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  1. Article ; Online: SG-APSIC1206

    Sifat Uz Zaman / Nihad Adnan

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol 3, Pp s32-s

    Effectiveness of sterilization practice in reprocessing medical devices among different multidisciplinary tertiary-care hospitals in Dhaka City

    2023  Volume 32

    Abstract: Objectives: Sterilization failure is one of the main causes of surgical-site infections. We assessed the effectiveness of the sterilization process of surgical instruments to determine the reasons for sterilization failure. Methods: In total, 100 ... ...

    Abstract Objectives: Sterilization failure is one of the main causes of surgical-site infections. We assessed the effectiveness of the sterilization process of surgical instruments to determine the reasons for sterilization failure. Methods: In total, 100 sterilization cycles were observed from February 4, 2022, to September 5, 2022, in hospitals in Dhaka City. We used sterilization quality assurance monitoring tools (ie, biological indicators) for rapid steam and ethylene oxide sterilization methods. Tests were performed using an automatic reading machine, chemical indicator strips, and indicator tape for both steam and ethylene oxide methods. For laboratory testing and data collection, APSIC guidelines were followed. All samples were incubated for 48 hours to cross check the accuracy of the auto-reader result. Results: All ethylene oxide sterilization cycles were 100% successful, as shown by the rapid biological indicator (auto-reader), chemical indicator strips, and indicator tape. However, 22% sterilization failure occurred with steam sterilization, which was confirmed by the auto-reader, chemical indicator strips, and indicator tape. All biological samples showed no growth after 48 hours of incubation, except the sample from steam sterilization, which did show growth after 48 hours of incubation. Conclusions: We detected 22% steam sterilization failure, and serious harm to patients could occur if these surgical instruments were used for surgery. Process recall would not have been not possible if rapid biological indicator tests had not been performed and other chemical monitoring tools had not been used. The regular use of monitoring tools according to guidelines can be a reliable solution to reduce surgical site infections caused by inappropriate sterilization of surgical instruments.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 630
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Fractionation and phytochemical composition of an ethanolic extract of

    Abdallah, Rola / Shaito, Abdullah A / Badran, Adnan / Baydoun, Serine / Sobeh, Mansour / Ouchari, Wafae / Sahri, Nihad / Eid, Ali H / Mesmar, Joelle Edward / Baydoun, Elias

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1331843

    Abstract: Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search for bioactives from natural ... ...

    Abstract Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search for bioactives from natural sources as alternative or complementary modalities to synthetic medicines; especially for cancer treatment, which incidence and mortality rates are on the rise worldwide.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1331843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Electrolyte Imbalance Among Bangladeshi Patients With COVID-19.

    Sharmin Moutushi, Shafia / Akter, Taslima / Haq, Md Ahsanul / Ahmad, Rahnuma / Sinha, Susmita / Adnan, Nihad / Haque, Mainul

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35352

    Abstract: Introduction Infection with SARS-CoV-2 begins in the lower respiratory tract, but COVID-19 often involves the renal system, resulting in serum electrolyte imbalance. Monitoring serum electrolyte levels and parameters of liver and kidney function is ... ...

    Abstract Introduction Infection with SARS-CoV-2 begins in the lower respiratory tract, but COVID-19 often involves the renal system, resulting in serum electrolyte imbalance. Monitoring serum electrolyte levels and parameters of liver and kidney function is essential to understand disease prognosis. Objectives This study aimed to determine the effect of imbalances in serum electrolytes and other parameters on COVID-19 severity. Material and method This retrospective study comprised 241 patients, ages 14 years and older, including 186 patients who were moderately affected and 55 who were categorized as severely affected by COVID-19. Serum electrolytes (sodium (Na
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Phylogenetic diversity and functional potential of the microbial communities along the Bay of Bengal coast.

    Akter, Salma / Rahman, M Shaminur / Ali, Hazrat / Minch, Benjamin / Mehzabin, Kaniz / Siddique, Md Moradul / Galib, Syed Md / Yesmin, Farida / Azmuda, Nafisa / Adnan, Nihad / Hasan, Nur A / Rahman, Sabita Rezwana / Moniruzzaman, Mohammad / Ahmed, Md Firoz

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18804

    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45996-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Classic and Current Opinions in Human Organ and Tissue Transplantation.

    Oli, Angus N / Babajide Rowaiye, Adekunle / Adejumo, Samson Adedeji / Anazodo, Francis Ifeanyi / Ahmad, Rahnuma / Sinha, Susmita / Haque, Mainul / Adnan, Nihad

    Cureus

    2022  Volume 14, Issue 11, Page(s) e30982

    Abstract: Graft tolerance is a pathophysiological condition heavily reliant on the dynamic interaction of the innate and adaptive immune systems. Genetic polymorphism determines immune responses to tissue/organ transplantation, and intricate humoral and cell- ... ...

    Abstract Graft tolerance is a pathophysiological condition heavily reliant on the dynamic interaction of the innate and adaptive immune systems. Genetic polymorphism determines immune responses to tissue/organ transplantation, and intricate humoral and cell-mediated mechanisms control these responses. In transplantation, the clinician's goal is to achieve a delicate equilibrium between the allogeneic immune response, undesired effects of the immunosuppressive drugs, and the existing morbidities that are potentially life-threatening. Transplant immunopathology involves sensitization, effector, and apoptosis phases which recruit and engages immunological cells like natural killer cells, lymphocytes, neutrophils, and monocytes. Similarly, these cells are involved in the transfer of normal or genetically engineered T cells. Advances in tissue transplantation would involve a profound knowledge of the molecular mechanisms that underpin the respective immunopathology involved and the design of precision medicines that are safe and effective.
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genome Sequences of Two Novel Coronavirus (SARS-CoV-2) Isolates from Dhaka, Bangladesh.

    Matin, M Abdul / Nahid, Abdullah Al / Sarkar, Bishajit / Ullah, M Asad / Araf, Yusha / Adnan, Nihad / Islam, Rashedul / Rahman, Mohammad Shahedur

    Microbiology resource announcements

    2021  Volume 10, Issue 27, Page(s) e0051121

    Abstract: This study reports the genome sequences of two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in the nasopharyngeal swab specimens of two coronavirus disease 2019 (COVID-19) patients from Dhaka, Bangladesh. ...

    Abstract This study reports the genome sequences of two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in the nasopharyngeal swab specimens of two coronavirus disease 2019 (COVID-19) patients from Dhaka, Bangladesh.
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00511-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author Correction

    Salma Akter / M. Shaminur Rahman / Hazrat Ali / Benjamin Minch / Kaniz Mehzabin / Md. Moradul Siddique / Syed Md. Galib / Farida Yesmin / Nafisa Azmuda / Nihad Adnan / Nur A. Hasan / Sabita Rezwana Rahman / Mohammad Moniruzzaman / Md Firoz Ahmed

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    Phylogenetic diversity and functional potential of the microbial communities along the Bay of Bengal coast

    2023  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Breast Cancer Management in the Era of Covid-19; Key Issues, Contemporary Strategies, and Future Implications.

    Prodhan, A H M Safayet Ullah / Islam, Dewan Zubaer / Khandker, Shahad Saif / Jamiruddin, Mohd Raeed / Abdullah, Adnan / Godman, Brian / Opanga, Sylvia / Kumar, Santosh / Sharma, Paras / Adnan, Nihad / Pisana, Alice / Haque, Mainul

    Breast cancer (Dove Medical Press)

    2023  Volume 15, Page(s) 51–89

    Abstract: During the COVID-19 pandemic, several priority diseases were not getting sufficient attention. Whilst breast cancer is a fatal disease affecting millions worldwide, identification and management of these patients did not initially attract critical ... ...

    Abstract During the COVID-19 pandemic, several priority diseases were not getting sufficient attention. Whilst breast cancer is a fatal disease affecting millions worldwide, identification and management of these patients did not initially attract critical attention to minimize the impact of lockdown, post-lockdown, and other measures. Breast cancer patients' conditions may not remain stable without proper care, worsening their prognosis. Proper care includes the timely instigation of surgery, systemic therapy, and psychological support. This includes low-and middle-income countries where there are already concerns with available personnel and medicines to adequately identify and treat these patients. Consequently, there was a need to summarize the current scenario regarding managing breast cancer care during COVID-19 across all countries, including any guidelines developed. We systematically searched three scientific databases and found 76 eligible articles covering the medical strategies of high-income countries versus LMICs. Typically, diagnostic facilities in hospitals were affected at the beginning of the pandemic following the lockdown and other measures. This resulted in more advanced-stage cancers being detected at initial presentation across countries, negatively impacting patient outcomes. Other than increased telemedicine, instigating neo-adjuvant endocrine therapy more often, reducing non-essential visits, and increasing the application of neo-adjuvant chemotherapy to meet the challenges, encouragingly, there was no other significant difference among patients in high-income versus LMICs. Numerous guidelines regarding patient management evolved during the pandemic to address the challenges posed by lockdowns and other measures, which were subsequently adopted by various high-income countries and LMICs to improve patient care. The psychological impact of COVID-19 and associated lockdown measures, especially during the peak of COVID-19 waves, and the subsequent effect on the patient's mental health must also be considered in this high-priority group. We will continue to monitor the situation to provide direction in future pandemics.
    Language English
    Publishing date 2023-01-27
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S390296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Disruptive Impact of COVID-19 on the Utilization of Cancer Chemotherapy-Related Healthcare Assistance at the Principal Nationwide Referral Hospital in Kenya.

    Njunge, Irene Mumbi / Okalebo, Faith / Kurdi, Amanj / Kumar, Santosh / Sinha, Susmita / Haque, Mainul / Adnan, Nihad / Meyer, Johanna C / Godman, Brian / Opanga, Sylvia

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50320

    Abstract: Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy ... ...

    Abstract Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy trends before and during the pandemic at Kenyatta National Hospital (KNH), the most wide-ranging referral infirmary in Kenya, along with associated factors to provide future guidance. Methods Time series analyses and patient interviews were undertaken at the KNH Cancer Treatment Centre. Patient data were analyzed descriptively and inferentially. The average quarterly scores of chemotherapy-related patients from January 2019 to December 2020 were computed for the time series analysis. Results A total of 241 participants were recruited. Of the participants, 164 (68%) were female, and the mean age was 55. Breast cancer was the most typical cancer type. Independent risk factors for missed chemotherapy sessions were a considerable increase in travel costs, rescheduled appointments alongside difficulties in securing an appointment, comorbidities, and marital status. There was a decline in chemotherapy utilization before COVID-19, with a sharp drop at the pandemic's peak. Conclusion COVID-19 and associated measures did appreciably affect the treatment of cancer patients with chemotherapy in this developing country, with several factors contributing to this. Efforts should be geared toward continuity of services during future pandemics in developing countries to improve patient outcomes.
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Phylogenetic diversity and functional potential of the microbial communities along the Bay of Bengal coast.

    Akter, Salma / Rahman, M Shaminur / Ali, Hazrat / Minch, Benjamin / Mehzabin, Kaniz / Siddique, Md Moradul / Galib, Syed Md / Yesmin, Farida / Azmuda, Nafisa / Adnan, Nihad / Hasan, Nur A / Rahman, Sabita Rezwana / Moniruzzaman, Mohammad / Ahmed, Md Firoz

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15976

    Abstract: The Bay of Bengal, the world's largest bay, is bordered by populous countries and rich in resources like fisheries, oil, gas, and minerals, while also hosting diverse marine ecosystems such as coral reefs, mangroves, and seagrass beds; regrettably, its ... ...

    Abstract The Bay of Bengal, the world's largest bay, is bordered by populous countries and rich in resources like fisheries, oil, gas, and minerals, while also hosting diverse marine ecosystems such as coral reefs, mangroves, and seagrass beds; regrettably, its microbial diversity and ecological significance have received limited research attention. Here, we present amplicon (16S and 18S) profiling and shotgun metagenomics data regarding microbial communities from BoB's eastern coast, viz., Saint Martin and Cox's Bazar, Bangladesh. From the 16S barcoding data, Proteobacteria appeared to be the dominant phylum in both locations, with Alteromonas, Methylophaga, Anaerospora, Marivita, and Vibrio dominating in Cox's Bazar and Pseudoalteromonas, Nautella, Marinomonas, Vibrio, and Alteromonas dominating the Saint Martin site. From the 18S barcoding data, Ochrophyta, Chlorophyta, and Protalveolata appeared among the most abundant eukaryotic divisions in both locations, with significantly higher abundance of Choanoflagellida, Florideophycidae, and Dinoflagellata in Cox's Bazar. The shotgun sequencing data reveals that in both locations, Alteromonas is the most prevalent bacterial genus, closely paralleling the dominance observed in the metabarcoding data, with Methylophaga in Cox's Bazar and Vibrio in Saint Martin. Functional annotations revealed that the microbial communities in these samples harbor genes for biofilm formation, quorum sensing, xenobiotics degradation, antimicrobial resistance, and a variety of other processes. Together, these results provide the first molecular insight into the functional and phylogenetic diversity of microbes along the BoB coast of Bangladesh. This baseline understanding of microbial community structure and functional potential will be critical for assessing impacts of climate change, pollution, and other anthropogenic disturbances on this ecologically and economically vital bay.
    MeSH term(s) Bays ; Phylogeny ; Microbiota ; Alteromonas ; Dinoflagellida
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43306-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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