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Article ; Online: Insomnia in male veterans with and without military sexual trauma receiving care within a VA medical center.

Makar, Karen / Mills, Audrey / Rivera, Louis A / Aguiar, Taylor L / He, Sean / Chakravorty, Subhajit

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2024

Abstract: Study objectives: This study evaluated the prevalence and correlates of insomnia in male Veterans with MST who currently receive care within a VAMC.: Methods: We evaluated cross-sectional data from a VAMC (N=138) using the following instruments: ISI, ...

Abstract	Study objectives: This study evaluated the prevalence and correlates of insomnia in male Veterans with MST who currently receive care within a VAMC. Methods: We evaluated cross-sectional data from a VAMC (N=138) using the following instruments: ISI, PCL-5, QIDS-SR, AUDIT-C, and a nightmare question for insomnia, PTSD, depression, and drinking, respectively. Bivariate and multivariable analyses assessed the relationship between ISI and other clinical variables. Results: About 31.9% screened positive for MST. When compared to those without MST (MST-), those with MST (MST+) had a higher prevalence of insomnia (95.5% vs 81.9%), higher ISI (20±5.1 vs. 16.7±7.2, p=0.003) and PCL-5 (48.5±14.4 vs. 38.2±19.8, p=0.0008) total scores. In the multivariable models, the ISI total score was associated with the PCL-5 total score (p=0.015) in MST+ individuals and with QIDS-SR (p<0.001) in MST- individuals. Conclusions: Most Veterans with MST within the VHA had insomnia, which was associated with their underlying psychiatric comorbidity.
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.11010
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Article ; Online: Prevalence and associations of multiple hypnotic prescriptions in a clinical sample.

Kolla, Bhanu Prakash / Mansukhani, Meghna P / Chakravorty, Subhajit / Frank, Jacob A / Coombes, Brandon J

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2023 Volume 20, Issue 5, Page(s) 793–800

Abstract: ... to personalize treatments for chronic insomnia.: Citation: Kolla BP, Mansukhani MP, Chakravorty S, Frank JA ...

Abstract	Study objectives: We examined the prevalence of multiple hypnotic prescriptions and its association with clinical and demographic characteristics from the electronic health record (EHR) in the Mayo Clinic Biobank. Methods: Adult participants enrolled in the Mayo Clinic Biobank with an EHR number of ≥ 1 year were included (n = 52,940). Clinical and demographic characteristics were compared between participants who were and were not prescribed any hypnotic approved for insomnia by the US Food and Drug Administration and/or trazodone and in those prescribed a single vs multiple (≥ 2) hypnotics. A phenotype-based, phenome-wide association study (PheWAS) examining associations between hypnotic prescriptions and diagnoses across the EHR was performed adjusting for demographic and other confounders. Results: A total of 17,662 (33%) participants were prescribed at least 1 hypnotic and 5,331 (10%) received ≥ 2 hypnotics. Participants who were prescribed a hypnotic were more likely to be older, female, White, with a longer EHR, and a greater number of diagnostic codes (all Conclusions: Receiving multiple hypnotic prescriptions is common and associated with a greater prevalence of psychiatric, chronic pain, and sleep-related movement disorders. Future studies should examine potential genetic associations with multiple hypnotic prescriptions to personalize treatments for chronic insomnia. Citation: Kolla BP, Mansukhani MP, Chakravorty S, Frank JA, Coombes BJ. Prevalence and associations of multiple hypnotic prescriptions in a clinical sample.
MeSH term(s)	Humans ; Male ; Female ; Hypnotics and Sedatives/therapeutic use ; Middle Aged ; Prevalence ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sleep Initiation and Maintenance Disorders/epidemiology ; Adult ; Aged ; Electronic Health Records/statistics & numerical data ; Drug Prescriptions/statistics & numerical data
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.10988
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Article ; Online: Military sexual trauma: Exploring the moderating role of restrictive emotionality among male veterans.

Rivera, Louis A / Liang, Christopher T H / Johnson, Nicole L / Chakravorty, Subhajit

Psychological trauma : theory, research, practice and policy

2021 Volume 14, Issue 3, Page(s) 410–420

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Humans ; Male ; Military Personnel/psychology ; Sex Offenses/psychology ; Sexual Trauma ; Stress Disorders, Post-Traumatic/psychology ; United States ; Veterans/psychology
Language	English
Publishing date	2021-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0000647
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Article ; Online: Mirtazapine-associated acute pancreatitis in a patient with insomnia and co-occurring psychiatric disorders.

He, Sean / Ikner, Taylor P / Taylor, Brittany V / Aguiar, Taylor / Thakur, Nina P / Chakravorty, Subhajit

Journal of the National Medical Association

2022

Abstract: We report the case of an African American patient who developed drug-associated acute pancreatitis without hypertriglyceridemia, after being treated with mirtazapine for major depressive disorder (MDD). Acute pancreatitis is characterized by rapid ... ...

Abstract	We report the case of an African American patient who developed drug-associated acute pancreatitis without hypertriglyceridemia, after being treated with mirtazapine for major depressive disorder (MDD). Acute pancreatitis is characterized by rapid inflammation and autodigestion of the pancreas, which may become life-threatening. Although heavy alcohol use and gallstones are the most common causes of acute pancreatitis, some medications are also known to cause drug-induced acute pancreatitis. This report describes a 47-year-old African American female with a history of MDD, insomnia, posttraumatic stress disorder (PTSD), and alcohol use disorder, who was prescribed mirtazapine. A literature search implicated mirtazapine as a rare cause of drug-induced acute pancreatitis. Some reports have suggested that mirtazapine-associated acute pancreatitis may be due to hypertriglyceridemia. This case report instead presents with a normal lipid panel, which is consistent with the majority of prior reports, and it is noteworthy for introducing an alternative mechanism. The Naranjo Adverse Drug Reaction (ADR) Probability Scale calculated an ADR of 5, indicating mirtazapine as the probable cause of the patient's drug-associated acute pancreatitis.
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	419737-9
ISSN	1943-4693 ; 0027-9684
ISSN (online)	1943-4693
ISSN	0027-9684
DOI	10.1016/j.jnma.2022.08.001
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Article ; Online: A lower sleep regularity index (SRI) is associated with relapse in individuals with alcohol use disorder following inpatient treatment.

Barb, Jennifer J / Brooks, Alyssa T / Kazmi, Narjis / Yang, Li / Chakravorty, Subhajit / Wallen, Gwenyth R

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21583

Abstract: The sleep regularity index (SRI) is used to measure an individual's sleep/wake consistency over time. The SRI has been associated with certain health risks; to date, research investigating the relationship between the SRI and relapse in individuals with ... ...

Abstract	The sleep regularity index (SRI) is used to measure an individual's sleep/wake consistency over time. The SRI has been associated with certain health risks; to date, research investigating the relationship between the SRI and relapse in individuals with alcohol use disorder (AUD) is lacking. The aim of this work was to evaluate the SRI and relapse in individuals with AUD following inpatient treatment. Individuals with AUD (n = 77, mean age = 49.5 ± 10.86) were assessed for 28-days following discharge from an inpatient treatment program. Logistic regression was applied to examine the impact of SRI on relapse as the outcome variable of interest. Sleep quality was lower in individuals who relapsed compared to those who did not. Moreover, SRI scores were significantly worse in those who relapsed compared to those who did not. Over the entire patient cohort, lower weekly SRI scores were significantly correlated with longer weekly nap duration. Logistic regression model results indicated that the overall SRI was a significant predictor of relapse. The SRI represents a relevant aspect of sleep health and should be considered when assessing an individual's sleeping patterns. Behavior based interventions related to the importance of individualized consistency in sleep and wake patterns may be particularly important for treatment seeking individuals with AUD not only during inpatient treatment, but also once these individuals have transitioned into their outpatient phase of recovery. These findings support the notion of SRI as a separate facet of sleep health worth investigating in at-risk, disease specific groups.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Alcoholism/complications ; Sleep Wake Disorders/complications ; Inpatients ; Sleep ; Recurrence ; Chronic Disease
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-26019-y
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Article ; Online: The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses.

Chakravorty, Subhajit / Kember, Rachel L / Mazzotti, Diego R / Dashti, Hassan S / Toikumo, Sylvanus / Gehrman, Philip R / Kranzler, Henry R

Drug and alcohol dependence

2023 Volume 251, Page(s) 110912

Abstract: Study objectives: We investigated whether genetic risk for insomnia and sleep duration abnormalities are associated with AUD and alcohol consumption. We also evaluated the causal relationships between sleep- and alcohol-related traits.: Methods: ... ...

Abstract	Study objectives: We investigated whether genetic risk for insomnia and sleep duration abnormalities are associated with AUD and alcohol consumption. We also evaluated the causal relationships between sleep- and alcohol-related traits. Methods: Individual-level phenotype and genotype data from the Million Veteran Program were used. Polygenic risk scores (PRS) were computed using summary statistics from two recent discovery GWAS of insomnia (N= 453,379 European-ancestry (EA) individuals) and sleep duration (N= 446,118 EAs) and tested for association with lifetime AUD diagnosis (N= 34,658 EA cases) and past-year Alcohol Use Disorders Identification Test-Consumption scale scores (AUDIT-C, N= 200,680 EAs). Bi-directional two-sample Mendelian Randomization (MR) analyses assessed causal associations between the two sleep traits and the two alcohol-related traits. Results: The insomnia PRS was positively associated with AUD at 2/9 PRS thresholds, with p<0.01 being the most significant (OR = 1.02, p = 3.48 × 10 Conclusion: The genetic risk for insomnia shows pleiotropy with AUD, and sleep continuity abnormalities have a causal influence on the development of AUD.
MeSH term(s)	Humans ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/genetics ; Alcoholism/epidemiology ; Alcoholism/genetics ; Mendelian Randomization Analysis ; Risk Factors ; Sleep/genetics ; Phenotype ; Genome-Wide Association Study
Language	English
Publishing date	2023-07-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2023.110912
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Article ; Online: Insomnia in Primary Care: Misreported, Mishandled, and Just Plain Missed.

Grandner, Michael A / Chakravorty, Subhajit

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2017 Volume 13, Issue 8, Page(s) 937–939

MeSH term(s)	Humans ; Perception ; Primary Health Care ; Sleep Initiation and Maintenance Disorders ; Surveys and Questionnaires ; Veterans
Language	English
Publishing date	2017-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.6688
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insomnia Symptoms With Subjective Short Sleep Duration in a Random Sample From the United Kingdom.

Kritikou, Ilia / Gehrman, Philip R / Mazzotti, Diego R / Chakravorty, Subhajit

The primary care companion for CNS disorders

2020 Volume 22, Issue 6

MeSH term(s)	Humans ; Sleep ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/epidemiology ; Time Factors ; United Kingdom/epidemiology
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.19br02585
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Article ; Online: Alcohol and sleep-related problems.

He, Sean / Hasler, Brant P / Chakravorty, Subhajit

Current opinion in psychology

2019 Volume 30, Page(s) 117–122

Abstract: Alcohol is one of the most commonly used psychoactive substances in the community. Many individuals use alcohol for its sleep-promoting effects. Nonetheless, alcohol disrupts sleep through multiple mechanisms, such as disrupting electrophysiologic sleep ... ...

Abstract	Alcohol is one of the most commonly used psychoactive substances in the community. Many individuals use alcohol for its sleep-promoting effects. Nonetheless, alcohol disrupts sleep through multiple mechanisms, such as disrupting electrophysiologic sleep architecture, triggering insomnia, and contributing to abnormalities of circadian rhythms and short sleep duration (SSD) in cross-sectional studies. Alcohol also increases breathing-related sleep events such as snoring and oxygen desaturation, especially in those with pre-existing problems. Emerging data demonstrate that insomnia may co-exist with SSD and circadian abnormalities. Future studies should unravel these tentative associations in individuals who misuse alcohol.
MeSH term(s)	Alcoholism/complications ; Humans ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Wake Disorders/etiology ; Snoring/etiology ; United States
Language	English
Publishing date	2019-04-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2831565-0
ISSN	2352-2518 ; 2352-250X ; 2352-250X
ISSN (online)	2352-2518 ; 2352-250X
ISSN	2352-250X
DOI	10.1016/j.copsyc.2019.03.007
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Article ; Online: Past-year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a US National Survey on Drug Use and Health (NSDUH) study.

Tubbs, Andrew S / Ghani, Sadia B / Naps, Michelle / Grandner, Michael A / Stein, Michael D / Chakravorty, Subhajit

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2021 Volume 18, Issue 3, Page(s) 809–816

Abstract: ... Citation: Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S. Past-year use or misuse ...

Abstract	Study objectives: Prescription use and misuse of opioids are linked to greater sleep disturbance. However, there are limited data on the prevalence of sedative-hypnotic medication use among persons who use opioids. Therefore, this study examined whether past-year sedative-hypnotic use among persons who used/misused opioids was higher than among individuals who did not use opioids. Methods: Data were acquired from the US National Survey on Drug Use and Health for 2015-2018. Use of a sedative benzodiazepine (temazepam, flurazepam, triazolam) or a Z-drug (eszopiclone, zaleplon, zolpidem) was examined in relation to use/misuse of an opioid within the past year. Logistic regression models estimated the associations between opioids and sedative-hypnotics using inverse probability of treatment weighting. A secondary machine learning analysis tested 6 binary classifiers to predict sedative-hypnotic use based on opioid use/misuse and other covariates. Results: Of 171,766 respondents, 24% used a prescription opioid whereas 3.6% misused an opioid in the past year. Among those who used a prescription opioid, 1.9% received a sedative benzodiazepine and 9% received a Z-drug during the same time frame. Use of an opioid was associated with greater odds of sedative benzodiazepine use (odds ratio, 4.4; 95% confidence interval, 3.61-5.4) and Z-drug use (odds ratio, 3.8; 95% confidence interval, 3.51-4.09), and stronger associations were noted for misuse of an opioid. Machine learning models accurately classified sedative-hypnotic medication use for > 70% of respondents based on opioid use/misuse. Conclusions: Sedative-hypnotic use is common among persons who use opioids, which is of concern given the elevated mortality risk with concurrent use of these substances. Citation: Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S. Past-year use or misuse of an opiod is associated with use of a sedative-hypnotic medication: a US National Survey on Drug Use and Health (NSDUH) study.
MeSH term(s)	Analgesics, Opioid/adverse effects ; Benzodiazepines/adverse effects ; Health Surveys ; Humans ; Hypnotics and Sedatives/adverse effects ; Opioid-Related Disorders/epidemiology
Chemical Substances	Analgesics, Opioid ; Hypnotics and Sedatives ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.9724
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