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  1. Article ; Online: Cold agglutinin autoimmune haemolytic anaemia associated with novel coronavirus (COVID-19).

    Zagorski, Emily / Pawar, Tushar / Rahimian, Shoja / Forman, Daniel

    British journal of haematology

    2020  Volume 190, Issue 4, Page(s) e183–e184

    MeSH term(s) Anemia, Hemolytic, Autoimmune/blood ; Anemia, Hemolytic, Autoimmune/etiology ; Anemia, Hemolytic, Autoimmune/immunology ; COVID-19/blood ; COVID-19/complications ; COVID-19/immunology ; Fatal Outcome ; Female ; Humans ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16892
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  2. Article ; Online: Amiodarone-Associated Myxedema Coma.

    Zagorski, Emily / Jayatilaka, Sahani / Hirani, Fizza / Donato, Anthony

    The American journal of case reports

    2020  Volume 21, Page(s) e926757

    Abstract: BACKGROUND Myxedema coma is an uncommon severe thyroid disorder that is fatal in 25-60% of cases. Although the differential diagnosis for altered mental status is extensive, including many more common causes such as infection, medication changes, ... ...

    Abstract BACKGROUND Myxedema coma is an uncommon severe thyroid disorder that is fatal in 25-60% of cases. Although the differential diagnosis for altered mental status is extensive, including many more common causes such as infection, medication changes, electrolyte abnormalities, and exacerbation of chronic illnesses, profound hypothyroidism is an uncommon cause that can be overlooked. CASE REPORT We describe the case of a 71-year-old man on long-term amiodarone treatment for atrial fibrillation who presented with altered mental status initially ascribed to uremia, hyponatremia, and pneumonia. When his mental status did not resolve, thyroid tests showed his thyroid-stimulating hormone level was 89 μIU/mL, along with clinical criteria for myxedema coma. CONCLUSIONS We suggest that thyroid function tests should be considered in encephalopathic older adults on amiodarone.
    MeSH term(s) Aged ; Amiodarone/adverse effects ; Coma/chemically induced ; Humans ; Hypothyroidism ; Male ; Myxedema/chemically induced ; Myxedema/diagnosis ; Thyroid Function Tests
    Chemical Substances Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2020-10-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.926757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A rare case of Whipple's disease with endocarditis in a patient with dextrocardia.

    Sullivan, Abigayle / Shrestha, Pragya / Basnet, Sijan / Herb, Ronald / Zagorski, Emily

    SAGE open medical case reports

    2020  Volume 8, Page(s) 2050313X20936952

    Abstract: We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with ... ...

    Abstract We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with acute heart failure symptoms, including severe dyspnea on exertion and worsening lower extremity edema in the setting of immunosuppression with steroids for a year-old diagnosis of polymyalgia rheumatica. One month prior to this presentation, the patient suffered a transient ischemic attack and during the workup, his transthoracic echocardiography showed myxomatous degeneration of posterior mitral leaflet, partially flail, with severe mitral regurgitation, which required mitral valve replacement. Genome sequencing of mitral valve anterior leaflet pathology detected
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X20936952
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  5. Article ; Online: Cold agglutinin autoimmune haemolytic anaemia associated with novel coronavirus (COVID‐19)

    Zagorski, Emily / Pawar, Tushar / Rahimian, Shoja / Forman, Daniel

    British Journal of Haematology

    2020  Volume 190, Issue 4

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16892
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: A rare case of Whipple’s disease with endocarditis in a patient with dextrocardia

    Abigayle Sullivan / Pragya Shrestha / Sijan Basnet / Ronald Herb / Emily Zagorski

    SAGE Open Medical Case Reports, Vol

    2020  Volume 8

    Abstract: We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with ... ...

    Abstract We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with acute heart failure symptoms, including severe dyspnea on exertion and worsening lower extremity edema in the setting of immunosuppression with steroids for a year-old diagnosis of polymyalgia rheumatica. One month prior to this presentation, the patient suffered a transient ischemic attack and during the workup, his transthoracic echocardiography showed myxomatous degeneration of posterior mitral leaflet, partially flail, with severe mitral regurgitation, which required mitral valve replacement. Genome sequencing of mitral valve anterior leaflet pathology detected Tropheryma whipplei as a causal agent of culture-negative endocarditis. The patient was treated with 6 weeks of ceftriaxone and ampicillin–sulbactam and further continued trimethoprim–sulfamethoxazole for 1 year. He continued antibiotic treatment with resolution of shortness of breath along with arthralgia.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Retraction for Braden et al., "Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression".

    Braden, Wesley A / Lenihan, Jon M / Lan, Zhengdao / Luce, K Scott / Zagorski, William / Bosco, Emily / Reed, Michael F / Cook, Jeanette G / Knudsen, Erik S

    Molecular and cellular biology

    2020  Volume 40, Issue 17

    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00319-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: How do eye size and facet lens size vary by age and sex in Acheta domesticus?

    Zagorski, Emily R / Merry, Justin W

    Bios. 2014 Sept., v. 85, no. 3

    2014  

    Abstract: Vision is essential to interactions with the environment and survival of many animals. House crickets, Acheta domesticus, are nocturnal insects with compound apposition eyes, and thus may have a specialized visual system selected for low-light vision. ... ...

    Abstract Vision is essential to interactions with the environment and survival of many animals. House crickets, Acheta domesticus, are nocturnal insects with compound apposition eyes, and thus may have a specialized visual system selected for low-light vision. Here, an analysis of regional variation in facet diameter around the eye of a cricket was conducted. Eye surface area was estimated and facet diameter was spot-sampled across the eyes of 13 adults and 13 juveniles. Juveniles had smaller facets than adults, and there was significant variation among eye regions in facet size. Specifically, larger facets were found in the posterior eye region. Overall, facets were large given the size of this animal's eye, which is consistent with what one might expect from a nocturnal insect under selection for high sensitivity. Furthermore, juveniles had proportionally larger facets than adults, which may indicate that the insects maximize the sensitivity of their ommatidia early in development, prior to increasing facet number to enhance visual resolution. No significant sexual dimorphism was found in absolute eye size, although males achieved equivalent eye size to females despite smaller body size. Regional variation was consistent between age classes and sexes.
    Keywords Acheta domesticus ; adults ; age structure ; animals ; body size ; early development ; females ; insects ; juveniles ; males ; ommatidia ; sexual dimorphism ; surface area ; vision
    Language English
    Dates of publication 2014-09
    Size p. 151-159.
    Publishing place Beta Beta Beta Biological Society
    Document type Article
    ZDB-ID 2175911-X
    ISSN 0005-3155
    ISSN 0005-3155
    DOI 10.1893%2F0005-3155-85.3.151
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression.

    Braden, Wesley A / Lenihan, Jon M / Lan, Zhengdao / Luce, K Scott / Zagorski, William / Bosco, Emily / Reed, Michael F / Cook, Jeanette G / Knudsen, Erik S

    publication RETRACTED

    Molecular and cellular biology

    2006  Volume 26, Issue 20, Page(s) 7667–7681

    Abstract: The retinoblastoma (RB) and p16ink4a tumor suppressors are believed to function in a linear pathway that is functionally inactivated in a large fraction of human cancers. Recent studies have shown that RB plays a critical role in regulating S phase as a ... ...

    Abstract The retinoblastoma (RB) and p16ink4a tumor suppressors are believed to function in a linear pathway that is functionally inactivated in a large fraction of human cancers. Recent studies have shown that RB plays a critical role in regulating S phase as a means for suppressing aberrant proliferation and controlling genome stability. Here, we demonstrate a novel role for p16ink4a in replication control that is distinct from that of RB. Specifically, p16ink4a disrupts prereplication complex assembly by inhibiting mini-chromosome maintenance (MCM) protein loading in G1, while RB was found to disrupt replication in S phase through attenuation of PCNA function. This influence of p16ink4a on the prereplication complex was dependent on the presence of RB and the downregulation of cyclin-dependent kinase (CDK) activity. Strikingly, the inhibition of CDK2 activity was not sufficient to prevent the loading of MCM proteins onto chromatin, which supports a model wherein the composite action of multiple G1 CDK complexes regulates prereplication complex assembly. Additionally, p16ink4a attenuated the levels of the assembly factors Cdt1 and Cdc6. The enforced expression of these two licensing factors was sufficient to restore the assembly of the prereplication complex yet failed to promote S-phase progression due to the continued absence of PCNA function. Combined, these data reveal that RB and p16ink4a function through distinct pathways to inhibit the replication machinery and provide evidence that stepwise regulation of CDK activity interfaces with the replication machinery at two discrete execution points.
    MeSH term(s) Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Chromosomes/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinases/metabolism ; DNA Replication/genetics ; Gene Expression ; Humans ; Nuclear Proteins/genetics ; Protein Binding ; Retinoblastoma/genetics ; Retinoblastoma/metabolism ; S Phase ; Signal Transduction
    Chemical Substances CDC6 protein, human ; Cell Cycle Proteins ; Cyclin-Dependent Kinase Inhibitor p16 ; Nuclear Proteins ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Language English
    Publishing date 2006-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Retracted Publication
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00045-06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: How do eye size and facet lens size vary by age and sex in Acheta domesticus?

    Zagorski, Emily R. / Merry Justin W.authorDepartment of Biology, Saint Francis University, Loretto, PA 15940-0600
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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