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  1. Book: 56 Behandlungsmethoden von Qin Bo-Wei

    Wu, Boping / Blalack, Jason / Qin, Bowei

    das Verschreiben präziser Arzneimittel

    2017  

    Title translation Qin Bo-Wei's 56 treatment methods
    Author's details klinischer Kommentar von Wu Bo-Ping ; übersetzt und bearbeitet von Jason Blalack
    Keywords Medicine, Chinese Traditional ; Materia Medica ; Chinesische Medizin ; Phytotherapie
    Subject Pflanzenmedizin ; Traditionelle chinesische Medizin ; TCM
    Language German
    Size 395 Seiten
    Edition Deutsche Lizenzausgabe, 1. Auflage
    Publisher BACOPA Verlag
    Publishing place Schiedlberg
    Publishing country Austria
    Document type Book
    Note Aus dem Englischen übersetzt
    HBZ-ID HT019548942
    ISBN 978-3-902735-25-6 ; 3-902735-25-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 38 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Systems Pharmacology Strategy for the Investigation of Action Mechanisms of Qin Herb Libanotis Buchtormensis (

    Feng, Rundong / Wang, Lifang / Chai, Hu / Jiao, Jie / Zhang, Peng / Zheng, Xu / Liu, Haijing / Zhang, Wenjuan / Wu, Suli

    Endocrine, metabolic & immune disorders drug targets

    2023  Volume 24, Issue 1, Page(s) 142–152

    Abstract: Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling ... one of the popular Qin herbs, which has been widely used for the treatment of various diseases ...

    Abstract Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling Mountain. Their unique curative effects on bone metabolic diseases and pain diseases have been favoured by the local people in clinical trials for thousands of years. Libanotis buchtormensis (Fisch.) DC. (LBD), is one of the popular Qin herbs, which has been widely used for the treatment of various diseases, such as osteoporosis, rheumatic, and cardiovascular diseases. However, due to the multiple compounds in LBD, the underlying molecular mechanisms of LBD remain unclear.
    Objective: This study aimed to systemically investigate the underlying mechanisms of LBD against bone diseases.
    Methods: In this study, a systems pharmacology platform included the potential active compound screening, target fishing, and network pharmacological analysis was employed to decipher the action mechanisms of LBD.
    Results: As a result, 12 potential active compounds and 108 targets were obtained. Furthermore, compound-target network and target-pathway network analysis showed that multi-components interacted with multi-targets and multi-pathways, i.e., MARK signalling pathway, mTORC1 signalling pathway, etc., involved in the regulation of the immune system and circulatory system. These results suggested the mechanisms of the therapeutic effects of LBD on various diseases through most compounds targeted by multiple targets.
    Conclusion: In conclusion, we successfully predicted the LBD bioactive compounds and potential targets, implying that LBD could be applied as a novel therapeutic herb in osteoporosis, rheumatic, and cardiovascular diseases. This work provides insight into the therapeutic mechanisms of LBD for treating various diseases.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Cardiovascular Diseases/drug therapy ; Osteoporosis/drug therapy ; Molecular Docking Simulation
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-07-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530323666230720143415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sustainability assessment of small hydropower from an ESG perspective: A case study of the Qin-Ba Mountains, China.

    Zhu, Jiwei / Zhang, Jianmei / Wu, Haojun / Yi, Xihan / Liu, Yu

    Journal of environmental management

    2023  Volume 350, Page(s) 119523

    Abstract: ... From an Environmental, Social, and Governance (ESG) perspective and using three SHP stations (GXD, WZL, and SJB) in the Qin-Ba ...

    Abstract Small hydropower (SHP) has made significant contributions to economic and social development in rural and remote mountainous regions. However, the adverse ecological-environmental impacts resulting from the SHP sector and challenges in hydropower management have become major areas of concern. From an Environmental, Social, and Governance (ESG) perspective and using three SHP stations (GXD, WZL, and SJB) in the Qin-Ba Mountains as case studies, we constructed a sustainability assessment system comprising 18 indicators across three dimensions. The hesitant fuzzy linguistic term sets (HFLTSs) and cloud models were employed to determine the sustainability level of SHP by characterizing the hesitancy of the evaluator and the uncertainty of the evaluated data. (1) The ecological-environmental protection (E) dimension was assigned the greatest weight, followed by the dimensions of social responsibility contribution (S) and corporate governance management (G). The weights of certain indicators, including the water qualification rate, river morphology maintenance, guaranteed rate of instream flow, comprehensive utilization, and production safety standardization grade were relatively high, conforming to the current context of green development prioritization in which ecological-environmental protection is of the utmost importance. (2) The overall sustainability levels of all three SHP stations were "good", with the E-dimension contributing the most and the G-dimension contributing the least to the sustainability goal. (3) The GXD, WZL, and SJB stations were ranked first, second, and third, respectively, in terms of their sustainability scores. This study provides an innovative perspective for the sustainability assessment of SHP. The evaluation method can be generalized to encompass multi-attribute decision-making problems. The findings of this study can aid in addressing the shortcomings associated with SHP development and promote sustainability within the SHP industry.
    MeSH term(s) Conservation of Natural Resources ; Uncertainty ; Industry ; China ; Rivers
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.119523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs.

    Pan, Zengfeng / Xie, Xuting / Chen, Yunliang / Pan, Simin / Wu, Zhiyun / Yang, Caiyi / Liang, Junjie / Zhang, Meilin / Wang, Qing / Chen, Jinyan / Zhou, Lian / Luo, Xia

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 107, Page(s) 154454

    Abstract: ... Although Huang Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and ... Conclusion: Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling ...

    Abstract Background: Colorectal cancer is associated with ulcerative colitis (UC). The infiltration of neutrophils is the main cause of DNA damage produced by inflammation in the intestinal epithelium. Under the action of peptidyl arginine deaminase 4 (PAD4), neutrophils dissociate chromatin and form neutrophil extracellular traps (NETs), which can aggravate tissue inflammation and encourage tumor development. Although Huang Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and treat digestive tract cancers, the underlying reasons were unclear.
    Methods: To demonstrate HQD could inhibits the initiation of colitis associated carcinogenesis by controlling NETs related inflammation, we first performed an AOM/DSS-generated colitis-associated carcinogenesis model to assess the efficacy of HQD in reducing neutrophil infiltration and anti-tumor activity. Then, using network pharmacology research, we investigated the potential mechanisms underlying those medicinal effects, as demonstrated by the detection of NETs aggregation and PAD4 expression changes in the colon.
    Results: HQD substantially reduced the number of colon cancers and the expression of Ki67, restored the level of intestinal tight junction protein occludin and ZO-1, and relieved the intestinal inflammation caused by TNF-α, IL-1β. At the same time, it inhibited neutrophil infiltration in the colon and improved the immunosurveillance of CD8
    Conclusion: Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling PAD4-dependent neutrophil extracellular traps.
    MeSH term(s) Animals ; Arginine/metabolism ; Carcinogenesis ; Chromatin/metabolism ; Colitis/chemically induced ; Colitis/complications ; Colitis/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Disease Models, Animal ; Extracellular Traps/metabolism ; Humans ; Inflammation/metabolism ; Ki-67 Antigen/metabolism ; Mice ; Mice, Inbred C57BL ; Occludin/metabolism ; Scutellaria baicalensis ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Chromatin ; Ki-67 Antigen ; Occludin ; Tumor Necrosis Factor-alpha ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2022-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
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  5. Article ; Online: A network pharmacology approach and experimental validation to investigate the anticancer mechanism of Qi-Qin-Hu-Chang formula against colitis-associated colorectal cancer through induction of apoptosis via JNK/p38 MAPK signaling pathway.

    Wu, Yuguang / Fang, Yulai / Li, Yanan / Au, Ryan / Cheng, Cheng / Li, Weiyang / Xu, Feng / Cui, Yuan / Zhu, Lei / Shen, Hong

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 3, Page(s) 117323

    Abstract: Ethnopharmacological relevance: The Qi-Qin-Hu-Chang Formula (QQHCF) is ...

    Abstract Ethnopharmacological relevance: The Qi-Qin-Hu-Chang Formula (QQHCF) is a traditional Chinese medicine prescription that is clinically used at the Affiliated Hospital of Nanjing University of Chinese Medicine for the treatment of colitis-associated colorectal cancer (CAC).
    Aim of the study: To evaluate the potential therapeutic effects of QQHCF on a CAC mouse model and investigate its underlying mechanisms using network pharmacology and experimental validation.
    Materials and methods: The active components and potential targets of QQHCF were obtained from Traditional Chinese Medicine Systems Pharmacology (TCMSP) and herb-ingredient-targets gene network were constructed by Cytoscape 3.9.2. Target genes of CAC were obtained from GeneCards, Online Mendelian Inheritance in Man, and DrugBank database. The drug disease target protein-protein interaction (PPI) network was constructed and the core targets were visualized and identified using Cytoscape. The Metascape database was used for GO and KEGG enrichment analysis. UHPLC-MS/MS was used to further identify the active compounds in QQHCF. Subsequently, the therapeutic effects and potential mechanism of QQHCF against CAC were investigated in AOM/DSS-induced CAC mouse in vivo, and HT-29 and HCT116 cells in vitro. Finally, interactions between JNK, p38, and active ingredients were assessed by molecular docking.
    Results: A total of 176 active compounds, 273 potential therapeutic targets, and 2460 CAC-related target genes were obtained. The number of common targets between QQHCF and CAC were 165. KEGG pathway analysis indicated that the MAPK signaling pathway was closely associated with CAC, which may be the potential mechanism of QQHCF against CAC. Network pharmacology and UHPLC-MS/MS analyses showed that the active compounds of QQHCF included quercetin, kaempferol, luteolin, wogonin, oxymatrine, lupanine, and baicalin. Animal experiments demonstrated that QQHCF reduced tumor load, number, and size in AOM/DSS-treated mice, and induced apoptosis in colon tissue. In vitro experiments further showed that QQHCF induced apoptosis and inhibited cell viability, migration, and invasion in HCT116 and HT-29 cells. Notably, QQHCF activated the JNK/p38 MAPK signaling pathway both in vivo and in vitro. Molecular docking analysis revealed an ability for the main components of QQHCF and JNK/p38 to bind.
    Conclusion: The present study demonstrated that QQHCF could ameliorate AOM/DSS-induced CAC in mice by activating the JNK/p38 MAPK signaling pathway. These results have important implications for the development of effective treatment strategies for CAC.
    MeSH term(s) Humans ; Animals ; Mice ; Qi ; Colitis-Associated Neoplasms ; Network Pharmacology ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Signal Transduction ; Apoptosis ; Databases, Genetic ; p38 Mitogen-Activated Protein Kinases ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-10-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  6. Article: Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs

    Pan, Zengfeng / Xie, Xuting / Chen, Yunliang / Pan, Simin / Wu, Zhiyun / Yang, Caiyi / Liang, Junjie / Zhang, Meilin / Wang, Qing / Chen, Jinyan / Zhou, Lian / Luo, Xia

    Phytomedicine. 2022 Dec., v. 107

    2022  

    Abstract: ... Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and treat ... treatment. Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling ...

    Abstract Colorectal cancer is associated with ulcerative colitis (UC). The infiltration of neutrophils is the main cause of DNA damage produced by inflammation in the intestinal epithelium. Under the action of peptidyl arginine deaminase 4 (PAD4), neutrophils dissociate chromatin and form neutrophil extracellular traps (NETs), which can aggravate tissue inflammation and encourage tumor development. Although Huang Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and treat digestive tract cancers, the underlying reasons were unclear. To demonstrate HQD could inhibits the initiation of colitis associated carcinogenesis by controlling NETs related inflammation, we first performed an AOM/DSS-generated colitis-associated carcinogenesis model to assess the efficacy of HQD in reducing neutrophil infiltration and anti-tumor activity. Then, using network pharmacology research, we investigated the potential mechanisms underlying those medicinal effects, as demonstrated by the detection of NETs aggregation and PAD4 expression changes in the colon. HQD substantially reduced the number of colon cancers and the expression of Ki67, restored the level of intestinal tight junction protein occludin and ZO-1, and relieved the intestinal inflammation caused by TNF-α, IL-1β. At the same time, it inhibited neutrophil infiltration in the colon and improved the immunosurveillance of CD8⁺T cells. The potential mechanisms of HQD intervention against UC and UC with neoplasia (UCN) were studied using network pharmacology, and 156 conjunct genes as well as numerous inflammation-related pathways were identified. Protein-protein interaction (PPI) analysis indicated that HQD inhibition of intestinal tumors might be related to the deactivation of PAD4, which was verified by the down-regulation of NETs, MPO-DNA complex levels, and PAD4 expression after HQD treatment. Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling PAD4-dependent neutrophil extracellular traps.
    Keywords DNA damage ; antineoplastic activity ; arginine ; carcinogenesis ; chromatin ; colon ; colorectal neoplasms ; digestive tract ; inflammation ; intestinal mucosa ; models ; neutrophils ; occludins ; protein-protein interactions ; tight junctions ; ulcerative colitis
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154454
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Amolops putaoensis Gan, Qin, Lwin, Li, Quan, Liu & Yu, 2020, a newly recorded torrent frog for China

    Zhang, Yin-Peng / Liu, Xiao-Long / Stuart, Bryan L. / Wu, Dong-Yi / Wang, Yeu-Farn / Che, Jing / Yuan, Zhi-Yong

    Herpetozoa. 2022 Nov. 22, v. 35 p.231-237

    2022  

    Abstract: AbstractAmolops putaoensis is a recently described torrent frog species from A. monticola group that is known only from its type locality, northern Myanmar. We compared morphology and mitochondrial DNA sequence data from ten recently collected adult ... ...

    Abstract AbstractAmolops putaoensis is a recently described torrent frog species from A. monticola group that is known only from its type locality, northern Myanmar. We compared morphology and mitochondrial DNA sequence data from ten recently collected adult male specimens from the upper Dulong River System in Gongshan County, Yunnan Province, China, to the original description of A. putaoensis. Both datasets strongly supported referring the Chinese specimens to A. putaoensis, extending the known range of this species by approximately 133.7 km distance into China. Molecular phylogenetic analyses recovered A. putaoensis to be closely related to A. aniqiaoensis, A. kohimaensis, A. monticola, and A. adicola. We use the newly collected Chinese specimens to expand the morphological description of the species.
    Keywords adults ; data collection ; frogs ; males ; nucleotide sequences ; phylogeny ; rivers ; China ; Myanmar ; Dulong River System ; herpetofauna ; national new record ; Ranidae
    Language English
    Dates of publication 2022-1122
    Size p. 231-237.
    Publishing place Pensoft Publishers
    Document type Article ; Online
    ZDB-ID 2474932-1
    ISSN 2682-955X
    ISSN 2682-955X
    DOI 10.3897/herpetozoa.35.e94745
    Database NAL-Catalogue (AGRICOLA)

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  8. Book: Qin Bo-Wei's 56 treatment methods

    Qin, Bowei / Wu, Boping / Blalack, Jason

    writing precise prescriptions

    2011  

    Title variant Zhi liao xin lu ; Qin Bowei's 56 treatment methods ; Qin Bo-Wei's fifty-six treatment methods
    Author's details clinical commentary by Wu Bo-Ping ; translated and edited by Jason Blalack
    MeSH term(s) Medicine, Chinese Traditional ; Materia Medica
    Language English
    Size xxiv, 359 p. :, ill. ;, 25 cm.
    Publisher Eastland Press
    Publishing place Seattle
    Document type Book
    Note Includes indexes.
    ISBN 9780939616749 ; 0939616742
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca

    Zhang, Chen-Long / Lin, Zi-Qi / Luo, Rui-Jie / Zhang, Xiao-Xin / Guo, Jia / Wu, Wei / Shi, Na / Deng, Li-Hui / Chen, Wei-Wei / Zhang, Xiao-Ying / Bharucha, Shameena / Huang, Wei / Sutton, Robert / Windsor, John A / Xue, Ping / Xia, Qing

    Evidence-based complementary and alternative medicine : eCAM

    2017  Volume 2017, Page(s) 5864945

    Abstract: Chai-Qin-Cheng-Qi decoction (CQCQD) improves intestinal motility in acute pancreatitis (AP ...

    Abstract Chai-Qin-Cheng-Qi decoction (CQCQD) improves intestinal motility in acute pancreatitis (AP), but the mechanism(s) require elucidation. We investigated the effects of CQCQD and carbachol, a prokinetic agent, on colonic smooth muscle cells (SMCs) in L-arginine-induced necrotising AP model in rats. In treatment groups, intragastric CQCQD (20 g/kg, 2 hourly × 3 doses) or intraperitoneal carbachol (60
    Language English
    Publishing date 2017-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2017/5864945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  10. Article ; Online: Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins.

    Andress, Arlise / Bei, Yanxia / Fonslow, Bryan R / Giri, Ritika / Wu, Yilong / Yates, John R / Carthew, Richard W

    The Journal of cell biology

    2016  Volume 213, Issue 2, Page(s) 201–211

    Abstract: ... Spindle-E (Spn-E). We found that the Spn-E protein physically associates with the Tudor domain protein Qin ... and the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3). Spn-E and Qin proteins are mutually ...

    Abstract Transposable elements (TEs) are silenced in germ cells by a mechanism in which PIWI proteins generate and use PIWI-interacting ribonucleic acid (piRNA) to repress expression of TE genes. piRNA biogenesis occurs by an amplification cycle in microscopic organelles called nuage granules, which are localized to the outer face of the nuclear envelope. One cofactor required for amplification is the helicase Spindle-E (Spn-E). We found that the Spn-E protein physically associates with the Tudor domain protein Qin and the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3). Spn-E and Qin proteins are mutually dependent for their exit from nuage granules, whereas Spn-E and both Aub and Ago3 are mutually dependent for their entry or retention in nuage. The result is a dynamic cycling of Spn-E and its associated factors in and out of nuage granules. This implies that nuage granules can be considered to be hubs for active, mobile, and transient complexes. We suggest that this is in some way coupled with the execution of the piRNA amplification cycle.
    MeSH term(s) Adenosine Triphosphatases/metabolism ; Animals ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Argonaute Proteins/physiology ; Biological Transport ; DNA Transposable Elements/physiology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila Proteins/physiology ; Models, Biological ; Nonlinear Dynamics ; Peptide Initiation Factors/metabolism ; RNA, Small Interfering/metabolism ; Regression Analysis ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/physiology
    Chemical Substances AGO3 protein, Drosophila ; Argonaute Proteins ; DNA Transposable Elements ; Drosophila Proteins ; Peptide Initiation Factors ; RNA, Small Interfering ; aub protein, Drosophila ; Qin protein, Drosophila (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Adenosine Triphosphatases (EC 3.6.1.-) ; spn-E protein, Drosophila (EC 3.6.1.-)
    Language English
    Publishing date 2016-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201411076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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