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  1. Article ; Online: Letter by Jurado-Román et al Regarding Article, "Laser Coronary Atherectomy and Polymeric Coronary Wires in Uncrossable Lesions: A Word of Caution".

    Jurado-Román, Alfonso / Wacinski, Piotr J / Egred, Mohaned

    Circulation. Cardiovascular interventions

    2024  Volume 17, Issue 3, Page(s) e013954

    MeSH term(s) Humans ; Atherectomy, Coronary/adverse effects ; Treatment Outcome ; Angioplasty, Balloon, Coronary ; Coronary Occlusion ; Lasers ; Coronary Angiography
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.123.013954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6746: Show issues Location:
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  2. Article ; Online: Rotational atherectomy of left main stem immediately after transcatheter aortic valve implantation in a patient with symptomatic severe aortic stenosis and an impaired left ventricular systolic function: a case report.

    Satti, Zahir / Farag, Mohamed / Egred, Mohaned / Alkhalil, Mohammad

    European heart journal. Case reports

    2023  Volume 7, Issue 7, Page(s) ytad301

    Abstract: Background: Severe aortic stenosis (AS) and coronary artery disease (CAD) often coexist since they both share the same risk factors and pathophysiology. Patients with severe AS with prohibitive surgical risk are often treated with transcatheter aortic ... ...

    Abstract Background: Severe aortic stenosis (AS) and coronary artery disease (CAD) often coexist since they both share the same risk factors and pathophysiology. Patients with severe AS with prohibitive surgical risk are often treated with transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as a staged or concurrent procedure. Significant calcified CAD and left ventricular (LV) systolic impairment in such patients would add more challenges to the management. A clear consensus on the timing of revascularization of such patients in relation to the TAVI procedure is lacking.
    Case summary: Herein, we present an 86-year-old male who presented to a local district hospital with non-ST-segment elevation myocardial infarction (N-STEMI) and decompensated heart failure. His transthoracic echocardiography showed moderate LV systolic impairment with low-flow severe AS. He was initially treated with dual anti-platelet and diuretic therapy and subsequently underwent coronary angiography that revealed severe calcified shelf-like left main stem (LMS) and moderate left anterior descending (LAD) disease. He was successfully treated with TAVI and rotational atherectomy (RA)-assisted PCI to LMS and LAD in the same setting.
    Conclusion: There is limited evidence on effective strategies to tackle high-risk angioplasty with concurrent TAVI in patients with impaired LV function. We performed TAVI and RA to LMS and LAD in the same setting using no mechanical circulatory support (MCS). Management strategies should be individualized to highly selected patients taking into account LMS involvement, calcium modulation strategies, haemodynamic instability, or cardiogenic shock and whether MCS is needed.
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad301
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  3. Article ; Online: CTO in Contemporary PCI.

    Farag, Mohamed / Egred, Mohaned

    Current cardiology reviews

    2021  Volume 18, Issue 1, Page(s) e310521193720

    Abstract: Percutaneous Coronary Intervention (PCI) of Chronic Total Occlusions (CTO) represents the most challenging procedure in modern endovascular treatments. In recent years, the success rate of CTO PCI has substantially improved, owing to increasing operator ... ...

    Abstract Percutaneous Coronary Intervention (PCI) of Chronic Total Occlusions (CTO) represents the most challenging procedure in modern endovascular treatments. In recent years, the success rate of CTO PCI has substantially improved, owing to increasing operator expertise and advancements in CTO equipment and algorithms as well as the development of expert consensus documents. In this review, we summarize existing evidence for CTO PCI, its success/ risk prediction scoring tools, procedural principles and complications and provide an insight into the future role of CTO PCI.
    MeSH term(s) Chronic Disease ; Coronary Angiography ; Coronary Occlusion/surgery ; Humans ; Percutaneous Coronary Intervention/methods ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2021-05-30
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/1573403X17666210531143519
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  4. Article: The Use of Thrombectomy during Primary Percutaneous Coronary Intervention: Resurrecting an Old Concept in Contemporary Practice.

    Satti, Zahir / Omari, Muntaser / Bawamia, Bilal / Cartlidge, Timothy / Egred, Mohaned / Farag, Mohamed / Alkhalil, Mohammad

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Optimal myocardial reperfusion during primary percutaneous coronary intervention (pPCI) is increasingly recognized to be beyond restoring epicardial coronary flow. Both invasive and non-invasive tools have highlighted the limitation of using this metric, ...

    Abstract Optimal myocardial reperfusion during primary percutaneous coronary intervention (pPCI) is increasingly recognized to be beyond restoring epicardial coronary flow. Both invasive and non-invasive tools have highlighted the limitation of using this metric, and more efforts are focused towards achieving optimal reperfusion at the level of the microcirculation. Recent data highlighted the close relationship between thrombus burden and impaired microcirculation in patients presenting with ST-segment elevation myocardial infarction (STEMI). Moreover, distal embolization was an independent predictor of mortality in patients with STEMI. Likewise, the development of no-reflow phenomenon has been directly linked with worse clinical outcomes. Adjunctive thrombus aspiration during pPCI is intuitively intended to remove atherothrombotic material to mitigate the risk of distal embolization and the no-reflow phenomenon (NRP). However, prior trials on the use of thrombectomy during pPCI did not support its routine use, with comparable clinical endpoints to patients who underwent PCI alone. This article aims to review the existing literature highlighting the limitation on the use of thrombectomy and provide future insights into trials investigating the role of thrombectomy in contemporary pPCI.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082291
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  5. Article: Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting in Complex Coronary Artery Disease: Long-term Clinical Outcomes from a High-volume Center.

    Hesse, Kerrick / Egred, Mohaned / Zaman, Azfar / Alkhalil, Mohammad / Farag, Mohamed

    Heart views : the official journal of the Gulf Heart Association

    2023  Volume 24, Issue 3, Page(s) 141–147

    Abstract: Background: Clinical equipoise between a percutaneous coronary intervention (PCI) and coronary artery bypass grafting surgery (CABG) in the treatment of complex coronary artery disease (CAD), including unprotected left main coronary artery (LMCA) and/or ...

    Abstract Background: Clinical equipoise between a percutaneous coronary intervention (PCI) and coronary artery bypass grafting surgery (CABG) in the treatment of complex coronary artery disease (CAD), including unprotected left main coronary artery (LMCA) and/or three-vessel disease (3VD), remains debatable.
    Methods: A retrospective analysis of an unselected cohort undergoing contemporary PCI versus CABG at a large center in 2015. Patients who received nonemergent treatment of unprotected LMCA and/or 3VD were included. The primary study endpoint was all-cause mortality at 5 years. Secondary endpoints included a composite of all-cause mortality, spontaneous myocardial infarction (MI), or ischemia-driven repeat revascularization at 30 days and 1 year.
    Results: Four hundred and thirty patients met the inclusion criteria, 225 had PCI, and 205 had CABG. PCI patients were older with frequent LMCA involvement and higher EuroSCORE yet they had a fourfold shorter in-hospital stay compared to CABG patients. At 5 years, there was no significant difference in the primary endpoint between CABG and PCI (adjusted Hazard ratios 0.68, 95% confidence interval: 0.38-1.22,
    Conclusions: In real-world long-term contemporary data, survival after PCI was comparable to CABG at 5 years in patients with unprotected LMCA and/or 3VD. At 1 year, the incidence of spontaneous MI and ischemia-driven repeat revascularization did not differ between the two cohorts. The mode of revascularization in these complex patients should be guided by the heart team.
    Language English
    Publishing date 2023-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2575257-1
    ISSN 0976-5123 ; 1995-705X
    ISSN (online) 0976-5123
    ISSN 1995-705X
    DOI 10.4103/heartviews.heartviews_116_22
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  6. Article ; Online: Percutaneous closure of giant saphenous vein graft aneurysm.

    Loh, Shu Xian / McQuillan, Conor / Sharabi, Alaa H / Egred, Mohaned

    European heart journal. Case reports

    2023  Volume 7, Issue 10, Page(s) ytad491

    Abstract: Background: Aneurysmal dilatation of saphenous vein grafts used for coronary artery bypass grafting is a rare complication. These aneurysms are often large in calibre and pose a risk of rupture with significant haemorrhage.: Case summary: We describe ...

    Abstract Background: Aneurysmal dilatation of saphenous vein grafts used for coronary artery bypass grafting is a rare complication. These aneurysms are often large in calibre and pose a risk of rupture with significant haemorrhage.
    Case summary: We describe a case whereby a large saphenous vein graft aneurysm is closed percutaneously using a vascular plug to cease flow and promote thrombosis of the aneurysm whilst reconstructing the occluded native artery to negate ischaemia.
    Conclusion: Saphenous vein graft aneurysms following coronary artery bypass graft are rare and late complications. The preferred modality of closure is via percutaneous approach that requires meticulous planning to achieve a good outcome.
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad491
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  7. Article ; Online: Management of antithrombotic therapy in patients at high bleeding risk after percutaneous coronary intervention for acute coronary syndromes: a case report.

    Mahmood, Hamid / Shahid, Farhan / Egred, Mohaned / Farag, Mohamed

    European heart journal. Case reports

    2022  Volume 6, Issue 6, Page(s) ytac224

    Abstract: Background: Choosing antithrombotic therapy for patients at high bleeding risk, particularly those requiring long-term anticoagulant therapy, who have acute coronary syndromes (ACS) and/or undergoing percutaneous coronary intervention (PCI) is becoming ... ...

    Abstract Background: Choosing antithrombotic therapy for patients at high bleeding risk, particularly those requiring long-term anticoagulant therapy, who have acute coronary syndromes (ACS) and/or undergoing percutaneous coronary intervention (PCI) is becoming increasingly complex.
    Case summary: A 78-year-old women was hospitalized with chest pain and a diagnosis of non-ST-elevation ACS was made. It was decided that the patient should undergo coronary angiogram with a view for angioplasty. Subsequently, she underwent successful PCI to the left anterior descending artery. Shortly after PCI, she was noted to be in atrial fibrillation. Furthermore, she had per rectal bleeding and acute kidney injury, which were managed conservatively. Aspirin and ticagrelor were stopped and she was discharged on dual antithrombotic therapy with clopidogrel and apixaban.
    Discussion: Available evidence, driven mainly from expert consensus documents, advocates a case-by-case comprehensive evaluation that integrates patient- and procedure-related factors to assess patients for thrombotic and bleeding tendencies to identify those who may gain most net clinical benefit of antithrombotic combination therapy. In general, if thrombotic drivers prevail, an augmented antithrombotic regime with a view for a longer duration should be planned, and if bleeding drivers prevail, a de-escalated regime with a view for a shorter duration should be sought.
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac224
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  8. Article ; Online: Drive-By Radial Artery Re-Entry: Extending Chronic Total Occlusion Techniques to the Peripheral Arteries.

    Mcquillan, Conor / Egred, Mohaned

    JACC. Case reports

    2020  Volume 2, Issue 15, Page(s) 2404–2407

    Abstract: Despite the success of the hybrid coronary chronic total occlusion percutaneous coronary intervention techniques, there has been little translation of these techniques into peripheral interventions. We describe a case of recanalization of an occluded ... ...

    Abstract Despite the success of the hybrid coronary chronic total occlusion percutaneous coronary intervention techniques, there has been little translation of these techniques into peripheral interventions. We describe a case of recanalization of an occluded radial artery that was dissected and re-entered using chronic total occlusion techniques before moving on to revascularize the coronary artery. (
    Language English
    Publishing date 2020-11-11
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.09.013
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  9. Article ; Online: Excimer Laser Coronary Angioplasty (ELCA): Fundamentals, Mechanism of Action, and Clinical Applications.

    Egred, Mohaned / Brilakis, Emmanouil S

    The Journal of invasive cardiology

    2020  Volume 32, Issue 2, Page(s) E27–E35

    Abstract: Laser coronary angioplasty was developed to modify atherosclerotic plaque and help with the acute and longer-term limitations of balloon angioplasty, namely, intimal dissection and restenosis, respectively. Excimer laser debulks and modifies the tissue ... ...

    Abstract Laser coronary angioplasty was developed to modify atherosclerotic plaque and help with the acute and longer-term limitations of balloon angioplasty, namely, intimal dissection and restenosis, respectively. Excimer laser debulks and modifies the tissue with its photochemical, photothermal, and photokinetic properties without causing significant injury. With important refinements and advancements, laser has gained a renewed place in treating complex and resistant coronary lesions after a disappointing start. When used in line with the instructions, laser is an important tool that allows the completion of difficult and complicated cases. It is a useful tool in the catheterization laboratory to treat lesions that are uncrossable or undilatable. Laser is also helpful in cases where a stent was deployed but remains under-expanded, with accumulating evidence of its efficacy in such cases. In addition, laser is increasingly used for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) to facilitate modification of the proximal CTO cap to allow penetration with a wire and completion of the procedure. Laser has been used in certain circumstances by experienced operators with simultaneous contrast rather than saline injection, to increase its effect and allow the successful completion of complex PCIs. This article outlines the scientific background, experimental data, practical procedural techniques, and clinical applications of excimer laser coronary angioplasty in the treatment of coronary artery disease.
    MeSH term(s) Angioplasty, Laser/instrumentation ; Angioplasty, Laser/methods ; Atherectomy, Coronary/instrumentation ; Atherectomy, Coronary/methods ; Coronary Angiography/methods ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Coronary Occlusion/etiology ; Coronary Occlusion/surgery ; Coronary Restenosis/etiology ; Coronary Restenosis/surgery ; Humans ; Lasers, Excimer/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods
    Language English
    Publishing date 2020-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3701: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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  10. Article ; Online: Pneumopericardium.

    Nazir, Ammar / Egred, Mohaned

    European heart journal

    2020  Volume 42, Issue 14, Page(s) 1445

    MeSH term(s) Humans ; Pneumopericardium/diagnostic imaging ; Pneumopericardium/etiology
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa692
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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