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  1. Article: An Urgent Call for Studies That Address the Cardiovascular Consequences of Legalization of Marijuana.

    Rezkalla, Shereif H / Kloner, Robert A

    Cardiology research

    2024  Volume 15, Issue 2, Page(s) 86–89

    Abstract: In about a decade, half of the United States has legalized marijuana for recreational use. The drug has been associated with acute myocardial infarction, acute stroke, congestive heart failure, and various cardiac arrythmias. Data have shown that ... ...

    Abstract In about a decade, half of the United States has legalized marijuana for recreational use. The drug has been associated with acute myocardial infarction, acute stroke, congestive heart failure, and various cardiac arrythmias. Data have shown that legalization of the drug led to an increase of its use as well as an increase in tetra hydro cannabinoid positive tests in patients admitted to emergency departments. In Colorado, one of the earlier states to implement legalization, there was an increase in traffic accidents, suicide rates, and even total mortality. However, there is a paucity of data on the effect of marijuana legalization on various cardiovascular events. It is prudent to have well-designed studies with enough power to provide consumers and health care providers the information they need to decide whether the risks of marijuana, especially on the cardiovascular front, are worth the "high" or potential benefits that have been described for other medical conditions.
    Language English
    Publishing date 2024-04-15
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Invasive versus Conservative Management in Coronary Artery Disease.

    Rezkalla, Shereif H / Kloner, Robert A

    Clinical medicine & research

    2023  Volume 21, Issue 2, Page(s) 95–104

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Myocardial Infarction/therapy ; Conservative Treatment ; Angina Pectoris ; Heart Failure
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2303793-3
    ISSN 1554-6179 ; 1539-4182
    ISSN (online) 1554-6179
    ISSN 1539-4182
    DOI 10.3121/cmr.2023.1806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ST Segment Elevation Myocardial Infarction in the COVID-19 Era: Appraisal of the Evidence.

    Nwaedozie, Somto / Rezkalla, Shereif H

    Clinical medicine & research

    2022  Volume 20, Issue 1, Page(s) 52–60

    Abstract: The COVID-19 pandemic continues to present a public health challenge and has had a significant impact on the presentation, time-dependent management, and clinical outcomes of ST elevation myocardial infarction (STEMI). Patients with COVID-19 and pre- ... ...

    Abstract The COVID-19 pandemic continues to present a public health challenge and has had a significant impact on the presentation, time-dependent management, and clinical outcomes of ST elevation myocardial infarction (STEMI). Patients with COVID-19 and pre-disposing cardiovascular risk factors like hypertension, hyperlipidemia, and diabetes mellitus are at a higher risk of developing STEMI, and global trends have highlighted delayed management of STEMI, which may contribute to worse clinical outcomes. Prolonged time to intervention has also resulted in an increased rate of no reflow, which is an independent risk factor for worse outcomes in these patients. Timely primary percutaneous coronary intervention (PCI) remains standard of care for STEMI and can be attained within the recommended 90 minutes timeline from hospital presentation. A coordinated, safe, standardized, algorithmic approach among emergency medical services, emergency departments, and cardiac catheterization laboratory is needed to ensure optimal patient outcome during and after the COVID-19 pandemic. The focus of this case report is to highlight the challenges of PCI for ST elevation myocardial infarction in the COVID-19 era.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Risk Factors ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2303793-3
    ISSN 1554-6179 ; 1539-4182
    ISSN (online) 1554-6179
    ISSN 1539-4182
    DOI 10.3121/cmr.2021.1707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Post-Acute Sequelae of SARS-COVID-2 Syndrome: Just the Beginning.

    Rezkalla, Shereif H / Kloner, Robert A

    Cardiology research

    2021  Volume 12, Issue 5, Page(s) 279–285

    Abstract: Viral diseases are some of the most common infections affecting humans. Despite the unpleasant symptoms, most people return to their normal lives without residual symptoms. Following the acute infectious phase of some viruses, however, in some ... ...

    Abstract Viral diseases are some of the most common infections affecting humans. Despite the unpleasant symptoms, most people return to their normal lives without residual symptoms. Following the acute infectious phase of some viruses, however, in some individuals symptoms may linger to the extent they are unable to return to a normal lifestyle. Following coronavirus disease 2019 infection, significant numbers of patients continued to have symptoms that persisted for months after hospital discharge. Symptoms spanned many organ systems and were prominent in the pulmonary and cardiovascular systems. The exact mechanism is not clear. This group of patients represents a new challenge to our health care systems. An organized, multi-disciplinary approach and further research are warranted to be ready to deliver better care to these patients.
    Language English
    Publishing date 2021-08-31
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Viral myocarditis: 1917-2020: From the Influenza A to the COVID-19 pandemics.

    Rezkalla, Shereif H / Kloner, Robert A

    Trends in cardiovascular medicine

    2020  Volume 31, Issue 3, Page(s) 163–169

    Abstract: Myocarditis is common during viral infection with cases described as early as the influenza pandemic of 1917, and the current COVID-19 pandemic is no exception. The hallmark is elevated troponin, which occurs in 36% of COVID patients, with ... ...

    Abstract Myocarditis is common during viral infection with cases described as early as the influenza pandemic of 1917, and the current COVID-19 pandemic is no exception. The hallmark is elevated troponin, which occurs in 36% of COVID patients, with electrocardiogram, echocardiogram, and cardiac magnetic resonance being valuable tools to assist in diagnosis. Cardiac inflammation may occur secondary to direct cardiac invasion with the virus, or to intense cytokine storm, often encountered during the course of the disease. Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and judicious use of beta-blockers are beneficial in management of myocarditis. Corticosteroids may be avoided during the very early phase of viral replication, but can be of clear benefit in hospitalized, critically ill patients. Statins are beneficial to shorten the course of the disease and may decrease mortality.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Humans ; Influenza A virus ; Influenza, Human/complications ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Myocarditis/diagnosis ; Myocarditis/therapy ; Myocarditis/virology ; Pandemics
    Language English
    Publishing date 2020-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3419: Show issues Location:
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  6. Article ; Online: Author Response to "Aspirin for Primary Prevention of Atherosclerotic Cardiovascular Disease and Colorectal Carcinomas".

    Soodi, Deepa / VanWormer, Jeffrey J / Rezkalla, Shereif H

    Clinical medicine & research

    2021  Volume 19, Issue 1, Page(s) 1–2

    MeSH term(s) Aspirin/therapeutic use ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/prevention & control ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/prevention & control ; Humans ; Primary Prevention
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2303793-3
    ISSN 1554-6179 ; 1539-4182
    ISSN (online) 1554-6179
    ISSN 1539-4182
    DOI 10.3121/cmr.2020.1645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6719: Show issues Location:
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  7. Article ; Online: Aspirin in Primary Prevention of Cardiovascular Events.

    Soodi, Deepa / VanWormer, Jeffrey J / Rezkalla, Shereif H

    Clinical medicine & research

    2020  Volume 18, Issue 2-3, Page(s) 89–94

    Abstract: Aspirin has demonstrated a clear benefit in secondary prevention of coronary syndrome, while aspirin's effect in primary prevention is unclear. This report will explore the role of aspirin as primary prevention for various vascular events. It strives to ... ...

    Abstract Aspirin has demonstrated a clear benefit in secondary prevention of coronary syndrome, while aspirin's effect in primary prevention is unclear. This report will explore the role of aspirin as primary prevention for various vascular events. It strives to provide a clear guide for clinicians on whether or not to prescribe aspirin for their patients for primary prevention. Current guidelines and recent trials failed to show clear benefit against primary prevention, with risks outweighing benefits in moderate to high risk patients. A thoughtful discussion between patients and their doctors should be conducted before beginning aspirin use. More studies are needed to gain a better understanding of aspirin use in primary prevention.
    MeSH term(s) Aspirin/therapeutic use ; Cardiovascular Diseases ; Humans ; Primary Prevention ; Risk Factors
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2303793-3
    ISSN 1554-6179 ; 1539-4182
    ISSN (online) 1554-6179
    ISSN 1539-4182
    DOI 10.3121/cmr.2020.1548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6719: Show issues Location:
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  8. Article ; Online: The Cardiovascular Effects of Cocaine.

    Havakuk, Ofer / Rezkalla, Shereif H / Kloner, Robert A

    Journal of the American College of Cardiology

    2017  Volume 70, Issue 1, Page(s) 101–113

    Abstract: Cocaine is the leading cause for drug-abuse-related visits to emergency departments, most of which are due to cardiovascular complaints. Through its diverse pathophysiological mechanisms, cocaine exerts various adverse effects on the cardiovascular ... ...

    Abstract Cocaine is the leading cause for drug-abuse-related visits to emergency departments, most of which are due to cardiovascular complaints. Through its diverse pathophysiological mechanisms, cocaine exerts various adverse effects on the cardiovascular system, many times with grave results. Described here are the varied cardiovascular effects of cocaine, areas of controversy, and therapeutic options.
    MeSH term(s) Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; Cocaine/adverse effects ; Global Health ; Humans ; Morbidity ; Substance-Related Disorders/complications
    Chemical Substances Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2017-07-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 196: Show issues

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  9. Article ; Online: Letter to the editor response.

    Stankowski, Rachel V / Kloner, Robert A / Rezkalla, Shereif H

    Trends in cardiovascular medicine

    2016  Volume 26, Issue 2, Page(s) 203

    MeSH term(s) Angina Pectoris/drug therapy ; Cocaine/adverse effects ; Female ; Humans ; Labetalol/therapeutic use ; Male
    Chemical Substances Cocaine (I5Y540LHVR) ; Labetalol (R5H8897N95)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2015.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Management of No-Reflow Phenomenon in the Catheterization Laboratory.

    Rezkalla, Shereif H / Stankowski, Rachel V / Hanna, Jennifer / Kloner, Robert A

    JACC. Cardiovascular interventions

    2017  Volume 10, Issue 3, Page(s) 215–223

    Abstract: At the conclusion of a primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, and after the cardiologist makes certain that there is no residual stenosis following stenting, assessment of coronary flow becomes the top ... ...

    Abstract At the conclusion of a primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, and after the cardiologist makes certain that there is no residual stenosis following stenting, assessment of coronary flow becomes the top priority. The presence of no-reflow is a serious prognostic sign. No-reflow can result in poor healing of the infarct and adverse left ventricular remodeling, increasing the risk for major adverse cardiac events, including congestive heart failure and death. To achieve normal flow, features associated with a high incidence of no-reflow must be anticipated, and measures must be undertaken to prevent its occurrence. In this review, the authors discuss various preventive strategies for no-reflow as well as pharmacological and nonpharmacological interventions that improve coronary blood flow, such as intracoronary adenosine and nitroprusside. Nonpharmacological therapies, such as induced hypothermia, were successful in animal studies, but their effectiveness in reducing no-reflow in humans remains to be determined.
    MeSH term(s) Angioplasty, Balloon, Coronary/adverse effects ; Animals ; Cardiac Catheterization/adverse effects ; Coronary Circulation/drug effects ; Humans ; No-Reflow Phenomenon/diagnosis ; No-Reflow Phenomenon/etiology ; No-Reflow Phenomenon/physiopathology ; No-Reflow Phenomenon/therapy ; Predictive Value of Tests ; Risk Factors ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/physiopathology ; ST Elevation Myocardial Infarction/therapy ; Treatment Outcome ; Vasodilator Agents/therapeutic use
    Chemical Substances Vasodilator Agents
    Language English
    Publishing date 2017-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2016.11.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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