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  1. Book ; Online: Regional innovation impact of universities

    Tijssen, Robert J. W. / Edwards, John / Jonkers, Koen

    2021  

    Author's details Robert Tijssen (Professor Emeritus of Science and Innovation Studies, Leiden University, the Netherlands and Professor, Stellenbosch University, South Africa), John Edwards (Senior Researcher, Universidade Nova de Lisboa, Portugal and Vice-President of the Policy Experimentation and Evaluation Platform), Koen Jonkers (Editor-in-Chief, European Commission, DG Joint Research Centre, Brussels, Belgium)
    Keywords GTB ; KJD ; JNMN ; JPQB ; University ; Impact ; Innovation ; Assessment ; Europe ; Regional Innovation Impact ; Smart Specialisation
    Language English
    Size 1 Online-Ressource (xxi, 216 Seiten), Illustrationen
    Publisher Edward Elgar Publishing
    Publishing place Cheltenham, Gloucestershire, UK ; Northampton MA, USA
    Publishing country Great Britain
    Document type Book ; Online
    Note English ; "Published: 14 May 2021" - Frontdoor ; Open Access
    HBZ-ID HT021047616
    ISBN 978-1-83910-053-6 ; 1-83910-053-2
    DOI 10.4337/9781839100536
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Prophages: an integral but understudied component of the human microbiome.

    Inglis, Laura K / Roach, Michael J / Edwards, Robert A

    Microbial genomics

    2024  Volume 10, Issue 1

    Abstract: Phages integrated into a bacterial genome - called prophages - continuously monitor the vigour of the host bacteria to determine when to escape the genome and to protect their host from other phage infections, and they may provide genes that promote ... ...

    Abstract Phages integrated into a bacterial genome - called prophages - continuously monitor the vigour of the host bacteria to determine when to escape the genome and to protect their host from other phage infections, and they may provide genes that promote bacterial growth. Prophages are essential to almost all microbiomes, including the human microbiome. However, most human microbiome studies have focused on bacteria, ignoring free and integrated phages, so we know little about how these prophages affect the human microbiome. To address this gap in our knowledge, we compared the prophages identified in 14 987 bacterial genomes isolated from human body sites to characterize prophage DNA in the human microbiome. Here, we show that prophage DNA is ubiquitous, comprising on average 1-5 % of each bacterial genome. The prophage content per genome varies with the isolation site on the human body, the health of the human and whether the disease was symptomatic. The presence of prophages promotes bacterial growth and sculpts the microbiome. However, the disparities caused by prophages vary throughout the body.
    MeSH term(s) Humans ; Prophages ; Bacteriophages ; Genome, Bacterial ; Microbiota ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Features and Follow-Up of the First Two Cases of Mpox From Trinidad and Tobago.

    Edwards, Robert Jeffrey / Edwards, Jonathan / Boyce, Gregory G

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53149

    Abstract: Mpox is a viral zoonotic disease that is endemic in Central and West Africa and belongs to ... ...

    Abstract Mpox is a viral zoonotic disease that is endemic in Central and West Africa and belongs to the
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prophage rates in the human microbiome vary by body site and host health.

    Inglis, Laura K / Roach, Michael J / Edwards, Robert A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Phages integrated into a bacterial genome-called prophages-continuously monitor the health of the host bacteria to determine when to escape the genome, protect their host from other phage infections, and may provide genes that promote bacterial growth. ... ...

    Abstract Phages integrated into a bacterial genome-called prophages-continuously monitor the health of the host bacteria to determine when to escape the genome, protect their host from other phage infections, and may provide genes that promote bacterial growth. Prophages are essential to almost all microbiomes, including the human microbiome. However, most human microbiome studies focus on bacteria, ignoring free and integrated phages, so we know little about how these prophages affect the human microbiome. We compared the prophages identified in 11,513 bacterial genomes isolated from human body sites to characterise prophage DNA in the human microbiome. Here, we show that prophage DNA comprised an average of 1-5% of each bacterial genome. The prophage content per genome varies with the isolation site on the human body, the health of the human, and whether the disease was symptomatic. The presence of prophages promotes bacterial growth and sculpts the microbiome. However, the disparities caused by prophages vary throughout the body.
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.04.539508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction for Picott et al., "Heterologous Expression of Active

    Picott, Katherine J / Flick, Robert / Edwards, Elizabeth A

    Applied and environmental microbiology

    2022  Volume 88, Issue 9, Page(s) e0058122

    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00581-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Structure of Nonregular Two-Level Designs

    Edwards, David J. / Mee, Robert W.

    Journal of the American Statistical Association. 2023 Apr. 3, v. 118, no. 542 p.1222-1233

    2023  

    Abstract: Two-level fractional factorial designs are often used in screening scenarios to identify active factors. This article investigates the block diagonal structure of the information matrix of nonregular two-level designs. This structure is appealing since ... ...

    Abstract Two-level fractional factorial designs are often used in screening scenarios to identify active factors. This article investigates the block diagonal structure of the information matrix of nonregular two-level designs. This structure is appealing since estimates of parameters belonging to different diagonal submatrices are uncorrelated. As such, the covariance matrix of the least squares estimates is simplified and the number of linear dependencies is reduced. We connect the block diagonal information matrix to the parallel flats design (PFD) literature and gain insights into the structure of what is estimable and/or aliased using the concept of minimal dependent sets. We show how to determine the number of parallel flats for any given design, and how to construct a design with a specified number of parallel flats. The usefulness of our construction method is illustrated by producing designs for estimation of the two-factor interaction model with three or more parallel flats. We also provide a fuller understanding of recently proposed group orthogonal supersaturated designs. Benefits of PFDs for analysis, including bias containment, are also discussed.
    Keywords Americans ; journals ; least squares ; models ; screening ; variance covariance matrix ; Bias ; Indicator function ; Interaction ; Minimal dependent set ; Parallel flats ; Supersaturated design
    Language English
    Dates of publication 2023-0403
    Size p. 1222-1233.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2064981-2
    ISSN 1537-274X
    ISSN 1537-274X
    DOI 10.1080/01621459.2021.1984927
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Insights into the solution structure of the hydrated uranyl ion from neutron scattering and EXAFS experiments.

    Edwards, Samuel J / Bowron, Daniel T / Baker, Robert J

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 36, Page(s) 13631–13635

    Abstract: The solution structure of 1.0 M Uranyl Chloride has been determined by the EPSR modelling of a combination of neutron scattering and EXAFS data. The experimental data show an equilibrium in solution between [ ... ...

    Abstract The solution structure of 1.0 M Uranyl Chloride has been determined by the EPSR modelling of a combination of neutron scattering and EXAFS data. The experimental data show an equilibrium in solution between [UO
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt02535c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Going 'Super Value' in New Zealand: cigarette pricing strategies during a period of sustained annual excise tax increases.

    Gendall, Philip / Gendall, Katherine / Branston, J Robert / Edwards, Richard / Wilson, Nick / Hoek, Janet

    Tobacco control

    2024  Volume 33, Issue 2, Page(s) 240–246

    Abstract: Background: Between 2010 and 2020, the New Zealand (NZ) Government increased tobacco excise tax by inflation plus 10% each year. We reviewed market structure changes and examined whether NZ tobacco companies shifted excise tax increases to maintain the ... ...

    Abstract Background: Between 2010 and 2020, the New Zealand (NZ) Government increased tobacco excise tax by inflation plus 10% each year. We reviewed market structure changes and examined whether NZ tobacco companies shifted excise tax increases to maintain the affordability of lower priced cigarette brands.
    Methods: We cluster-analysed market data that tobacco companies supply to the NZ Ministry of Health, created four price partitions and examined the size and share of these over time. For each partition, we analysed cigarette brand numbers and market share, calculated the volume-weighted real stick price for each year and compared this price across different price partitions. We calculated the net real retail price (price before tax) for each price partition and compared these prices before and after plain packaging took effect.
    Results: The number and market share of Super Value and Budget brands increased, while those of Everyday and Premium brands decreased. Differences between the price of Premium and Super Value brands increased, as did the net retail price difference for these partitions. Following plain packaging's implementation, Super Value brand numbers more than doubled; contrary to industry predictions, the price difference between these and higher priced brands did not narrow.
    Conclusions: Between 2010 and 2020, NZ tobacco companies introduced more Super Value cigarette brands and shifted excise tax increases to reduce the impact these had on low-priced brands. Setting a minimum retail price for cigarettes could curtail tobacco companies' ability to undermine tobacco taxation policies designed to reduce smoking.
    MeSH term(s) Humans ; New Zealand ; Commerce ; Tobacco Products ; Smoking ; Taxes ; Costs and Cost Analysis ; Tobacco Industry
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tc-2021-057232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3651: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The role of sleep disturbance in reduced accuracy on a divided attention task among patients with fibromyalgia.

    Wilson, Jenna M / Meints, Samantha M / Edwards, Robert R / Yamin, Jolin B / Moore, David J

    Pain reports

    2024  Volume 9, Issue 1, Page(s) e1

    Abstract: Introduction: Patients with fibromyalgia show impaired cognitive performance compared with healthy, pain-free controls. Sleep disturbance, anxiety, and depression are highly prevalent among patients with fibromyalgia, and each is associated with ... ...

    Abstract Introduction: Patients with fibromyalgia show impaired cognitive performance compared with healthy, pain-free controls. Sleep disturbance, anxiety, and depression are highly prevalent among patients with fibromyalgia, and each is associated with impaired cognitive performance. Yet, limited work has explored whether psychosocial factors contribute to group differences in cognitive performance.
    Objectives: This secondary data analysis investigated differences in cognitive performance between patients with fibromyalgia and healthy controls, and whether psychosocial factors accounted for these differences.
    Methods: Adults with fibromyalgia (N = 24) and healthy, pain-free controls (N = 26) completed 2 cognitive tasks and the Patient-Reported Outcomes Measurement Information System sleep disturbance, anxiety, and depression short forms. Independent samples
    Results: Patients with fibromyalgia demonstrated poorer accuracy for divided attention compared with healthy controls, and sleep disturbance mediated this group difference. On the attentional switching task, healthy controls showed a greater switch-cost for accuracy compared with patients with fibromyalgia, but there was no group difference in reaction time. Anxiety and depression were not related to cognitive performance.
    Conclusion: We found that patients with fibromyalgia reported greater sleep disturbance and, in turn, had poorer accuracy on the divided attention task. Sleep disturbance is modifiable with behavioral interventions, such as cognitive behavioral therapy, and may be a target for improving sleep quality and cognitive performance among patients with fibromyalgia.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 2471-2531
    ISSN (online) 2471-2531
    DOI 10.1097/PR9.0000000000001122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The integrated on-chip isolation and detection of circulating tumour cells.

    Abusamra, Sophia M / Barber, Robert / Sharafeldin, Mohamed / Edwards, Claire M / Davis, Jason J

    Sensors & diagnostics

    2024  Volume 3, Issue 4, Page(s) 562–584

    Abstract: Circulating tumour cells (CTCs) are cancer cells shed from a primary tumour which intravasate into the blood stream and have the potential to extravasate into distant tissues, seeding metastatic lesions. As such, they can offer important insight into ... ...

    Abstract Circulating tumour cells (CTCs) are cancer cells shed from a primary tumour which intravasate into the blood stream and have the potential to extravasate into distant tissues, seeding metastatic lesions. As such, they can offer important insight into cancer progression with their presence generally associated with a poor prognosis. The detection and enumeration of CTCs is, therefore, critical to guiding clinical decisions during treatment and providing information on disease state. CTC isolation has been investigated using a plethora of methodologies, of which immunomagnetic capture and microfluidic size-based filtration are the most impactful to date. However, the isolation and detection of CTCs from whole blood comes with many technical barriers, such as those presented by the phenotypic heterogeneity of cell surface markers, with morphological similarity to healthy blood cells, and their low relative abundance (∼1 CTC/1 billion blood cells). At present, the majority of reported methods dissociate CTC isolation from detection, a workflow which undoubtedly contributes to loss from an already sparse population. This review focuses on developments wherein isolation and detection have been integrated into a single-step, microfluidic configuration, reducing CTC loss, increasing throughput, and enabling an on-chip CTC analysis with minimal operator intervention. Particular attention is given to immune-affinity, microfluidic CTC isolation, coupled to optical, physical, and electrochemical CTC detection (quantitative or otherwise).
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2635-0998
    ISSN (online) 2635-0998
    DOI 10.1039/d3sd00302g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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