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  1. Book: Wiley encyclopedia of chemical biology / 3

    Begley, Tadhg P.

    2009  

    Author's details Tadhg P. Begley, chief advisor
    Collection Wiley encyclopedia of chemical biology
    Language English
    Size XVIII, 799 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015828581
    ISBN 978-0-470-47019-0 ; 0-470-47019-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11236 order for loan Magazin

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  2. Book: Wiley encyclopedia of chemical biology / 1

    Begley, Tadhg P.

    2009  

    Author's details Tadhg P. Begley, chief advisor
    Collection Wiley encyclopedia of chemical biology
    Language English
    Size XX, 721 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015700180
    ISBN 978-0-471-75399-5 ; 0-471-75399-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11234 order for loan Magazin

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  3. Book: Wiley encyclopedia of chemical biology / 2

    Begley, Tadhg P.

    2009  

    Author's details Tadhg P. Begley, chief advisor
    Collection Wiley encyclopedia of chemical biology
    Language English
    Size XVIII, 785 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015828573
    ISBN 978-0-470-47018-3 ; 0-470-47018-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11235 order for loan Magazin

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  4. Book: Wiley encyclopedia of chemical biology / 4

    Begley, Tadhg P.

    2009  

    Author's details Tadhg P. Begley, chief advisor
    Collection Wiley encyclopedia of chemical biology
    Language English
    Size XVIII, 805 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015828589
    ISBN 978-0-470-47020-6 ; 0-470-47020-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11237 order for loan Magazin

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  5. Book ; Collection: Wiley encyclopedia of chemical biology

    Begley, Tadhg P.

    2009  

    Title variant Encyclopedia of chemical biology
    Author's details Tadhg P. Begley, chief advisor
    Keywords Biochemistry ; Biochemistry / Encyclopedias ; Biochemistry / Encyclopedias / English ; Biochemie ; Enzyklopädie
    Subject Biologische Chemie ; Konversationslexikon ; Universalenzyklopädie ; Universallexikon ; Allgemeinlexikon
    Language English
    Dates of publication 2009-9999
    Publisher Wiley
    Publishing place Hoboken, NJ u.a.
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT015699251
    ISBN 978-0-471-75477-0 ; 0-471-75477-3
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Cofactor biosynthesis

    Begley, Tadhg P.

    a mechanistic perspective

    (Vitamins and hormones ; 61)

    2001  

    Author's details guest ed.: Tadhg Begley
    Series title Vitamins and hormones ; 61
    Collection
    Language English
    Size XI, 361 S.
    Publisher Academic Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012906671
    ISBN 0-12-709861-5 ; 978-0-12-709861-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 238 -61- verfügbar in Königswinter Königswinter

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  7. Article ; Online: Alkylcysteine Sulfoxide C-S Monooxygenase Uses a Flavin-Dependent Pummerer Rearrangement.

    Hazra, Sohan / Begley, Tadhg P

    Journal of the American Chemical Society

    2023  Volume 145, Issue 22, Page(s) 11933–11938

    Abstract: Flavoenzymes are highly versatile and participate in the catalysis of a wide range of reactions, including key reactions in the metabolism of sulfur-containing compounds. S-Alkyl cysteine is formed primarily by the degradation of S-alkyl glutathione ... ...

    Abstract Flavoenzymes are highly versatile and participate in the catalysis of a wide range of reactions, including key reactions in the metabolism of sulfur-containing compounds. S-Alkyl cysteine is formed primarily by the degradation of S-alkyl glutathione generated during electrophile detoxification. A recently discovered S-alkyl cysteine salvage pathway uses two flavoenzymes (CmoO and CmoJ) to dealkylate this metabolite in soil bacteria. CmoO catalyzes a stereospecific sulfoxidation, and CmoJ catalyzes the cleavage of one of the sulfoxide C-S bonds in a new reaction of unknown mechanism. In this paper, we investigate the mechanism of CmoJ. We provide experimental evidence that eliminates carbanion and radical intermediates and conclude that the reaction proceeds via an unprecedented enzyme-mediated modified Pummerer rearrangement. The elucidation of the mechanism of CmoJ adds a new motif to the flavoenzymology of sulfur-containing natural products and demonstrates a new strategy for the enzyme-catalyzed cleavage of C-S bonds.
    MeSH term(s) Mixed Function Oxygenases ; Cysteine/metabolism ; Sulfoxides ; Sulfur ; Flavins
    Chemical Substances Mixed Function Oxygenases (EC 1.-) ; Cysteine (K848JZ4886) ; Sulfoxides ; Sulfur (70FD1KFU70) ; Flavins
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Biochemistry: Origin of a key player in methane biosynthesis.

    Begley, Tadhg P

    Nature

    2017  Volume 543, Issue 7643, Page(s) 49–50

    MeSH term(s) Biochemistry ; Cell Respiration ; Methane
    Chemical Substances Methane (OP0UW79H66)
    Language English
    Publishing date 2017--02
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature21507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  9. Article ; Online: Mechanistic Studies on CysS - A Vitamin B

    Wang, Yuanyou / Begley, Tadhg P

    Journal of the American Chemical Society

    2020  Volume 142, Issue 22, Page(s) 9944–9954

    Abstract: Cobalamin (Cbl)-dependent ... ...

    Abstract Cobalamin (Cbl)-dependent radical
    MeSH term(s) Amides/chemistry ; Amides/metabolism ; Biocatalysis ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Molecular Structure ; S-Adenosylmethionine/chemistry ; S-Adenosylmethionine/metabolism
    Chemical Substances Amides ; S-Adenosylmethionine (7LP2MPO46S) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b06454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in

    Mondal, Anushree / Lai, Rung-Yi / Fedoseyenko, Dmytro / Giri, Nitai / Begley, Tadhg P

    Journal of the American Chemical Society

    2023  Volume 145, Issue 8, Page(s) 4421–4430

    Abstract: The yeast thiamin pyrimidine synthase THI5p catalyzes one of the most complex organic rearrangements found in primary metabolism. In this reaction, the active site His66 and PLP are converted to thiamin pyrimidine in the presence of Fe(II) and oxygen. ... ...

    Abstract The yeast thiamin pyrimidine synthase THI5p catalyzes one of the most complex organic rearrangements found in primary metabolism. In this reaction, the active site His66 and PLP are converted to thiamin pyrimidine in the presence of Fe(II) and oxygen. The enzyme is a single-turnover enzyme. Here, we report the identification of an oxidatively dearomatized PLP intermediate. We utilize oxygen labeling studies, chemical-rescue-based partial reconstitution experiments, and chemical model studies to support this identification. In addition, we also identify and characterize three shunt products derived from the oxidatively dearomatized PLP.
    MeSH term(s) Candida albicans ; Pyrimidines/chemistry ; Thiamine/chemistry ; Oxygen ; Oxidative Stress
    Chemical Substances Pyrimidines ; Thiamine (X66NSO3N35) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c08560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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