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  1. Article ; Online: Genetics and epigenetics approaches as a path to the future of addiction science.

    West, Anne E / Day, Jeremy J

    Molecular and cellular neurosciences

    2023  Volume 127, Page(s) 103898

    MeSH term(s) Epigenesis, Genetic ; Behavior, Addictive/genetics
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1046640-x
    ISSN 1095-9327 ; 1044-7431
    ISSN (online) 1095-9327
    ISSN 1044-7431
    DOI 10.1016/j.mcn.2023.103898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3035: Show issues Location:
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  2. Article ; Online: Single-cell transcriptional profiling in brain reward structures.

    Day, Jeremy J / Martinowich, Keri

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 1, Page(s) 243–244

    MeSH term(s) Reward ; Brain
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type News ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01394-2
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  3. Article ; Online: Genetic and epigenetic editing in
nervous system
.

    Day, Jeremy J

    Dialogues in clinical neuroscience

    2020  Volume 21, Issue 4, Page(s) 359–368

    Abstract: Numerous neuronal functions depend on the precise spatiotemporal regulation of gene expression, and the cellular machinery that contributes to this regulation is frequently disrupted in neurodevelopmental, neuropsychiatric, and neurological disease ... ...

    Abstract Numerous neuronal functions depend on the precise spatiotemporal regulation of gene expression, and the cellular machinery that contributes to this regulation is frequently disrupted in neurodevelopmental, neuropsychiatric, and neurological disease states. Recent advances in gene editing technology have enabled increasingly rapid understanding of gene sequence variation and gene regulatory function in the central nervous system. Moreover, these tools have provided new insights into the locus-specific functions of epigenetic modifications and enabled epigenetic editing at specific gene loci in disease contexts. Continued development of clustered regularly interspaced short palindromic repeats (CRISPR)-based tools has provided not only cell-specific modulation, but also rapid induction profiles that permit sophisticated interrogation of the temporal dynamics that contribute to brain health and disease. This review summarizes recent advances in genetic editing, transcriptional modulation, and epigenetic reorganization, with a focus on applications to neuronal systems and potential uses in brain disorders characterized by genetic sequence variation or transcriptional dysregulation.
.
    MeSH term(s) Animals ; Brain Diseases/drug therapy ; Brain Diseases/genetics ; Central Nervous System/physiopathology ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Epigenesis, Genetic/genetics ; Epigenomics/methods ; Gene Editing/methods ; Humans
    Language English
    Publishing date 2020-01-13
    Publishing country France
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
    DOI 10.31887/DCNS.2019.21.4/jday
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Morphine, the microbiome, and fatty acids: short chains make a big link in opioid reward.

    Tuscher, Jennifer J / Day, Jeremy J

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2021  Volume 46, Issue 12, Page(s) 2039–2040

    MeSH term(s) Analgesics, Opioid/pharmacology ; Fatty Acids ; Microbiota ; Morphine ; Receptors, Opioid, mu ; Reward
    Chemical Substances Analgesics, Opioid ; Fatty Acids ; Receptors, Opioid, mu ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-021-01093-4
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  5. Article: Chst9

    Andraka, Emma / Phillips, Robert A / Brida, Kasey L / Day, Jeremy J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Opioids produce addictive, analgesic, and euphoric effects via actions at mu opioid receptors (μORs). The μOR is encoded by ... ...

    Abstract Opioids produce addictive, analgesic, and euphoric effects via actions at mu opioid receptors (μORs). The μOR is encoded by the
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.16.562623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Distinct roles of

    Bach, Svitlana V / Bauman, Allison J / Hosein, Darya / Tuscher, Jennifer J / Ianov, Lara / Greathouse, Kelsey M / Henderson, Benjamin W / Herskowitz, Jeremy H / Martinowich, Keri / Day, Jeremy J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Brain-derived neurotrophic factor ( ...

    Abstract Brain-derived neurotrophic factor (
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.05.535694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons.

    Bach, Svitlana V / Bauman, Allison J / Hosein, Darya / Tuscher, Jennifer J / Ianov, Lara / Greathouse, Kelsey M / Henderson, Benjamin W / Herskowitz, Jeremy H / Martinowich, Keri / Day, Jeremy J

    Hippocampus

    2024  Volume 34, Issue 5, Page(s) 218–229

    Abstract: Brain-derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning and memory. The rodent Bdnf gene contains nine 5' non-coding exons (I-IXa), which are spliced to a common 3' ... ...

    Abstract Brain-derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning and memory. The rodent Bdnf gene contains nine 5' non-coding exons (I-IXa), which are spliced to a common 3' coding exon (IX). Transcription of individual Bdnf variants, which all encode the same BDNF protein, is initiated at unique promoters upstream of each non-coding exon, enabling precise spatiotemporal and activity-dependent regulation of Bdnf expression. Although prior evidence suggests that Bdnf transcripts containing exon I (Bdnf I) or exon IV (Bdnf IV) are uniquely regulated by neuronal activity, the functional significance of different Bdnf transcript variants remains unclear. To investigate functional roles of activity-dependent Bdnf I and IV transcripts, we used a CRISPR activation system in which catalytically dead Cas9 fused to a transcriptional activator (VPR) is targeted to individual Bdnf promoters with single guide RNAs, resulting in transcript-specific Bdnf upregulation. Bdnf I upregulation is associated with gene expression changes linked to dendritic growth, while Bdnf IV upregulation is associated with genes that regulate protein catabolism. Upregulation of Bdnf I, but not Bdnf IV, increased mushroom spine density, volume, length, and head diameter, and also produced more complex dendritic arbors in cultured rat hippocampal neurons. In contrast, upregulation of Bdnf IV, but not Bdnf I, in the rat hippocampus attenuated contextual fear expression. Our data suggest that while Bdnf I and IV are both activity-dependent, BDNF produced from these promoters may serve unique cellular, synaptic, and behavioral functions.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.23600
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    Zs.A 3227: Show issues Location:
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  8. Article ; Online: Multigenerational epigenetic inheritance: One step forward, two generations back.

    Tuscher, Jennifer J / Day, Jeremy J

    Neurobiology of disease

    2019  Volume 132, Page(s) 104591

    Abstract: Modifications to DNA and histone proteins serve a critical regulatory role in the developing and adult brain, and over a decade of research has established the importance of these "epigenetic" modifications in a wide variety of brain functions across the ...

    Abstract Modifications to DNA and histone proteins serve a critical regulatory role in the developing and adult brain, and over a decade of research has established the importance of these "epigenetic" modifications in a wide variety of brain functions across the lifespan. Epigenetic patterns orchestrate gene expression programs that establish the phenotypic diversity of various cellular classes in the central nervous system, play a key role in experience-dependent gene regulation in the adult brain, and are commonly implicated in neurodevelopmental, psychiatric, and neurodegenerative disease states. In addition to these established roles, emerging evidence indicates that epigenetic information can potentially be transmitted to offspring, giving rise to inter- and trans-generational epigenetic inheritance phenotypes. However, our understanding of the cellular events that participate in this information transfer is incomplete, and the ability of this transfer to overcome complete epigenetic reprogramming during embryonic development is highly controversial. This review explores the existing literature on multigenerational epigenetic mechanisms in the central nervous system. First, we focus on the cellular mechanisms that may perpetuate or counteract this type of information transfer, and consider how epigenetic modification in germline and somatic cells regulate important aspects of cellular and organismal development. Next, we review the potential phenotypes resulting from ancestral experiences that impact gene regulatory modifications, including how these changes may give rise to unique metabolic phenotypes. Finally, we discuss several caveats and technical limitations that influence multigenerational epigenetic effects. We argue that studies reporting multigenerational epigenetic changes impacting the central nervous system must be interpreted with caution, and provide suggestions for how epigenetic information transfer can be mechanistically disentangled from genetic and environmental influences on brain function.
    MeSH term(s) Animals ; Brain ; Epigenesis, Genetic ; Gene Expression Regulation ; Humans ; Neurogenesis
    Language English
    Publishing date 2019-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2019.104591
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  9. Article ; Online: Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma.

    Flanagan, Jeremy P M / Fog, Lotte S / Astrahan, Melvin A / Talbot, Lachie J / McKay, Daniel / Phillips, Claire / McKenzie, John D / O'Day, Roderick

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2024  

    Abstract: Objective: Ruthenium-106 brachytherapy is commonly used to treat uveal melanomas. Most centres prescribe a radiation dose to the tumour apex that is calculated with the tumour located in the centre of the plaque. Recent work suggests that D: Methods: ...

    Abstract Objective: Ruthenium-106 brachytherapy is commonly used to treat uveal melanomas. Most centres prescribe a radiation dose to the tumour apex that is calculated with the tumour located in the centre of the plaque. Recent work suggests that D
    Methods: The time required to deliver 100 Gy to the tumour apices of representative tumours ranging from 2- to 6-mm thickness with central plaque positioning was calculated in Plaque Simulator™. This treatment time was used for further calculations, including D
    Results: D
    Conclusion: D
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2024.03.007
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    Zs.A 588: Show issues Location:
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  10. Article ; Online: New approaches to manipulating the epigenome.

    Day, Jeremy J

    Dialogues in clinical neuroscience

    2014  Volume 16, Issue 3, Page(s) 345–357

    Abstract: Cellular processes that control transcription of genetic information are critical for cellular function, and are often implicated in psychiatric and neurological disease states. Among the most critical of these processes are epigenetic mechanisms, which ... ...

    Abstract Cellular processes that control transcription of genetic information are critical for cellular function, and are often implicated in psychiatric and neurological disease states. Among the most critical of these processes are epigenetic mechanisms, which serve to link the cellular environment with genomic material. Until recently our understanding of epigenetic mechanisms has been limited by the lack of tools that can selectively manipulate the epigenome with genetic, cellular, and temporal precision, which in turn diminishes the potential impact of epigenetic processes as therapeutic targets. This review highlights an emerging suite of tools that enable robust yet selective interrogation of the epigenome. In addition to allowing site-specific epigenetic editing, these tools can be paired with optogenetic approaches to provide temporal control over epigenetic processes, allowing unparalleled insight into the function of these mechanisms. This improved control promises to revolutionize our understanding of epigenetic modifications in human health and disease states.
    MeSH term(s) Animals ; Cognition Disorders/genetics ; Epigenesis, Genetic/physiology ; Epigenomics ; Humans ; Mental Disorders/genetics ; Optogenetics
    Language English
    Publishing date 2014-09
    Publishing country France
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
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