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  1. Book ; Online: Oceanography and Marine Biology

    Hawkins, S. J / Todd, P. A / Russell, B. D / Lemasson, A. J / Allcock, A. L / Byrne, M / Firth, L. B / Lucas, C. H / Marzinelli, E. M / Mumby, P. J / Sharples, J / Smith, I. P / Swearer, S. E

    An annual review. Volume 61

    2023  

    Keywords Applied ecology ; The Earth: natural history general ; Oceanography (seas) ; Environmental science, engineering & technology ; Climate change ; Marine biology ; oceanography ; marine biology ; marine science ; environmental science ; fisheries ; fish biology ; crustaceans ; climate change
    Language English
    Size 1 electronic resource (376 pages)
    Publisher Taylor and Francis
    Publishing place Boca Raton, Abingdon
    Document type Book ; Online
    Note English
    HBZ-ID HT030612922
    ISBN 9781003363873 ; 1003363873
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Oceanography and Marine Biology : An Annual Review, Volume 59

    Hawkins, S.J. / Lemasson, A. J. / Allcock, A.L. / Bates, A. E. / Byrne, M. / Evans, A J. / Firth, L.B. / Marzinelli, E.M. / Russell, B.D. / Smith, I.P. / Swearer, S.E. / Todd, P.A.

    2021  

    Keywords Lifestyle, sport & leisure ; Earth sciences, geography, environment, planning ; Technology, engineering, agriculture ; Mathematics & science ; oceanography, climate change, reefs, marine science, marine conservation, marine research
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290418
    ISBN 9781003138846 ; 1003138845
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Oxygen consumption rate during recovery from loss of equilibrium induced by warming, hypoxia, or exhaustive exercise in rainbow darter (Etheostoma caeruleum).

    Borowiec, Brittney G / Firth, Britney L / Craig, Paul M

    Journal of fish biology

    2024  

    Abstract: Animals routinely encounter environmental (e.g., high temperatures and hypoxia) as well ... as physiological perturbations (e.g., exercise and digestion) that may threaten homeostasis. However, comparing ...

    Abstract Animals routinely encounter environmental (e.g., high temperatures and hypoxia) as well as physiological perturbations (e.g., exercise and digestion) that may threaten homeostasis. However, comparing the relative threat or "disruptiveness" imposed by different stressors is difficult, as stressors vary in their mechanisms, effects, and timescales. We exploited the fact that several acute stressors can induce the loss of equilibrium (LOE) in fish to (i) compare the metabolic recovery profiles of three environmentally relevant stressors and (ii) test the concept that LOE could be used as a physiological calibration for the intensity of different stressors. We focused on Etheostoma caeruleum, a species that routinely copes with environmental fluctuations in temperature and oxygen and that relies on burst swimming to relocate and avoid predators, as our model. Using stop-flow (intermittent) respirometry, we tracked the oxygen consumption rate (MO
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4814: Show issues
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  4. Article: Letter: Improved localisation by subtraction of E.M.I. scans.

    Firth, J L / Ladurner, G / Zilkha, E / Iliff, L D

    Lancet (London, England)

    1975  Volume 2, Issue 7935, Page(s) 609

    MeSH term(s) Adult ; Female ; Humans ; Image Enhancement ; Radionuclide Imaging ; Subtraction Technique
    Language English
    Publishing date 1975-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(75)90202-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  5. Article: Clearing the air: clarifying the causal role of smoking in mental illness.

    Firth, Joseph / Wootton, Robyn E / Sawyer, Chelsea / Taylor, Gemma M

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2023  Volume 22, Issue 1, Page(s) 151–152

    Language English
    Publishing date 2023-01-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.21023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Investigating the role of common cis-regulatory variants in modifying penetrance of putatively damaging, inherited variants in severe neurodevelopmental disorders.

    Wigdor, Emilie M / Samocha, Kaitlin E / Eberhardt, Ruth Y / Chundru, V Kartik / Firth, Helen V / Wright, Caroline F / Hurles, Matthew E / Martin, Hilary C

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8708

    Abstract: Recent work has revealed an important role for rare, incompletely penetrant inherited coding variants in neurodevelopmental disorders (NDDs). Additionally, we have previously shown that common variants contribute to risk for rare NDDs. Here, we ... ...

    Abstract Recent work has revealed an important role for rare, incompletely penetrant inherited coding variants in neurodevelopmental disorders (NDDs). Additionally, we have previously shown that common variants contribute to risk for rare NDDs. Here, we investigate whether common variants exert their effects by modifying gene expression, using multi-cis-expression quantitative trait loci (cis-eQTL) prediction models. We first performed a transcriptome-wide association study for NDDs using 6987 probands from the Deciphering Developmental Disorders (DDD) study and 9720 controls, and found one gene, RAB2A, that passed multiple testing correction (p = 6.7 × 10
    MeSH term(s) Child ; Humans ; Penetrance ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci/genetics ; Neurodevelopmental Disorders/genetics ; Transcriptome
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58894-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Topography-based modulation of environmental factors as a mechanism for intertidal microhabitat formation: A basis for marine ecological design.

    Bauer, Franz / Knights, Antony M / Hanley, Mick E / Griffin, John N / Foggo, Andy / Brown, Austin / Firth, Louise B

    Marine pollution bulletin

    2024  Volume 202, Page(s) 116358

    Abstract: ... thereby alter their surrounding microenvironment to the benefit of local organisms (e.g., resource ...

    Abstract Topographic complexity is often considered to be closely associated with habitat complexity and niche diversity; however, complex topography per se does not imply habitat suitability. Rather, ecologically suitable habitats may emerge if topographic features interact with environmental factors and thereby alter their surrounding microenvironment to the benefit of local organisms (e.g., resource provisioning, stress mitigation). Topography may thus act as a key modulator of abiotic stressors and biotic pressures, particularly in environmentally challenging intertidal systems. Here, we review how topography can alter microhabitat conditions with respect to four resources required by intertidal organisms: a source of energy (light, suspended food particles, prey, detritus), water (hydration, buffering of light, temperature and hydrodynamics), shelter (temperature, wave exposure, predation), and habitat space (substratum area, propagule settlement, movement). We synthesize mechanisms and quantitative findings of how environmental factors can be altered through topography and suggest an organism-centered 'form-follows-ecological-function' approach to designing multifunctional marine infrastructure.
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2024.116358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding patient and family utilisation of community-based palliative care services out-of-hours: Additional analysis of systematic review evidence using narrative synthesis.

    Goodrich, Joanna / Watson, Caleb / Gaczkowska, Inez / Harding, Richard / Evans, Catherine / Firth, Alice / Murtagh, Fliss E M

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0296405

    Abstract: Background: Community-based out-of-hours services are an integral component of end-of-life care. However, there is little understanding of how patients and families utilise these services. This additional analysis of a systematic review aims to ... ...

    Abstract Background: Community-based out-of-hours services are an integral component of end-of-life care. However, there is little understanding of how patients and families utilise these services. This additional analysis of a systematic review aims to understand and identify patterns of out-of-hours service use and produce recommendations for future service design.
    Method: Data on service use was extracted and secondary analysis undertaken, from a systematic review of models of community out-of-hours services. Narrative synthesis was completed, addressing four specific aspects of service use: 1.Times when patients/families/healthcare professionals need to contact out-of-hours services; 2. Who contacts out-of-hours services; 3. Whether a telephone call, centre visit or home visit is provided; 4. Who responds to out-of-hours calls.
    Results: Community-based out-of-hours palliative care services were most often accessed between 5pm and midnight, especially on weekdays (with reports of 69% of all calls being made out-of-hours). Family members and carers were the most frequent callers to of the services (making between 60% and 80% of all calls). The type of contact (telephone, centre visit or home visit) varied based on what was offered and on patient need. Over half of services were led by a single discipline (nurse).
    Conclusions: Out-of-hours services are highly used up to midnight, and particularly by patients' family and carers. Recommendations to commissioners and service providers are to: • Increase provision of out-of-hours services between 5pm and midnight to reflect the increased use at these times. • Ensure that family and carers are provided with clear contact details for out-of-hours support. • Ensure patient records can be easily accessed by health professionals responding to calls, making the triage process easier. • Listen to patients, family and carers in the design of out-of-hours services, including telephone services. • Collect data systematically on out-of-hours-service use and on outcomes for patients who use the service.
    MeSH term(s) Humans ; Palliative Care ; Community Health Services ; Terminal Care ; Hospice Care ; After-Hours Care
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An isotonic protein solution favorably modulated the porcine intestinal immune response and cellular adhesion markers and reduced PEDV shedding in vivo.

    Masiuk, Dmytro M / Kokariev, Andrii V / Buzoianu, Stefan G / Firth, Ava M / Nedzvetsky, Victor S

    Veterinary immunology and immunopathology

    2024  Volume 271, Page(s) 110753

    Abstract: ... the drinking water of 14 day old PEDV-infected piglets with the IPS on the content of E-cadherin, fibronectin ... virus shedding. Levels of E-cadherin and fibronectin, both of which are structural proteins in the intestine ... to control. Overall, the IPS used in this study enhanced epithelial intercellular adhesion (E-cadherin) and ...

    Abstract Porcine epidemic diarrhea virus (PEDV) causes immensely large economic losses worldwide in the swine industry. PEDV attacks the intestine, disrupts intestinal epithelium morphology and barrier integrity, and results in profound diarrhea and high mortality. A commercially available isotonic protein solution (IPS) (Tonisity Px) has anecdotally been reported to be effective in supportive treatment of piglets with active PEDV infections. This study evaluated the effects of supplementing (or not) the drinking water of 14 day old PEDV-infected piglets with the IPS on the content of E-cadherin, fibronectin, interferon-alpha (IFN-α), and matrix metalloproteinase 9 (MMP-9) in duodenal tissue. The content of PEDV DNA in feces was also measured. Though both groups had similar PEDV shedding at day 1, IPS piglets had significantly lower PEDV shedding at day 5, 14 and 21. The IPS group also had a shorter duration of PEDV virus shedding. Levels of E-cadherin and fibronectin, both of which are structural proteins in the intestine, remained unchanged from baseline in the IPS group, whereas the same molecules decreased significantly in the control group. IFN-α, an antiviral cytokine, and MMP-9, an enzyme that aids in tissue remodeling, were increased at days 5 and 14 post infection, and then decreased at day 21 post-infection in the IPS group compared to control. Overall, the IPS used in this study enhanced epithelial intercellular adhesion (E-cadherin) and extracellular matrix structure (fibronectin), resulted in significantand favorable changes in MMP-9 activity, and favorably modulated IFN-α production. This is the first report of this panel of biomarkers, especially MMP-9 and IFN-α, in the face of in vivo PEDV infection. This is also the first report to investigate a commercially available swine product that does not need to be administered in solid feed, and that is already registered for use throughout Asia, Europe, South America, and North America. Overall, the results of this study serve to clarify the behavior of 4 key biomarkers in the presence of in vivo PEDV infection. The results also indicate that IPS (Tonisity Px) supplementation is a viable intervention to modulate the porcine intestinal immune response with favorable effects on the intestine.
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 754160-0
    ISSN 1873-2534 ; 0165-2427
    ISSN (online) 1873-2534
    ISSN 0165-2427
    DOI 10.1016/j.vetimm.2024.110753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2177: Show issues Location:
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  10. Article ; Online: The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging.

    Smith, Lydia M / Greenwood, Hannah E / Tyrrell, Will E / Edwards, Richard S / de Santis, Vittorio / Baark, Friedrich / Firth, George / Tanc, Muhammet / Terry, Samantha Y A / Herrmann, Anne / Southworth, Richard / Witney, Timothy H

    Npj imaging

    2024  Volume 1, Page(s) 1

    Abstract: Mouse models are invaluable tools for radiotracer development and validation. They are, however, expensive, low throughput, and are constrained by animal welfare considerations. Here, we assessed the chicken chorioallantoic membrane (CAM) as an ... ...

    Abstract Mouse models are invaluable tools for radiotracer development and validation. They are, however, expensive, low throughput, and are constrained by animal welfare considerations. Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging studies. NCI-H460 FLuc cells grown in Matrigel on the CAM formed vascularized tumors of reproducible size without compromising embryo viability. By designing a simple method for vessel cannulation it was possible to perform dynamic PET imaging in ovo, producing high tumor-to-background signal for both
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2948-197X
    ISSN (online) 2948-197X
    DOI 10.1038/s44303-023-00001-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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