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Article ; Online: Early predictors of functional disability in Guillain-Barré Syndrome.

Tunç, Abdulkadir

2019 Volume 119, Issue 4, Page(s) 555–559

Abstract: This study investigated the predictors of prognosis at admission and after the first month in Guillain-Barré syndrome (GBS) patients. This retrospective study used the electronic records of 81 GBS patients. Age, gender, previous GBS history, antecedent ... ...

Abstract	This study investigated the predictors of prognosis at admission and after the first month in Guillain-Barré syndrome (GBS) patients. This retrospective study used the electronic records of 81 GBS patients. Age, gender, previous GBS history, antecedent febrile illness and presence of cranial nerve dysfunction were recorded. Detailed neurological examinations, routine biochemical and haematological investigations, cerebrospinal fluid (CSF) analysis and electrophysiological studies, GBS subtypes and treatments were assessed. Hughes disability scores (HDSs) were evaluated at the end of the first day and first month. The GBS patient group included 44 male (54.3%) and 37 female (45.7%) patients. The mean age was 52.2 ± 18.5. The mean HDS score was 2.96 at admission and 1.94 at the end of the first month. Plasma sodium, albumin, and CSF protein levels were significantly correlated with low admission HDS scores (p = 0.03, p = 0.011, p = 0.036, and p < 0.001, respectively). Age, plasma sodium, albumin, neutrophil, neutrophil/lymphocyte ratio (NLR) levels, C-reactive protein (CRP) and CSF protein levels were significantly correlated with poor prognosis at the end of the first month (p < 0.05). Concomitant cranial nerve palsies were significantly correlated with low HDS scores (p = 0.011, p = 0.02) but antecedent events were not correlated with functional disability (p = 0.686, p = 0.413). Decreased albumin and sodium levels and increased CSF protein levels indicated poor GBS prognosis. Higher age, elevated NLR, and higher CRP levels indicated worse prognosis at the end of the first month. However, further studies are needed.
MeSH term(s)	Adult ; Age Factors ; Aged ; Female ; Guillain-Barre Syndrome/blood ; Guillain-Barre Syndrome/diagnosis ; Humans ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Prognosis ; Retrospective Studies ; Serum Albumin ; Sodium/blood
Chemical Substances	Serum Albumin ; Sodium (9NEZ333N27)
Language	English
Publishing date	2019-04-08
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-019-01133-3
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Article ; Online: Evaluation of inflammatory markers in patients with migraine

Aysel Tekeşin / Abdülkadir Tunç

Archives of Clinical and Experimental Medicine, Vol 4, Iss 1, Pp 37-

2019 Volume 40

Abstract: Aim: The aim of this study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare ... ...

Abstract	Aim: The aim of this study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare with levels measured in healthy subjects. Methods: This retrospective case-control study included 136 migraine patients and 80 healthy controls who were admitted to our neurology outpatient clinic or emergency between June 2017 and June 2018. Laboratory examinations, disease characteristics, presence of aura, and the presence of white matter hyperintensities (WMHs) were recorded and demographic features and laboratory data were compared between two groups.Results: The mean age of the case group was 36.9 ± 10.6 years and the control group was 37 ± 12 years. In the patient group, total bilirubin, direct bilirubin, indirect bilirubin, and lymphocyte values were significantly lower than the control group. NLR, hsCRP, and ESR levels were significantly higher in the patient group than the control group. The patient and control groups did not show a significant difference according to the presence of WMHs. In the group with aura, monocyte and MHR values were higher than those without aura. The hsCRP values in the group with aura were significantly lower than the group without aura. Conclusion: This study showed that low bilirubin and high NLR, MHR, hsCRP, and ESR values might be potential inflammatory markers in migraine patients. These markers may contribute to our understanding of the pathophysiology of migraine. Since the cost of these tests is cheap and they are widely used, it is possible to believe that they may be useful for protecting migraine patients against long-term comorbidities.
Keywords	Migraine ; inflammation ; laboratories ; biomarker ; Migren ; enflamasyon ; laboratuvar ; biyomarker ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Archives of Clinical and Experimental Medicine
Document type	Article ; Online
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Article ; Online: Determining the utility of minimum F-wave latency alterations in the electrodiagnosis of ulnar neuropathy at the elbow.

Tunç, Abdulkadir / Güzel, Vildan / Tekeşin, Aysel / Şengül, Yıldızhan

Arquivos de neuro-psiquiatria

2021 Volume 79, Issue 3, Page(s) 195–200

Abstract: Background: Ulnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy. There is little information about the application of F-wave studies for evaluation of UNE.: Objective: The aim of this study was to evaluate the ... ...

Abstract	Background: Ulnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy. There is little information about the application of F-wave studies for evaluation of UNE. Objective: The aim of this study was to evaluate the diagnostic value of minimum F-wave (F-min) latency alterations by comparing this with nerve conduction analyses in UNE-suspected patients. Methods: Ninety-four UNE-suspected patients were admitted to this study. Sensory and motor nerve conduction and F-wave analyses on the median and ulnar nerves were performed on both upper extremities. Results: A total of 188 upper extremities of 94 patients were examined. Their mean age was 41.4±12.9 years, and 69 patients were female (73.4%). The mean ulnar-nerve across-elbow motor conduction velocity (MCV) in the affected arms was significantly slower than the velocity in healthy arms. The mean ulnar-nerve F-min latencies were significantly longer in the affected arms. Fifty-one patients were electrophysiologically diagnosed as presenting UNE (54.2%). Significantly slower mean ulnar-nerve across-elbow MCV, longer mean ulnar-nerve F-min latency and longer distal onset latency were detected in UNE-positive arms. Lastly, patients who were symptomatic but had normal nerve conduction were evaluated separately. Only the mean ulnar F-min latency was significantly longer in this group, compared with the healthy arms. Conclusion: Our study confirmed the utility of F-min latency measurements in the electrodiagnosis of UNE. F-wave latency differences can help in making an early diagnosis to provide better treatment options.
MeSH term(s)	Adult ; Elbow ; Electrodiagnosis ; Female ; Humans ; Male ; Middle Aged ; Neural Conduction ; Ulnar Nerve ; Ulnar Neuropathies/diagnosis
Language	English
Publishing date	2021-04-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	418916-4
ISSN	1678-4227 ; 0004-282X
ISSN (online)	1678-4227
ISSN	0004-282X
DOI	10.1590/0004-282X-ANP-2020-0193
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Article: Inflammatory biomarkers in benign paroxysmal positional vertigo: A Turkey case-control study.

Tekeşin, Aysel / Tunç, Abdulkadir

Ideggyogyaszati szemle

2019 Volume 71, Issue 11-12, Page(s) 411–416

Abstract: Objective - Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vertigo. Inflammation is a hypothetic etiological factor in BPPV. The aim of this study was to evaluate inflammatory biomarker levels in BPPV patients and ... ...

Title translation	Gyulladásos biomarkerek benignus paroxysmalis pozicionális vertigóban: törökországi eset-kontroll vizsgálat.
Abstract	Objective - Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vertigo. Inflammation is a hypothetic etiological factor in BPPV. The aim of this study was to evaluate inflammatory biomarker levels in BPPV patients and compare these with the healthy subjects. Materials and methods - This prospective case-control study was conducted with 114 newly diagnosed BPPV patients and age- and sex- matched 83 healthy subjects. The laboratory investigations included serum hemogram, full biochemistry profiles, vitamin levels, thyroid hormone profiles, high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte to HDL-cholesterol ratio (MHR) values were calculated and compared between the patients and healthy subjects. Results - The mean age was 39.1 ± 12.4 years for patients, and 37.0 ± 11.9 for controls. Vitamin B12, hematocrit (Hct), creatinine, urea, and fT4 values, lymphocyte, total bilirubin, direct bilirubin and indirect bilirubin levels were significantly lower in BPPV patients (p ˂ 0.05), while HDL, SGOT, and ESR values were significantly higher. In the BPPV patients the mean NLR, PLR, and mean platelet volume (MPV) values were significantly higher than in the control subjects. Neutrophil, platelet, monocyte, MHR, and CRP values were similar in both groups (p ˃ 0.05). Conclusion - Our result suggests that NLR, PLR, MPV, ESR, and bilirubin levels should be taken into account as potential biomarkers of BPPV. As they are inexpensive parameters and widely available, they can be used in clinical practice for prediction of BPPV. However, further large-scale studies are required to confirm this relationship.
MeSH term(s)	Adult ; Benign Paroxysmal Positional Vertigo/blood ; Benign Paroxysmal Positional Vertigo/diagnosis ; Biomarkers/blood ; Blood Sedimentation ; Case-Control Studies ; Creatine Kinase/blood ; Humans ; Middle Aged ; Prospective Studies ; Turkey
Chemical Substances	Biomarkers ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2019-01-03
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2240317-6
ISSN	0019-1442
ISSN	0019-1442
DOI	10.18071/isz.71.0411
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Article ; Online: Inflammatory markers are beneficial in the early stages of cerebral venous thrombosis.

Tekesin, Aysel / Tunç, Abdulkadir

Arquivos de neuro-psiquiatria

2019 Volume 77, Issue 2, Page(s) 101–105

Abstract: Background: Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT.: Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare ...

Abstract	Background: Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT. Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare these with healthy individuals. Methods: This prospective case-control study was conducted with 36 newly-diagnosed CVT patients age- and sex-matched with 40 healthy individuals. The laboratory investigations included a serum hemogram, full biochemistry profiles, high sensitivity C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-HDL cholesterol ratio (MHR) values were calculated and compared between the patients and healthy participants. Results: The mean age was 41.4 ± 11.8 years for patients, and 39.3 ± 12.5 for controls. Lymphocyte, total bilirubin, indirect bilirubin, and HDL levels were significantly lower in CVT patients (p < 0.05), while CRP, and ESR values were significantly higher. In the CVT patients the mean NLR and PLR values were significantly higher than in the control individuals. Smoking rates, alcohol consumption, white blood cell, neutrophil, platelet, and MHR values were similar in both groups (p 0.05). Conclusions: We suggest that NLR, PLR, CRP, ESR, and bilirubin can be used in clinical practice for prediction of CVT in suspected patients as they are inexpensive parameters and widely available. However, further large-scale studies are required to confirm this relationship.
MeSH term(s)	Adult ; Bilirubin/blood ; Biomarkers/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; Case-Control Studies ; Cerebral Veins ; Cholesterol, HDL/blood ; Female ; Humans ; Inflammation/blood ; Logistic Models ; Lymphocyte Count ; Male ; Mean Platelet Volume ; Middle Aged ; Neutrophils ; Platelet Count ; Prospective Studies ; Reference Values ; Statistics, Nonparametric ; Venous Thrombosis/blood ; Young Adult
Chemical Substances	Biomarkers ; Cholesterol, HDL ; C-Reactive Protein (9007-41-4) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2019-02-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	418916-4
ISSN	1678-4227 ; 0004-282X
ISSN (online)	1678-4227
ISSN	0004-282X
DOI	10.1590/0004-282X20190001
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Article ; Online: Restless legs syndrome/Willis-Ekbom disease in multiple sclerosis: a contributing factor for anxiety, disability, sleep disorder, and quality of life.

Seferoğlu, Meral / Sivaci, Ali Özhan / Tunç, Abdulkadir

Arquivos de neuro-psiquiatria

2020 Volume 78, Issue 11, Page(s) 708–712

Abstract: Background: Restless legs syndrome (RLS) is one of the most common and burdensome sleep disorders in the course of multiple sclerosis (MS).: Objective: To evaluate common MS-related symptoms and consequences between groups with and without RLS and ... ...

Abstract	Background: Restless legs syndrome (RLS) is one of the most common and burdensome sleep disorders in the course of multiple sclerosis (MS). Objective: To evaluate common MS-related symptoms and consequences between groups with and without RLS and further assess the association of quality of life determinants with RLS symptom severity. Methods: According to their RLS status, 46 relapsing-remitting MS patients were divided into MS-RLS+ (n=19) and MS-RLS- groups (n=27). Specific questionnaires were administered to assess the patients' health-related quality of life (HRQoL), fatigue levels, sleep quality, daily sleepiness, anxiety, and depression symptoms. Functional capacity was examined using the Expanded Disability Status Scale (EDSS). Results: The prevalence of RLS was 41.3%. Compared to the MS-RLS- group, those with RLS had higher EDSS scores, more cranial and spinal lesions, longer disease duration, and were older. In the MS-RLS+ group, symptom severity scores were positively correlated with higher anxiety and poorer sleep quality. The symptom severity score was negatively correlated with mental HRQoL and pain scores. Conclusion: In conclusion, the findings of the current study indicate the negative impact of RLS on functional capacity, anxiety, sleep quality, and mental HRQoL of MS patients. Further studies using more accurate diagnostic strategies for identifying RLS and other sleep disorders are necessary to clarify the association of MS with RLS and explore relevant clinical implications.
MeSH term(s)	Anxiety/epidemiology ; Anxiety/etiology ; Cross-Sectional Studies ; Humans ; Multiple Sclerosis/complications ; Quality of Life ; Restless Legs Syndrome/epidemiology ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Surveys and Questionnaires
Language	English
Publishing date	2020-12-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	418916-4
ISSN	1678-4227 ; 0004-282X
ISSN (online)	1678-4227
ISSN	0004-282X
DOI	10.1590/0004-282X20200084
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Article: Clinical significance and prognostic value of serum autoantibody tests in multiple sclerosis.

Öncel, Samet / Şule Dalkılıç, Şule / Sayan, Saadet / Darol, Elif / Zafer, Ayşe / Kara, Derya / Tunç, Abdulkadir

Neurologia i neurochirurgia polska

2023 Volume 58, Issue 1, Page(s) 60–65

Abstract: Introduction: It is known that multiple sclerosis (MS) often coexists with other autoimmune diseases. Hence, autoantibody (auto-Ab) tests may prove useful in the differential diagnosis of MS. The objectives of this study were to: (a) investigate the ... ...

Abstract	Introduction: It is known that multiple sclerosis (MS) often coexists with other autoimmune diseases. Hence, autoantibody (auto-Ab) tests may prove useful in the differential diagnosis of MS. The objectives of this study were to: (a) investigate the prevalence of auto-Ab positivity at the beginning of the MS diagnostic process; (b) assess whether Auto-Ab+ and Auto-Ab- patients differ in baseline clinical, laboratory, and radiological parameters; and (c) investigate the prognostic value during a two-year follow-up period. Material and methods: This retrospective study consisted of 450 patients aged between 18 and 55 years. All patients underwent a wide range of auto-Ab tests, anti-nuclear antibody (ANA) tests in particular. The expanded disability status scale (EDSS) scores of the patients were recorded at the time of diagnosis and at the end of a two-year follow-up period. Results: The mean age of the 212 patients, 148 (69.8%) female and 64 (30.2%) male, included in the study sample was 37 ± 10.83 years. The rate of relapsing cases was 84% (178). Oligoclonal band (OCB) was positive in 142 (86.6%) of the 164 tested cases. At least one of the auto-Ab tests was positive in 51 (24.1%) of the cases. ANA test was positive in 21 (9.9%) cases. There was no significant difference between patients with at least one positive auto-Ab test and without any positive auto-Ab test and between ANA-positive and ANA-negative patients in terms of age, gender, clinical features of MS, presence of brain stem lesion, presence of spinal lesion, OCB positivity, level of clinical improvement after the first pulse steroid treatment, family history, presence of comorbidity, presence of autoimmune disease, or EDSS scores recorded at the end of the two-year follow-up period (p > 0.05). Conclusions: Our study findings revealed that Auto-Ab positivity was more common in MS patients than in the general population. However, given their limited contribution to the diagnosis and differential diagnosis of MS with no effect on the prognostic process, auto-Ab tests should be requested only in the event of accompanying autoimmune disease symptoms, and in cases where the diagnosis of MS may be suspected.
MeSH term(s)	Humans ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Autoantibodies ; Multiple Sclerosis/diagnosis ; Prognosis ; Retrospective Studies ; Clinical Relevance ; Oligoclonal Bands
Chemical Substances	Autoantibodies ; Oligoclonal Bands
Language	English
Publishing date	2023-07-19
Publishing country	Poland
Document type	Journal Article
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
DOI	10.5603/PJNNS.a2023.0047
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Article ; Online: Clinical and demographic characteristics of late-onset multiple sclerosis: LOMS-TR study.

Sıvacı, Ali Özhan / Seferoğlu, Meral / Piri Çınar, Bilge / Uzunköprü, Cihat / Beckmann, Yeşim / Güngör Doğan, İpek / Çetinkaya Tezer, Damla / Tunç, Abdulkadir / Ethemoğlu, Özlem / Gümüş, Haluk / Açıkgöz, Mustafa / Yalaz Tekan, Ülgen / Demir, Serkan

Multiple sclerosis and related disorders

2024 Volume 84, Page(s) 105469

Abstract: Objectives: Multiple sclerosis (MS), which is known as a young-adult age disease, is called late-onset MS (LOMS) when it occurs at the age of 50 and older. In our study, we aimed to analyse the clinical and demographic characteristics, comorbidities, ... ...

Abstract	Objectives: Multiple sclerosis (MS), which is known as a young-adult age disease, is called late-onset MS (LOMS) when it occurs at the age of 50 and older. In our study, we aimed to analyse the clinical and demographic characteristics, comorbidities, diagnostic and treatment challenges and prognosis of LOMS. Methods: In a retrospective analysis of 136 patients diagnosed with multiple sclerosis (MS) after the age of 50, based on the 2017 McDonald criteria, and who were under observation in eight distinct MS centers across Turkey; demographic information, clinical characteristics of the disease, oligoclonal band (OCB) status, initial and current Expanded Disability Status Scale (EDSS) values, administered treatments, and the existence of spinal lesions on magnetic resonance imaging (MRI) were investigated. Results: The mean age of the 136 patients was 60.96±6.42 years (51-79), the mean age at diagnosis was 54.94±4.30 years, and 89 (65.4 %) of the patients were female. Most of the cases, 61.1 % (83) had at least one comorbidity. In 97 patients who underwent lumbar puncture (LP), OCB positivity was observed in 63.6 %. In 114 patients (83.8 %), spinal lesions were detected on MRI. Eighty-seven patients had relapsing-remitting MS (RRMS) (64 %), 27 patients had secondary progressive MS (SPMS) (19.9 %), and 22 patients had primary progressive MS (PPMS) (16.2 %). The mean EDSS at the time of diagnosis was 2.44±1.46, and the mean current EDSS was 3.15±2.14. Conclusions: In LOMS patients, the rates of delay in the diagnostic process, treatment disruption and progressive disease are higher than in the general MS population. The high rates of LP applying and OCB positivity of this study may indicate the habit of looking for clear evidences in advanged age in our country. This situation and comorbidities may cause a delay in diagnosis and eliminates the window of opportunity for early diagnosis. Although the high number of spinal lesions is a known marker for progressive disease, it is an issue that needs to be discussed whether the increased frequency of progressive course at older ages is due to the nature of the disease or immune aging itself.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Aged ; Male ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/therapy ; Retrospective Studies ; Multiple Sclerosis, Chronic Progressive/diagnostic imaging ; Multiple Sclerosis, Chronic Progressive/epidemiology ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/epidemiology ; Oligoclonal Bands ; Demography ; Disease Progression
Chemical Substances	Oligoclonal Bands
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2024.105469
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Article ; Online: Carpal tunnel syndrome: Investigating the sensitivity of initial-diagnosis with electro-diagnostic tests in 600 cases and associated risk factors especially manual milking.

Tunç, Abdulkadir / Güngen, Belma Doğan

Journal of back and musculoskeletal rehabilitation

2017 Volume 30, Issue 2, Page(s) 333–338

Abstract: Background: Electro-diagnostic studies are the most reliable methods in diagnosis of carpal tunnel syndrome (CTS). Although there are many risk factors associated with CTS, there are a limited number of studies in the literature indicating that manual ... ...

Abstract	Background: Electro-diagnostic studies are the most reliable methods in diagnosis of carpal tunnel syndrome (CTS). Although there are many risk factors associated with CTS, there are a limited number of studies in the literature indicating that manual milking, which is frequently seen in Turkey, is a risk factor for CTS. Objective: The purpose of this study was to evaluate demographic findings of cases referred due to initial diagnosis of CTS as well as aetiological data especially manual milking and to investigate the sensitivity of initial diagnosis of CTS. Methods: Six hundred patients, who were referred to our electromyography laboratory due to initial diagnosis of CTS, were included. Demographic findings, duration of complaints, existence of diabetes mellitus, and manual milking histories of all patients were recorded. Sensitivity of initial diagnosis was investigated based on electro-diagnostic test results. Results: According to electro-diagnostic test results, 289 of the patients were diagnosed with CTS (48.17%). 110 (18.3%) of 600 patients had a history of manual milking. In 94 of this group (85.4%), CTS was detected. Statistically significant correlation was found between CTS and age, female gender, duration of complaints, obesity and manual milking. Conclusions: This study confirms that manual milking is an important risk factor for CTS in addition to female gender, age, symptom duration and obesity. The fact that sensitivity of initial diagnosis of CTS was found to be low according to electro-diagnostic test results indicates importance of detailed clinical evaluation.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carpal Tunnel Syndrome/diagnosis ; Carpal Tunnel Syndrome/physiopathology ; Electromyography/methods ; Female ; Humans ; Male ; Middle Aged ; Risk Factors ; Sensitivity and Specificity ; Sex Factors ; Turkey ; Young Adult
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1184721-9
ISSN	1878-6324 ; 1053-8127
ISSN (online)	1878-6324
ISSN	1053-8127
DOI	10.3233/BMR-160547
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Article ; Online: Cervical vestibular evoked myogenic potentials and video head impulse test studies: alternative methods for detecting brainstem involvement in multiple sclerosis.

Eğilmez, Oğuz Kadir / Tunç, Abdülkadir / Yılmaz, Mahmut Sinan / Şahiner, Büşra Gebeş / Koçoğlu, Mehmet / Eryılmaz, Halil Alper / Güven, Mehmet

Acta oto-laryngologica

2022 Volume 142, Issue 2, Page(s) 168–174

Abstract: Background: Brainstem involvement (BSI) has been reported as a major predictive factor for future disability in Multiple Sclerosis (MS).: Aims/objectives: To evaluate whether Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) and Video Head ... ...

Abstract	Background: Brainstem involvement (BSI) has been reported as a major predictive factor for future disability in Multiple Sclerosis (MS). Aims/objectives: To evaluate whether Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) and Video Head Impulse Test (vHIT) can be used to detect demyelinating lesions in vestibular pathways in MS. Material and methods: Fifty three people with MS and 40 controls were evaluated with Dizziness Handicap Inventory (DHI), vHIT and cVEMP. Results: The median value of DHI in MS group was significantly higher than controls ( Conclusions and significance: vHIT and cVEMP can be used in diagnosis and follow-up of people with MS without demyelinating brainstem lesions on MRI.
MeSH term(s)	Brain Stem/diagnostic imaging ; Head Impulse Test/methods ; Humans ; Multiple Sclerosis/diagnosis ; Reflex, Vestibulo-Ocular ; Semicircular Canals ; Vestibular Evoked Myogenic Potentials/physiology
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2022.2039759
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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