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  1. Book ; Online ; E-Book: The autoimmune diseases

    Rose, Noel R. / Mackay, Ian R.

    2020  

    Author's details edited by Noel R. Rose, Ian R. Mackay
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxiii, 1508 Seiten), Illustrationen
    Edition Sixth edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020363737
    ISBN 978-0-12-812242-6 ; 9780128121023 ; 0-12-812242-0 ; 0128121025
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online: Encyclopedia of medical immunology

    Mackay, Ian R.

    (Springer Reference)

    2014  

    Author's details Ian R. Mackay ... ed.-in-chief
    Series title Springer Reference
    Language German
    Dates of publication 2014-9999
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT018444065
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: The autoimmune diseases

    Rose, Noel R. / Mackay, Ian R.

    2014  

    Author's details ed. by Noel R. Rose ; Ian R. MacKay
    Keywords Autoimmune diseases
    Subject code 616.978
    Language English
    Size XXXIII, 1267 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018169864
    ISBN 978-0-12-384929-8 ; 9780123849304 ; 0-12-384929-2 ; 0123849306
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 720 available for loan (reading room) Lesesaal EG

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  5. Book: Intolerant bodies

    Anderson, Warwick / Mackay, Ian R.

    a short history of autoimmunity

    (Johns Hopkins biographies of disease)

    2014  

    Author's details Warwick Anderson and Ian R. Mackay
    Series title Johns Hopkins biographies of disease
    Keywords Autoimmune Diseases / history
    Language English
    Size XII, 250 S.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Physiology with obstacles -- Immunological thought styles -- A sense of unlimited possibilities -- The science of self -- Doing biographical work -- Reframing self
    HBZ-ID HT018389807
    ISBN 978-1-4214-1533-8 ; 1-4214-1533-X ; 1421415348 ; 9781421415345
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 608 available for loan (reading room) Lesesaal EG

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  6. Book ; Conference proceedings: Mechanisms of autoimmunity: a tribute to Professor Ian Mackay

    Mackay, Ian R. / Kitching, A. Richard

    a selection of papers presented at the 11th Australasian Autoimmunity Workshop ; [6 - 8 July 2007, Melbourne]

    (Journal of autoimmunity ; 31,3 = Special issue)

    2008  

    Event/congress Australasian Autoimmunity Workshop (11, 2007, Melbourne)
    Author's details guest ed.: A. Richard Kitching
    Series title Journal of autoimmunity ; 31,3 = Special issue
    Collection
    Language English
    Size S. 197 - 310: Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015850498
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2368 -31- not available for loan Zeitschriften-Lesesaal

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  7. Article ; Online: Designing profitable and climate-smart farms using virtual reality.

    Lasseur, Remy / Laurenson, Seth / Ali, Mohsin / Loh, Ian / Mackay, Mike

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286723

    Abstract: Many pastoral farmers are searching for ways to lower the carbon emission footprint that is generated by livestock. Planting trees on the farm is currently a popular option for farmers to offset their emissions yet requires knowledge of suitable tree ... ...

    Abstract Many pastoral farmers are searching for ways to lower the carbon emission footprint that is generated by livestock. Planting trees on the farm is currently a popular option for farmers to offset their emissions yet requires knowledge of suitable tree species and locations to plant them. This paper describes a decision-support tool aimed at helping farmers to create and visualise different planting designs while balancing the objectives of sequestering carbon and maintaining farm profitability. We take an innovative approach by combining virtual reality technology with biophysical models to create an environment where the user can actively create virtual future farm scenarios. Through the creation process, the user can simultaneously balance multiple objectives including farm aesthetics, economic returns, business and environmental ambitions, and carbon emissions (net) balance. For this proof-of-concept study, we incorporate virtual reality technology in Unreal Engine, environmental and financial data, and high-resolution spatial layers from an operational 400-hectare livestock farm in New Zealand.
    MeSH term(s) Animals ; Humans ; Farms ; Dairying ; Farmers ; Livestock ; Virtual Reality ; Carbon
    Chemical Substances Carbon (7440-44-0)
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Autoimmune hepatitis: what must be said.

    Mackay, Ian R

    Experimental and molecular pathology

    2012  Volume 93, Issue 3, Page(s) 350–353

    Abstract: Autoimmune hepatitis (AIH) was first studied under its earlier name of "chronic active hepatitis" (CAH) from the 1950s, coincident with a renaissance of interest in autoimmunity. The definition of autoimmune serum reactants in disease, including CAH, ... ...

    Abstract Autoimmune hepatitis (AIH) was first studied under its earlier name of "chronic active hepatitis" (CAH) from the 1950s, coincident with a renaissance of interest in autoimmunity. The definition of autoimmune serum reactants in disease, including CAH, gave new insights into chronic hepatitis and liver cirrhosis, and led to refinements of Burnet's clonal selection theory of acquired immunity, 1957-59. Various discoveries including serological reactants in CAH prompted its designation in 1965 as autoimmune hepatitis, and treatment with immunosuppressive drug regimens transformed outcomes and survival. Serological observations further indicated that AIH could exist as either of two types, clinically similar but genetically different: Type 1 aligned more with the non-organ-specific multisystem diseases, and the infrequent Type 2 more with the organ-specific diseases. However, events in either type that could explain the onset of autoimmunity in the normally tolerogenic milieu of the liver have not been discerned. In the genetically predisposed individual, initiation may depend on non-specific death of hepatocytes after which fragments derived from disordered apoptosis acquire the capacity for ongoing auto-immunogenic stimulation. Insufficiency in numbers and function of Treg populations appears important in the promotion of this autoimmune process.
    MeSH term(s) Autoimmunity/immunology ; Genetic Predisposition to Disease ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/genetics ; Hepatitis, Autoimmune/immunology ; Humans ; Immune Tolerance ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2012-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2012.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 183: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A 50-year experience with autoimmune hepatitis: and where are we now?

    Mackay, Ian R

    Journal of gastroenterology

    2010  Volume 46 Suppl 1, Page(s) 17–28

    Abstract: Background: Autoimmune hepatitis (AIH) as chronic active hepatitis became recognized in the 1940s as a progressive hyperglobulinemic disease affecting younger women attributed to persisting virus infection of the liver: autoimmunity then was barely on ... ...

    Abstract Background: Autoimmune hepatitis (AIH) as chronic active hepatitis became recognized in the 1940s as a progressive hyperglobulinemic disease affecting younger women attributed to persisting virus infection of the liver: autoimmunity then was barely on the horizon.
    Early observations: The lupus erythematosus (LE) cell reported in 1948 signified the presence of antinuclear autoantibodies, promoting perceptions of autoimmunity in certain chronic diseases. Recognition of LE cells in chronic hepatitis led to the designation of 'lupoid hepatitis', with autoimmunity further substantiated by anti-cytoplasmic autoantibodies detected by complement fixation. Next a serum reactant with smooth muscle of rodent stomach was found to have a wider distribution and became identified as an autoantibody to filamentous (F) actin. Therapy with corticosteroids proved effective, particularly combined with azathioprine. Various trials showed greatly improved survival and established modern therapy of AIH. An HLA-based predisposition (B8, DR3) was the first pointer to a genetic etiology.
    Recent advances: Recombinant or purified autoantigenic substrates have led to automated assays, which, together with improved immunofluorescence procedures, allow serological confidence in diagnosis and institution of effective immunosuppressive therapies. The liver-kidney 'microsomal' autoantigen reactive with cytochrome P450 2D6 distinguishes two serological types of AIH that appear pathogenetically distinct. Molecular characterization of antigens and epitopes remains wanting in type 1 AIH.
    Future prospects: The challenge remains with both types of AIH to elucidate in molecular terms the genetic and environmental basis of pathogenesis from initiation to ultimate progression and cirrhosis (when inadequately treated). Advancing technologies are bringing this goal closer to being attainable.
    MeSH term(s) Age Factors ; Antibodies, Antinuclear/immunology ; Disease Progression ; Female ; Genetic Predisposition to Disease ; Glucocorticoids/therapeutic use ; HLA Antigens/immunology ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/genetics ; Hepatitis, Autoimmune/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Sex Factors
    Chemical Substances Antibodies, Antinuclear ; Glucocorticoids ; HLA Antigens ; Immunosuppressive Agents
    Language English
    Publishing date 2010-11-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-010-0325-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 620: Show issues Location:
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  10. Article ; Online: Travels and travails of autoimmunity: a historical journey from discovery to rediscovery.

    Mackay, Ian R

    Autoimmunity reviews

    2010  Volume 9, Issue 5, Page(s) A251–8

    Abstract: Consideration on autoimmunity began, as did immunology itself, around year 1900, first with Ehrlich's doctrine of 'horror autotoxicus', then interpreted as 'autoimmunity cannot happen'. Yet by 1904 the antibody nature of the autohemolysin responsible for ...

    Abstract Consideration on autoimmunity began, as did immunology itself, around year 1900, first with Ehrlich's doctrine of 'horror autotoxicus', then interpreted as 'autoimmunity cannot happen'. Yet by 1904 the antibody nature of the autohemolysin responsible for cold hemoglobinuria was described, and soon confirmed, but without generating any durable concept on autoimmunization as a cause of disease. Reasons included Ehrlich's doctrine, the particular directions that immunology was to take after the initial advances, and a greater preoccupation with bodily responses to extrinsic rather than autologous substances. So, during 1915-1945, autoimmunity underwent a long eclipse despite, during this time, some potentially telling studies relating to brain, kidney and other diseases. The 'awakening' dates from 1945 when a general theoretical concept did appear feasible. Knowledge accrued from applications of several research undertakings mostly for purposes quite unrelated to the proof of autoimmunization: the use of adjuvants; the Coombes anti-globulin reaction; the Waaler-Rose rheumatoid factor; Hargraves' LE cell; the Witebsky-Rose experimental induction of thyroiditis with autologous thyroid gland, and others. By the early 1960s resistance to the idea of autoimmunization had weakened, perhaps hastened by a monograph on autoimmune disease published in 1963, and surely by the consensus reached at a large international conference published as proceedings in 1965. This present conspectus arbitrarily concludes at year 1965, recognizing that the history of autoimmunity even now is far from over.
    MeSH term(s) Animals ; Autoimmune Diseases/history ; Autoimmune Diseases/immunology ; Autoimmunity/immunology ; Hemoglobinuria, Paroxysmal/immunology ; History, 20th Century ; Humans ; Kidney/immunology ; Mice ; Rheumatoid Factor/immunology ; Thyroid Gland/immunology
    Chemical Substances Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2010-03
    Publishing country Netherlands
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2009.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5913: Show issues Location:
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