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  1. Article ; Online: I would but I cannot, I can but I do not want: unmet needs of people with HIV in the long-acting era.

    Mazzitelli, Maria / Sasset, Lolita / Mengato, Daniele / Cattelan, Annamaria

    AIDS (London, England)

    2023  Volume 37, Issue 4, Page(s) 707–708

    MeSH term(s) Humans ; HIV Infections ; Health Services Needs and Demand ; Health Services Accessibility
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  2. Article ; Online: HIV testing and linkage to care: are we missing some opportunities?

    Mazzitelli, Maria / Sasset, Lolita / Leoni, Davide / Barbaro, Francesco / Marinello, Serena / Cattelan, Anna Maria

    AIDS (London, England)

    2022  Volume 36, Issue 14, Page(s) 2085–2087

    MeSH term(s) Humans ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Testing
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Letter
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  3. Article ; Online: Use of self-prescribed medications and complementary medicines in a cohort of women with HIV.

    Mazzitelli, Maria / Sasset, Lolita / Trunfio, Mattia / di Meco, Eugenia / Frater, Alessia / Leoni, Davide / Cattelan, Annamaria

    AIDS (London, England)

    2022  Volume 36, Issue 4, Page(s) 617–619

    MeSH term(s) Cohort Studies ; Complementary Therapies ; Female ; HIV Infections/drug therapy ; Humans
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Letter
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  4. Article ; Online: Immune System Deficiencies Do Not Alter SARS-CoV-2 Evolutionary Rate but Favour the Emergence of Mutations by Extending Viral Persistence.

    Manuto, Laura / Bado, Martina / Cola, Marco / Vanzo, Elena / Antonello, Maria / Mazzotti, Giorgia / Pacenti, Monia / Cordioli, Giampaolo / Sasset, Lolita / Cattelan, Anna Maria / Toppo, Stefano / Lavezzo, Enrico

    Viruses

    2024  Volume 16, Issue 3

    Abstract: During the COVID-19 pandemic, immunosuppressed patients showed prolonged SARS-CoV-2 infections, with several studies reporting the accumulation of mutations in the viral genome. The weakened immune system present in these individuals, along with the ... ...

    Abstract During the COVID-19 pandemic, immunosuppressed patients showed prolonged SARS-CoV-2 infections, with several studies reporting the accumulation of mutations in the viral genome. The weakened immune system present in these individuals, along with the effect of antiviral therapies, are thought to create a favourable environment for intra-host viral evolution and have been linked to the emergence of new viral variants which strongly challenged containment measures and some therapeutic treatments. To assess whether impaired immunity could lead to the increased instability of viral genomes, longitudinal nasopharyngeal swabs were collected from eight immunocompromised patients and fourteen non-immunocompromised subjects, all undergoing SARS-CoV-2 infection. Intra-host viral evolution was compared between the two groups through deep sequencing, exploiting a probe-based enrichment method to minimise the possibility of artefactual mutations commonly generated in amplicon-based methods, which heavily rely on PCR amplification. Although, as expected, immunocompromised patients experienced significantly longer infections, the acquisition of novel intra-host viral mutations was similar between the two groups. Moreover, a thorough analysis of viral quasispecies showed that the variability of viral populations in the two groups is comparable not only at the consensus level, but also when considering low-frequency mutations. This study suggests that a compromised immune system alone does not affect SARS-CoV-2 within-host genomic variability.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Pandemics ; Mutation ; Quasispecies
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coinfection of severe acute respiratory syndrome coronavirus 2 and HIV in a teaching hospital: still much to learn.

    Sasset, Lolita / Di Meco, Eugenia / Cavinato, Silvia / Cattelan, Anna M

    AIDS (London, England)

    2020  Volume 34, Issue 11, Page(s) 1694–1696

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coinfection/virology ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; HIV Infections/complications ; HIV Infections/virology ; Hospitals, Teaching ; Humans ; Italy ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000002609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  6. Article ; Online: Achievement of Primary Prevention Cardiometabolic Targets in Women with HIV: An Urgent Call to Action to Pursue Cardiovascular Health.

    Mazzitelli, Maria / Scaglione, Vincenzo / Cozzolino, Claudia / Zuin, Marco / Putaggio, Cristina / Bragato, Beatrice / Vania, Eleonora / Sasset, Lolita / Leoni, Davide / Baldo, Vincenzo / Cattelan, Annamaria

    Viruses

    2024  Volume 16, Issue 4

    Abstract: Background: Cardiometabolic health has become crucial, especially for women with HIV (WWH). We assessed the achievement of targets for hypertension, dyslipidemia, and diabetes (H/Dy/DT) in primary prevention in a WWH cohort.: Methods: Cross-sectional ...

    Abstract Background: Cardiometabolic health has become crucial, especially for women with HIV (WWH). We assessed the achievement of targets for hypertension, dyslipidemia, and diabetes (H/Dy/DT) in primary prevention in a WWH cohort.
    Methods: Cross-sectional analysis including all WWH in our clinic, excluding those who had a myocardial infarction. H/Dy/DT achievement was assessed by both EACS guidelines and individual cardiovascular risk, CVR (measured by ESC calculator), using logistic regression to evaluate differences in H/Dy/DT achievement between migrant and Italian women.
    Results: We included 292 WWH, 55.5% Italian and 44.5% migrant women; the median age was 50 (IQR:42-58) years, 94.5% had undetectable HIV-RNA, 55.1% had a high level of education, 27.1% were smokers, and 19.2% did regularly physical exercise. Overall, 76%, 19%, and 5% of women presented a low, a high, and a very high CVR, respectively. Among Italians, 28.4% and 6.2% women presented a high and a very high CVR, respectively. Considering migrants, 7.7% and 3.8% women presented a high and a very high CVR, respectively. Overall, among migrant women, those with a high CVR were more likely to be not at target than those with a low risk (especially for LDL-c and blood pressure among people on treatment), despite the fact that we did not detect a statistically significant difference. By contrast, migrants were more likely to achieve glycemic targets than Italians (
    Conclusions: H/Dy/DT target achievement is suboptimal, especially in migrants. A more aggressive pharmacological treatment, also assessing adherence to medical prescriptions, and promotion of healthy lifestyle should be urgently implemented, possibly redrawing the current model of care.
    MeSH term(s) Humans ; Female ; Middle Aged ; HIV Infections/prevention & control ; Adult ; Cross-Sectional Studies ; Cardiovascular Diseases/prevention & control ; Primary Prevention/methods ; Italy/epidemiology ; Dyslipidemias/epidemiology ; Hypertension ; Risk Factors ; Diabetes Mellitus/epidemiology ; Transients and Migrants
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: Changing patterns and clinical outcomes of hospitalized patients with COVID‑19 severe pneumonia treated with remdesivir according to vaccination status: results from a real‑world retrospective study.

    Mengato, Daniele / Mazzitelli, Maria / Francavilla, Andrea / Bettio, Monica / Sasset, Lolita / Presa, Nicolò / Pivato, Lisa / Menzo, Sara Lo / Trevenzoli, Marco / Venturini, Francesca / Gregori, Dario / Cattelan, Anna Maria

    Clinical and experimental medicine

    2023  Volume 23, Issue 6, Page(s) 2757

    Language English
    Publishing date 2023-06-07
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01088-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5481: Show issues Location:
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  8. Article ; Online: COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients.

    Angioni, Roberta / Sasset, Lolita / Cioccarelli, Chiara / Sánchez-Rodríguez, Ricardo / Bertoldi, Nicole / Putaggio, Cristina C / Viola, Antonella / Cattelan, Annamaria / Molon, Barbara

    Viruses

    2022  Volume 14, Issue 3

    Abstract: Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns ( ... ...

    Abstract Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Real life use of dolutegravir doravirine dual regimen in experienced elderly PLWH with multiple comorbidities and on polypharmacy: A retrospective analysis.

    Mazzitelli, Maria / Sasset, Lolita / Leoni, Davide / Putaggio, Cristina / Cattelan, Anna Maria

    Medicine

    2021  Volume 100, Issue 52, Page(s) e28488

    Abstract: Abstract: By increasing life expectancy of people living with HIV, the most clinical challenge is managing both drug-to-drug interactions and comorbidities (especially metabolic). Doravirine (DOR), a new non-nucleoside reverse transcriptase inhibitor, ... ...

    Abstract Abstract: By increasing life expectancy of people living with HIV, the most clinical challenge is managing both drug-to-drug interactions and comorbidities (especially metabolic). Doravirine (DOR), a new non-nucleoside reverse transcriptase inhibitor, recently approved for the treatment of HIV, could be a good companion of dolutegravir (DTG) in a dual regimen for experienced elderly patients with multimorbidity and polypharmacy.We herein report our preliminary experience in a small cohort of elderly patients (>50 years of age) with multimorbidity and on polypharmacy who were switched to DOR/DTG dual regimen and followed-up for 3 months. The study was conducted at the Infectious and Tropical Diseases Unit of Padua University Hospital, Italy.Eighteen patients were included, 72.2% males and 27.8% postmenopausal women, mean age was of 61.3 years (7.6), 50% experienced AIDS events. Switches to DOR and DTG were mainly due to high cardiovascular and metabolic risk (72.2%), and interactions among comedications (50%). Antiretrovirals that subjects were switched off were mostly boosted protease inhibitors 66.7%. We observed a viral suppression among all subjects. Interestingly, we observed a statistically significant reduction in body mass index, body weight and waist circumference, eGFR, and a significant increase in serum creatinine levels. No significant changes in CD4+ T cell count was observed from the baseline. Lipid and fasting glucose values did not change significantly.To the best of our knowledge this is the first experience reporting real-life outcome of switch to DTG + DOR in elderly with multimorbidity and on polypharmacy. From our very preliminary data the dual combination of DTG and DOR could be a good treatment strategy for these subjects. However, our findings need to be validated on a greater number of patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Infant ; Male ; Middle Aged ; Oxazines/therapeutic use ; Piperazines/therapeutic use ; Polypharmacy ; Pyridones/therapeutic use ; Retrospective Studies ; Treatment Outcome ; Triazoles/therapeutic use ; Viral Load/drug effects
    Chemical Substances Anti-HIV Agents ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; Triazoles ; doravirine (913P6LK81M) ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.171: Show issues Location:
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  10. Article: Coinfection of severe acute respiratory syndrome coronavirus 2 and HIV in a teaching hospital: still much to learn

    Sasset, Lolita / Di Meco, Eugenia / Cavinato, Silvia / Cattelan, Anna M

    AIDS

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #708374
    Database COVID19

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