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Article ; Online: Cytotoxic T-lymphocyte Antigen-4 (

VAN Nguyen, Song / Shamoun, Levar / Landerholm, Kalle / Andersson, Roland E / Wagsater, Dick / Dimberg, Jan

2021 Volume 35, Issue 2, Page(s) 969–975

Abstract: Background/aim: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays ... a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim ...

Abstract	Background/aim: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC. Patients and methods: Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction. Results: Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC-related death. Conclusion: The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC.
MeSH term(s)	CTLA-4 Antigen/genetics ; Colorectal Neoplasms/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Sweden
Chemical Substances	CTLA-4 Antigen ; CTLA4 protein, human
Language	English
Publishing date	2021-02-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12339
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Article ; Online: Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T.

Dewey, Rebecca Susan / Dineen, Robert A / Clemence, Matthew / Dick, Olivier / Bowtell, Richard / Kitterick, Padraig T

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2022 Volume 42, Issue 10, Page(s) e1449–e1456

Abstract: Background: Brain magnetic resonance imaging in patients with cochlear implants (CIs) is impacted by image artefacts.: Hypothesis: The optimal positioning of the CI to minimize artefacts is unknown. This study aimed to characterize the dependence of ... ...

Abstract	Background: Brain magnetic resonance imaging in patients with cochlear implants (CIs) is impacted by image artefacts. Hypothesis: The optimal positioning of the CI to minimize artefacts is unknown. This study aimed to characterize the dependence of the extent and distribution of the artefact on CI positioning. Methods: Three normally hearing individuals underwent magnetic resonance imaging using a standard T1-weighted 3D sequence. Scans were acquired with a non-functioning CI placed underneath a swimming cap at four plausible scalp positions on each side, and without the CI in situ. The artefact in each image was assessed quantitatively using voxel-based techniques. Two radiologists also independently rated the likely impact of the artefact on the detection of pathology for 20 neuroradiological locations. Results: The procedure was well tolerated. The most postero-inferior CI positions resulted in the smallest apparent artefacts. Radiological evaluations suggested that artefacts would likely limit pathology detection in the ipsilateral temporal, parietal, and occipital lobes, regardless of CI location. Pathology detection in contralateral structures and anterior corpus callosum was rarely affected. Certain CI locations appeared to selectively spare ipsilateral structures, for example, postero-inferior CI locations selectively spared ipsilateral midbrain, deep grey matter, and frontal lobes. Conclusion: A CI placed under a swimming cap is a feasible tool for observing the effect of CI location on image usability within a single subject and potentially informing surgical planning. Regardless of CI placement, artefacts involving ipsilateral parietal, temporal, and occipital lobes severely limited diagnostic image utility. Between 35% and 70% of neuroradiological features were deemed unaffected by the implant.
MeSH term(s)	Artifacts ; Brain ; Cochlear Implantation ; Cochlear Implants ; Humans ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000003281
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Book ; Thesis: Immunregulation durch CD4+ CD 25+ V delta 2 gamma delta-T Zellen

Dick, Marie

2014

Author's details	vorgelegt von Marie Dick, geb. Fleuster
Language	German
Size	91 S. : graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Tübingen, Univ., Diss., 2014
HBZ-ID	HT018435637
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals.

Aghaallaei, Narges / Dick, Advaita M / Tsingos, Erika / Inoue, Daigo / Hasel, Eva / Thumberger, Thomas / Toyoda, Atsushi / Leptin, Maria / Wittbrodt, Joachim / Bajoghli, Baubak

Science advances

2021 Volume 7, Issue 29

Abstract: αβ and γδ T cells are two distinct sublineages that develop in the vertebrate thymus. Thus far ... However, the proportion of αβ/γδ T cells varies in different vertebrate taxa. How this process is regulated in species ... that tend to produce a high frequency of γδ T cells is unstudied. Using an in vivo teleost model, the medaka ...

Abstract	αβ and γδ T cells are two distinct sublineages that develop in the vertebrate thymus. Thus far, their differentiation from a common progenitor is mostly understood to be regulated by intrinsic mechanisms. However, the proportion of αβ/γδ T cells varies in different vertebrate taxa. How this process is regulated in species that tend to produce a high frequency of γδ T cells is unstudied. Using an in vivo teleost model, the medaka, we report that progenitors first enter a thymic niche where their development into γδ T cells is favored. Translocation from this niche, mediated by chemokine receptor Ccr9b, is a prerequisite for their differentiation into αβ T cells. On the other hand, the thymic niche also generates opposing gradients of the cytokine interleukin-7 and chemokine Ccl25a, and, together, they influence the lineage outcome. We propose a previously unknown mechanism that determines the proportion of αβ/γδ lineages within species.
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abg3613
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Article ; Online: Association of CMV-specific T-cell immunity and risk of CMV infection in lung transplant recipients.

Veit, Tobias / Pan, Ming / Munker, Dieter / Arnold, Paola / Dick, Andrea / Kunze, Susanne / Meiser, Bruno / Schneider, Christian / Michel, Sebastian / Zoller, Michael / Böhm, Stephan / Walter, Julia / Behr, Jürgen / Kneidinger, Nikolaus / Kauke, Teresa

Clinical transplantation

2021 Volume 35, Issue 6, Page(s) e14294

Abstract: ... provided by CMV-specific T-cells in lung transplant recipients. The aim of the study was to assess ... whether a specific T-cell response is associated with the risk for CMV infection in seronegative patients who are ...

Abstract	Background: Protecting against CMV infection and maintaining CMV in latent state are largely provided by CMV-specific T-cells in lung transplant recipients. The aim of the study was to assess whether a specific T-cell response is associated with the risk for CMV infection in seronegative patients who are at high risk for delayed CMV infection. Methods: All CMV-seronegative recipients (R-) from CMV-seropositive donors (D+) between January 2018 and April 2019 were included and retrospectively screened for CMV infection before and after assessment of CMV-specific cell-mediated immunity. Results: Thirty-one of the 50 patients (62%) developed early-onset CMV infection. Lower absolute neutrophil counts were significantly associated with early-onset CMV infection. Antiviral prophylaxis was ceased after 137.2 ± 42.8 days. CMV-CMI were measured at a median of 5.5 months after LTx. 19 patients experienced early and late-onset CMV infection after prophylaxis withdrawal within 15 months post transplantation. Positive CMV-CMI was significantly associated with lower risk of late-onset CMV infection after transplantation in logistic and cox-regression analysis (OR=0.05, p = .01; OR=2,369, p = .026). Conclusion: D+/R- lung transplant recipients are at high risk of developing early and late-onset CMV infection. Measurement of CMV-CMI soon after transplantation might further define the CMV infection prediction risk in LTx recipients being at high risk for CMV viremia.
MeSH term(s)	Antiviral Agents/therapeutic use ; Cytomegalovirus ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/etiology ; Humans ; Lung ; Retrospective Studies ; T-Lymphocytes ; Transplant Recipients
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-04-03
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14294
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Article: Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice.

Obr, Martin / Percipalle, Mathias / Chernikova, Darya / Yang, Huixin / Thader, Andreas / Pinke, Gergely / Porley, Dario / Mansky, Louis M / Dick, Robert A / Schur, Florian Km

bioRxiv : the preprint server for biology

2023

Abstract: Human T-cell leukemia virus type 1 (HTLV-1) has an atypical immature particle morphology compared ...

Abstract	Human T-cell leukemia virus type 1 (HTLV-1) has an atypical immature particle morphology compared to other retroviruses. This indicates that these particles are formed in a way that is unique. Here we report the results of cryo-electron tomography (cryo-ET) studies of HTLV-1 virus-like particles (VLPs) assembled
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.24.548988
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Article ; Online: Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients.

Nikolic, Tatjana / Suwandi, Jessica S / Wesselius, Joris / Laban, Sandra / Joosten, Antoinette M / Sonneveld, Petra / Mul, Dick / Aanstoot, Henk-Jan / Kaddis, John S / Zwaginga, Jaap Jan / Roep, Bart O

Frontiers in immunology

2022 Volume 13, Page(s) 1054968

Abstract: ... Tolerogenic dendritic cells (tolDC) inhibit antigen-specific proinflammatory T-cells, generate antigen ... specific regulatory T-cells and promote IL-10 production : Methods: A placebo-controlled, dose ... peptide. Immunoregulatory effects were monitored by antigen-specific T-cell assays and flow and mass ...

Abstract	Introduction: Restoration of immune tolerance may halt progression of autoimmune diseases. Tolerogenic dendritic cells (tolDC) inhibit antigen-specific proinflammatory T-cells, generate antigen-specific regulatory T-cells and promote IL-10 production Methods: A placebo-controlled, dose escalation phase 1 clinical trial in nine adult patients with long-standing type 1 diabetes (T1D) demonstrated the safety and feasibility of two (prime-boost) vaccinations with tolDC pulsed with a proinsulin peptide. Immunoregulatory effects were monitored by antigen-specific T-cell assays and flow and mass cytometry. Results: The tolDC vaccine induced a profound and durable decline in pre-existing autoimmune responses to the vaccine peptide up to 3 years after therapy and temporary decline in CD4 and CD8+ T-cell responses to other islet autoantigens. While major leukocyte subsets remained stable, ICOS Discussion: Our data identify immune correlates of mechanistic efficacy of intradermally injected tolDC reducing proinsulin autoimmunity in T1D.
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1054968
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Article ; Online: Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.

Khatamzas, Elham / Antwerpen, Markus H / Rehn, Alexandra / Graf, Alexander / Hellmuth, Johannes Christian / Hollaus, Alexandra / Mohr, Anne-Wiebe / Gaitzsch, Erik / Weiglein, Tobias / Georgi, Enrico / Scherer, Clemens / Stecher, Stephanie-Susanne / Gruetzner, Stefanie / Blum, Helmut / Krebs, Stefan / Reischer, Anna / Leutbecher, Alexandra / Subklewe, Marion / Dick, Andrea /

Zange, Sabine / Girl, Philipp / Müller, Katharina / Weigert, Oliver / Hopfner, Karl-Peter / Stemmler, Hans-Joachim / von Bergwelt-Baildon, Michael / Keppler, Oliver T / Wölfel, Roman / Muenchhoff, Maximilian / Moosmann, Andreas

Nature communications

2022 Volume 13, Issue 1, Page(s) 5586

Abstract: ... neutralization of SARS-CoV-2. Additionally, four mutations emerge in non-spike regions encoding three CD8 T cell ... by CD8 T cells from convalescent donors is reduced compared to its ancestral peptide ... impacts of CD8 T cells on SARS-CoV-2 mutations, at least in those with humoral immunodeficiency, warrant ...

Abstract	Antibodies against the spike protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can drive adaptive evolution in immunocompromised patients with chronic infection. Here we longitudinally analyze SARS-CoV-2 sequences in a B cell-depleted, lymphoma patient with chronic, ultimately fatal infection, and identify three mutations in the spike protein that dampen convalescent plasma-mediated neutralization of SARS-CoV-2. Additionally, four mutations emerge in non-spike regions encoding three CD8 T cell epitopes, including one nucleoprotein epitope affected by two mutations. Recognition of each mutant peptide by CD8 T cells from convalescent donors is reduced compared to its ancestral peptide, with additive effects resulting from double mutations. Querying public SARS-CoV-2 sequences shows that these mutations have independently emerged as homoplasies in circulating lineages. Our data thus suggest that potential impacts of CD8 T cells on SARS-CoV-2 mutations, at least in those with humoral immunodeficiency, warrant further investigation to inform on vaccine design.
MeSH term(s)	CD8-Positive T-Lymphocytes ; COVID-19/therapy ; Epitopes, T-Lymphocyte/genetics ; Humans ; Immunization, Passive ; Lymphoma ; Mutation ; Nucleoproteins/genetics ; Peptides/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Vaccines
Chemical Substances	Epitopes, T-Lymphocyte ; Nucleoproteins ; Peptides ; Spike Glycoprotein, Coronavirus ; Vaccines ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-32772-5
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Article ; Online: CAR T cells or allogeneic transplantation as standard of care for advanced large B-cell lymphoma: an intent-to-treat comparison.

Dreger, Peter / Dietrich, Sascha / Schubert, Maria-Luisa / Selberg, Lorenz / Bondong, Andrea / Wegner, Mandy / Stadtherr, Peter / Kimmich, Christoph / Kosely, Florentina / Schmitt, Anita / Pavel, Petra / Liebers, Nora / Luft, Thomas / Hegenbart, Ute / Radujkovic, Aleksandar / Ho, Anthony Dick / Müller-Tidow, Carsten / Schmitt, Michael

Blood advances

2020 Volume 4, Issue 24, Page(s) 6157–6168

Abstract: CD19-directed chimeric antigen receptor (CAR) T-cell treatment has evolved as standard of care (SOC ... board decision recommending SOC CAR T-cell treatment between July 2018 and February 2020, or alloHCT ... Altogether, 41 and 60 patients for whom CAR T cells and alloHCT were intended, respectively, were included ...

Abstract	CD19-directed chimeric antigen receptor (CAR) T-cell treatment has evolved as standard of care (SOC) for multiply relapsed/refractory (R/R) large B-cell lymphoma (LBCL). However, its potential benefit over allogeneic hematopoietic cell transplantation (alloHCT) remains unclear. We compared outcomes with both types of cellular immunotherapy (CI) by intention to treat (ITT). Eligble were all patients with R/R LBCL and institutional tumor board decision recommending SOC CAR T-cell treatment between July 2018 and February 2020, or alloHCT between January 2004 and February 2020. Primary end point was overall survival (OS) from indication. Altogether, 41 and 60 patients for whom CAR T cells and alloHCT were intended, respectively, were included. In both cohorts, virtually all patients had active disease at indication. CI was recommended as part of second-line therapy for 21 alloHCT patients but no CAR T-cell patients. Median OS from indication was 475 days with CAR T cells vs 285 days with alloHCT (P = .88) and 222 days for 39 patients for whom alloHCT beyond second line was recommended (P = .08). Of CAR T-cell and alloHCT patients, 73% and 65%, respectively, proceeded to CI. After CI, 12-month estimates for nonrelapse mortality, relapse incidence, progression-free survival, and OS for CAR T cells vs alloHCT were 3% vs 21% (P = .04), 59% vs 44% (P = .12), 39% vs 33% (P = .97), and 68% vs 54% (P = .32), respectively. In conclusion, CAR T-cell outcomes were not inferior to alloHCT outcomes, whether measured by ITT or from CI administration, supporting strategies preferring CAR T cells over alloHCT as first CI for multiply R/R LBCL.
MeSH term(s)	Antigens, CD19 ; Humans ; Neoplasm Recurrence, Local ; Standard of Care ; T-Lymphocytes ; Transplantation, Homologous
Chemical Substances	Antigens, CD19
Language	English
Publishing date	2020-12-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2020003036
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Article ; Online: David T. Yue: in memoriam.

Dick, Ivy E / Colecraft, Henry M

Neuron

2015 Volume 85, Issue 6, Page(s) 1158–1161

MeSH term(s)	Bioengineering/history ; Calcium Channels/metabolism ; History, 20th Century ; History, 21st Century ; Humans ; Neurosciences/history ; United States
Chemical Substances	Calcium Channels
Language	English
Publishing date	2015-05-05
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2015.02.040
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