LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Cognitive-behavioural therapy for depression in people with a somatic disease: meta-analysis of randomised controlled trials.

    Beltman, Matthijs W / Voshaar, Richard C Oude / Speckens, Anne E

    The British journal of psychiatry : the journal of mental science

    2010  Volume 197, Issue 1, Page(s) 11–19

    Abstract: Background: Meta-analyses on psychological treatment for depression in individuals with a somatic disease are limited to specific underlying somatic diseases, thereby neglecting the generalisability of the interventions.: Aims: To examine the ... ...

    Abstract Background: Meta-analyses on psychological treatment for depression in individuals with a somatic disease are limited to specific underlying somatic diseases, thereby neglecting the generalisability of the interventions.
    Aims: To examine the effectiveness of cognitive-behavioural therapy (CBT) for depression in people with a diversity of somatic diseases.
    Method: Meta-analysis of randomised controlled trials evaluating CBT for depression in people with a somatic disease. Severity of depressive symptoms was pooled using the standardised mean difference (SMD).
    Results: Twenty-nine papers met inclusion criteria. Cognitive-behavioural therapy was superior to control conditions with larger effects in studies restricted to participants with depressive disorder (SMD = -0.83, 95% CI -1.36 to -0.31, P<0.001) than in studies of participants with depressive symptoms (SMD = -0.16, 95% CI -0.27 to -0.06, P = 0.001). Subgroup analyses showed that CBT was not superior to other psychotherapies.
    Conclusions: Cognitive-behavioural therapy significantly reduces depressive symptoms in people with a somatic disease, especially in those who meet the criteria for a depressive disorder.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cognitive Therapy ; Depression/etiology ; Depression/therapy ; Depressive Disorder/etiology ; Depressive Disorder/therapy ; Disease/psychology ; Female ; Humans ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; Sensitivity and Specificity ; Treatment Outcome
    Language English
    Publishing date 2010-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.bp.109.064675
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes.

    Wijaya, Lukas S / Rau, Carina / Braun, Theresa S / Marangoz, Serif / Spegg, Vincent / Vlasveld, Matthijs / Albrecht, Wiebke / Brecklinghaus, Tim / Kamp, Hennicke / Beltman, Joost B / Hengstler, Jan G / van de Water, Bob / Leist, Marcel / Schildknecht, Stefan

    Cell biology and toxicology

    2021  Volume 38, Issue 5, Page(s) 847–864

    Abstract: Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how ... ...

    Abstract Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intracellular glutathione can be elevated transiently to render cells more resistant toward harmful conditions. The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes. In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL). Application of siRNA-based intervention approaches confirmed the involvement of the Nrf2-GCL axis in the observed elevation of intracellular glutathione levels. Quantitative activation of Nrf2 by NFT, and the subsequent rise in glutathione, were similar as observed with the potent experimental Nrf2 activator diethyl maleate. The elevation of glutathione levels, observed even 48 h after withdrawal of NFT, rendered cells resistant to different stressors such as the mitochondrial inhibitor rotenone, the redox cycler paraquat, the proteasome inhibitors MG-132 or bortezomib, or high concentrations of NFT. Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery. Graphical abstract.
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Antioxidants/pharmacology ; Bortezomib/pharmacology ; Glutamate-Cysteine Ligase/metabolism ; Glutamate-Cysteine Ligase/pharmacology ; Glutathione/metabolism ; Hepatocytes/metabolism ; Humans ; NF-E2-Related Factor 2/metabolism ; Nitrofurantoin/metabolism ; Nitrofurantoin/pharmacology ; Oxidative Stress ; Paraquat/metabolism ; Paraquat/pharmacology ; Proteasome Inhibitors/pharmacology ; RNA, Small Interfering/metabolism ; Rotenone/metabolism ; Rotenone/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antioxidants ; NF-E2-Related Factor 2 ; Proteasome Inhibitors ; RNA, Small Interfering ; Rotenone (03L9OT429T) ; Bortezomib (69G8BD63PP) ; Nitrofurantoin (927AH8112L) ; Glutamate-Cysteine Ligase (EC 6.3.2.2) ; Glutathione (GAN16C9B8O) ; Paraquat (PLG39H7695)
    Language English
    Publishing date 2021-05-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 48824-0
    ISSN 1573-6822 ; 0742-2091
    ISSN (online) 1573-6822
    ISSN 0742-2091
    DOI 10.1007/s10565-021-09610-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top