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Article: Autoimmune cytopenias in chronic lymphocytic leukemia.

Haider, M Shabih / Khan, Saleem Ahmed / Nasiruddin / Shahid, Samra

2019 Volume 35, Issue 5, Page(s) 1334–1338

Abstract: Objective: To determine the frequency of autoimmune cytopenias in chronic lymphocytic leukemia.: Methods: This cross sectional study was carried out at Department of Hematology, Army Medical College Rawalpindi, in collaboration with Military Hospital ...

Abstract	Objective: To determine the frequency of autoimmune cytopenias in chronic lymphocytic leukemia. Methods: This cross sectional study was carried out at Department of Hematology, Army Medical College Rawalpindi, in collaboration with Military Hospital Rawalpindi and Armed Forces institute of Pathology Rawalpindi from 1st January 2018 to 1st October 2018. Sample size of 64 was calculated using WHO calculator. Age and gender of patients was noted. Frequency of autoimmune hemolytic anaemia, immune thrombocytopenic purpura, pure red cell aplasia and autoimmune agranulocytosis were determined in diagnosed patients of chronic lymphocytic leukemia by various laboratory tests in our study population. Results: A total of 64 patients were included in the study, 53 (82.8%) were males and 11(17.2%) were females. Mean age of patients was 65 years. Autoimmune hemolytic anaemia was observed in 5/64 (7.8%) of patients. Immune thrombocytopenic purpura was seen in 2/64 (3.1%) patients. Autoimmune granuloytopenia and pure red cell aplasia were not seen in any patient. Conclusion: Autoimmune hemolytic anaemia and immune thrombocytopenic purpura are the most common causes of immune cytopenias in patients of CLL. Immune cytopenias should always be identified by laboratory tests as their management differs from other cytopenias which occur due to various other causes.
Language	English
Publishing date	2019-08-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.35.5.369
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Article ; Online: Vitamin D Knowledge and Awareness Is Associated with Physical Activity among Adults: A Cross-Sectional Survey.

Al-Daghri, Nasser M / Alfawaz, Hanan A / Khan, Nasiruddin / Saadawy, Gamal M / Sabico, Shaun

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: The relation between knowledge and awareness of vitamin D (VD) and physical activity in adults has not been well studied. The present cross-sectional study aims to demonstrate this relation among adults living in Saudi Arabia. A total of 774 adults ... ...

Abstract	The relation between knowledge and awareness of vitamin D (VD) and physical activity in adults has not been well studied. The present cross-sectional study aims to demonstrate this relation among adults living in Saudi Arabia. A total of 774 adults participated and were stratified based on self-reports of whether they were physically active (PA group, N = 562) or not (non-PA, N = 212). The prevalence of VD awareness and its health effects were significantly higher in the PA group compared with their counterparts (97 vs. 93.4%; p = 0.02 and 92.3 vs. 81.6%; p < 0.001, respectively). Sunlight was the preferred overall source of VD among the PA group (91.1%) followed by food, supplements, and fortified foods. Sardine, salmon, oily fish (63.7%) and eggs (54.6%) were reported as good dietary sources. Other positive attitudes, represented by taking supplement or multivitamins (51.2%), high sun exposure (33.1%), and daily duration of exposure to sunlight (15−30 min; 53.4%) were higher in the PA than the non-PA group (p values < 0.05). The body parts exposed to the sun among the PA group were arms (67.1%), hands (64.1%), face and hands (62.5%), legs (58.5%), and face (53.2%), while sunscreen cream (47.2%) was their preferred sun-protection method. High levels of knowledge and positive attitudes were reported by the PA group compared with the non-PA group in regard to walking outdoors for sun exposure (80.6 vs. 62.7%; p < 0.001). Information about good dietary sources, the role of VD in human health, associated diseases, positive attitudes to sun exposure, and the use of supplements or multivitamins were among the determinants of VD knowledge and awareness. In conclusion, VD knowledge and awareness are positively associated with self-reported physical activity in adults. Further objective classifications of PA may strengthen the results of the present investigation.
MeSH term(s)	Animals ; Adult ; Humans ; Vitamin D ; Cross-Sectional Studies ; Vitamin D Deficiency/epidemiology ; Health Knowledge, Attitudes, Practice ; Vitamins ; Exercise
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021601
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Article: Evaluation of safety and efficacy profile of

Alam, Mohd Ashraf / Nasiruddin, Mohammad / Haque, Shahzad F / Khan, Rahat Ali

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2020 Volume 31, Issue 1, Page(s) 21–31

Abstract: Chronic kidney disease (CKD) encompasses a spectrum of different pathophysio- logic processes associated with abnormal kidney function. When it reaches end-stage renal disease (ESRD), the only option is dialysis and renal transplantation. This is ... ...

Abstract	Chronic kidney disease (CKD) encompasses a spectrum of different pathophysio- logic processes associated with abnormal kidney function. When it reaches end-stage renal disease (ESRD), the only option is dialysis and renal transplantation. This is unaffordable by most patients. Hence, newer treatment modalities are being looked for, which can slow down the progression of CKD and delay the development of ESRD. This study aimed to evaluate the efficacy and safety of Nigella sativa oil as an add-on therapy in addition to alpha-keto analogue of essential amino acids in patients with CKD Stages 3 and 4. The study was conducted at a tertiary care center in North India on patients with CKD Stages 3 and 4. It was a prospective, comparative, and open-labeled study. One hundred and fifty patients were enrolled and were randomly divided into two interventional groups. Fourteen patients were lost to follow-up. Group I (control) which had 66 patients received conservative management of CKD consisting of alpha-keto analogue (600 mg tablet three times a day), whereas Group II (test) which had 70 patients received conservative management along with alpha-keto analogue and N. sativa oil (2.5 mL, per orally, once daily) for 12 weeks. Hemogram, renal function, and serum electrolyte tests were done, and adverse events were recorded at baseline and at4, 8, and 12 weeks of treatment. After 12 weeks of treatment, there was a marked improvement in clinical features and biochemical parameters in both the control and test groups. There were a significant reduction in blood urea, serum creatinine, and 24-h total urine protein and a significant improvement in 24-h total urine volume and glomerular filtration rate. N. sativa oil supplementation along with alpha-keto analogue is more more efficacious and safe in delaying the progression of disease patients with CKD Stages 3 and 4.
MeSH term(s)	Administration, Oral ; Adult ; Amino Acids, Essential/administration & dosage ; Amino Acids, Essential/adverse effects ; Amino Acids, Essential/therapeutic use ; Creatinine/blood ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Plant Oils/administration & dosage ; Plant Oils/adverse effects ; Plant Oils/therapeutic use ; Prospective Studies ; Renal Insufficiency, Chronic/drug therapy ; Young Adult
Chemical Substances	Amino Acids, Essential ; Plant Oils ; Creatinine (AYI8EX34EU) ; caraway oil (C2J9B08Q3I)
Language	English
Publishing date	2020-03-04
Publishing country	Saudi Arabia
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.279943
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Article ; Online: Genetic Evidence in Favor of a Polyketide Origin of Acremeremophilanes, the Fungal "Sesquiterpene" Metabolites.

Bansal, Ravindra / Sethy, Sunil Kumar / Khan, Zareen / Shaikh, Nasiruddin / Banerjee, Kaushik / Mukherjee, Prasun K

Microbiology spectrum

2022 Volume 10, Issue 4, Page(s) e0179322

Abstract: Eremophilanes are a large group of "sesquiterpenes" produced by plants and fungi, with more than 180 compounds being known in fungi alone. Many of these compounds are phytotoxic, antimicrobial, anticancer and immunomodulators, and hence are of great ... ...

Abstract	Eremophilanes are a large group of "sesquiterpenes" produced by plants and fungi, with more than 180 compounds being known in fungi alone. Many of these compounds are phytotoxic, antimicrobial, anticancer and immunomodulators, and hence are of great economic values. Acremeremophilanes A to O have earlier been reported in a marine isolate of
MeSH term(s)	Carbon/metabolism ; Polycyclic Sesquiterpenes ; Polyketide Synthases/genetics ; Polyketide Synthases/metabolism ; Polyketides/metabolism ; Terpenes/metabolism ; Trichoderma/genetics ; Trichoderma/metabolism
Chemical Substances	Polycyclic Sesquiterpenes ; Polyketides ; Terpenes ; Carbon (7440-44-0) ; Polyketide Synthases (79956-01-7)
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01793-22
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Article ; Online: Comparison of Phytochemical Constituents and Pharmacological Activities of Various Solvent Extracts Obtained from

Nasiruddin / Chen, Guangying / Li, Xiaobao / Minghui, Ji / Masood, Tariq / Safir, Waqas / Khan, Muhammad Ali / Numan, Muhammad / Khan, Arsalan / Zeeshan, Muhammad / Zeb, Shah

BioMed research international

2022 Volume 2022, Page(s) 2486979

Abstract: Millettia ... ...

Abstract	Millettia speciosa
MeSH term(s)	Powders ; Solvents ; Millettia ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Sunscreening Agents ; Palmitic Acid ; Phytochemicals/pharmacology ; Flavonoids/pharmacology ; Flavonoids/analysis ; Emollients ; Methanol
Chemical Substances	Powders ; Solvents ; Plant Extracts ; Sunscreening Agents ; Palmitic Acid (2V16EO95H1) ; Phytochemicals ; Flavonoids ; Emollients ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2022-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/2486979
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Article: Rheological characterization of vegetable oil blends: Effect of shear rate, temperature, and short‐term heating

Hasan, Wijdan / Khan, Muhammad Nasiruddin

Journal of food process engineering. 2020 June, v. 43, no. 6

2020

Abstract: Rheological characterization of canola–olive and canola–sesame blends was carried out. The canola–olive and canola–sesame blends were prepared in the vol/vol ratios of 90:10, 70:30, and 50:50. The rheology was studied at shear rates 1–132 s⁻¹ and ... ...

Abstract	Rheological characterization of canola–olive and canola–sesame blends was carried out. The canola–olive and canola–sesame blends were prepared in the vol/vol ratios of 90:10, 70:30, and 50:50. The rheology was studied at shear rates 1–132 s⁻¹ and temperatures 15–65°C (288.15–338.15 K) before and after heating for 5, 10, and 15 min. Viscosity varied linearly with percentage composition of blend. Power law, Sisko, Cross, and Carreau equations for viscosity‐shear relation, and Arrhenius and Williams–Landel–Ferry (WLF) equations for viscosity‐temperature relation were evaluated. The reduced χ² values for the 70:30 canola–olive blend at 25°C were 7.84 × 10⁻⁵, 2.28 × 10⁻⁵, 1.26 × 10⁻⁶, and 1.23 × 10⁻⁶ for Power law, Sisko, Cross, and Carreau equations, respectively. Best fits were produced by Cross and Carreau for viscosity‐shear relation and by WLF equation for viscosity‐temperature relation. Short‐term heating was had no significant effect on the rheological profiles of the pure oils and their blends. PRACTICAL APPLICATIONS: Rheological characterization of vegetable oil blends could be helpful to engineers and scientists in formulation of vegetable oil blends for edible purposes and in designing the required process equipment. Curve fitting studies in rheology are especially helpful because the fitted equations can be used to solve complex flow problems encountered in engineering. The study could also be of interest to researchers and formulators in the field of biolubricants as well as medicinal oil formulations.
Keywords	biolubricants ; canola oil ; equations ; equipment ; heat ; olive oil ; rheology ; temperature ; vegetable oil ; viscosity
Language	English
Dates of publication	2020-06
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	752358-0
ISSN	0145-8876
ISSN	0145-8876
DOI	10.1111/jfpe.13396
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sex-Specific Cut-Offs of Seven Adiposity Indicators and Their Performance in Predicting Metabolic Syndrome in Arab Adults

Hanan A. Alfawaz / Nasiruddin Khan / Mohammed G. A. Ansari / Malak N. K. Khattak / Gamal M. Saadawy / Nasser M. Al-Daghri

Journal of Clinical Medicine, Vol 12, Iss 23, p

2023 Volume 7280

Abstract: This study aimed to assess several indicators of adiposity and their effectiveness in predicting metabolic syndrome (MetS) and identify their cut-off values among general Saudi adults. Consequently, 833 participants (49% male and 51% female) aged 42.2 ± ... ...

Abstract	This study aimed to assess several indicators of adiposity and their effectiveness in predicting metabolic syndrome (MetS) and identify their cut-off values among general Saudi adults. Consequently, 833 participants (49% male and 51% female) aged 42.2 ± 11.9 years (408 MetS and 425 as controls) were enrolled into this cross-sectional study. Information on demographics, anthropometrics and biochemical results was retrieved from a registry. MetS was defined according to the National Cholesterol Education Program’s (NCEP III) criteria. Overall, the lipid accumulation product (LAP) and waist–TG index (WTI) had the highest discriminatory ability for MetS (area under the curve (AUC): 0.857 and 0.831), respectively, followed by the visceral adiposity index (VAI) and dysfunctional adiposity index (DAI) (AUC: 0.819 and 0.804), respectively. Based on gender, the LAP and WTI were the best indicators for discriminating MetS and presented the highest Youden index values, with cut-off values of 49.8 (sensitivity 68.5%, specificity 82.4%), and 8.7 (sensitivity 70.7%, specificity 81.9%), respectively, in females and 46.2 (sensitivity 85.6%, specificity 76.3%) and 8.9 (sensitivity 73.9%, specificity 84.8%), respectively, in males. The LAP and WTI performed well in both genders with a superior ability to identify MetS in males and could be used to predict MetS in Saudi adults.
Keywords	obesity ; metabolic syndrome components ; BMI ; Saudi Arabia ; Medicine ; R
Subject code	001
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Sex-Specific Cut-Offs of Seven Adiposity Indicators and Their Performance in Predicting Metabolic Syndrome in Arab Adults.

Alfawaz, Hanan A / Khan, Nasiruddin / Ansari, Mohammed G A / Khattak, Malak N K / Saadawy, Gamal M / Al-Daghri, Nasser M

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract	This study aimed to assess several indicators of adiposity and their effectiveness in predicting metabolic syndrome (MetS) and identify their cut-off values among general Saudi adults. Consequently, 833 participants (49% male and 51% female) aged 42.2 ± 11.9 years (408 MetS and 425 as controls) were enrolled into this cross-sectional study. Information on demographics, anthropometrics and biochemical results was retrieved from a registry. MetS was defined according to the National Cholesterol Education Program's (NCEP III) criteria. Overall, the lipid accumulation product (LAP) and waist-TG index (WTI) had the highest discriminatory ability for MetS (area under the curve (AUC): 0.857 and 0.831), respectively, followed by the visceral adiposity index (VAI) and dysfunctional adiposity index (DAI) (AUC: 0.819 and 0.804), respectively. Based on gender, the LAP and WTI were the best indicators for discriminating MetS and presented the highest Youden index values, with cut-off values of 49.8 (sensitivity 68.5%, specificity 82.4%), and 8.7 (sensitivity 70.7%, specificity 81.9%), respectively, in females and 46.2 (sensitivity 85.6%, specificity 76.3%) and 8.9 (sensitivity 73.9%, specificity 84.8%), respectively, in males. The LAP and WTI performed well in both genders with a superior ability to identify MetS in males and could be used to predict MetS in Saudi adults.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237280
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Article ; Online: Distribution, sources, and pollution levels of toxic metal(loid)s in an urban river (Ichamati), Bangladesh using SOM and PMF modeling with GIS tool

Nasiruddin, Md / Islam, Abu Reza Md Towfiqul / Siddique, Md. Abu Bakar / Hasanuzaman, Md / Hassan, Md Mahedi / Akbor, Md Ahedul / Hasan, Mehedi / Islam, Md Saiful / Khan, Rahat / Al Amin, Md / Pal, Subodh Chandra / Idris, Abubakr Mustafa / Kumar, Satendra

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 8 p.20934-20958

2023

Abstract: Indexical assessment coupled with a self-organizing map (SOM) and positive matrix factorization (PMF) modeling of toxic metal(loid)s in sediment and water of the aquatic environment provides valuable information from the environmental management ... ...

Abstract	Indexical assessment coupled with a self-organizing map (SOM) and positive matrix factorization (PMF) modeling of toxic metal(loid)s in sediment and water of the aquatic environment provides valuable information from the environmental management perspective. However, in northwest Bangladesh, indexical and modeling assessments of toxic metal(loid)s in surface water and sediment are still rare. Toxic metal(loid)s were measured in sediment and surface water from an urban polluted river (Ichamati) in northwest Bangladesh using an atomic absorption spectrophotometer to assess distribution, pollution levels, sources, and potential environmental risks to the aquatic environment. The mean concentrations (mg/kg) of metal(loid)s in water are as follows: Fe (871) > Mn (382) > Cr (72.4) > Zn (34.2) > Co (20.8) > Pb (17.6) > Ni (16.7) > Ag (14.9) > As (9.0) > Cu (5.63) > Cd (2.65), while in sediment, the concentration follows the order, Fe (18,725) > Mn (551) > Zn (213) > Cu (47.6) > Cr (30.2) > Ni (24.2) > Pb (23.8) > Co (9.61) > As (8.23) > Cd (0.80) > Ag (0.60). All metal concentrations were within standard guideline values except for Cr and Pb for water and Cd, Zn, Cu, Pb, and As for sediment. The outcomes of eco-environmental indices, including contamination and enrichment factors and geo-accumulation index, differed spatially, indicating that most of the sediment sites were moderately to highly polluted by Cd, Zn, and As. Cd and Zn content can trigger ecological risks. The positive matrix factorization (PMF) model recognized three probable sources of sediment, i.e., natural source (49.39%), industrial pollution (19.72%), and agricultural source (30.92%), and three possible sources of water, i.e., geogenic source (45.41%), industrial pollution (22.88%), and industrial point source (31.72%), respectively. SOM analysis identified four spatial patterns, e.g., Fe–Mn-Ag, Cd–Cu, Cr-Pb-As-Ni, and Zn–Co in water and three patterns, e.g., Mn-Co–Ni-Cr, Cd-Cu-Pb–Zn, and As-Fe-Ag in sediment. The spatial distribution of entropy water quality index values shows that the southwestern area possesses “poor” quality water. Overall, the levels of metal(loid) pollution in the investigated river surpassed a critical threshold, which might have serious consequences for the river’s aquatic biota and human health in the long run.
Keywords	aquatic environment ; atomic absorption spectrometry ; entropy ; environmental management ; guidelines ; human health ; models ; pollution ; rivers ; sediments ; surface water ; toxicity ; water quality ; Bangladesh
Language	English
Dates of publication	2023-02
Size	p. 20934-20958.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23617-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Power Generation from Coal in Pakistan

Ghazia Anjum / M. Nasiruddin Khan

Pakistan Journal of Analytical & Environmental Chemistry, Vol 18, Iss 1, Pp 54-

Assessment of Physicochemical Pollutant Indicators in Indigenous Reserves in Comparison to the Foreign Coal

2017 Volume 63

Abstract: Electricity production through coal combustion is the only viable solution in minimum timing. As environmental chemists, our primary goal is to assess environmental hazards and suggest cost-effective technologies for reducing combustion pollutants. In ... ...

Abstract	Electricity production through coal combustion is the only viable solution in minimum timing. As environmental chemists, our primary goal is to assess environmental hazards and suggest cost-effective technologies for reducing combustion pollutants. In the present study, indigenous coal samples from different mines were analyzed for their physicochemical properties and toxic metals. Five samples from foreign coal mines were also studied for comparison purposes and already in use for power generation. The sulfur content in Thar coal (0.62 %) is similar to foreign samples of Indonesian and Mozambique samples (0.35 – 1.63 %). Heating values of local coals show their potential as future fuel. The principal component analysis was applied to the data. It interprets that the concentration of toxic metals in indigenous and foreign samples is lower than the reported Greece samples. The concentration of metals in Badin coal samples is similar to foreign studied samples and is lower than the reported China, South Africa and other local samples. Copper (77.64 mg/kg), Zinc (63.23 mg/kg), Chromium (75.80 mg/kg), Mercury (0.22 mg/kg) and Manganese (119.07 mg/kg) are found to be high in Thar and Lead (49.41 mg/kg) in Lakhra. Balochistan is elevated in the concentration of nickel (52.63 mg/kg). It becomes obligatory for the policy makers of the country to suggest legislation for the use of appropriate Clean Coal Technologies (CCT) in the use of the coal in power sector.
Keywords	Indigenous coal ; Power generation ; Trace metals ; Pollutants ; CCT ; Environmental sciences ; GE1-350 ; Analytical chemistry ; QD71-142
Subject code	500 ; 670
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	National Centre of Excellence in Analytical Chemsitry
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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