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Article: The ANA profile: quality and cost-effective laboratory utilization.

Clough, J D / Calabrese, L H / Valenzuela, R

1989 Volume 56, Issue 3, Page(s) 245–248

Abstract: The ANA Profile was introduced in 1981 and computerized in 1984 as a means of facilitating follow ... to contain antinuclear antibodies (ANA). A second purpose was to avoid unnecessary specific antibody testing ... on negative or low-titer sera. This study was done to evaluate the effectiveness of the computerized ANA ...

Abstract	The ANA Profile was introduced in 1981 and computerized in 1984 as a means of facilitating follow-up testing for specific antibodies (anti-nDNA, anti-Sm, anti-RNP, anti-La/SS-B) in sera found to contain antinuclear antibodies (ANA). A second purpose was to avoid unnecessary specific antibody testing on negative or low-titer sera. This study was done to evaluate the effectiveness of the computerized ANA Profile reporting system in accomplishing these purposes. The authors compared ordering practices during two two-week periods, one in 1984 and a second in 1988, and found that follow-up testing on positive sera had improved from 27% to 70% with a reduction in unnecessary specific-antibody testing of ANA-negative or low-titer sera from 11% to 1.6%. In 1988 dollars, the annual savings from eliminating unnecessary testing was calculated to be $12,000. The ANA Profile has been partially successful in accomplishing the purposes for which it was introduced.
MeSH term(s)	Antibodies, Antinuclear/analysis ; Cost-Benefit Analysis ; Diagnosis, Computer-Assisted ; Humans ; Lupus Erythematosus, Systemic/economics ; Lupus Erythematosus, Systemic/immunology
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	1989-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	0891-1150
ISSN	0891-1150
DOI	10.3949/ccjm.56.3.245
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Article ; Online: Commentary on: Tooth Loss, Periodontal Disease, and Mild Cognitive Impairment Among Hispanic/Latino Immigrants: The Moderating Effect of Age at Immigration.

Zea, Ana M / Henshaw, Michelle M / Calabrese, Joseph M

The journals of gerontology. Series A, Biological sciences and medical sciences

2023 Volume 78, Issue 6, Page(s) 947–948

MeSH term(s)	Humans ; Cognitive Dysfunction ; Emigrants and Immigrants ; Emigration and Immigration ; Hispanic or Latino/psychology ; Periodontal Diseases ; Tooth Loss ; Age Factors
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glad050
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Article: Personnel Scheduling during the COVID-19 Pandemic: A Probabilistic Graph-Based Approach.

Davoodi, Mansoor / Batista, Ana / Senapati, Abhishek / Calabrese, Justin M

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 13

Abstract: Effective personnel scheduling is crucial for organizations to match workload demands. However, staff scheduling is sometimes affected by unexpected events, such as the COVID-19 pandemic, that disrupt regular operations. Limiting the number of on-site ... ...

Abstract	Effective personnel scheduling is crucial for organizations to match workload demands. However, staff scheduling is sometimes affected by unexpected events, such as the COVID-19 pandemic, that disrupt regular operations. Limiting the number of on-site staff in the workplace together with regular testing is an effective strategy to minimize the spread of infectious diseases like COVID-19 because they spread mostly through close contact with people. Therefore, choosing the best scheduling and testing plan that satisfies the goals of the organization and prevents the virus's spread is essential during disease outbreaks. In this paper, we formulate these challenges in the framework of two Mixed Integer Non-linear Programming (MINLP) models. The first model aims to derive optimal staff occupancy and testing strategies to minimize the risk of infection among employees, while the second is aimed only at optimal staff occupancy under a random testing strategy. To solve the problems expressed in the models, we propose a canonical genetic algorithm as well as two commercial solvers. Using both real and synthetic contact networks of employees, our results show that following the recommended occupancy and testing strategy reduces the risk of infection 25-60% under different scenarios. The minimum risk of infection can be achieved when the employees follow a planned testing strategy. Further, vaccination status and interaction rate of employees are important factors in developing scheduling strategies that minimize the risk of infection.
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11131917
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Article ; Online: Personnel Scheduling during the COVID-19 Pandemic

Mansoor Davoodi / Ana Batista / Abhishek Senapati / Justin M. Calabrese

Healthcare, Vol 11, Iss 1917, p

A Probabilistic Graph-Based Approach

2023 Volume 1917

Abstract	Effective personnel scheduling is crucial for organizations to match workload demands. However, staff scheduling is sometimes affected by unexpected events, such as the COVID-19 pandemic, that disrupt regular operations. Limiting the number of on-site staff in the workplace together with regular testing is an effective strategy to minimize the spread of infectious diseases like COVID-19 because they spread mostly through close contact with people. Therefore, choosing the best scheduling and testing plan that satisfies the goals of the organization and prevents the virus’s spread is essential during disease outbreaks. In this paper, we formulate these challenges in the framework of two Mixed Integer Non-linear Programming (MINLP) models. The first model aims to derive optimal staff occupancy and testing strategies to minimize the risk of infection among employees, while the second is aimed only at optimal staff occupancy under a random testing strategy. To solve the problems expressed in the models, we propose a canonical genetic algorithm as well as two commercial solvers. Using both real and synthetic contact networks of employees, our results show that following the recommended occupancy and testing strategy reduces the risk of infection 25–60% under different scenarios. The minimum risk of infection can be achieved when the employees follow a planned testing strategy. Further, vaccination status and interaction rate of employees are important factors in developing scheduling strategies that minimize the risk of infection.
Keywords	personnel scheduling ; presence strategy ; testing strategy ; pandemic ; COVID-19 ; Medicine ; R
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Effects of

Magalhães, Isadora de Fátima Braga / Figueirêdo, Ana Letícia Marinho / da Silva, Elizeu Mendes / de Miranda, Adryan Adam Batalha / da Rocha, Cláudia Quintino / da Silva Calabrese, Katia / Almeida-Souza, Fernando / Abreu-Silva, Ana Lúcia

Plants (Basel, Switzerland)

2023 Volume 12, Issue 9

Abstract: New agents that can suppress inflammatory responses are being sought, since chronic inflammation is associated with several pathologies. This work aims to elucidate phytochemicals from the hydroethanolic extract of ... ...

Abstract	New agents that can suppress inflammatory responses are being sought, since chronic inflammation is associated with several pathologies. This work aims to elucidate phytochemicals from the hydroethanolic extract of mistletoe
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12091814
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Article: Leishmanicidal and immunomodulatory activity of

de Araújo, Sandra Alves / Silva, Carla Maria Pereira / Costa, Carolina Silva / Ferreira, Clarissa Sousa Costa / Ribeiro, Helen Silva / da Silva Lima, Aldilene / Quintino da Rocha, Cláudia / Calabrese, Kátia da Silva / Abreu-Silva, Ana Lucia / Almeida-Souza, Fernando

Heliyon

2024 Volume 10, Issue 2, Page(s) e24622

Abstract: Leishmaniases are infectious-parasitic diseases that impact public health around the world. Antileishmanial drugs presented toxicity and increase in parasitic resistance. Studies with natural products show an alternative to this effect, and several ... ...

Abstract	Leishmaniases are infectious-parasitic diseases that impact public health around the world. Antileishmanial drugs presented toxicity and increase in parasitic resistance. Studies with natural products show an alternative to this effect, and several metabolites have demonstrated potential in the treatment of various diseases.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24622
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Article: In Vitro Antioxidant and Antitrypanosomal Activities of Extract and Fractions of

Araújo, Sandra Alves de / Lima, Aldilene da Silva / Rocha, Cláudia Quintino da / Previtalli-Silva, Henrique / Hardoim, Daiana de Jesus / Taniwaki, Noemi Nosomi / Calabrese, Kátia da Silva / Almeida-Souza, Fernando / Abreu-Silva, Ana Lucia

Biology

2023 Volume 12, Issue 7

Abstract: Chagas disease is a severe infectious and parasitic disease caused by the ... ...

Abstract	Chagas disease is a severe infectious and parasitic disease caused by the protozoan
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070895
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Article ; Online: Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil

Fernando ALMEIDA-SOUZA / Iara dos Santos da Silva OLIVEIRA / Isadora de Fátima Braga MAGALHÃES / Noemi Nosomi TANIWAKI / Kátia da Silva CALABRESE / Ana Lucia ABREU-SILVA

Acta Amazonica, Vol 54, Iss

2024 Volume 1

Abstract: ABSTRACT In the Amazon region, andiroba (Carapa guianensis) oil is among the most used products by the local population due to its medicinal properties. Previously, our group described the leishmanicidal activity of three limonoid-rich fractions from ... ...

Abstract	ABSTRACT In the Amazon region, andiroba (Carapa guianensis) oil is among the most used products by the local population due to its medicinal properties. Previously, our group described the leishmanicidal activity of three limonoid-rich fractions from andiroba oil. This work aimed to evaluate the antioxidant activity and ultrastructural changes in Leishmania amazonensis treated with these limonoid-rich fractions from andiroba oil: 6α,11β-diacetoxygedunin; 11β-hydroxygedunin; and a fraction with both 6α,11β-diacetoxygedunin +11β-hydroxygedunin. The antioxidant activity was evaluated by the DPPH method and ultrastructural changes were evaluated by transmission electron microscopy. The fraction with both 6α,11β-diacetoxygedunin + 11β-hydroxygedunin displayed the best antioxidant activity (IC50 330.35 ± 8.60 µg mL-1; p=0.0022) compared to the 6α,11β-diacetoxygedunin fraction. The three fractions induced structural changes to mitochondria and kinetoplasts of L. amazonensis, in addition to lipid bodies, vacuolization, and vesicles in the flagellar pocket, indicating that the limonoid-rich fractions from andiroba oil can induce structural damage to Leishmania.
Keywords	leishmaniasis ; crabwood ; DPPH ; transmission electron microscopy ; Carapa guianensis ; Science (General) ; Q1-390
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Instituto Nacional de Pesquisas da Amazônia
Document type	Article ; Online
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Article ; Online: Coding principles of the canonical cortical microcircuit in the avian brain.

Calabrese, Ana / Woolley, Sarah M N

Proceedings of the National Academy of Sciences of the United States of America

2015 Volume 112, Issue 11, Page(s) 3517–3522

Abstract: Mammalian neocortex is characterized by a layered architecture and a common or "canonical" microcircuit governing information flow among layers. This microcircuit is thought to underlie the computations required for complex behavior. Despite the absence ... ...

Abstract	Mammalian neocortex is characterized by a layered architecture and a common or "canonical" microcircuit governing information flow among layers. This microcircuit is thought to underlie the computations required for complex behavior. Despite the absence of a six-layered cortex, birds are capable of complex cognition and behavior. In addition, the avian auditory pallium is composed of adjacent information-processing regions with genetically identified neuron types and projections among regions comparable with those found in the neocortex. Here, we show that the avian auditory pallium exhibits the same information-processing principles that define the canonical cortical microcircuit, long thought to have evolved only in mammals. These results suggest that the canonical cortical microcircuit evolved in a common ancestor of mammals and birds and provide a physiological explanation for the evolution of neural processes that give rise to complex behavior in the absence of cortical lamination.
MeSH term(s)	Action Potentials/physiology ; Animals ; Auditory Cortex/physiology ; Birds ; Finches/physiology ; Interneurons/physiology ; Male ; Nerve Net/physiology ; Noise
Language	English
Publishing date	2015-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1408545112
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Article ; Online: A Web-Based COVID-19 Tool for Testing Residents in Retirement Homes: Development Study.

Davoodi, Mansoor / Batista, Ana / Mertel, Adam / Senapati, Abhishek / Abdussalam, Wildan / Vyskocil, Jiri / Barbieri, Giuseppe / Fan, Kai / Schlechte-Welnicz, Weronika / M Calabrese, Justin

JMIR formative research

2023 Volume 7, Page(s) e45875

Abstract: Background: Long-term care facilities have been widely affected by the COVID-19 pandemic. Empirical evidence demonstrated that older people are the most impacted and are at higher risk of mortality after being infected. Regularly testing care facility ... ...

Abstract	Background: Long-term care facilities have been widely affected by the COVID-19 pandemic. Empirical evidence demonstrated that older people are the most impacted and are at higher risk of mortality after being infected. Regularly testing care facility residents is a practical approach to detecting infections proactively. In many cases, the care staff must perform the tests on the residents while also providing essential care, which in turn causes imbalances in their working time. Once an outbreak occurs, suppressing the spread of the virus in retirement homes (RHs) is challenging because the residents are in contact with each other, and isolation measures cannot be widely enforced. Regular testing strategies, on the other hand, have been shown to effectively prevent outbreaks in RHs. However, high-frequency testing may consume substantial staff working time, which results in a trade-off between the time invested in testing and the time spent providing essential care to residents. Objective: We developed a web application (Retirement Home Testing Optimizer) to assist RH managers in identifying effective testing schedules for residents. The outcome of the app, called the "testing strategy," is based on dividing facility residents into groups and then testing no more than 1 group per day. Methods: We created the web application by incorporating influential factors such as the number of residents and staff, the average rate of contacts, the amount of time spent to test, and constraints on the test interval and size of groups. We developed mixed integer nonlinear programming models for balancing staff workload in long-term care facilities while minimizing the expected detection time of a probable infection inside the facility. Additionally, by leveraging symmetries in the problem, we proposed a fast and efficient local search method to find the optimal solution. Results: Considering the number of residents and staff and other practical constraints of the facilities, the proposed application computes the optimal trade-off testing strategy and suggests the corresponding grouping and testing schedule for residents. The current version of the application is deployed on the server of the Where2Test project and is accessible on their website. The application is open source, and all contents are offered in English and German. We provide comprehensive instructions and guidelines for easy use and understanding of the application's functionalities. The application was launched in July 2022, and it is currently being tested in RHs in Saxony, Germany. Conclusions: Recommended testing strategies by our application are tailored to each RH and the goals set by the managers. We advise the users of the application that the proposed model and approach focus on the expected scenarios, that is, the expected risk of infection, and they do not guarantee the avoidance of worst-case scenarios.
Language	English
Publishing date	2023-11-21
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/45875
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