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  1. Article ; Online: False-positive anti-PLA2R ELISA testing in patients with diabetes mellitus.

    Caza, Tiffany N / Larsen, Christopher P

    Kidney international

    2023  Volume 103, Issue 2, Page(s) 425

    MeSH term(s) Humans ; Enzyme-Linked Immunosorbent Assay ; Glomerulonephritis, Membranous ; Receptors, Phospholipase A2 ; Diabetes Mellitus/diagnosis ; Autoantibodies
    Chemical Substances Receptors, Phospholipase A2 ; Autoantibodies
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.11.004
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    Zs.A 797: Show issues Location:
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  2. Article ; Online: Serologic Studies in Membranous Nephropathy: Novel Strategies and Strengthened Associations.

    Caza, Tiffany N / Larsen, Christopher P

    Kidney360

    2022  Volume 4, Issue 2, Page(s) 128–130

    MeSH term(s) Humans ; Glomerulonephritis, Membranous ; Serologic Tests
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lipoic acid in neural epidermal growth factor-like 1-associated membranous nephropathy: more than a coincidence?

    Caza, Tiffany N / Larsen, Christopher P

    Kidney international

    2022  Volume 101, Issue 2, Page(s) 418–419

    MeSH term(s) EGF Family of Proteins ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Humans ; Kidney ; Receptors, Phospholipase A2 ; Thioctic Acid/adverse effects
    Chemical Substances EGF Family of Proteins ; Receptors, Phospholipase A2 ; Thioctic Acid (73Y7P0K73Y)
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.12.001
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  4. Article ; Online: Nephronophthisis: a pathological and genetic perspective.

    Wolf, Matthias T F / Bonsib, Stephen M / Larsen, Christopher P / Hildebrandt, Friedhelm

    Pediatric nephrology (Berlin, Germany)

    2023  

    Abstract: Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most frequent genetic causes for kidney failure (KF) in children and adolescents. Over 20 genes cause NPHP and over 90 genes contribute to renal ciliopathies often ... ...

    Abstract Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most frequent genetic causes for kidney failure (KF) in children and adolescents. Over 20 genes cause NPHP and over 90 genes contribute to renal ciliopathies often involving multiple organs. About 15-20% of NPHP patients have additional extrarenal symptoms affecting other organs than the kidneys. The involvement of additional organ systems in syndromic forms of NPHP is explained by shared expression of most NPHP gene products in centrosomes and primary cilia, a sensory organelle present in most mammalian cells. This finding resulted in the classification of NPHP as a ciliopathy. If extrarenal symptoms are present in addition to NPHP, these disorders are defined as NPHP-related ciliopathies (NPHP-RC) and can involve the retina (e.g., with Senior-Løken syndrome), CNS (central nervous system) (e.g., with Joubert syndrome), liver (e.g., Boichis and Arima syndromes), or bone (e.g., Mainzer-Saldino and Sensenbrenner syndromes). This review focuses on the pathological findings and the recent genetic advances in NPHP and NPHP-RC. Different mechanisms and signaling pathways are involved in NPHP ranging from planar cell polarity, sonic hedgehog signaling (Shh), DNA damage response pathway, Hippo, mTOR, and cAMP signaling. A number of therapeutic interventions appear to be promising, ranging from vasopressin receptor 2 antagonists such as tolvaptan, cyclin-dependent kinase inhibitors such as roscovitine, Hh agonists such as purmorphamine, and mTOR inhibitors such as rapamycin.
    Language English
    Publishing date 2023-11-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06174-8
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    Zs.A 2196: Show issues Location:
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  5. Article ; Online: EXT1 and NCAM1-associated membranous lupus nephritis in a cohort of patients undergoing repeat kidney biopsies.

    Miller, Paul P / Caza, Tiffany / Larsen, Christopher P / Charu, Vivek

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 38, Issue 2, Page(s) 396–404

    Abstract: ... had a higher average estimated glomerular filtration rate (eGFR; 141 versus 108 mL/min/1.73 m2; P = 0 ... 04), lower average percent global glomerulosclerosis (0.5 versus 12%; P = 0.05), lower average ... interstitial fibrosis and tubular atrophy (2.5 versus 11.7%; P = 0.06) and lower average total National ...

    Abstract Background: Exostosin 1/2 (EXT1/2) and neural cell adhesion molecule 1 (NCAM1) associated membranous lupus nephritis (MLN) may represent distinct disease phenotypes with prognostic significance.
    Methods: We searched our archives for patients with systemic lupus erythematous (SLE) and at least two kidney biopsies demonstrating MLN. Each biopsy was stained for EXT1 and NCAM1 and scored as positive or negative. Histopathologic and clinical data were reviewed.
    Results: We identified 31 patients with a clinical diagnosis of SLE and at least two kidney biopsies with MLN. A total of 28 patients (90%) showed concordant staining for EXT1 and NCAM1 in both biopsies; 8 patients (26%) were EXT1 positive and NCAM1 negative, 18 patients (58%) were EXT1 negative and NCAM1 negative and 2 patients (7%) were EXT1 negative and NCAM1 positive. A total of three patients (10%) had discordant EXT1 staining between their first and last biopsies; two patients (7%) were EXT1 positive in their first biopsy and EXT1 negative in the last biopsy and one patient (3%) was EXT1 negative in his first biopsy and EXT1 positive in the last biopsy. Compared with the EXT1-negative cohort at the time of the first biopsy, the EXT1-positive cohort had a higher average estimated glomerular filtration rate (eGFR; 141 versus 108 mL/min/1.73 m2; P = 0.04), lower average percent global glomerulosclerosis (0.5 versus 12%; P = 0.05), lower average interstitial fibrosis and tubular atrophy (2.5 versus 11.7%; P = 0.06) and lower average total National Institutes of Health (NH) chronicity scores (0.75 versus 2.33; P = 0.05). On long-term follow-up, the rate of change in eGFR did not significantly differ between the two groups (P = 0.24). One EXT1-positive patient (12.5%) developed stage 4 chronic kidney disease (CKD) or end-stage kidney disease (ESKD) compared with four patients (20%) in the EXT-negative group and two of the three EXT1-discordant patients (P = 0.38).
    Conclusions: We performed the largest retrospective repeat-biopsy study to evaluate EXT1 and NCAM1 autoantigens in MLN. Our data demonstrate that EXT1 positivity is associated with better kidney function at the time of diagnosis and raises the possibility that EXT1 status may change throughout the disease course of MLN.
    MeSH term(s) Humans ; Lupus Nephritis/pathology ; Retrospective Studies ; Glomerulonephritis, Membranous/pathology ; Lupus Erythematosus, Systemic/pathology ; Biopsy ; Kidney/pathology ; Neural Cell Adhesion Molecules ; CD56 Antigen
    Chemical Substances Neural Cell Adhesion Molecules ; NCAM1 protein, human ; CD56 Antigen
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac058
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  6. Article ; Online: Author Correction: COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19.

    Velez, Juan Carlos Q / Caza, Tiffany / Larsen, Christopher P

    Nature reviews. Nephrology

    2020  Volume 16, Issue 10, Page(s) 614

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00341-y
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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  7. Article ; Online: Associations Between Dietary Patterns and Kidney Health Assessed in the Population-Based CHRIS Study Using Reduced Rank Regression.

    Barbieri, Giulia / Garcia-Larsen, Vanessa / Lundin, Rebecca / Fujii, Ryosuke / Melotti, Roberto / Gögele, Martin / Christopher, Kenneth B / Cazzoletti, Lucia / Pramstaller, Peter P / Zanolin, Maria Elisabetta / Pattaro, Cristian / Hantikainen, Essi

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2024  

    Abstract: Objective: While diet plays a key role in chronic kidney disease (CKD) management, the potential for diet to impact CKD prevention in the general population is less clear. Using a priori knowledge, we derived disease-related dietary patterns (DPs) ... ...

    Abstract Objective: While diet plays a key role in chronic kidney disease (CKD) management, the potential for diet to impact CKD prevention in the general population is less clear. Using a priori knowledge, we derived disease-related dietary patterns (DPs) through reduced rank regression (RRR) and investigated associations with kidney function, separately focusing on generally healthy individuals and those with self-reported kidney diseases, hypertension, or diabetes mellitus.
    Methods: Eight thousand six hundred eighty-six participants from the population-based Cooperative Health Research in South Tyrol study were split into a group free of kidney disease, hypertension and diabetes (n = 6,133) and a group with any of the 3 conditions (n = 2,553). Diet was assessed through the self-administered Global Allergy and Asthma Network of Excellence food frequency questionnaire and DPs were derived through RRR selecting food frequency questionnaire-derived sodium, potassium, phosphorus, and protein intake as mediators. Outcomes were creatinine-based estimated glomerular filtration rate, urinary albumin-to-creatinine ratio, CKD and microalbuminuria. Multiple linear and logistic models were used to assess associations between RRR-based DPs and kidney outcomes separately in the 2 analytic groups.
    Results: We identified 3 DPs, where high adherence reflected high levels of all nutrients (DP1), high potassium-phosphorus and low protein-sodium levels (DP2), and low potassium-sodium and high protein-phosphorus levels (DP3), respectively. We observed heterogeneous associations with kidney outcomes, varying by analytic group and sex. Kidney outcomes were much more strongly associated with DPs than with single nutrients.
    Conclusion: RRR is a feasible approach to estimate disease-related DPs and explore the combined effects of nutrients on kidney health. Heterogeneous associations across kidney outcomes suggest possible specificity to kidney function or damage. In individuals reporting kidney disease, hypertension or diabetes, specific dietary habits were associated with better kidney health, indicating that disease-specific dietary interventions can be effective for disease control.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2024.03.003
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    Zs.A 3273: Show issues Location:
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  8. Article ; Online: Infantile Nephrocalcinosis Resulting From a Pathogenic CYP24A1 Mutation.

    Murphy, Joel D / Joseph, Mark / Larsen, Christopher P

    Kidney international reports

    2019  Volume 4, Issue 6, Page(s) 893–897

    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2019.04.016
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  9. Article ; Online: COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19.

    Velez, Juan Carlos Q / Caza, Tiffany / Larsen, Christopher P

    Nature reviews. Nephrology

    2020  Volume 16, Issue 10, Page(s) 565–567

    MeSH term(s) AIDS-Associated Nephropathy/epidemiology ; AIDS-Associated Nephropathy/etiology ; AIDS-Associated Nephropathy/genetics ; Apolipoprotein L1/genetics ; Apolipoprotein L1/metabolism ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; DNA/genetics ; Global Health ; Humans ; Incidence ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Polymorphism, Single Nucleotide ; SARS-CoV-2
    Chemical Substances APOL1 protein, human ; Apolipoprotein L1 ; DNA (9007-49-2)
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-0332-3
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  10. Article ; Online: Renal Manifestations of Inflammatory Bowel Disease.

    Ambruzs, Josephine M / Larsen, Christopher P

    Rheumatic diseases clinics of North America

    2018  Volume 44, Issue 4, Page(s) 699–714

    Abstract: Renal and urinary involvement has been reported to occur in 4% to 23% of inflammatory bowel disease (IBD) patients. Parenchymal renal disease is rare and most commonly affects glomerular and tubulointerstitial compartments. The most common findings on ... ...

    Abstract Renal and urinary involvement has been reported to occur in 4% to 23% of inflammatory bowel disease (IBD) patients. Parenchymal renal disease is rare and most commonly affects glomerular and tubulointerstitial compartments. The most common findings on renal biopsy of IBD patients are IgA nephropathy and tubulointerstitial nephritis. Overall morbidity of IBD-related renal manifestations is significant, and there is often only a short window of injury reversibility. This, along with subtle clinical presentation, requires a high index of suspicion and routine monitoring of renal function. There are no established guidelines for the optimal screening and monitoring of renal function in IBD patients.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/physiopathology ; Pain/diagnosis ; Pain/etiology ; Pain Management
    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2018.06.007
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