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Book ; Online: Haemagglutination assay (HAT)

Cox, Rebecca

SOP Identifier LAB006

2021

Institution	VACCELERATE
Author's details	VACCELERATE ; Author: Rebecca Cox
Keywords	COVID-19
Subject	Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
Subject code	610
Language	English
Size	1 Online-Ressource (8 Seiten), Illustrationen, Diagramme
Edition	Edition: version 1
Publisher	VACCELERATE
Publishing place	Cologe
Publishing country	Germany
Document type	Book ; Online
Note	Open Access
HBZ-ID	HT021478617
DOI	10.4126/FRL01-006434989
Database	Repository for Life Sciences

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Book ; Online: Safety of COVID-19 vaccines in pregnancy

Sadarangani, Manish / Bettinger, Julie A. / Cox, Rebecca J. / Cornely, Oliver Andreas

VACCELERATE Webinar OCTOBER 25 2022

2022

Abstract: This study took place in November 2021 and aimed to determine the frequency and nature of significant health events among pregnant females after COVID-19 vaccination, compared with unvaccinated pregnant controls and vaccinated non-pregnant individuals. ... ...

Title variant	Safety of COVID-19 vaccines in pregnancy : a Canadian National Vaccine Safety (CANVAS) network cohort study
Institution	VACCELERATE
Author's details	VACCELERATE ; presenter: Manish Sadarangani, Julie A. Bettinger ; moderator: Rebecca J. Cox ; organizor: VACCELERATE (Coordinator: Prof. Oliver A. Cornely)
Abstract	This study took place in November 2021 and aimed to determine the frequency and nature of significant health events among pregnant females after COVID-19 vaccination, compared with unvaccinated pregnant controls and vaccinated non-pregnant individuals. The working group set up an observational cohort study, set in seven Canadian provinces and territories. More than 1 million pregnant and non-pregnant females aged 15-49 years were enrolled as study participants. Data were collected primarily by self-reported survey after both vaccine doses, with telephone follow-up for those reporting any medically attended event. In this webinar, the results of the study will be presented, which give answer to the question if COVID-19 mRNA vaccines have a good safety profile in pregnancy and can be recommended. The speakers will also introduce the Canadian Vaccine Safety Network (CANVAS), which in addition to monitoring the seasonal influenza vaccine safety, monitors vaccine safety for other and new vaccines, and provides a platform for vaccine acceptability studies.
Keywords	COVID-19
Subject	Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
Subject code	610
Language	English
Size	1 Online-Ressource (1 Videodatei, Lauflänge: 00:56:34)
Publisher	VACCELERATE
Publishing place	Cologne
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT021575667
DOI	10.4126/FRL01-006438188
Database	Repository for Life Sciences

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Article ; Online: Linking repetitive negative thinking and insomnia symptoms: A longitudinal trait-state model.

Olatunji, Bunmi O / Knowles, Kelly A / Cox, Rebecca C / Cole, David A

Journal of anxiety disorders

2023 Volume 97, Page(s) 102732

Abstract: Sleep disturbance is highly debilitating, and an abundance of research suggests that repetitive negative thinking (i.e., rumination, worry) may contribute to the development and maintenance of maladaptive sleep patterns, such as insomnia symptoms. ... ...

Abstract	Sleep disturbance is highly debilitating, and an abundance of research suggests that repetitive negative thinking (i.e., rumination, worry) may contribute to the development and maintenance of maladaptive sleep patterns, such as insomnia symptoms. Although repetitive negative thinking is often conceptualized as a 'trait' risk factor for anxiety-related disorders, it is unclear if it consists of time-varying (TV) or state-like features versus time-invariant (TI) or trait-like characteristics. Furthermore, it is unclear if it is the TV or TI components of repetitive negative thinking that contribute to insomnia symptoms that is commonly observed in anxiety-related disorders. In a 6-wave, 5-month longitudinal study, community participants (N = 1219) completed measures of rumination, worry, transdiagnostic repetitive negative thinking, and insomnia symptoms. A latent variable (trait-state-occasion) model was applied to the measures of repetitive negative thinking. The results showed that although estimates of TI factor variance and TV factor variance were both significant for latent repetitive negative thinking, worry, and rumination, the proportion of TI factor variance (0.82-0.89) was greater than the amount of TV factor variance (0.11-0.19). Although TV factor stability was statistically significant for latent repetitive negative thinking, rumination, and worry, the magnitude of the coefficients was small. Furthermore, regression weights for the latent repetitive negative thinking, rumination, and worry TI factor were significant and larger than those for the TV factor in predicting insomnia symptoms at each of the six time points. These findings suggest that repetitive negative thinking is largely TI, and it is this TI component that contributes to insomnia symptoms. Implications for conceptualizations of repetitive negative thinking as a predisposing and perpetuating factor in insomnia for anxiety and related disorders are discussed.
MeSH term(s)	Humans ; Sleep Initiation and Maintenance Disorders/diagnosis ; Pessimism ; Longitudinal Studies ; Thinking ; Anxiety/diagnosis ; Surveys and Questionnaires
Language	English
Publishing date	2023-06-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	619417-5
ISSN	1873-7897 ; 0887-6185
ISSN (online)	1873-7897
ISSN	0887-6185
DOI	10.1016/j.janxdis.2023.102732
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Article ; Online: Longitudinal trajectories of coronavirus anxiety and health behavior use before and after the U.S. 2020 presidential election: The effects of political orientation.

Olatunji, Bunmi O / Cox, Rebecca C / Cole, David A

Journal of anxiety disorders

2022 Volume 92, Page(s) 102643

Abstract: Although heightened anxiety and health behavior use (i.e., masking, hand washing) may be viewed as an adaptive response to the coronavirus (COVID-19) pandemic, it is unclear how the politicization of the pandemic has influenced the trajectory of such ... ...

Abstract	Although heightened anxiety and health behavior use (i.e., masking, hand washing) may be viewed as an adaptive response to the coronavirus (COVID-19) pandemic, it is unclear how the politicization of the pandemic has influenced the trajectory of such responses. Accordingly, the present study examined differences between those that identify as more conservative or liberal in the trajectory of anxiety and health behaviors during the pandemic. This study also examines shifts in this trajectory before and after the presidential election. As part of a larger study, participants (N = 374) completed a symptom survey starting on May 27, 2020 every 2 weeks for a total of 15 timepoints over 30 weeks. The findings showed that more conservative participants reported lower levels of COVID-19 anxiety and less health behavior use compared to more liberal participants. In fact, anxiety levels increased slightly for more liberal participants and decreased slightly for more conservative participants during the pre-election time frame. Health behavior use also decreased more rapidly for conservative participants than for liberal participants during the pre-election time frame. However, COVID-19 anxiety and health behavior use rose sharply and similarly for both liberal and conservative individuals after the election. Importantly, these patterns were independent of state level variability in COVID-19 positivity and death rates. Subsequent analysis also revealed significant relations between COVID-19 anxiety and health behavior use that was slightly stronger among conservatives. Implications of these findings for navigating the influence of political ideology on anxiety-related responses during a public health emergency like the COVID-19 pandemic are discussed.
MeSH term(s)	Humans ; Pandemics ; COVID-19 ; Politics ; Health Behavior ; Anxiety
Language	English
Publishing date	2022-10-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	619417-5
ISSN	1873-7897 ; 0887-6185
ISSN (online)	1873-7897
ISSN	0887-6185
DOI	10.1016/j.janxdis.2022.102643
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Article: Prospects and Challenges in the Development of Universal Influenza Vaccines.

Madsen, Anders / Cox, Rebecca Jane

Vaccines

2020 Volume 8, Issue 3

Abstract: Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can ... ...

Abstract	Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can target a broader range of influenza viruses. The development and licensure of a universal influenza vaccine could provide a game changing option for the control of influenza by protecting against all influenza A and B viruses. Here we review important findings and considerations regarding the development of universal influenza vaccines and what we can learn from this moving forward with a SARS-CoV-2 vaccine design.
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines8030361
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Article ; Online: Not just antibodies: B cells and T cells mediate immunity to COVID-19.

Cox, Rebecca J / Brokstad, Karl A

Nature reviews. Immunology

2020 Volume 20, Issue 10, Page(s) 581–582

MeSH term(s)	Antibodies, Viral/biosynthesis ; Asymptomatic Diseases ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Cytokines/biosynthesis ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunization, Passive/methods ; Immunoglobulin G/biosynthesis ; Immunoglobulin M/biosynthesis ; Immunologic Memory ; Lymphocyte Activation ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/virology ; Time Factors
Chemical Substances	Antibodies, Viral ; Cytokines ; Immunoglobulin G ; Immunoglobulin M
Keywords	covid19
Language	English
Publishing date	2020-08-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-00436-4
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Article: The genetics of adipose tissue metabolism.

Dumbell, Rebecca / Cox, Roger D

Royal Society open science

2024 Volume 11, Issue 2, Page(s) 231478

Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.231478
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Article ; Online: Researchers' experiences of the design and conduct challenges associated with parallel-group cluster-randomised trials and views on a novel open-cohort design.

Surr, Claire / Marsden, Laura / Griffiths, Alys / Cox, Sharon / Fossey, Jane / Martin, Adam / Prevost, A Toby / Walshe, Catherine / Walwyn, Rebecca

PloS one

2024 Volume 19, Issue 2, Page(s) e0297184

Abstract: Background: Two accepted designs exist for parallel-group cluster-randomised trials (CRTs). Closed-cohort designs follow the same individuals over time with a single recruitment period before randomisation, but face challenges in settings with high ... ...

Abstract	Background: Two accepted designs exist for parallel-group cluster-randomised trials (CRTs). Closed-cohort designs follow the same individuals over time with a single recruitment period before randomisation, but face challenges in settings with high attrition. (Repeated) cross-sectional designs recruit at one or more timepoints before and/or after randomisation, collecting data from different individuals present in the cluster at these timepoints, but are unsuitable for assessment of individual change over time. An 'open-cohort' design allows individual follow-up with recruitment before and after cluster-randomisation, but little literature exists on acceptability to inform their use in CRTs. Aim: To document the views and experiences of expert trialists to identify: a) Design and conduct challenges with established parallel-group CRT designs,b) Perceptions of potential benefits and barriers to implementation of open-cohort CRTs,c) Methods for minimising, and investigating the impact of, bias in open-cohort CRTs. Methods: Qualitative consultation via two expert workshops including triallists (n = 24) who had worked on CRTs over a range of settings. Workshop transcripts were analysed using Descriptive Thematic Analysis utilising inductive and deductive coding. Results: Two central organising concepts were developed. Design and conduct challenges with established CRT designs confirmed that current CRT designs are unable to deal with many of the complex research and intervention circumstances found in some trial settings (e.g. care homes). Perceptions of potential benefits and barriers of open cohort designs included themes on: approaches to recruitment; data collection; analysis; minimising/investigating the impact of bias; and how open-cohort designs might address or present CRT design challenges. Open-cohort designs were felt to provide a solution for some of the challenges current CRT designs present in some settings. Conclusions: Open-cohort CRT designs hold promise for addressing the challenges associated with standard CRT designs. Research is needed to provide clarity around definition and guidance on application.
MeSH term(s)	Humans ; Research Design ; Cross-Sectional Studies ; Research Personnel ; Compulsive Behavior ; Bias
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Psychometric properties of a daily obsessive-compulsive symptom scale for ecological momentary assessment.

Cox, Rebecca C / Knowles, Kelly A / Jessup, Sarah C / Adamis, Alexandra M / Olatunji, Bunmi O

Journal of obsessive-compulsive and related disorders

2023 Volume 39

Abstract: Despite growing interest in ecological momentary assessment (EMA) in psychopathology and clinical observation of day-to-day fluctuations in obsessive-compulsive disorder (OCD) symptoms, there is not a standardized EMA measure of such symptoms that can ... ...

Abstract	Despite growing interest in ecological momentary assessment (EMA) in psychopathology and clinical observation of day-to-day fluctuations in obsessive-compulsive disorder (OCD) symptoms, there is not a standardized EMA measure of such symptoms that can guide systematic research. In the absence of such a measure, prior EMA research in OCD has utilized heterogeneous approaches to sampling momentary and daily OCD symptoms, which limits the ability to compare results between studies. The present study sought to examine the psychometric properties of a daily OCD symptom (d-OCS) measure that assesses common OCD symptom themes (e.g., contamination, checking, intrusive thoughts) in a sample of adults with OCD (
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ISSN	2211-3649
ISSN	2211-3649
DOI	10.1016/j.jocrd.2023.100840
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Article ; Online: Hyperopia in schoolchildren: Investigating the impact on vision and determining appropriate methods for screening.

Hopkins, Shelley / Read, Scott A / Cox, Rebecca A / Oduro, Bright A / Strang, Niall / Wood, Joanne M

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2023 Volume 44, Issue 1, Page(s) 42–51

Abstract: Introduction: Hyperopia is associated with reduced vision and educational outcomes in schoolchildren. This study explored the impact of clinically significant hyperopia (≥+2.00 D) on visual function in schoolchildren and compared the ability of ... ...

Abstract	Introduction: Hyperopia is associated with reduced vision and educational outcomes in schoolchildren. This study explored the impact of clinically significant hyperopia (≥+2.00 D) on visual function in schoolchildren and compared the ability of different screening tests (alone and in combination) to detect this level of hyperopia. Methods: Vision testing including monocular logMAR visual acuity (VA) measured to threshold (distance [DVA], near [NVA] and DVA through a plus lens [+2.50 D]), stereoacuity and cycloplegic autorefraction (tropicamide 1%) were undertaken on 263 schoolchildren (mean age: 11.76 years ± 3.38) in Queensland, Australia. Vision measures were compared between children with clinically significant hyperopia in at least one meridian (≥+2.00 D) and emmetropia/low hyperopia (>0.00 and <+2.00 D). Receiver operating curve (ROC) analysis was performed to identify optimal pass/fail criteria for each test and the diagnostic accuracy of individual and combinations of tests. Results: Thirty-two children had clinically significant hyperopia and 225 had emmetropia/low hyperopia. DVA and NVA were worse (p < 0.01), while the difference in DVA through a plus lens was less in children with clinically significant hyperopia (p < 0.01). ROC analysis for individual tests resulted in areas under the curve (AUCs) ranging from 0.65 to 0.85. Combining screening tests revealed that failing one or more of the following tests was most effective for detecting hyperopia: DVA, NVA and difference in DVA through a plus lens, resulting in a sensitivity and specificity of 72% and 81%, respectively. Conclusion: Significant differences in visual function existed between schoolchildren with clinically significant hyperopia and emmetropia/low hyperopia. Combining measures of DVA and NVA and the difference in DVA through a plus lens demonstrated good discriminative ability for detecting clinically significant hyperopia in this population.
MeSH term(s)	Child ; Humans ; Hyperopia/diagnosis ; Visual Acuity ; Vision Tests ; Emmetropia ; Sensitivity and Specificity ; Vision Screening/methods
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.13236
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