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  1. Article ; Online: Is antibiotic exposure associated with an increased risk of developing necrotizing enterocolitis and bronchopulmonary dysplasia in very low birth weight infants?

    Kuo, Shu-Chen / Chen, Shu-Fen / Wang, Peng-Hui

    Journal of the Chinese Medical Association : JCMA

    2022  Volume 85, Issue 12, Page(s) 1160–1161

    Language English
    Publishing date 2022-10-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000821
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2699: Show issues Location:
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  2. Article ; Online: Letter to the Editor: Appropriate timing for the removal of urinary catheter after laparoscopic surgery for benign gynecologic diseases may still be uncertain.

    Chen, Shu-Fen / Kuo, Shu-Chen / Wang, Peng-Hui

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2022  Volume 158, Issue 3, Page(s) 766–768

    MeSH term(s) Device Removal ; Female ; Genital Diseases, Female/surgery ; Gynecologic Surgical Procedures ; Humans ; Laparoscopy ; Urinary Catheterization ; Urinary Catheters/adverse effects
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14330
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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  3. Article ; Online: Pregnant women with COVID-19.

    Lee, Wen-Ling / Kuo, Shu-Chen / Wang, Peng-Hui

    Taiwanese journal of obstetrics & gynecology

    2022  Volume 61, Issue 2, Page(s) 197–198

    MeSH term(s) COVID-19 ; Female ; Humans ; Pregnancy ; Pregnant Women
    Language English
    Publishing date 2022-02-10
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 2202946-1
    ISSN 1875-6263 ; 1875-6263
    ISSN (online) 1875-6263
    ISSN 1875-6263
    DOI 10.1016/j.tjog.2022.02.003
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  4. Article: [Legal Liability for Negligence: Nurse Aides Working in Hospitals].

    Kuo, Shu-Chen / Lay, Huey-Jen

    Hu li za zhi The journal of nursing

    2021  Volume 68, Issue 4, Page(s) 14–22

    Abstract: Nurse aides are the most important direct-care providers and are indispensable in caring for hospitalized patients. Most of the hospitalized patients who need care in their daily lives hire nurse aides as regular caregivers. Care work involves numerous ... ...

    Abstract Nurse aides are the most important direct-care providers and are indispensable in caring for hospitalized patients. Most of the hospitalized patients who need care in their daily lives hire nurse aides as regular caregivers. Care work involves numerous risks, and negligent care that results in patient injury may put a nurse aid caregiver at risk of litigation. To help nurse aides better understand their care duties, the concept of risk and prevention in care and three civil lawsuit cases involving negligence in care are presented in this paper. In the legal cases, the nurse aides were found guilty of causing death or injury due to negligence, highlighting that these caregivers did not meet their duty of care in providing care to their patients. These cases are used to analyze the causes of care negligence and the types of negligence and to propose preventive strategies for hospitals, care providers, and nurse aides to implement preventive measures and enforce self-autonomy. In addition, regular government programs focused on inspection, supervision, and accreditation can strengthen the supervision and responsibilities of hospitals. Nurse aides are expected to fulfill their care duties and develop ethical norms as well as internalize these into their personal beliefs as the framework for providing care. It is hoped that nurse aides will understand and fulfill their care duties to prevent patient injury or death due to negligence as part of their duty to protect patient rights.
    MeSH term(s) Hospitals ; Humans ; Liability, Legal ; Malpractice ; Nursing Assistants
    Language Chinese
    Publishing date 2021-08-02
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ISSN 0047-262X
    ISSN 0047-262X
    DOI 10.6224/JN.202108_68(4).03
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  5. Article ; Online: The effects of maternal body weight and gestational diabetes mellitus on the risk of the delivery of large-for-gestational age babies: Synergistic or additive?

    Kuo, Shu-Chen / Lee, Wen-Ling / Wang, Peng-Hui

    Taiwanese journal of obstetrics & gynecology

    2022  Volume 61, Issue 3, Page(s) 413–414

    MeSH term(s) Birth Weight ; Body Mass Index ; Body Weight ; Diabetes, Gestational ; Female ; Gestational Age ; Humans ; Pregnancy ; Weight Gain
    Language English
    Publishing date 2022-05-20
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 2202946-1
    ISSN 1875-6263 ; 1875-6263
    ISSN (online) 1875-6263
    ISSN 1875-6263
    DOI 10.1016/j.tjog.2022.03.004
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  6. Article: Factors associated with the utilization of antenatal care services among pregnant women in Eswatini - A cross-sectional study.

    Mkhonta, Zama / Lu, Yu-Ying / Kuo, Shu-Chen / Liu, Chieh-Yu

    African journal of reproductive health

    2023  Volume 26, Issue 12, Page(s) 67–77

    Abstract: The study aimed to assess the utilization of antenatal care services and its associated factors among pregnant women in Eswatini. A cross-sectional study was adopted. Convenience sampling was conducted in a public referral hospital in central Eswatini ... ...

    Abstract The study aimed to assess the utilization of antenatal care services and its associated factors among pregnant women in Eswatini. A cross-sectional study was adopted. Convenience sampling was conducted in a public referral hospital in central Eswatini from 1st of August to the 30 of September 2021. A total of 400 newly delivered women who met the inclusion criteria were recruited. SPSS version 22.0 was used to analyze data including descriptive and bivariate analysis. Results indicated that only 13% of pregnant women booked their first ANC in the first trimester and 24.8% of them attended less than four ANC visits. Maternal education, gestational age, gravity, pregnant-related complications, medical history, and maternal health literacy were significantly associated with the utilization of ANC services (p < .05). To increase the utilization of ANC service, healthcare professionals should pay special attention to pregnant women with tertiary education, gave birth below 38 weeks, multi-gravities, medical history, and poor maternal health literacy.
    MeSH term(s) Female ; Pregnancy ; Humans ; Prenatal Care/methods ; Pregnant Women ; Cross-Sectional Studies ; Eswatini ; Parturition ; Patient Acceptance of Health Care ; Ethiopia
    Language English
    Publishing date 2023-08-16
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 2111906-5
    ISSN 1118-4841
    ISSN 1118-4841
    DOI 10.29063/ajrh2022/v26i12.8
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  7. Article ; Online: Effectiveness of empathic caring on stress and depression for women with recurrent miscarriage: A randomized controlled trial.

    Chang, Shu-Chen / Kuo, Pao-Lin / Chen, Chung-Hey

    Complementary therapies in clinical practice

    2021  Volume 43, Page(s) 101367

    Abstract: Aim: The purpose of this study was to investigate the effectiveness of empathic caring on sleep quality, depression, stress, and social support in women with recurrent miscarriage.: Materials and methods: Sixty-two eligible women were randomly ... ...

    Abstract Aim: The purpose of this study was to investigate the effectiveness of empathic caring on sleep quality, depression, stress, and social support in women with recurrent miscarriage.
    Materials and methods: Sixty-two eligible women were randomly assigned to either the experimental group (n = 31), which received three face-to-face nursing counseling sessions, or the control group (n = 31). Outcome measures included the Pittsburgh Sleep Quality Index, Edinburgh Prenatal Depression Scale, Perceived Stress Scale, and Interpersonal Support Evaluation List.
    Results: Paired-sample t-tests revealed that, after receiving nursing counseling, the participants in the experimental group showed significant decreases in stress and depression. However, no significant mean differences were found in the control group between the pretest and the 12-week posttest for any of the four outcome measures.
    Conclusion: Clinical healthcare professionals may incorporate empathic caring into health-promotion protocols to assist women with recurrent miscarriage to improve their psychosocial health.
    MeSH term(s) Abortion, Habitual/therapy ; Counseling ; Depression/therapy ; Empathy ; Female ; Humans ; Pregnancy ; Social Support
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2182834-9
    ISSN 1873-6947 ; 1744-3881
    ISSN (online) 1873-6947
    ISSN 1744-3881
    DOI 10.1016/j.ctcp.2021.101367
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4912: Show issues Location:
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  8. Article ; Online: Gypenoside XIII regulates lipid metabolism in HepG2 hepatocytes and ameliorates nonalcoholic steatohepatitis in mice.

    Cheng, Shu-Chen / Liou, Chian-Jiun / Wu, Ya-Xuan / Yeh, Kuo-Wei / Chen, Li-Chen / Huang, Wen-Chung

    The Kaohsiung journal of medical sciences

    2024  Volume 40, Issue 3, Page(s) 280–290

    Abstract: Gypenoside XIII is isolated from Gynostemma pentaphyllum (Thunb.) Makino. In mice, G. pentaphyllum extract and gypenoside LXXV have been shown to improve non-alcoholic steatohepatitis (NASH). This study investigated whether gypenoside XIII can regulate ... ...

    Abstract Gypenoside XIII is isolated from Gynostemma pentaphyllum (Thunb.) Makino. In mice, G. pentaphyllum extract and gypenoside LXXV have been shown to improve non-alcoholic steatohepatitis (NASH). This study investigated whether gypenoside XIII can regulate lipid accumulation in fatty liver cells or attenuate NASH in mice. We used HepG2 hepatocytes to establish a fatty liver cell model using 0.5 mM oleic acid. Fatty liver cells were treated with different concentrations of gypenoside XIII to evaluate the molecular mechanisms of lipid metabolism. In addition, a methionine/choline-deficient diet induced NASH in C57BL/6 mice, which were given 10 mg/kg gypenoside XIII by intraperitoneal injection. In fatty liver cells, gypenoside XIII effectively suppressed lipid accumulation and lipid peroxidation. Furthermore, gypenoside XIII significantly increased SIRT1 and AMPK phosphorylation to decrease acetyl-CoA carboxylase phosphorylation, reducing fatty acid synthesis activity. Gypenoside XIII also decreased lipogenesis by suppressing sterol regulatory element-binding protein 1c and fatty acid synthase production. Gypenoside XIII also increased lipolysis and fatty acid β-oxidation by promoting adipose triglyceride lipase and carnitine palmitoyltransferase 1, respectively. In an animal model of NASH, gypenoside XIII effectively decreased the lipid vacuole size and number and reduced liver fibrosis and inflammation. These findings suggest that gypenoside XIII can regulate lipid metabolism in fatty liver cells and improve liver fibrosis in NASH mice. Therefore, gypenoside XIII has potential as a novel agent for the treatment of NASH.
    MeSH term(s) Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Lipid Metabolism ; Gynostemma/chemistry ; Gynostemma/metabolism ; Mice, Inbred C57BL ; Hepatocytes/metabolism ; Fatty Acids/metabolism ; Fatty Acids/pharmacology ; Lipids/pharmacology ; Liver Cirrhosis/metabolism ; Liver/metabolism ; Plant Extracts
    Chemical Substances gypenoside ; Fatty Acids ; Lipids ; Plant Extracts
    Language English
    Publishing date 2024-01-31
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12795
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3187: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Tolerized Microglia Protect Neurons Against Endotoxin-Induced TNF-α Production via an LBP-Dependent Intracellular p38 MAPK Signaling Pathway.

    Kuo, Hsing-Chun / Chen, Shiou-Lan / Chiu, Shu-Chen / Lee, Kam-Fai / Chu, Chun-Hsien

    Inflammation

    2023  Volume 46, Issue 5, Page(s) 2011–2023

    Abstract: The development of microglial endotoxin tolerance (ET) is a critical event in protecting neurons against excessive immune responses when microglia are administered two consecutive lipopolysaccharide (LPS) challenges. However, the intrinsic mechanisms of ... ...

    Abstract The development of microglial endotoxin tolerance (ET) is a critical event in protecting neurons against excessive immune responses when microglia are administered two consecutive lipopolysaccharide (LPS) challenges. However, the intrinsic mechanisms of microglia shape ET programs and protect neurons remain unclear. This study aimed to determine whether extracellular autocrine cascades or intracellular signaling pathways are involved in ET microglia-mediated tumor necrosis factor-alpha (TNF-α) reduction and neuroprotection. Neuron-glia cultures composed of astroglia, neurons, and microglia were performed in different conditions: with or without serum or LPS-binding proteins (LBP), along with an induction approach of ET. Enzyme-linked immunosorbent assay results revealed that LPS induced TNF-α tolerance of microglia in an LBP-dependent manner. Furthermore, we determined whether the early pro-inflammatory cytokines induced by LPS might contribute to the development of microglial ET. Our data showed that the neutralization of TNF-α using an anti-TNF-α antibody had no change in the TNF-α tolerance of microglia during the ET challenge. Furthermore, pre-incubation of TNF-α, interleukin-1 beta, and prostaglandin E2 failed to induce any TNF-α tolerance in microglia after LPS treatment. Moreover, using three specific chemical inhibitors that respectively blocked the activities of the mitogen-activated protein kinases (MAPKs) namely p38, c-Jun N-terminal kinase and extracellular signal-related kinases revealed that inhibition of p38 MAPK by SB203580 disrupted the tolerated microglia-mediated TNF-α reduction and neuroprotection. In summary, our findings demonstrated that the LPS pre-treatment immediately programmed the microglial ET to prevent endotoxin-induced TNF-α production and neuronal damage through the intracellular p38 MAPK signaling pathway.
    MeSH term(s) Endotoxins/toxicity ; Lipopolysaccharides ; MAP Kinase Signaling System ; Microglia/metabolism ; Neurons/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; Signal Transduction ; Tumor Necrosis Factor Inhibitors/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Endotoxins ; Lipopolysaccharides ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-023-01858-7
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    Zs.A 1401: Show issues Location:
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  10. Article: Terminalia catappa

    Chang, Chin-Kuo / Chu, Shu-Chen / Huang, Jing-Yang / Chen, Pei-Ni / Hsieh, Yih-Shou

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 963589

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.963589
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