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Article ; Online: Lifespan normative data (18-89 years) for Raven's Advanced Progressive Matrices Set I.

Murphy, Patrick / Foley, Jennifer / Mole, Joe / Van Harskamp, Natasja / Cipolotti, Lisa

2023 Volume 17, Issue 2, Page(s) 417–429

Abstract: ... lifespan (18-89 years) for the APM Set I. Data are presented in five age cohorts (total N = 352), including ...

Abstract	Raven's Advanced Progressive Matrices (APM) Set I is a validated and brief test of fluid intelligence, ideal for use in busy clinical settings. However, there is a dearth of normative data allowing an accurate interpretation of APM scores. To address this, we present normative data from across the adult lifespan (18-89 years) for the APM Set I. Data are presented in five age cohorts (total N = 352), including two older adult cohorts (65-79 years and 80-89 years), which allows age-standardized assessment. We also present data from a validated measure of premorbid intellectual ability, which was absent from previous standardizations of longer forms of the APM. In line with previous findings, a striking age-related decline was noted, beginning relatively early in adulthood and most marked amongst lower-scoring individuals. Older adults did not demonstrate difficulty with specific test items or make an increased proportion of specific errors. Sex was not a significant predictor of performance. The data set is of particular use in the neuropsychological assessment of older adults, given the known susceptibility of fluid intelligence to both the effects of normal ageing and acquired brain injury in older age. The results are discussed in light of theories of neurological ageing.
MeSH term(s)	Humans ; Aged ; Longevity ; Intelligence ; Intelligence Tests ; Aging ; Cognition
Language	English
Publishing date	2023-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2380753-2
ISSN	1748-6653 ; 1748-6645
ISSN (online)	1748-6653
ISSN	1748-6645
DOI	10.1111/jnp.12308
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Article ; Online: Preserved fluid intelligence in the context of impaired executive functions.

Cipolotti, Lisa / Mole, Joe / Nelson, Amy / Van-Harskamp, Natasja / Shallice, Tim / Nachev, Parashkev

Cortex; a journal devoted to the study of the nervous system and behavior

2022 Volume 156, Page(s) 86–89

MeSH term(s)	Humans ; Executive Function ; Intelligence ; Neuropsychological Tests ; Cognitive Dysfunction ; Intelligence Tests ; Frontal Lobe
Language	English
Publishing date	2022-09-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2022.09.002
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Article ; Online: Long-term study of the cognitive profile of Moyamoya Disease in adults.

Chan, Edgar / Gal, Ana-Marija / Van Harskamp, Natasja / Adams, Matthew E / Brown, Martin M / Werring, David J / Cipolotti, Lisa / Simister, Robert

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2023 Volume 32, Issue 6, Page(s) 107064

Abstract: Moyamoya Disease (MMD) is a rare cerebrovascular disorder which can have significant cognitive consequences. The aim of the current study was to describe comprehensively the domain-specific cognitive profile of adult patients with MMD and to assess ... ...

Abstract	Moyamoya Disease (MMD) is a rare cerebrovascular disorder which can have significant cognitive consequences. The aim of the current study was to describe comprehensively the domain-specific cognitive profile of adult patients with MMD and to assess whether this changes in the absence of recurrent stroke over long-term follow-up. Comprehensive neuropsychological assessment covering seven cognitive domains was conducted on 61 adult patients with MMD at baseline and then at up to 3 further time points during follow up (median=2.31, 4.87 and 7.12 years). Although 27 patients had had prior surgical revasculariation, none had surgery between neuropsychological assessments. Cognitive impairment was common. At baseline, impairment in executive functions was most frequent (57%), followed by performance IQ (36%), speed of information processing (31%) and visual memory (30%). We found that the neuropsychological profile remains broadly stable over long-term follow-up with no clear indication of improvement or significant decline. The pattern of impairment also did not differ depending on age of onset or whether there was a history of either prior stroke at presentation or revascularisation surgery at presentation.
MeSH term(s)	Humans ; Adult ; Moyamoya Disease/complications ; Moyamoya Disease/diagnostic imaging ; Moyamoya Disease/psychology ; Cognition ; Executive Function ; Stroke/diagnosis ; Stroke/etiology ; Neuropsychological Tests
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2023.107064
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Article ; Online: Preparing for the New Joint Commission Requirements: a Model for Tracking Outcomes of an Ambulatory Antibiotic Stewardship Program in Primary Care.

Hempel, Eliana V / Duca, Nicholas / Kipp, Ryan / van Harskamp, John / Caputo, Gregory

Journal of general internal medicine

2021 Volume 36, Issue 3, Page(s) 762–766

Abstract: Since 2007, inpatient antibiotic stewardship programs have been required for all Joint Commission-accredited hospitals in the USA. Given the frequency of ambulatory antibiotic prescribing, in June 2019, the Joint Commission released new standards for ... ...

Abstract	Since 2007, inpatient antibiotic stewardship programs have been required for all Joint Commission-accredited hospitals in the USA. Given the frequency of ambulatory antibiotic prescribing, in June 2019, the Joint Commission released new standards for antibiotic stewardship programs in ambulatory healthcare. This report identified five elements of performance (EPs): (1) Identify an antimicrobial stewardship leader, (2) establish an annual antimicrobial stewardship goal, (3) implement evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) provide clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collect, analyze, and report data related to the antimicrobial stewardship goal. We provide eight practical tips for implementing the EPs for antimicrobial stewardship: (1) Identify a collaborative leadership team, (2) partner with informatics, (3) identify national prescribing patterns, (4) perform a needs assessment based on local prescribing patterns, (5) review guidelines for diagnosis and treatment of the selected condition, (6) identify systems-level interventions to help support providers in making appropriate treatment decisions, (7) prioritize individual EPs for your institution, and (8) re-assess local data to identify areas of strength and deficiency in local practice.
MeSH term(s)	Ambulatory Care Facilities ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Humans ; Primary Health Care
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-01-08
Publishing country	United States
Document type	Editorial
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-020-06365-1
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Article ; Online: Cognitive and social impairments in patients with superficial siderosis.

van Harskamp, N J / Rudge, P / Cipolotti, L

Brain : a journal of neurology

2005 Volume 128, Issue Pt 5, Page(s) 1082–1092

Abstract: Superficial siderosis of the CNS is a rare condition, caused by deposition of haemosiderin in the superficial layers of the CNS due to repeated chronic subarachnoid or intraventricular haemorrhage. Typically, the hindbrain structures, especially the ... ...

Abstract	Superficial siderosis of the CNS is a rare condition, caused by deposition of haemosiderin in the superficial layers of the CNS due to repeated chronic subarachnoid or intraventricular haemorrhage. Typically, the hindbrain structures, especially the cerebellum, are most affected. There is a surprising lack of studies investigating in detail the behavioural functioning of patients with such a condition. In this study, we document for the first time the cognitive, social and emotional processing of six patients with a confirmed clinical diagnosis of superficial siderosis. They were aged between 40 and 62 years, with a mean age of 50.2 years; four were male. We administered a comprehensive battery of general cognitive ability and social cognitive tasks. A review of MRI was also undertaken. The findings indicate selective cognitive impairments affecting speech production, visual recall memory and executive functions. In addition, a selective pattern of social dysfunction, affecting the ability to represent other people's mental states, was found. These behavioural dysfunctions are reported in the context of MRI-documented lesions maximally involving the cerebellum, in particular the superior vermis, as well as the medial and inferior frontal cortex. These results suggest that superficial siderosis is associated with a distinct pattern of cognitive and social impairments. They are consistent with the recently proposed role of the cerebellum as a modulator of cognitive, social and emotional functions.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Emotions ; Female ; Humans ; Interpersonal Relations ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Siderosis/pathology ; Siderosis/psychology ; Social Perception
Language	English
Publishing date	2005-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awh487
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Article: Selective impairments for addition, subtraction and multiplication. implications for the organisation of arithmetical facts.

van Harskamp, N J / Cipolotti, L

Cortex; a journal devoted to the study of the nervous system and behavior

2001 Volume 37, Issue 3, Page(s) 363–388

Abstract: This study reports for the first time a selective impairment for simple addition in patient FS. Moreover, patient VP presented with a selective impairment for simple multiplication and patient DT with a selective impairment for simple subtraction. These ... ...

Abstract	This study reports for the first time a selective impairment for simple addition in patient FS. Moreover, patient VP presented with a selective impairment for simple multiplication and patient DT with a selective impairment for simple subtraction. These findings are discussed in the context of two of the most influential models for the organisation of arithmetical facts in memory (Dehaene and Cohen, 1995, 1997, and Dagenbach and McCloskey, 1992). Dehaene and Cohen (1995, 1997) have proposed that dissociation between arithmetical facts result from a selective impairment to two different types of processing: rote verbal memory for multiplication and simple addition vs. quantity processing for subtraction and division. Dagenbach and McCloskey (1992) suggest dissociation between arithmetical facts result from a selective damage to segregated memory networks specific for each operation. We will argue that our findings are problematic for Dehaene's model and in good accord with McCloskey's view.
MeSH term(s)	Aged ; Atrophy/complications ; Atrophy/pathology ; Brain/pathology ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mathematics ; Memory Disorders/diagnosis ; Middle Aged ; Severity of Illness Index ; Wechsler Scales
Language	English
Publishing date	2001-06
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/s0010-9452(08)70579-3
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Article ; Online: Neuropsychological and neuroimaging characteristics of classical superficial siderosis.

Chan, Edgar / Sammaraiee, Yezen / Banerjee, Gargi / Martin, Andreas Flores / Farmer, Simon / Cowley, Peter / Sayal, Parag / Kharytaniuk, Natallia / Eleftheriou, Perla / Porter, John / van Harskamp, Natasja / Cipolotti, Lisa / Werring, David J

Journal of neurology

2021 Volume 268, Issue 11, Page(s) 4238–4247

Abstract: Objective: To define the neuropsychological and neuroimaging characteristics of classical infratentorial superficial siderosis (iSS), a rare but disabling disorder defined by hemosiderin deposition affecting the superficial layers of the cerebellum, ... ...

Abstract	Objective: To define the neuropsychological and neuroimaging characteristics of classical infratentorial superficial siderosis (iSS), a rare but disabling disorder defined by hemosiderin deposition affecting the superficial layers of the cerebellum, brainstem and spinal cord, usually associated with a slowly progressive neurological syndrome of deafness, ataxia and myelopathy. Methods: We present the detailed neuropsychological and neuroimaging findings in 16 patients with iSS (mean age 57 years; 6 female). Results: Cognitive impairment was present in 8/16 (50%) of patients: executive dysfunction was the most prevalent (44%), followed by impairment of visual recognition memory (27%); other cognitive domains were largely spared. Disease symptom duration was significantly correlated with the number of cognitive domains impaired (r = 0.59, p = 0.011). Mood disorders were also common (anxiety 62%, depression 38%, both 69%) but not associated with disease symptom duration. MRI findings revealed siderosis was not only in infratentorial brain regions, but also in characteristic widespread symmetrical supratentorial brain regions, independent of disease duration and degree of cognitive impairment. The presence of small vessel disease markers was very low and did not account for the cognitive impairment observed. Conclusion: Neuropsychological disturbances are common in iSS and need to be routinely investigated. The lack of association between the anatomical extent of hemosiderin and cognitive impairment or disease duration suggests that hemosiderin itself is not directly neurotoxic. Additional biomarkers of iSS disease severity and progression are needed for future research and clinical trials.
MeSH term(s)	Brain/diagnostic imaging ; Brain Stem ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neuroimaging ; Siderosis/complications ; Siderosis/diagnostic imaging
Language	English
Publishing date	2021-04-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-021-10548-z
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Article ; Online: Multiple biomarkers for the prediction of short and long-term mortality after ST-segment elevation myocardial infarction: the Amsterdam Groningen collaboration.

Damman, Peter / Kampinga, Marthe A / van der Horst, Iwan C C / Woudstra, Pier / Grundeken, Maik J / Kuijt, Wichert J / Harskamp, Ralf E / Nijsten, Maarten W N / Zijlstra, Felix / Tijssen, Jan G P / de Smet, Bart J G L / de Winter, Robbert J

Journal of thrombosis and thrombolysis

2012 Volume 36, Issue 1, Page(s) 42–46

Abstract: ... Our objective was to determine whether multiple biomarkers (glucose, N-terminal pro-brain natriuretic peptide ... were treated with primary PCI. The mortality rates in the low- (n = 1,531), intermediate- (n = 403) and ... high-risk (n = 421) groups were 4.8, 16.1, and 43.9 %, respectively. The differences were observed ...

Abstract	Multiple biomarkers improve prognostication for long-term mortality in ST-segment elevation myocardial infarction (STEMI). However, one-third of mortality after STEMI occurs within initial discharge. Our objective was to determine whether multiple biomarkers (glucose, N-terminal pro-brain natriuretic peptide (NT-proBNP), and estimated glomerular filtration rate (eGFR)) predict both short-term as long-term mortality in STEMI. We used a patient-pooled dataset of consecutive STEMI patients, with complete biomarkers, who underwent primary percutaneous coronary intervention (PCI) in two single centers (Amsterdam and Groningen). With a previously developed multimarker risk score, based on three biomarkers, patients were indicated as low-, intermediate- or high risk. Cumulative 4-year mortality was estimated with the Kaplan-Meier method and compared with a log-rank test. We compared short-term and long-term mortality with a landmark set at 30 days because previous studies have shown that mortality largely occurs within 30 days. A total of 2,355 STEMI-patients were treated with primary PCI. The mortality rates in the low- (n = 1,531), intermediate- (n = 403) and high-risk (n = 421) groups were 4.8, 16.1, and 43.9 %, respectively. The differences were observed at a follow-up up to 30 days (log-rank p < 0.001) as well as after 30 days (log-rank p < 0.001). A multimarker risk score, based on admission levels of glucose, NT-proBNP, and eGFR identifies STEMI patients at low-, intermediate-, and high-risk for short-term and long-term mortality.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Glucose/metabolism ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/mortality ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Percutaneous Coronary Intervention ; Risk Factors ; Time Factors
Chemical Substances	Biomarkers ; Blood Glucose ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2012-09-28
Publishing country	Netherlands
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-012-0809-4
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Article ; Online: Bemesting grove dennenopstanden

de Graaf, N. / van Harskamp, J. / Schmidt, P.

Nederlands Bosbouwtijdschrift

1993 Volume 65

Keywords	Life Science
Language	Dutch
Publishing country	nl
Document type	Article ; Online
ZDB-ID	415435-6
ISSN	0369-3651 ; 0028-2057
ISSN	0369-3651 ; 0028-2057
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Article ; Online: Differences in birth weight between immigrants' and natives' children in Europe and Australia: a LifeCycle comparative observational cohort study.

Florian, Sandra / Ichou, Mathieu / Panico, Lidia / Pinel-Jacquemin, Stéphanie / Vrijkotte, Tanja G M / Harskamp-van Ginkel, Margreet W / Huang, Rae-Chi / Carson, Jennie / Rodriguez, Loreto Santa Marina / Subiza-Pérez, Mikel / Vrijheid, Martine / Fernández-Barrés, Sílvia / Yang, Tiffany C / Wright, John / Corpeleijn, Eva / Cardol, Marloes / Isaevska, Elena / Moccia, Chiara / Kooijman, Marjolein N /

Voerman, Ellis / Jaddoe, Vincent / Welten, Marieke / Spada, Elena / Rebagliato, Marisa / Beneito, Andrea / Ronfani, Luca / Charles, Marie-Aline

BMJ open

2023 Volume 13, Issue 3, Page(s) e060932

Abstract: ... Longitudinale Française depuis l'Enfance-France (N=12 494), the Raine Study-Australia (N=2283), Born in Bradford ... UK (N=4132), Amsterdam Born Children and their Development study-Netherlands (N=4030) and ... the Generation R study-Netherlands (N=4877). We include male and female babies born to immigrant and native ...

Abstract	Objective: Research on adults has identified an immigrant health advantage, known as the 'immigrant health paradox', by which migrants exhibit better health outcomes than natives. Is this health advantage transferred from parents to children in the form of higher birth weight relative to children of natives? Setting: Western Europe and Australia. Participants: We use data from nine birth cohorts participating in the LifeCycle Project, including five studies with large samples of immigrants' children: Etude Longitudinale Française depuis l'Enfance-France (N=12 494), the Raine Study-Australia (N=2283), Born in Bradford-UK (N=4132), Amsterdam Born Children and their Development study-Netherlands (N=4030) and the Generation R study-Netherlands (N=4877). We include male and female babies born to immigrant and native parents. Primary and secondary outcome measures: The primary outcome is birth weight measured in grams. Different specifications were tested: birth weight as a continuous variable including all births (DV1), the same variable but excluding babies born with over 4500 g (DV2), low birth weight as a 0-1 binary variable (1=birth weight below 2500 g) (DV3). Results using these three measures were similar, only results using DV1 are presented. Parental migration status is measured in four categories: both parents natives, both born abroad, only mother born abroad and only father born abroad. Results: Two patterns in children's birth weight by parental migration status emerged: higher birth weight among children of immigrants in France (+12 g, p<0.10) and Australia (+40 g, p<0.10) and lower birth weight among children of immigrants in the UK (-82 g, p<0.05) and the Netherlands (-80 g and -73 g, p<0.001) compared with natives' children. Smoking during pregnancy emerged as a mechanism explaining some of the birth weight gaps between children of immigrants and natives. Conclusion: The immigrant health advantage is not universally transferred to children in the form of higher birth weight in all host countries. Further research should investigate whether this cross-national variation is due to differences in immigrant communities, social and healthcare contexts across host countries.
MeSH term(s)	Adult ; Pregnancy ; Humans ; Male ; Female ; Child ; Birth Weight ; Europe/epidemiology ; Emigrants and Immigrants ; Australia/epidemiology ; Cohort Studies
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-060932
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