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Article ; Online: Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inversa in patients of paediatric age: a pilot prospective study.

Bettoli, V / Toni, G / Odorici, G / Forconi, R / Corazza, M

2021 Volume 185, Issue 1, Page(s) 216–217

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Clindamycin ; Hidradenitis Suppurativa/drug therapy ; Humans ; Prospective Studies ; Rifampin
Chemical Substances	Anti-Bacterial Agents ; Clindamycin (3U02EL437C) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.19867
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Article ; Online: Facial palsy after administration of immune checkpoint inhibitors: case report, literature review and clinical care management.

Mezni, Essia / Corazza, Giovanni / Mari, Roxane / Coze, Stephanie / Charrier, Nathalie / Chanez, Brice / Chretien, Anne Sophie / Rochigneux, Philippe

Frontiers in immunology

2024 Volume 15, Page(s) 1375497

Abstract: Neurological immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICI) are rare complications of immunotherapy, particularly dreadful for patients and clinical teams. Indeed, neurological irAEs are potentially severe and their ... ...

Abstract	Neurological immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICI) are rare complications of immunotherapy, particularly dreadful for patients and clinical teams. Indeed, neurological irAEs are potentially severe and their diagnosis require prompt recognition and treatment. Additionally, the spectrum of neurological irAEs is broad, affecting either neuromuscular junction, peripheral or central nervous system. Here, we described the case of a 55-year man with metastatic melanoma, facing a brutal right peripheral cerebral palsy after his third ipilimumab/nivolumab infusion. After the case presentation, we reviewed the literature about this rare complication of immunotherapy, and described its diagnosis work-up and clinical management.
MeSH term(s)	Male ; Humans ; Nivolumab/therapeutic use ; Immune Checkpoint Inhibitors/adverse effects ; Ipilimumab/therapeutic use ; Facial Paralysis/chemically induced ; Facial Paralysis/drug therapy ; Melanoma
Chemical Substances	Nivolumab (31YO63LBSN) ; Immune Checkpoint Inhibitors ; Ipilimumab
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Review ; Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1375497
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Book ; Online: Unravelling looping efficiency of stochastic Cosserat polymers

Corazza, Giulio / Singh, Raushan

2021

Abstract: ... of fluctuating polymers (e.g. DNA) is important in many applications in molecular biology and chemistry ...

Abstract	Understanding looping probabilities, including the particular case of ring-closure or cyclization, of fluctuating polymers (e.g. DNA) is important in many applications in molecular biology and chemistry. In a continuum limit the configuration of a polymer is a curve in the group SE(3) of rigid body displacements, whose energy can be modelled via the Cosserat theory of elastic rods. Cosserat rods are a more detailed version of the classic wormlike-chain (WLC) model, which we show to be more appropriate in short-length scale, or stiff, regimes, where the contributions of extension and shear deformations are not negligible and lead to undiscovered high values for the cyclization probabilities (or J-factors). Characterizing the stochastic fluctuations about minimizers of the energy by means of Laplace expansions in a (real) path integral formulation, we develop efficient analytical approximations for the two cases of full looping, in which both end-to-end relative translation and rotations are prescribed, and of marginal looping probabilities, where only end-to-end translation is prescribed. For isotropic Cosserat rods, certain looping boundary value problems admit non-isolated families of critical points of the energy due to an associated continuous symmetry. For the first time, taking inspiration from (imaginary) path integral techniques, a quantum mechanical probabilistic treatment of Goldstone modes in statistical rod mechanics sheds light on J-factor computations for isotropic rods in the semi-classical context. All the results are achieved exploiting appropriate Jacobi fields arising from Gaussian path integrals, and show good agreement when compared with intense Monte Carlo simulations for the target examples. Comment: Comments are welcome!
Keywords	Condensed Matter - Statistical Mechanics ; Quantitative Biology - Biomolecules
Subject code	612
Publishing date	2021-09-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Experimental model of nephropathy associated with diabetes mellitus in mice.

Silva, Pâmela Henrique / Silva, Patrícia Henrique / Corazza, Adalberto Vieira / Silva, Josivaldo Godoy da / Silva, Iandara Schettert

Acta cirurgica brasileira

2023 Volume 38, Page(s) e381123

Abstract: ... for induction of nephropathy by ischemia and reperfusion (I/R) and induction of DM by injection ... weighing approximately 20 g, were divided into four groups: G1: control (n = 24), G2: nephropathy group (N ... n = 7), G3, DM (n = 9), and G4: N+DM (n = 24). Arteriovenous stenosis (I/R) of the left kidney was ...

Abstract	Purpose: Nontransmissible chronic diseases, such as diabetes mellitus (DM) and nephropathy, affect a significant portion of the population, often treated due to injuries that require healing and regeneration. To create an experimental model of associated comorbidities, for healing and regeneration studies, protocols for induction of nephropathy by ischemia and reperfusion (I/R) and induction of DM by injection of streptozotocin (STZ) were associated. Methods: Sixty-four mice (Mus musculus), female, adult, Swiss strain, weighing approximately 20 g, were divided into four groups: G1: control (n = 24), G2: nephropathy group (N) (n = 7), G3, DM (n = 9), and G4: N+DM (n = 24). Arteriovenous stenosis (I/R) of the left kidney was performed as the first protocol. The animals received a hyperlipidemic diet for 7 days after the injection of STZ (150 mg/kg, via i.p.) and an aqueous glucose solution (10%) for 24 h. The animals in the G3 and G4 groups were observed for 14 days before receiving the diet and STZ. The evolution of nephropathy was observed using a urine test strip and the DM, through the analysis of blood glucose with a reagent strip on a digital monitor. Results: The ischemic induction protocols of nephropathy and DM with STZ, associated, were sustainable, low-cost, and without deaths. There were alterations compatible with initial renal alterations, in the first 14 days, such as increased urinary density, pH alteration, presence of glucose, proteins and leukocytes, when compared to the control group. DM was confirmed by the presence of hyperglycemia 7 days after induction and its evolution after 14 days. The animals in the G4 group showed constant weight loss when compared to the other groups. It was possible to observe morphological alterations in the kidneys submitted to I/R, regarding coloration, during surgery and after the end of the observation period, in the volume and size of the left kidney, when compared to the contralateral kidney. Conclusions: It was possible to induce nephropathy and DM associated in the same animal, in a simple way, confirmed with rapid tests, without losses, providing a basis for future studies.
MeSH term(s)	Rats ; Female ; Mice ; Animals ; Rats, Wistar ; Diabetes Mellitus, Experimental/metabolism ; Kidney/metabolism ; Diabetic Nephropathies/metabolism ; Blood Glucose ; Models, Theoretical ; Streptozocin/metabolism
Chemical Substances	Blood Glucose ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2023-05-01
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 1678-2674
ISSN (online)	1678-2674
ISSN	1678-2674
DOI	10.1590/acb381123
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Article ; Online: Effects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2, Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis: A CONSORT RCT.

Teixeira, Flavia F C / Cardoso, Flavia G R / Ferreira, Nadia S / Corazza, Bruna J M / Valera, Marcia M C / Nascimento, Gustavo G / Martinho, Frederico C

Journal of endodontics

2022 Volume 48, Issue 8, Page(s) 975–984

Abstract: Introduction: This Consolidated Standards of Reporting Trials randomized clinical trial investigated T helper (Th1, Th2, Th9, Th17, and Tfh) and regulatory T (Treg) cell-type cytokines and their networks in apical periodontitis (AP). We also assessed ... ...

Abstract	Introduction: This Consolidated Standards of Reporting Trials randomized clinical trial investigated T helper (Th1, Th2, Th9, Th17, and Tfh) and regulatory T (Treg) cell-type cytokines and their networks in apical periodontitis (AP). We also assessed the effects of calcium hydroxide [Ca(OH)2] intracanal medications (ICMs) on helper T and Treg cell-type cytokines. Methods: Twenty teeth with primary endodontic infection and apical periodontitis were randomly divided into two groups: Ca(OH)2 + saline solution (n = 10) and Ca (OH)2 + 2% chlorhexidine-gel (n = 10). Samples were collected from the periradicular tissue fluid (PTF) before (PTFs1) and after 14 days of ICMs (PTFs2). The Human High Sensitivity T Cell Panel was used to quantify target T-helper (Th)1: interelukin (IL)-2, IL-12, and interferon-gamma (IFN-γ); Th2: IL-4, IL-5, and IL-13; Th9: IL-9; Th17: IL-17; T follicular helper cells (Tfh): IL-21; and Treg-cell-type cytokine: IL-10. Results: Th1-type cytokines were higher than Th2-type ones, at PTFs1. Positive (+) associations were found among all Th1-type cytokines and all Th2-type cytokines. There were negative (-) correlations between all Th1- and Th2-type cytokines. Size of radiolucent lesions and symptoms (tenderness to percussion and/or pain on palpation) were positively correlated with Th1-type cytokines, IL-17, and IL-21 but negatively correlated with Th2-type cytokines and IL-10 (all, P < .001). Both ICMs increased Th2-type cytokines and IL-10 (P < .05) and decreased Th1-type cytokines, IL-17, and IL-21 (P < .05), with no differences among them (P > .05). Conclusions: Complex T-cell cytokine networks are involved in AP. Both Ca(OH)2 ICMs effectively increased IL-4, IL-5, IL-10, and IL-13 and lowered IL-2, IL-12, IL-17, IL-21, and IFN-γ.
MeSH term(s)	Calcium Hydroxide/therapeutic use ; Cytokines ; Humans ; Interferon-gamma ; Interleukin-10 ; Interleukin-12 ; Interleukin-13 ; Interleukin-17 ; Interleukin-4 ; Interleukin-5 ; Periapical Periodontitis/drug therapy ; T Follicular Helper Cells ; T-Lymphocytes, Regulatory ; Th1 Cells ; Th17 Cells ; Th2 Cells
Chemical Substances	Cytokines ; Interleukin-13 ; Interleukin-17 ; Interleukin-5 ; Interleukin-10 (130068-27-8) ; Interleukin-12 (187348-17-0) ; Interleukin-4 (207137-56-2) ; Interferon-gamma (82115-62-6) ; Calcium Hydroxide (PF5DZW74VN)
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2022.04.010
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Article: Creative Potential in Science: Conceptual and Measurement Issues.

Lubart, Todd / Kharkhurin, Anatoliy V / Corazza, Giovanni Emanuele / Besançon, Maud / Yagolkovskiy, Sergey R / Sak, Ugur

Frontiers in psychology

2022 Volume 13, Page(s) 750224

Abstract: ... of focusing on individual (e.g., Science Fairs) or collaborative (e.g., Science Olympiads) work. Third ...

Abstract	This paper examines the concept of creative potential as it applies in science. First, conceptual issues concerning the definition of creative potential are explored, highlighting that creative potential is a moving target, and measures of creative potential are estimates of future behavior. Then three main ways to detect creative potential are examined. First, a person's previous accomplishments in science can be analyzed. These accomplishments can be regarded as predictors of future creative performance. Second, science talent competitions can help to detect creative potential in children and adolescents. There are particular types of talent competitions differing from each other by the extent of focusing on individual (e.g., Science Fairs) or collaborative (e.g., Science Olympiads) work. Third, to measure an individual's creative potential, psychometric tools such as Creative Scientific Ability Test (C-SAT), Test of Scientific Creativity Animations for Children (TOSCAC), and Evaluation of Potential Creativity (EPoC) can be used. These tools are conceptualized in terms of two scientific activities: hypothesis generation and hypothesis testing. In a final section, these three types of measures are placed in a novel time-space framework as applied to creative potential. Suggestions for future work are also discussed.
Language	English
Publishing date	2022-06-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.750224
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Article ; Online: Seven years-experience of adalimumab therapy for Hidradenitis Suppurativa in a real-life dermatologic setting.

Odorici, Giulia / Pacetti, Lucrezia / Forconi, Riccardo / Schettini, Natale / Zedde, Pierantonia / Corazza, Monica / Bettoli, Vincenzo

The Journal of dermatological treatment

2021 Volume 33, Issue 4, Page(s) 2063–2067

Abstract: Introduction: Hidradenitis Suppurativa (HS) often causes severe impairment of the quality of life of patients affected, as it is characterized by recurrent relapses of inflammation and predisposes to retractive scars, with severe alteration of anatomy ... ...

Abstract	Introduction: Hidradenitis Suppurativa (HS) often causes severe impairment of the quality of life of patients affected, as it is characterized by recurrent relapses of inflammation and predisposes to retractive scars, with severe alteration of anatomy of the affected regions. Adalimumab is currently the only approved long-term biological therapy for this disease. Material and method: We retrospectively review the data of HS patients treated with Adalimumab at the 'Hidradenitis Suppurativa Clinic', University of Ferrara, Italy since the drug was first available to October 2020. The aim is to describe our real-life experience in a clinical outpatient service. We assessed the main demographic features, therapy duration, reasons of suspension and efficacy (evaluated by HiSCR - Hidradenitis Score) in relation to surgical procedures, hospitalization, number of areas involved by the disease and BMI > 30. We also assessed the aspects related to the use of adalimumab's biosimilar. Results: Data on 76 patients, with a mean age of 38.26 ± 14.74 years and mean BMI 28.10 ± 5.92 were collected. Most of the treated patients had Hurley stage III (58/76); mean Sartorius score was 115.5 ± 55.86, mean IHS4 was 76.1 ± 44.3. A statistically significant correlation between hospitalization and cessation of adalimumab, the loss of the achievement of the HiSCR, and surgery was found. No need to do surgery was a protective factor against the failure of adalimumab treatment, meaning that the most severe cases are more likely to fail the biological therapy. Conclusion: New scenarios are opening up in clinical practice: the arrival of biosimilars allow greater sustainability of expenditure, while the anti-IL17 allow the patient who has failed therapy with adalimumab a valid and safe therapeutic option to be undertaken. A comprehensive care including hospitalization, a specific antibiotic therapy and surgical treatment is often mandatory to achieve a satisfactory control of the disease.
MeSH term(s)	Adalimumab/adverse effects ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Biosimilar Pharmaceuticals/therapeutic use ; Hidradenitis Suppurativa/drug therapy ; Humans ; Middle Aged ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; Biosimilar Pharmaceuticals ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2021.1914309
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Article: Occurrence of Pink Patch of Perennial Ryegrass Caused by Limonomyces roseipellis in Italy.

Maccaroni, M / Corazza, L / Buonaurio, R / Cappelli, C

Plant disease

2019 Volume 86, Issue 1, Page(s) 74

Abstract: ... on maize flour and sand medium (2) at 22 ± 2°C for 14 days. Inoculum (20 g) was added to a sterile mixture ... of sand and peat moss (1:1; 640 g). Two hundred seeds of L. perenne (cv. Amadeus) were sown in boxes ...

Abstract	In March 1999, an unusual pink gelatinous mycelium was observed on several cultivars of perennial ryegrass (Lolium perenne L.) turf grown in experimental plots in Saint Andrea d'Agliano, Perugia (central Italy). Approximately 50% of the turf area showed symptoms on susceptible varieties. The same symptoms, although with lower severity, were observed during the following year in two experimental fields in northern Italy. The presence of mycelium on infected leaf blades was extensive during periods of high relative humidity and high temperature. The disease decreased progressively when weather conditions became dry and cold. A fungus, characterized by pink colonies, was consistently isolated from leaves of affected plants on potato dextrose agar (pH 5.5). On the basis of the presence of clamp connections and binucleate hyphal cells, the fungus was identified as Limonomyces roseipellis Stalpers & Loerakker, the causal agent of pink patch of turfgrass (1,3). For the pathogenicity test, one isolate of L. roseipellis was grown on maize flour and sand medium (2) at 22 ± 2°C for 14 days. Inoculum (20 g) was added to a sterile mixture of sand and peat moss (1:1; 640 g). Two hundred seeds of L. perenne (cv. Amadeus) were sown in boxes containing infested or noninfested soil as a control. Boxes were kept in a greenhouse at 22 ± 2°C, 80% relative humidity, and 14 h of sunlight per day. Four to five weeks after sowing, typical lesions resembling natural symptoms were observed only on plants grown in inoculum-infested soil, and L. roseipellis was consistently reisolated from diseased plants. Pink patch is probably underestimated in turf since the symptoms are less severe compared with red thread caused by Laetisaria fuciformis (McAlpine) Burdsall, and the development of mycelium of Limonomyces roseipellis is slower. References: (1) J. D. Kaplan and N. Jackson. Plant Dis. 67:159, 1983. (2) Y. L. Nene et al. ICRISAT Inf. Bull. 10:1, 1981. (3) J. A. Stalpers and W. M. Loerakker. Can. J. Bot. 60:529, 1982.
Language	English
Publishing date	2019-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS.2002.86.1.74A
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Article ; Online: Pathogenesis, diagnosis and treatment of anaemia in immune-mediated gastrointestinal disorders.

Bergamaschi, Gaetano / Di Sabatino, Antonio / Corazza, Gino R

British journal of haematology

2018 Volume 182, Issue 3, Page(s) 319–329

Abstract: Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most ... ...

Abstract	Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most prevalent extra-intestinal manifestation of immune-mediated GI disorders. Anaemia is most commonly due to iron deficiency and/or inflammation, but vitamin deficiencies and, more infrequently, autoimmune haemolysis or drug-induced myelosuppression can be involved. Here we address several issues related to the differential diagnosis and treatment of anaemia in immune-mediated GI disorders, giving particular relevance to the problem of iron deficiency anaemia associated with inflammation. It is emphasized how, in most cases, anaemias due to iron or vitamin deficiencies are best treated by parenteral administration of the deficient factor(s), and how the available high dose intravenous (IV) iron formulations can reduce ambulatory and social costs of IV iron supplementation, while improving patient's compliance to treatment. Actual and future treatment possibilities for anaemia of inflammation, involving the use of erythropoiesis stimulating agents, biologicals and hepcidin inhibitors are discussed.
MeSH term(s)	Anemia/diagnosis ; Anemia/etiology ; Anemia/therapy ; Autoimmune Diseases/complications ; Celiac Disease/complications ; Diagnosis, Differential ; Gastritis, Atrophic/complications ; Gastrointestinal Diseases/complications ; Humans ; Inflammatory Bowel Diseases/complications
Language	English
Publishing date	2018-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15254
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Article ; Online: Thermal injury caused by the explosion of a lithium-ion mobile phone battery.

Corazza, M / Forconi, R / Musmeci, D / Toni, G / Borghi, A

Journal of the European Academy of Dermatology and Venereology : JEADV

2017 Volume 32, Issue 2, Page(s) e43–e44

MeSH term(s)	Adult ; Burns/etiology ; Cell Phone ; Electric Power Supplies ; Explosions ; Female ; Humans ; Lithium ; Thigh
Chemical Substances	Lithium (9FN79X2M3F)
Language	English
Publishing date	2017-08-16
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.14494
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