LIVIVO - Search results -

Search results

Result 1 - 10 of total 289

Search options

Article ; Online: Microbial survival mechanisms within serpentinizing Mariana forearc sediments.

Mullis, Megan M / Selwyn, Jason D / Kevorkian, Richard / Tague, Eric D / Castro, Hector F / Campagna, Shawn R / Lloyd, Karen G / Reese, Brandi Kiel

FEMS microbiology ecology

2023 Volume 99, Issue 2

Abstract: Marine deep subsurface sediment is often a microbial environment under energy-limited conditions. However, microbial life has been found to persist and even thrive in deep subsurface environments. The Mariana forearc represents an ideal location for ... ...

Abstract	Marine deep subsurface sediment is often a microbial environment under energy-limited conditions. However, microbial life has been found to persist and even thrive in deep subsurface environments. The Mariana forearc represents an ideal location for determining how microbial life can withstand extreme conditions including pH 10-12.5 and depleted nutrients. The International Ocean Discovery Program Expedition 366 to the Mariana Convergent Margin sampled three serpentinizing seamounts located along the Mariana forearc chain with elevated concentrations of methane, hydrogen, and sulfide. Across all three seamount summits, the most abundant transcripts were for cellular maintenance such as cell wall and membrane repair, and the most abundant metabolic pathways were the Entner-Doudoroff pathway and tricarboxylic acid cycle. At flank samples, sulfur cycling involving taurine assimilation dominated the metatranscriptomes. The in situ activity of these pathways was supported by the detection of their metabolic intermediates. All samples had transcripts from all three domains of Bacteria, Archaea, and Eukarya, dominated by Burkholderiales, Deinococcales, and Pseudomonales, as well as the fungal group Opisthokonta. All samples contained transcripts for aerobic methane oxidation (pmoABC) and denitrification (nirKS). The Mariana forearc microbial communities show activity not only consistent with basic survival mechanisms, but also coupled metabolic reactions.
MeSH term(s)	Seawater/microbiology ; Bacteria/genetics ; Bacteria/metabolism ; Archaea/genetics ; Archaea/metabolism ; Geologic Sediments/microbiology ; Methane/metabolism ; Phylogeny
Chemical Substances	Methane (OP0UW79H66)
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	283722-5
ISSN	1574-6941 ; 0168-6496
ISSN (online)	1574-6941
ISSN	0168-6496
DOI	10.1093/femsec/fiad003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2967: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Book: Urologic surgery

Bensimon, Hector / Bresette, John F. / Bensimon, Richard H.

1991

Author's details	Hector Bensimon. Contributions by John F. Bresette ; Richard H. Bensimon
Keywords	Urogenital System / surgery / atlases ; Urologic Diseases / surgery / atlases ; Urologische Chirurgie
Subject	Operative Urologie ; Urologie
Language	English
Size	XI, 451 S. : zahlr. Ill.
Publisher	McGraw-Hill
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT003943757
ISBN	0-07-004795-2 ; 978-0-07-004795-2
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
1991 A 5524	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Al servicio de Su Católica Majestad. La concesión de mercedes de las órdenes militares castellanas a miembros del Consejo de Órdenes y del Consejo de Castilla en el reinado de Felipe III (1598-1621) = At the Service of His Catholic Majesty. The Concession of Mercedes of the Castilian Military Orders to Members of the Council of Orders and of the Council of Castile in the Reign of Felipe III (1598-1621)

Héctor Linares González

Espacio, Tiempo y Forma. Serie IV, Historia Moderna, Vol 0, Iss 31, Pp 155-

2018 Volume 182

Abstract: ... para sus milicias (N. Monteiro y F. Olival) se integraron entre los mecanismos de remuneración de servicios ... Portuguese historiography for their institutions (N. Monteiro and F. Olival)- were integrated between the ... rich heritage set that these militias acquired from the kings of Castile and Leon in gratitude to the ...

Abstract	Las encomiendas de las órdenes militares castellanas constituían, junto con los bienes propios de la dignidad maestral, un extenso y rico conjunto patrimonial que estas milicias fueron adquiriendo de los reyes de Castilla y León en gratitud a los servicios prestados en la Reconquista. Con la incorporación perpetua de los Maestrazgos de las órdenes en la Corona de Castilla en 1523 se puso en manos de esta institución el derecho a dispensar las mercedes de las encomiendas, así como los títulos conferidos a estas milicias: los estatutos de caballero y comendador. Por ello, tras la incorporación, las encomiendas, dignidad del comendador, y los hábitos militares, como ya señaló la historiografía portuguesa para sus milicias (N. Monteiro y F. Olival) se integraron entre los mecanismos de remuneración de servicios de la Monarquía Católica. Desde esta perspectiva, este trabajo pretende, siguiendo las líneas marcadas por la historiografía lusa, el estudio de la concesión de encomiendas y hábitos de las tres órdenes militares de Castilla a miembros de los Consejos de Órdenes y Castilla en el reinado de Felipe III, intentando insertar estas mercedes dentro de la “economía de la merced” estableciendo, además, redes de parentelas y clientelas entorno a estas mercedes. The commanderies of the Castilian military orders constituted an extensive and rich heritage set that these militias acquired from the kings of Castile and Leon in gratitude to the services rendered in the Reconquest. With the perpetual incorporation of the orders in the Crown of Castile, the right to dispense the commanderies was placed in the catholic monarchy, as well as the titles conferred to these militias: the statutes of knight and commander. For that reason, after the incorporation, the commanderies -dignity of the commander, and the military habits, as already indicated by the Portuguese historiography for their institutions (N. Monteiro and F. Olival)- were integrated between the mechanisms of remuneration of services to the Catholic Monarchy . From this perspective, this paper intends the study of the granting of encomiendas and habits of the three military orders of Castile to members of the Councils of Orders and Castile in the reign of Felipe III, trying to insert these mercedes within the "economía de la merced" establishment, in addition to the networks of relatives and clienteles around these mercedes.
Keywords	Encomiendas ; Órdenes Militares ; Consejeros ; Felipe III ; Duque de Lerma = Commanderies ; Military Orders ; Counselors ; Philiph III ; Duke of Lerma ; History (General) and history of Europe ; D ; History (General) ; D1-2009 ; Modern history ; 1453- ; D204-475
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Universidad Nacional de Educación a Distancia (UNED)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Intragenic

Cancers

2023 Volume 16, Issue 1

Abstract: Epidermal growth factor receptor variant III (EGFRvIII, the deletion of exons 2-7) is a recurrent ... ...

Abstract	Epidermal growth factor receptor variant III (EGFRvIII, the deletion of exons 2-7) is a recurrent intragenic
Language	English
Publishing date	2023-12-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16010006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: An overview of antifungal drugs and their use for treatment of deep and superficial mycoses in animals.

Hector, Richard F

Clinical techniques in small animal practice

2005 Volume 20, Issue 4, Page(s) 240–249

Abstract: Fungal infections are often challenging to manage, given the limited numbers of therapeutics and a general lack of applicable clinical literature for their use in a given animal species. This article reviews some of the underlying principles that can ... ...

Abstract	Fungal infections are often challenging to manage, given the limited numbers of therapeutics and a general lack of applicable clinical literature for their use in a given animal species. This article reviews some of the underlying principles that can affect the therapeutic outcome for a given antifungal, and provides specific information from the literature that is intended to highlight the distinctive properties of the most commonly used antifungals in veterinary medicine to better facilitate their successful application in clinical practice.
MeSH term(s)	Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Animals ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillus/drug effects ; Candida/drug effects ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Griseofulvin/pharmacology ; Griseofulvin/therapeutic use ; Itraconazole/pharmacology ; Itraconazole/therapeutic use ; Ketoconazole/pharmacology ; Ketoconazole/therapeutic use ; Microbial Sensitivity Tests ; Mycoses/drug therapy ; Mycoses/microbiology ; Mycoses/pathology ; Mycoses/veterinary ; Severity of Illness Index
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4) ; Griseofulvin (32HRV3E3D5) ; Amphotericin B (7XU7A7DROE) ; Fluconazole (8VZV102JFY) ; Ketoconazole (R9400W927I)
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2139971-2
ISSN	1558-2272 ; 1096-2867
ISSN (online)	1558-2272
ISSN	1096-2867
DOI	10.1053/j.ctsap.2005.07.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Measuring cellular immunity in coccidioidomycosis: the time is now.

Ampel, Neil M / Hector, Richard F

Mycopathologia

2010 Volume 169, Issue 6, Page(s) 425–426

MeSH term(s)	Coccidioides/immunology ; Coccidioidin/immunology ; Coccidioidomycosis/diagnosis ; Coccidioidomycosis/immunology ; Humans ; Hypersensitivity, Delayed/immunology ; Immunity, Cellular/immunology ; Mexico ; Skin Tests/methods
Chemical Substances	spherulin ; Coccidioidin (12622-73-0)
Language	English
Publishing date	2010-02-16
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	391081-7
ISSN	1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
ISSN (online)	1573-0832
ISSN	0369-299X ; 0301-486X ; 0027-5530
DOI	10.1007/s11046-010-9285-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.99: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: New β-glucan inhibitors as antifungal drugs.

Hector, Richard F / Bierer, Donald E

Expert opinion on therapeutic patents

2011 Volume 21, Issue 10, Page(s) 1597–1610

Abstract: Introduction: New classes of synthetic and semi-synthetic β-glucan inhibitors have recently emerged, providing analogs that, in some cases, have been proven to have a high degree of activity against fungi, offering the prospect of alternatives to the ... ...

Abstract	Introduction: New classes of synthetic and semi-synthetic β-glucan inhibitors have recently emerged, providing analogs that, in some cases, have been proven to have a high degree of activity against fungi, offering the prospect of alternatives to the commercially available lipopeptide/echinocandin agents caspofungin, micafungin and anidulafungin. Area covered: This review covers applications disclosing compound classes that include synthetic pyridazinone analogs, bicyclic heteroaryl ring compounds, aniline derivates, and semi-synthetic echinocandin and enfumafungin derivatives. MK-3118 is an analog of the natural product enfumafungin that, in particular, shows promise as it has a spectrum of activity comparable with caspofungin but has the advantageous property of oral bioavailability. Expert opinion: The diversity of chemical classes in the present review, which have demonstrable activity against β-glucan and the prospect of oral bioavailability, offers hope that safe and effective antifungal drugs will emerge and be commercialized. Of particular note, the Merck compound MK-3118, with solid evidence of efficacy based on preclinical data, has moved into clinical trials.
MeSH term(s)	Administration, Oral ; Animals ; Antifungal Agents/adverse effects ; Antifungal Agents/pharmacokinetics ; Antifungal Agents/pharmacology ; Biological Availability ; Drug Design ; Glycosides/pharmacokinetics ; Glycosides/pharmacology ; Humans ; Mycoses/drug therapy ; Mycoses/microbiology ; Patents as Topic ; Triterpenes/pharmacokinetics ; Triterpenes/pharmacology ; beta-Glucans/antagonists & inhibitors
Chemical Substances	Antifungal Agents ; Glycosides ; Triterpenes ; beta-Glucans ; ibrexafungerp (A92JFM5XNU)
Language	English
Publishing date	2011-07-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1186201-4
ISSN	1744-7674 ; 0962-2594 ; 1354-3776
ISSN (online)	1744-7674
ISSN	0962-2594 ; 1354-3776
DOI	10.1517/13543776.2011.603899
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3962: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility.

Linck, Richard W / Chemes, Hector / Albertini, David F

Journal of assisted reproduction and genetics

2016 Volume 33, Issue 2, Page(s) 141–156

Abstract: This review article provides a critical analysis of the structure and molecular mechanisms of the microtubule axoneme of cilia and sperm flagella and their associated elements required for male fertility.A broad range of genetic and molecular defects ( ... ...

Abstract	This review article provides a critical analysis of the structure and molecular mechanisms of the microtubule axoneme of cilia and sperm flagella and their associated elements required for male fertility.A broad range of genetic and molecular defects (ciliopathies) are considered in the context of human diseases involving impaired motility in cilia and sperm flagella, providing provocative thought for future research in the area of male infertility.
MeSH term(s)	Axoneme/pathology ; Axoneme/ultrastructure ; Cilia ; Flagella/pathology ; Flagella/ultrastructure ; Humans ; Infertility, Male/genetics ; Infertility, Male/pathology ; Male ; Reproductive Techniques, Assisted ; Spermatozoa/pathology ; Spermatozoa/ultrastructure
Language	English
Publishing date	2016-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-016-0652-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1985: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 77, Issue 2, Page(s) 186–193

Abstract: Background: The vast majority of coronavirus disease 2019 (COVID-19) disease occurs in outpatients where treatment is limited to antivirals for high-risk subgroups. Acebilustat, a leukotriene B4 inhibitor, has potential to reduce inflammation and ... ...

Abstract	Background: The vast majority of coronavirus disease 2019 (COVID-19) disease occurs in outpatients where treatment is limited to antivirals for high-risk subgroups. Acebilustat, a leukotriene B4 inhibitor, has potential to reduce inflammation and symptom duration. Methods: In a single-center trial spanning Delta and Omicron variants, outpatients were randomized to 100 mg/d of oral acebilustat or placebo for 28 days. Patients reported daily symptoms via electronic query through day 28 with phone follow-up on day 120 and collected nasal swab samples on days 1-10. The primary outcome was sustained symptom resolution to day 28. Secondary 28-day outcomes included time to first symptom resolution, area under the curve (AUC) for longitudinal daily symptom scores, duration of viral shedding through day 10, and symptoms on day 120. Results: Sixty participants were randomized to each study arm. At enrollment, the median duration was 4 days (interquartile range, 3-5 days), and the median number of symptoms was 9 (7-11). Most patients (90%) were vaccinated, with 73% having neutralizing antibodies. A minority of participants (44%; 35% in the acebilustat arm and 53% in placebo) had sustained symptom resolution at day 28 (hazard ratio, 0.6 [95% confidence interval, .34-1.04]; P = .07 favoring placebo). There was no difference in the mean AUC for symptom scores over 28 days (difference in mean AUC, 9.4 [95% confidence interval, -42.1 to 60.9]; P = .72). Acebilustat did not affect viral shedding or symptoms at day 120. Conclusions: Sustained symptoms through day 28 were common in this low-risk population. Despite this, leukotriene B4 antagonism with acebilustat did not shorten symptom duration in outpatients with COVID-19. Clinical Trials Registration. NCT04662060.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Leukotriene B4 ; Outpatients ; Double-Blind Method ; Treatment Outcome
Chemical Substances	acebilustat ; Leukotriene B4 (1HGW4DR56D)
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad187
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.

The EMBO journal

2022 Volume 41, Issue 17, Page(s) e109205

Abstract: Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue ... ...

Abstract	Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue phenotype of mammary epithelial spheroids. Cells interacting with reconstituted basement membrane in 3D had reduced levels of total and actin-associated filamin and decreased cortical actin tension that increased plasma membrane protrusions to promote negative plasma membrane curvature and plasma membrane protein associations linked to protein secretion. By contrast, cells engaging a reconstituted basement membrane in 2D had high cortical actin tension that forced filamin unfolding and endoplasmic reticulum (ER) associations. Enhanced filamin-ER interactions increased levels of PKR-like ER kinase effectors and ER-plasma membrane contact sites that compromised calcium homeostasis and diminished cell viability. Consequently, cells with decreased cortical actin tension had reduced ER stress and survived better. Consistently, cortical actin tension in cellular spheroids regulated polarized basement membrane membrane deposition and sensitivity to exogenous stress. The findings implicate cortical actin tension-mediated filamin unfolding in ER function and underscore the importance of tissue mechanics in organoid homeostasis.
MeSH term(s)	Actins/metabolism ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Epithelial Cells/metabolism ; Filamins/metabolism ; Phenotype
Chemical Substances	Actins ; Filamins
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2021109205
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito