cognate receptors. The dynorphin (DYN)/ ...

    Abstract Cortical circuits control a plethora of behaviors, from sensation to cognition. The cortex is enriched with neuropeptides and receptors that play a role in information processing, including opioid peptides and their cognate receptors. The dynorphin (DYN)/kappa-opioid receptor (KOR) system has been implicated in the processing of sensory and motivationally-charged emotional information and is highly expressed in cortical circuits. This is important as dysregulation of DYN/KOR signaling in limbic and cortical circuits has been implicated in promoting negative affect and cognitive deficits in various neuropsychiatric disorders. However, research investigating the role of this system in controlling cortical circuits and computations therein is limited. Here, we review the (1) basic anatomy of cortical circuits, (2) anatomical architecture of the cortical DYN/KOR system, (3) functional regulation of cortical synaptic transmission and microcircuit function by the DYN/KOR system, (4) regulation of behavior by the cortical DYN/KOR system, (5) implications for the DYN/KOR system for human health and disease, and (6) future directions and unanswered questions for the field. Further work elucidating the role of the DYN/KOR system in controlling cortical information processing and associated behaviors will be of importance to increasing our understanding of principles underlying neuropeptide modulation of cortical circuits, mechanisms underlying sensation and perception, motivated and emotional behavior, and cognition. Increased emphasis in this area of study will also aid in the identification of novel ways to target the DYN/KOR system to treat neuropsychiatric disorders.
    MeSH term(s) Dynorphins ; Humans ; Opioid Peptides ; Receptors, Opioid, kappa ; Synaptic Transmission
    Chemical Substances Opioid Peptides ; Receptors, Opioid, kappa ; Dynorphins (74913-18-1)
    Language English
    Publishing date 2021-02-15
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_440
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Dynorphin / kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner.

    Yarur, Hector E / Casello, Sanne M / Tsai, Valerie S / Enriquez-Traba, Juan / Kore, Rufina / Wang, Huikun / Arenivar, Miguel / Tejeda, Hugo A

    Molecular psychiatry

    2023  Volume 28, Issue 11, Page(s) 4801–4813

    Abstract: The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin (Dyn) / kappa-opioid receptor (KOR) system is highly enriched in ... ...

    Abstract The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin (Dyn) / kappa-opioid receptor (KOR) system is highly enriched in the mPFC, and its dysregulation is implicated in neuropsychiatric disorders. However, it is unclear how the Dyn / KOR system modulates excitatory and inhibitory circuits that are integral for mPFC information processing and behavioral control. Here, we provide a circuit-based framework wherein mPFC Dyn / KOR signaling regulates excitation-inhibition balance by toggling which afferents drive mPFC neurons. Dyn / KOR regulation of afferent inputs is pathway-specific. Dyn acting on presynaptic KORs inhibits glutamate release from afferent inputs to the mPFC, including the basolateral amygdala (BLA), paraventricular nucleus of the thalamus, and contralateral cortex. The majority of excitatory synapses to mPFC neurons, including those from the ventral hippocampus (VH), do not express presynaptic KOR, rendering them insensitive to Dyn / KOR modulation. Dyn / KOR signaling also suppresses afferent-driven recruitment of specific inhibitory sub-networks, providing a basis for Dyn to disinhibit mPFC circuits. Specifically, Dyn / KOR signaling preferentially suppresses SST interneuron- relative to PV interneuron-mediated inhibition. Selective KOR action on afferents or within mPFC microcircuits gates how distinct limbic inputs drive spiking in mPFC neurons. Presynaptic Dyn / KOR signaling decreases KOR-positive input-driven (e.g. BLA) spiking of mPFC neurons. In contrast, KOR-negative input recruitment of mPFC neurons is enhanced by Dyn / KOR signaling via suppression of mPFC inhibitory microcircuits. Thus, by acting on distinct circuit elements, Dyn / KOR signaling shifts KOR-positive and negative afferent control of mPFC circuits, providing mechanistic insights into the role of neuropeptides in shaping mPFC function. Together, these findings highlight the utility of targeting the mPFC Dyn / KOR system as a means to treat neuropsychiatric disorders characterized by dysregulation in mPFC integration of long-range afferents with local inhibitory microcircuits.
    MeSH term(s) Dynorphins/metabolism ; Receptors, Opioid, kappa ; Prefrontal Cortex/metabolism ; Neurons/metabolism ; Basolateral Nuclear Complex/metabolism
    Chemical Substances Dynorphins (74913-18-1) ; Receptors, Opioid, kappa
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02226-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top