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Article: Syagrus coronata

Dos Santos Nunes, Ricardo Gomes / de Amorim, Luciclaudio Cassimiro / Bezerra, Iverson Conrado / da Silva, Artur José / Dos Santos, Carlos Alonso Leite / Gubert, Priscila / de Menezesa, Irwin Rose Alencar / Duarte, Antonia Eliene / Barros, Luiz Marivando / da Silveira Andrade-da-Costa, Belmira Lara / Dos Santos, Márcia Vanusa / Dos Santos Correia, Maria Tereza / da Rosa, Michelle Melgarejo

Journal of toxicology and environmental health. Part A

2024 Volume 87, Issue 12, Page(s) 497–515

Abstract: One prominent aspect of Parkinson's disease (PD) is the presence of elevated levels of free radicals, including reactive oxygen species (ROS). ...

Abstract	One prominent aspect of Parkinson's disease (PD) is the presence of elevated levels of free radicals, including reactive oxygen species (ROS).
MeSH term(s)	Animals ; Rotenone ; Drosophila melanogaster ; Molecular Docking Simulation ; Oxidative Stress ; Antioxidants/pharmacology ; Nitric Oxide/metabolism ; Movement Disorders
Chemical Substances	Rotenone (03L9OT429T) ; Antioxidants ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287394.2024.2338431
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Article ; Online: Association between child's behaviour during first dental appointment and effectiveness of dental plaque removal by caregivers.

Mourão, Priscila Seixas / Coelho, Valéria Silveira / Souto-Souza, Débora / Machado, Gabrielly Fernandes / Moreira, Luana Viviam / Duarte-Rodrigues, Lucas / Ramos-Jorge, Joana / Ramos-Jorge, Maria Letícia

International journal of dental hygiene

2023 Volume 21, Issue 3, Page(s) 569–574

Abstract: Objective: To evaluate the association between the behaviour of children aged 1 to 4 years during their dental appointment and the effectiveness of dental plaque removal by caregivers.: Methods: This longitudinal study with intervention had the ... ...

Abstract	Objective: To evaluate the association between the behaviour of children aged 1 to 4 years during their dental appointment and the effectiveness of dental plaque removal by caregivers. Methods: This longitudinal study with intervention had the participation of 146 children (mean age = 34.89 months), 75 of whom (51.4%) showed positive behaviour (+ and ++) and 71 (48.6%), negative behaviour (- and - -). The children were evaluated at the first dental appointment, according to the Frankl scale. They were subjected to an assessment of oral conditions, and their plaque level was recorded (Quigley-Hein Index modified by Turesky) using the Evince® device. Caregivers received oral hygiene guidance. The dental plaque assessment was performed before giving the oral hygiene guidance and 14 days later. The statistical analysis included a descriptive assessment and the Wilcoxon test (p < 0.05). Results: Mean dental plaque levels dropped significantly from the first to the second assessment (p < 0.001). The sample was divided according to the child's behaviour, observing that only the group of children with positive behaviour showed significantly less dental plaque in the second assessment (p < 0.001). Conclusion: The positive behaviour of children aged 1 to 4 years during the first dental appointments is associated with more effective dental plaque removal by caregivers.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Longitudinal Studies ; Dental Plaque/prevention & control ; Caregivers ; Oral Hygiene ; Dental Plaque Index
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2252118-5
ISSN	1601-5037 ; 1601-5029
ISSN (online)	1601-5037
ISSN	1601-5029
DOI	10.1111/idh.12653
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Zs.A 6768: Show issues

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Article ; Online: Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke.

Porto, Germano Duarte / Haupenthal, Daniela Pacheco Dos Santos / Souza, Priscila Soares / Silveira, Gustavo de Bem / Nesi, Renata Tiscoski / Feuser, Paulo Emilio / Possato, Jonathann Corrêa / de Andrade, Vanessa Moraes / Pinho, Ricardo Aurino / Silveira, Paulo Cesar Lock

Journal of biomedical materials research. Part B, Applied biomaterials

2021 Volume 110, Issue 6, Page(s) 1234–1244

Abstract: Inhalation of harmful particles appears as a primary factor for the onset and establishment of chronic obstructive pulmonary disease (COPD). Cigarette smoke acutely promotes an exacerbated inflammatory response with oxidative stress induction with DNA ... ...

Abstract	Inhalation of harmful particles appears as a primary factor for the onset and establishment of chronic obstructive pulmonary disease (COPD). Cigarette smoke acutely promotes an exacerbated inflammatory response with oxidative stress induction with DNA damage. Administration of Gold Nanoparticles (GNPs) with 20 nm in different concentrations can revert damages caused by external aggravations. The effects of GNPs in a COPD process have not been observed until now. The objective of this work was to evaluate the therapeutic effects of intranasal administration of different doses of GNPs after acute exposure to industrial cigarette smoke. Thirty male Swiss mice were randomly divided into five groups: Sham; cigarette smoke (CS); CS + GNPs 2.5 mg/L; CS + GNPs 7.5 mg/L and CS + GNPs 22.5 mg/L. The animals were exposed to the commercial cigarette with filter in an acrylic inhalation chamber and treated with intranasal GNPs for five consecutive days. The results demonstrate that exposure to CS causes an increase in inflammatory cytokines, histological changes, oxidative and nitrosive damage in the lung, as well as increased damage to the DNA of liver cells, blood plasma and lung. Among the three doses of GNPs (2.5, 7.5, and 22.5 mg/L) used, the highest dose had better anti-inflammatory effects. However, GNPs at a dose of 7.5 mg/L showed better efficacies in reducing ROS formation, alveolar diameter, and the number of inflammatory cells in histology, in addition to significantly reduced rate of DNA damage in lung cells without additional systemic genotoxicity already caused by cigarette smoke.
MeSH term(s)	Administration, Intranasal ; Animals ; Bronchoalveolar Lavage Fluid ; Cigarette Smoking ; Gold/pharmacology ; Lung/pathology ; Male ; Metal Nanoparticles ; Mice ; Mice, Inbred C57BL ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/pathology ; Nicotiana
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.34994
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Article ; Online: Home Blood Pressure Monitoring and Blood Pressure Control in Treated Hypertensives.

Brandão, Andréa Araujo / Barroso, Weimar Kunz Sebba / Feitosa, Audes / Barbosa, Eduardo Costa Duarte / Miranda, Roberto Dischinger / Vitorino, Priscila Valverde de Oliveira / Pozzan, Roberto / Ribeiro, Lucio Paulo / Epelman, Abraham / Saraiva, Giovanni Alves / Silveira, Fabio Serra / Braga, Antônio Almeida / Gomes, Marco Mota

Arquivos brasileiros de cardiologia

2022 Volume 119, Issue 2, Page(s) 353–357

Title translation	Monitorização Residencial da Pressão Arterial e Controle Pressórico em Hipertensos Tratados.
MeSH term(s)	Blood Pressure/physiology ; Blood Pressure Determination ; Blood Pressure Monitoring, Ambulatory ; Humans ; Hypertension
Language	Portuguese
Publishing date	2022-08-05
Publishing country	Brazil
Document type	Letter
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20220038
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Zs.A 548: Show issues

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Article ; Online: The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models.

Teixeira, Silvia A / Luzzi, Mayara de Cassia / Martin, Ana Carolina Baptista Moreno / Duarte, Terence Teixeira / Leal, Mônica de Oliveira / Teixeira, Gustavo Ramos / Reis, Monise Tadin / Junior, Carlos Roberto Almeida / Santos, Karina / Melendez, Matias Eliseo / Silva, Diego da Cunha Silveira Alves da / Bernécule, Priscila Neves / Firmino, Higor Vinicius Lourenço / Alves, Ana Laura Vieira / Guimarães, Denise Peixoto / Borduqui, João Vitor / Laus, Ana Carolina / Mançano, Bruna Minniti / Reis, Rui Manuel

Veterinary sciences

2022 Volume 9, Issue 11

Abstract: The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, ... ...

Abstract	The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9110636
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Article ; Online: Teaching Dental Students to Understand the Temporomandibular Joint Using MRI: Comparison of Conventional and Digital Learning Methods.

Arús, Nádia A / da Silva, Átila M / Duarte, Rogério / da Silveira, Priscila F / Vizzotto, Mariana B / da Silveira, Heraldo L D / da Silveira, Heloisa E D

Journal of dental education

2017 Volume 81, Issue 6, Page(s) 752–758

Abstract: The aims of this study were to evaluate and compare the performance of dental students in interpreting the temporomandibular joint (TMJ) with magnetic resonance imaging (MRI) scans using two learning methods (conventional and digital interactive learning) ...

Abstract	The aims of this study were to evaluate and compare the performance of dental students in interpreting the temporomandibular joint (TMJ) with magnetic resonance imaging (MRI) scans using two learning methods (conventional and digital interactive learning) and to examine the usability of the digital learning object (DLO). The DLO consisted of tutorials about MRI and anatomic and functional aspects of the TMJ. In 2014, dental students in their final year of study who were enrolled in the elective "MRI Interpretation of the TMJ" course comprised the study sample. After exclusions for nonattendance and other reasons, 29 of the initial 37 students participated in the study, for a participation rate of 78%. The participants were divided into two groups: a digital interactive learning group (n=14) and a conventional learning group (n=15). Both methods were assessed by an objective test applied before and after training and classes. Aspects such as support and training requirements, complexity, and consistency of the DLO were also evaluated using the System Usability Scale (SUS). A significant between-group difference in the posttest results was found, with the conventional learning group scoring better than the DLO group, indicated by mean scores of 9.20 and 8.11, respectively, out of 10. However, when the pretest and posttest results were compared, both groups showed significantly improved performance. The SUS score was 89, which represented a high acceptance of the DLO by the users. The students who used the conventional method of learning showed superior performance in interpreting the TMJ using MRI compared to the group that used digital interactive learning.
MeSH term(s)	Computer-Assisted Instruction ; Education, Dental/methods ; Educational Measurement ; Humans ; Learning ; Magnetic Resonance Imaging ; Temporomandibular Joint/anatomy & histology ; Temporomandibular Joint/diagnostic imaging ; Temporomandibular Joint/physiology ; Temporomandibular Joint Disorders/diagnostic imaging
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	410579-5
ISSN	1930-7837 ; 0022-0337
ISSN (online)	1930-7837
ISSN	0022-0337
DOI	10.21815/JDE.016.038
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Article ; Online: Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells.

Corrocher, Flávia Adolfo / Bueno de Paiva, Luciana / Duarte, Adriana Silva Santos / Ferro, Karla Priscila / Silveira, Leonardo Dos Reis / de Lima, Tanes Iamamura / Olalla Saad, Sara Teresinha / Lazarini, Mariana

Leukemia & lymphoma

2017 Volume 59, Issue 6, Page(s) 1501–1504

MeSH term(s)	Biomarkers ; Bone Marrow Cells/metabolism ; Gene Expression Regulation, Leukemic ; Gene Silencing ; Glucose/metabolism ; Glycolysis ; Humans ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/metabolism ; Metabolic Networks and Pathways ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism
Chemical Substances	Biomarkers ; NR4A1 protein, human ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2017-10-17
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2017.1387900
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Article ; Online: Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial.

Silveira, Marcelo Augusto Duarte / Menezes, Matheus de Alencar / de Souza, Sergio Pinto / Galvão, Erica Batista Dos Santos / Berretta, Andresa Aparecida / Caldas, Juliana / Teixeira, Maurício Brito / Gomes, Marcel Miranda Dantas / Damiani, Lucas Petri / Bahiense, Bruno Andrade / Cabral, Julia Barros / De Oliveira, Cicero Wandson Luiz Macedo / Mascarenhas, Talita Rocha / Pinheiro, Priscila Carvalho Guedes / Alves, Milena Souza / de Melo, Rodrigo Morel Vieira / Leite, Flávia Mendes / Nonaka, Carolina Kymie Vasques / Souza, Bruno Solano de Freitas /

Baptista, Nathália Ursoli / Teles, Flávio / da Guarda, Suzete Farias / Mendes, Ana Verena Almeida / Passos, Rogério da Hora

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18405

Abstract: SARS-CoV-2 and its different variants caused a "wave and wave" pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. ... ...

Abstract	SARS-CoV-2 and its different variants caused a "wave and wave" pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. Afterwards, we decided to evaluate the impact of EPP-AF in hospitalized patients during the third wave of the pandemic. BeeCovid2 was a randomized, double-blind, placebo-controlled clinical trial in hospitalized COVID-19 adult patients. Patients were allocated to receive an oral dose of 900 mg/day of EPP-AF® or placebo for 10 days. The primary outcome was length of hospital stay. Secondary outcomes included safety, secondary infection rate, duration of oxygen therapy dependency, acute kidney injury and need for intensive care. Patients were followed up for 28 days after admission. We enrolled 188 patients; 98 were assigned to the propolis group and 90 to the placebo group. The post-intervention length of hospital stay was of 6.5 ± 6.0 days in the propolis group versus 7.7 ± 7.1 days in the control group (95% CI - 0.74 [- 1.94 to 0.42]; p = 0.22). Propolis did not have significant impact on the need for oxygen supplementation or frequency of AKI. There was a significant difference in the incidence of secondary infection between groups, with 6.1% in the propolis group versus 18.9% in the control group (95% CI - 0.28 [0.1-0.76], p = 0.01). The use of EPP-AF was considered safe and associated with a decrease in secondary infections. The drug was not associated with a significant reduction in length of hospital stay. ClinicalTrials.gov (NCT04800224).
MeSH term(s)	Adult ; Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Propolis/therapeutic use ; Brazil/epidemiology ; Coinfection/drug therapy ; Double-Blind Method ; Treatment Outcome
Chemical Substances	Propolis (9009-62-5)
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43764-w
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Article: Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review.

Berbert, Taisa Rocha Navasconi / de Mello, Tatiane França Perles / Wolf Nassif, Priscila / Mota, Camila Alves / Silveira, Aline Verzignassi / Duarte, Giovana Chiqueto / Demarchi, Izabel Galhardo / Aristides, Sandra Mara Alessi / Lonardoni, Maria Valdrinez Campana / Vieira Teixeira, Jorge Juarez / Silveira, Thaís Gomes Verziganassi

Dermatology research and practice

2018 Volume 2018, Page(s) 9014726

Abstract: The first choice drugs for the treatment of cutaneous and mucocutaneous leishmaniasis are pentavalent antimonials, sodium stibogluconate, or meglumine antimoniate. However, the treatment with these drugs is expensive, can cause serious adverse effects, ... ...

Abstract	The first choice drugs for the treatment of cutaneous and mucocutaneous leishmaniasis are pentavalent antimonials, sodium stibogluconate, or meglumine antimoniate. However, the treatment with these drugs is expensive, can cause serious adverse effects, and is not always effective. The combination of two drugs by different routes or the combination of an alternative therapy with systemic therapy can increase the efficacy and decrease the collateral effects caused by the reference drugs. In this systematic review we investigated publications that described a combination of nonconventional treatment for cutaneous and mucocutaneous with pentavalent antimonials. A literature review was performed in the databases Web of Knowledge and PubMed in the period from 01
Language	English
Publishing date	2018-12-24
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2548952-5
ISSN	1687-6113 ; 1687-6105
ISSN (online)	1687-6113
ISSN	1687-6105
DOI	10.1155/2018/9014726
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Article ; Online: The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial.

Silveira, Marcelo Augusto Duarte / de Souza, Sergio Pinto / Dos Santos Galvão, Erica Batista / Teixeira, Maurício Brito / Gomes, Marcel Miranda Dantas / Damiani, Lucas Petri / Bahiense, Bruno Andrade / Cabral, Julia Barros / De Oliveira, Cicero Wandson Luiz Macedo / Mascarenhas, Talita Rocha / Pinheiro, Priscila Carvalho Guedes / Alves, Milena Souza / de Melo, Rodrigo Morel Vieira / Berretta, Andresa Aparecida / Leite, Flávia Mendes / Nonaka, Carolina Kymie Vasques / de Freitas Souza, Bruno Solano / Mendes, Ana Verena Almeida / da Guarda, Suzete Farias /

da Hora Passos, Rogério

Trials

2022 Volume 23, Issue 1, Page(s) 255

Abstract: Background: The 2019 coronavirus disease (COVID-19) pandemic continues to spread and affects large numbers of people with unprecedented impacts. Experimental evidence has already been obtained for use of the standardized extract of Brazilian green ... ...

Abstract	Background: The 2019 coronavirus disease (COVID-19) pandemic continues to spread and affects large numbers of people with unprecedented impacts. Experimental evidence has already been obtained for use of the standardized extract of Brazilian green propolis (EPP-AF) against viral targets, and clinical rationality has been demonstrated for testing this extract as an adjunct to treatment in patients affected by COVID-19. The BeeCovid2 study aims to assess whether EPP-AF has an impact on the improvement of patients hospitalized with COVID-19 by reducing the length of hospital stay. Methods: BeeCovid2 is a randomized, double-blinded, placebo-controlled clinical study being conducted in Brazil to provide further evidence on the effectiveness of standardized green propolis extract as an adjunctive treatment for adults hospitalized with COVID-19. Hospitalized patients over 18 years of age with a confirmed diagnosis of COVID-19 and up to 14 days of symptoms were included. Patients under mechanical ventilation at randomization, pregnant women, cancer patients, transplanted or using immunosuppression, HIV patients, patients who used propolis in the last 30 days, bacterial or fungal infection at randomization, impossibility of using medication orally or enterally, and advanced chronic diseases (e.g., advanced heart failure, severe liver disease, and end-stage chronic kidney disease). Enrolled patients are randomized at a 1:1 ratio to receive placebo or standardized propolis extract (900 mg/day) for 10 days. The study treatments are administered in a double-blinded manner, and patients are followed for 28 days. The primary outcome is the difference in length of hospital stay in days between groups. Secondary outcomes include the need for mechanical ventilation, the rate of secondary infection, rate of acute kidney injury, the need for renal replacement therapy, the requirement for vasoactive drugs, the use of an intra-aortic balloon pump (IABP), and the use of extracorporeal membrane oxygenation (ECMO). Discussion: This trial is very useful and will provide more data on the effectiveness of using the standardized Brazilian green propolis extract as an adjunctive treatment in association with standard care in adults hospitalized with moderate to severe acute COVID-19. Trial registration: ClinicalTrials.gov NCT04800224 . Registered on March 16, 2021.
MeSH term(s)	Adolescent ; Adult ; Brazil ; Female ; HIV Infections/drug therapy ; Humans ; Plant Extracts ; Pregnancy ; Propolis/adverse effects ; Randomized Controlled Trials as Topic ; COVID-19 Drug Treatment
Chemical Substances	Plant Extracts ; Propolis (9009-62-5)
Language	English
Publishing date	2022-04-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06176-1
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