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  1. Article: Competitive action between Brassinosteroid and tracheary element differentiation inhibitory factor in controlling xylem cell differentiation.

    Kondo, Yuki

    Plant biotechnology (Tokyo, Japan)

    2022  Volume 39, Issue 1, Page(s) 59–64

    Abstract: For permanent secondary growth in plants, cell proliferation and differentiation should be strictly controlled in the vascular meristem consisting of (pro)cambial cells. A peptide hormone tracheary element differentiation inhibitory factor (TDIF) ... ...

    Abstract For permanent secondary growth in plants, cell proliferation and differentiation should be strictly controlled in the vascular meristem consisting of (pro)cambial cells. A peptide hormone tracheary element differentiation inhibitory factor (TDIF) functions to inhibit xylem differentiation, while a plant hormone brassinosteroid (BR) promotes xylem differentiation in (pro)cambial cells. However, it remains unclear how TDIF and BR cooperate to regulate xylem differentiation for the proper maintenance of the vascular meristem. In this study, I developed an easy evaluation method for xylem differentiation frequency in a vascular induction system Vascular cell Induction culture System Using Arabidopsis Leaves (VISUAL) by utilizing a xylem-specific luciferase reporter line. In this quantitative system, TDIF suppressed and BR promoted xylem differentiation in a dose-dependent manner, respectively. Moreover, simultaneous treatment of TDIF and BR with (pro)cambial cells revealed that they can cancel their each other's effect on xylem differentiation, suggesting a competitive relationship between TDIF and BR. Thus, mutual inhibition of "ON" and "OFF" signal enables the fine-tuned regulation of xylem differentiation in the vascular meristem.
    Language English
    Publishing date 2022-06-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.21.1109a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Patients' Informational Needs for Pharmacotherapy and Health Literacy].

    Kondo, Yuki

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2021  Volume 141, Issue 3, Page(s) 387–391

    Abstract: Health literacy is defined as the ability to obtain, evaluate, and scrutinize health information and make appropriate decisions and actions. The spread of the Internet means that medical and drug information is becoming increasingly accessible to ... ...

    Abstract Health literacy is defined as the ability to obtain, evaluate, and scrutinize health information and make appropriate decisions and actions. The spread of the Internet means that medical and drug information is becoming increasingly accessible to patients. However, there is also a large amount of inappropriate and biased medical- and drug-related information on the Internet. Therefore, patients require a high level of health literacy to ensure the effectiveness and safety of pharmacotherapy. In particular, outpatients need a high level of health literacy because they use their own medications without the supervision of healthcare professionals. In this article, I discuss the situation of health literacy and access to pharmaceutical information on the Internet in Japan. Furthermore, issues related to providing drug information to specific populations are explained using the example of chronic kidney disease. It is essential for all pharmaceutical information stakeholders to work together to solve these problems.
    MeSH term(s) Decision Making ; Drug Information Services ; Drug Therapy ; Health Literacy/statistics & numerical data ; Health Services Needs and Demand ; Humans ; Internet ; Japan/epidemiology ; Nonprescription Drugs ; Outpatients ; Renal Insufficiency, Chronic/drug therapy ; Safety ; Treatment Outcome
    Chemical Substances Nonprescription Drugs
    Language Japanese
    Publishing date 2021-02-27
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.20-00207-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  3. Article: Editorial: Effective methods to promote appropriate use of medicines.

    Huang, Yen-Ming / Kondo, Yuki / Tachi, Tomoya

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1331906

    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1331906
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  4. Article ; Online: Multiple roles of brassinosteroid signaling in vascular development.

    Furuya, Tomoyuki / Ohashi-Ito, Kyoko / Kondo, Yuki

    Plant & cell physiology

    2024  

    Abstract: Brassinosteroids (BRs) are plant steroid hormones that control growth and stress responses. In the context of development, BRs play diverse roles in controlling cell differentiation and tissue patterning. The vascular system, which is essential for ... ...

    Abstract Brassinosteroids (BRs) are plant steroid hormones that control growth and stress responses. In the context of development, BRs play diverse roles in controlling cell differentiation and tissue patterning. The vascular system, which is essential for transporting water and nutrients throughout the plant body, initially establishes a tissue pattern during primary development and then dramatically increases the number of vascular cells during secondary development. This complex developmental process is properly regulated by a network consisting of various hormonal signalling pathways. Genetic studies have revealed that mutants defective in BR biosynthesis or the BR signalling cascade exhibit a multifaceted vascular development phenotype. Furthermore, BR crosstalk with other plant hormones, including peptide hormones, coordinately regulates vascular development. Recently, the involvement of BR in vascular development, especially in xylem differentiation, has also been suggested in plant species other than the model plant Arabidopsis thaliana. In this review, we briefly summarize the recent findings on the roles of BR in primary and secondary vascular development in Arabidopsis and other species.
    Language English
    Publishing date 2024-04-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 208907-5
    ISSN 1471-9053 ; 0032-0781
    ISSN (online) 1471-9053
    ISSN 0032-0781
    DOI 10.1093/pcp/pcae037
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    In stock of ZB MED Bonn / Germany

    Z 79/710: Show issues

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  5. Article ; Online: Comprehensive analysis of downstream transcriptomic features in the competitive relationships between BEH3 and other BES/BZR transcription factors.

    Furuya, Tomoyuki / Kondo, Yuki

    Genes & genetic systems

    2023  Volume 98, Issue 2, Page(s) 89–92

    Abstract: Members of a plant-specific BES/BZR transcription factor (TF) family including BRI1-EMS-SUPPRESSOR 1 (BES1) and BRASSINAZOLE-RESISTANT 1 (BZR1) regulate various developmental processes and environmental responses. Recently, we reported that BES1/BZR1 ... ...

    Abstract Members of a plant-specific BES/BZR transcription factor (TF) family including BRI1-EMS-SUPPRESSOR 1 (BES1) and BRASSINAZOLE-RESISTANT 1 (BZR1) regulate various developmental processes and environmental responses. Recently, we reported that BES1/BZR1 Homolog 3 (BEH3) exhibited a competitive effect toward other BES/BZR TFs. In this study, we analyzed transcriptome profiles in BEH3-overexpressing plants and compared them with those of BES1 and BZR1 double gain-of-function mutants. We identified 46 differentially expressed genes (DEGs), which were downregulated in the gain-of-function mutants of BES1 and BZR1 but upregulated upon BEH3 overexpression. In these DEGs, putative BES1 and BZR1 direct-targeted genes were highly enriched. In addition, these DEGs contained not only known brassinosteroid biosynthetic enzymes, but also some NAC TFs, which negatively regulate brassinosteroid-inactivating enzymes. Moreover, the iron sensor and the iron-deficient response-related bHLH TFs were also included. Taken together, our findings indicate that a competitive relationship between BEH3 and other BES/BZR TFs exists in various BES/BZR binding target genes.
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; Transcriptome ; Brassinosteroids/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances Transcription Factors ; DNA-Binding Proteins ; Brassinosteroids ; Arabidopsis Proteins ; BES (10191-18-1)
    Language English
    Publishing date 2023-06-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1323536-9
    ISSN 1880-5779 ; 1341-7568
    ISSN (online) 1880-5779
    ISSN 1341-7568
    DOI 10.1266/ggs.23-00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3466: Show issues Location:
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  6. Article: Feasibility of emergent reperfusion therapy using paclitaxel-coated balloons for acute coronary syndrome: lessons from the PEBSI Study.

    Kondo, Yuki / Ishikawa, Tetsuya / Taguchi, Isao

    Cardiovascular diagnosis and therapy

    2023  Volume 13, Issue 5, Page(s) 763–767

    Language English
    Publishing date 2023-09-25
    Publishing country China
    Document type Editorial
    ZDB-ID 2685043-6
    ISSN 2223-3660 ; 2223-3652
    ISSN (online) 2223-3660
    ISSN 2223-3652
    DOI 10.21037/cdt-2023-3
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  7. Article ; Online: Primary role of dextromethorphan in prolonged toxic encephalopathy with intermittent rhythmic slow-wave activity on electroencephalogram: A case report.

    Sasaki, Takeshi / Mizoguchi, Kosuke / Genda, Keiko / Endo, Shoko / Kondo, Yuki / Mikami, Tomoko / Arakaki, Hiroshi

    Psychiatry and clinical neurosciences

    2024  Volume 78, Issue 3, Page(s) 212–214

    MeSH term(s) Humans ; Dextromethorphan/pharmacology ; Electroencephalography
    Chemical Substances Dextromethorphan (7355X3ROTS)
    Language English
    Publishing date 2024-01-23
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13634
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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.238: Show issues Location:
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  8. Article ; Online: Reconstitutive approach for investigating plant vascular development.

    Kondo, Yuki

    Journal of plant research

    2018  Volume 131, Issue 1, Page(s) 23–29

    Abstract: Plants generate various tissues and organs via a strictly regulated developmental program. The plant vasculature is a complex tissue system consisting of xylem and phloem tissues with a layer of cambial cells in between. Multiple regulatory steps are ... ...

    Abstract Plants generate various tissues and organs via a strictly regulated developmental program. The plant vasculature is a complex tissue system consisting of xylem and phloem tissues with a layer of cambial cells in between. Multiple regulatory steps are involved in vascular development. Although molecular and genetic studies have uncovered a variety of key factors controlling vascular development, studies of the actual functions of these factors have been limited due to the inaccessibility of the plant vasculature. Thus, to obtain a different perspective, culture systems have been widely used to analyze the sequential processes that occur during vascular development. A tissue culture system known as VISUAL, in which molecular genetic analysis can easily be performed, was recently established in Arabidopsis thaliana. This reconstitutive approach to vascular development enables this process to be investigated quickly and easily. In this review, I summarize our recent knowledge of the regulatory mechanisms underlying vascular development and provide future perspectives on vascular analyses that can be performed using VISUAL.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/growth & development ; Molecular Biology/methods ; Phloem/growth & development ; Xylem/growth & development
    Language English
    Publishing date 2018-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-017-0998-1
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  9. Article ; Online: Structural Validity of the Mini-Balance Evaluation Systems Test in Individuals With Spinocerebellar Ataxia: A Rasch Analysis Study.

    Miyata, Kazuhiro / Kondo, Yuki / Bando, Kyota / Hara, Takatoshi / Takahashi, Yuji

    Archives of physical medicine and rehabilitation

    2024  Volume 105, Issue 4, Page(s) 742–749

    Abstract: Objective: To examine the structural validity of the Mini-Balance Evaluation Systems Test (Mini-BESTest) in individuals with spinocerebellar ataxia (SCA).: Design: Methodological research on data gathered in a cross-sectional study. A Rasch analysis ... ...

    Abstract Objective: To examine the structural validity of the Mini-Balance Evaluation Systems Test (Mini-BESTest) in individuals with spinocerebellar ataxia (SCA).
    Design: Methodological research on data gathered in a cross-sectional study. A Rasch analysis was conducted (partial credit model).
    Setting: Inpatients in a hospital rehabilitation setting.
    Participants: A pooled sample of patients with SCA (N=65 [total 110 data]; 23 women, 42 men; mean±SD age 63.1±9.9y).
    Interventions: Not applicable.
    Main outcome measures: We evaluated the Mini-BESTest's category structure, unidimensionality, and measurement accuracy (0: unable to perform or requiring help to 2: normal performance).
    Results: The Mini-BESTest rating scale fulfilled the category functioning criteria. The analysis of the standardized Rasch residuals showed the scale's unidimensionality, but there were 7 item pairs indicating local dependence. All of the items fit the underlying scale construct (dynamic balance), with the exception of item #1, "Sit to stand," which was an underfit. The Mini-BESTest demonstrated adequate reliability (person separation reliability=.87) and separated the patients into 5 strata. The item-difficulty measures ranged from -4.49 to 2.02 logits, and the person ability-item difficulty matching was very good (the mean of person ability=-.07 logits and the mean of item difficulty=.00). No floor or ceiling effects were detected. The keyform identified items with small (#11, "Walk with head turns, horizontal") and large (#3, "Stand on 1 leg") item thresholds.
    Conclusions: The Mini-BESTest has a unidimensional balance assessment scale with good category structure and reliability even for individuals with SCA. However, it also has some inherent shortcomings such as fit statistics, local item dependencies, and item thresholds. The results obtained when the Mini-BESTest is administered to patients with cerebellar ataxia should, thus, be interpreted cautiously.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Aged ; Cross-Sectional Studies ; Reproducibility of Results ; Postural Balance ; Disability Evaluation ; Psychometrics ; Spinocerebellar Ataxias
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2023.12.015
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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.71: Show issues Location:
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  10. Article ; Online: Highly efficient multi-resonance thermally activated delayed fluorescence material toward a BT.2020 deep-blue emitter.

    Ochi, Junki / Yamasaki, Yuki / Tanaka, Kojiro / Kondo, Yasuhiro / Isayama, Kohei / Oda, Susumu / Kondo, Masakazu / Hatakeyama, Takuji

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2361

    Abstract: An ultrapure deep-blue multi-resonance-induced thermally activated delayed fluorescence material (DOB2-DABNA-A) is designed and synthesized. Benefiting from a fully resonating extended helical π-conjugated system, this compound has a small ... ...

    Abstract An ultrapure deep-blue multi-resonance-induced thermally activated delayed fluorescence material (DOB2-DABNA-A) is designed and synthesized. Benefiting from a fully resonating extended helical π-conjugated system, this compound has a small ΔE
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46619-8
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