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  1. Article ; Online: Michael Duchowny: Mentor and mensch.

    Devinsky, Orrin

    Epilepsy & behavior : E&B

    2023  Volume 152, Page(s) 109544

    MeSH term(s) Humans ; Mentors
    Language English
    Publishing date 2023-12-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5289: Show issues Location:
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  2. Article ; Online: The refined carbohydrate-insulin model of obesity.

    Devinsky, Orrin

    The American journal of clinical nutrition

    2022  Volume 115, Issue 2, Page(s) 592–593

    MeSH term(s) Dietary Carbohydrates ; Humans ; Insulin ; Obesity
    Chemical Substances Dietary Carbohydrates ; Insulin
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqab387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tribute to Steven Schachter, MD.

    Devinsky, Orrin

    Epilepsy & behavior : E&B

    2022  , Page(s) 108706

    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2022.108706
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  4. Article ; Online: Epilepsy Mortality: The Unseen and Unknown.

    Devinsky, Orrin

    Neurology

    2021  Volume 98, Issue 3, Page(s) 93–94

    MeSH term(s) Epilepsy ; Humans
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000013069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Wearable Digital Health Technology for Epilepsy.

    Donner, Elizabeth / Devinsky, Orrin / Friedman, Daniel

    The New England journal of medicine

    2024  Volume 390, Issue 8, Page(s) 736–745

    MeSH term(s) Humans ; Digital Health ; Wearable Electronic Devices ; Epilepsy/diagnosis ; Epilepsy/therapy ; Technology
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2301913
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  6. Article ; Online: Everolimus for epilepsy in paediatric tuberous sclerosis complex.

    Devinsky, Orrin

    The Lancet. Child & adolescent health

    2018  Volume 2, Issue 7, Page(s) 467–469

    MeSH term(s) Adolescent ; Child ; Epilepsy ; Everolimus ; Humans ; Seizures ; Sirolimus ; Tuberous Sclerosis
    Chemical Substances Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2018-05-24
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(18)30128-7
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  7. Article ; Online: Video Analyses of Sudden Unexplained Deaths in Toddlers.

    Gould, Laura / Reid, Codi-Ann / Rodriguez, Alcibiades J / Devinsky, Orrin

    Neurology

    2024  Volume 102, Issue 3, Page(s) e208038

    Abstract: Background and objectives: More than 2,900 US children aged younger than 4 years die from unknown causes each year, accounting for more than 219,000 life years lost annually. They are mostly sleep-related and unwitnessed with unremarkable autopsies, ... ...

    Abstract Background and objectives: More than 2,900 US children aged younger than 4 years die from unknown causes each year, accounting for more than 219,000 life years lost annually. They are mostly sleep-related and unwitnessed with unremarkable autopsies, limiting our understanding of death mechanisms. We sought to understand potential mechanisms of death by evaluating videos of sudden deaths in toddlers.
    Methods: In our registry of 301 sudden unexplained child deaths, a series of 7 consecutively enrolled cases with home video recordings of the child's last sleep period were independently assessed by 8 physicians for video quality, movement, and sound.
    Results: Four boys and 3 girls (13-27 months at death) with terminal videos shared similar demographic features to the 293 other registry cases without video recordings. Five video recordings were continuous and 2 were triggered by sound or motion. Two lacked audio. All continuous recordings included a terminal convulsive event lasting 8-50 seconds; 4 children survived for >2.5 minutes postconvulsion. Among discontinuous videos, time lapses limited review; 1 suggested a convulsive event. Six were prone with face down, and 1 had autopsy evidence of airway obstruction. Primary cardiac arrhythmias were not supported; all 7 children had normal cardiac pathology and whole-exome sequencing identified no known cardiac disease variants.
    Discussion: Audio-visual recordings in 7 toddlers with unexplained sudden deaths strongly implicate that deaths were related to convulsive seizures, suggesting that many unexplained sleep-related deaths may result from seizures.
    MeSH term(s) Male ; Female ; Humans ; Child, Preschool ; Infant ; Death, Sudden/epidemiology ; Death, Sudden/etiology ; Heart Diseases/complications ; Arrhythmias, Cardiac/complications ; Seizures, Febrile ; Seizures/complications ; Cause of Death ; Death, Sudden, Cardiac/etiology
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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    Zs.MO 374: Show issues

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  8. Article ; Online: Dravet syndrome seizure frequency and clustering: Placebo-treated patients in clinical trials.

    Nabbout, Rima / Hyland, Kerry / Loftus, Rachael / Nortvedt, Charlotte / Devinsky, Orrin

    Epilepsy & behavior : E&B

    2024  Volume 155, Page(s) 109774

    Abstract: Objective: Dravet syndrome is a rare developmental epilepsy syndrome associated with severe, treatment-resistant seizures. Since seizures and seizure clusters are linked to morbidity, reduced quality of life, and premature mortality, a greater ... ...

    Abstract Objective: Dravet syndrome is a rare developmental epilepsy syndrome associated with severe, treatment-resistant seizures. Since seizures and seizure clusters are linked to morbidity, reduced quality of life, and premature mortality, a greater understanding of these outcomes could improve trial designs. This analysis explored seizure types, seizure clusters, and factors affecting seizure cluster variability in Dravet syndrome patients.
    Methods: Pooled post-hoc analyses were performed on data from placebo-treated patients in GWPCARE 1B and GWPCARE 2 randomized controlled phase III trials comparing cannabidiol and placebo in Dravet syndrome patients aged 2-18 years. Multivariate stepwise analysis of covariance of log-transformed convulsive seizure cluster frequency was performed, body weight and body mass index z-scores were calculated, and incidence of adverse events was assessed. Data were summarized in three age groups.
    Results: We analyzed 124 placebo-treated patients across both studies (2-5 years: n = 35; 6-12 years: n = 52; 13-18 years: n = 37). Generalized tonic-clonic seizures followed by myoclonic seizures were the most frequent seizure types. Mean and median convulsive seizure cluster frequency overall decreased between baseline and maintenance period but did not change significantly during the latter; variation in convulsive seizure cluster frequency was observed across age groups. Multivariate analysis suggested correlations between convulsive seizure cluster frequency and age (positive), and body mass index (BMI) (negative).
    Interpretation: Post-hoc analyses suggested that potential relationships could exist between BMI, age and convulsive seizure cluster variation. Results suggested that seizure cluster frequency may be a valuable outcome in future trials. Further research is needed to confirm our findings.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2024.109774
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  9. Article: Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.

    Bauer, Jennifer / Devinsky, Orrin / Rothermel, Markus / Koch, Henner

    Frontiers in neurology

    2023  Volume 13, Page(s) 1040648

    Abstract: Epilepsy has a high prevalence and can severely impair quality of life and increase the risk of premature death. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in drug-resistant epilepsy and most often results from respiratory ... ...

    Abstract Epilepsy has a high prevalence and can severely impair quality of life and increase the risk of premature death. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in drug-resistant epilepsy and most often results from respiratory and cardiac impairments due to brainstem dysfunction. Epileptic activity can spread widely, influencing neuronal activity in regions outside the epileptic network. The brainstem controls cardiorespiratory activity and arousal and reciprocally connects to cortical, diencephalic, and spinal cord areas. Epileptic activity can propagate trans-synaptically or
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1040648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seizure Clusters: Morbidity and Mortality.

    Bauman, Kristie / Devinsky, Orrin

    Frontiers in neurology

    2021  Volume 12, Page(s) 636045

    Abstract: Seizure clusters, an intermediate between single seizure and status epilepticus, are associated with morbidity, impaired quality of life, and premature mortality. The relationship between seizure clusters and sudden unexplained death in epilepsy (SUDEP) ... ...

    Abstract Seizure clusters, an intermediate between single seizure and status epilepticus, are associated with morbidity, impaired quality of life, and premature mortality. The relationship between seizure clusters and sudden unexplained death in epilepsy (SUDEP) is poorly understood. Here, we define seizure clusters; review comorbid psychiatric disorders and memory deficits associated with seizure clusters; and review cases of witnessed SUDEP for which seizure frequency prior to death is available. Patients with a history of seizure clusters have a 2.5 fold increased risk for SUDEP, and one third of patients with monitored in hospital SUDEP experienced a cluster of generalized tonic clonic seizures prior to death. Understanding the effects of seizure frequency and duration on SUDEP risk could yield new insights in SUDEP pathophysiology and new targets for intervention.
    Language English
    Publishing date 2021-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.636045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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