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  1. Article ; Online: Comments on "human-climate interaction during the Early Upper Paleolithic: testing the hypothesis of an adaptive shift between the Proto-Aurignacian and the Early Aurignacian" by William E. Banks, Francesco d'Errico, João Zilhão.

    Ronchitelli, Annamaria / Benazzi, Stefano / Boscato, Paolo / Douka, Katerina / Moroni, Adriana

    Journal of human evolution

    2014  Volume 73, Page(s) 107–111

    MeSH term(s) Climate ; Fossils ; Humans ; Models, Biological
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Comment ; News
    ZDB-ID 120141-4
    ISSN 1095-8606 ; 0047-2484
    ISSN (online) 1095-8606
    ISSN 0047-2484
    DOI 10.1016/j.jhevol.2013.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 976: Show issues Location:
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  2. Article ; Online: Autosomal Dominant Polycystic Kidney Disease: Is There a Role for Autophagy?

    Ponticelli, Claudio / Moroni, Gabriella / Reggiani, Francesco

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disorder initiated by mutations in ... ...

    Abstract Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disorder initiated by mutations in either
    MeSH term(s) Humans ; Aged ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/genetics ; Epithelial-Mesenchymal Transition ; Kidney ; Autophagy ; Cysts
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914666
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  3. Article: Monoclonal gammopathy in lupus nephritis.

    Donato, Beatriz / Reggiani, Francesco / Calatroni, Marta / Angelini, Claudio / Moroni, Gabriella

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 9, Page(s) 1940–1941

    MeSH term(s) Humans ; Lupus Nephritis/complications ; Lupus Nephritis/drug therapy ; Paraproteinemias/complications
    Language English
    Publishing date 2023-05-15
    Publishing country Italy
    Document type Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/mqfpi4
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    Zs.A 2002: Show issues Location:
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  4. Article ; Online: Anti-inflammatory (Colchicine) Treatment for Secondary Prevention in Coronary Artery Disease: A Milestone has Been Met.

    Moroni, Francesco / Abbate, Antonio

    Journal of cardiovascular pharmacology

    2023  Volume 82, Issue 4, Page(s) 237–240

    MeSH term(s) Humans ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/prevention & control ; Coronary Artery Disease/complications ; Colchicine/therapeutic use ; Secondary Prevention ; Anti-Inflammatory Agents/adverse effects ; Inflammation/drug therapy
    Chemical Substances Colchicine (SML2Y3J35T) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001467
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  5. Article ; Online: Transcatheter Pulmonary Valve Implantation in Repaired Tetralogy of Fallot and Anomalous Left Coronary Artery Origin.

    Moroni, Alice / Giugno, Luca / Sturla, Francesco / Oliva, Omar Alessandro / Carminati, Mario

    JACC. Case reports

    2024  Volume 29, Issue 6, Page(s) 102247

    Abstract: We describe a rare and extremely challenging case of transcatheter pulmonary valve implantation in repaired tetralogy of Fallot and anomalous origin of the left main coronary artery from the right coronary sinus. Procedural planning based on advanced ... ...

    Abstract We describe a rare and extremely challenging case of transcatheter pulmonary valve implantation in repaired tetralogy of Fallot and anomalous origin of the left main coronary artery from the right coronary sinus. Procedural planning based on advanced multimodality imaging and 3-dimensional technology proved to be the key to procedural success.
    Language English
    Publishing date 2024-02-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102247
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  6. Article ; Online: Autophagy: A Silent Protagonist in Kidney Transplantation.

    Ponticelli, Claudio / Reggiani, Francesco / Moroni, Gabriella

    Transplantation

    2023  

    Abstract: Autophagy is a lysosome-dependent regulated mechanism that recycles unnecessary cytoplasmic components. It is now known that autophagy dysfunction may have a pathogenic role in several human diseases and conditions, including kidney transplantation. Both ...

    Abstract Autophagy is a lysosome-dependent regulated mechanism that recycles unnecessary cytoplasmic components. It is now known that autophagy dysfunction may have a pathogenic role in several human diseases and conditions, including kidney transplantation. Both defective and excessive autophagy may induce or aggravate several complications of kidney transplantation, such as ischemia-reperfusion injury, alloimmune response, and immunosuppressive treatment and side effects. Although it is still complicated to measure autophagy levels in clinical practice, more attention should be paid to the factors that may influence autophagy. In kidney transplantation, the association of low doses of a mammalian target of rapamycin inhibitor with low doses of a calcineurin inhibitor may be of benefit for autophagy modulation. However, further studies are needed to explore the role of other autophagy regulators.
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004862
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    Zs.A 488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 509: Show issues

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  7. Article ; Online: Autophagy and podocytopathy.

    Ponticelli, Claudio / Moroni, Gabriella / Reggiani, Francesco

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 9, Page(s) 1931–1939

    Abstract: Autophagy is a complex process of lysosomal-dependent degradation of unwanted cellular material. In response to endogenous or exogenous stimuli, autophagy is induced and regulated by two kinases: the AMP activated kinase and the mammalian target of ... ...

    Abstract Autophagy is a complex process of lysosomal-dependent degradation of unwanted cellular material. In response to endogenous or exogenous stimuli, autophagy is induced and regulated by two kinases: the AMP activated kinase and the mammalian target of rapamycin (mTOR). Cells activated by Unc-51-like kinase 1 form a double membrane complex that sequesters the cargo (phagophore) and elongates producing spherical vesicles (autophagosomes). These reach and fuse with lysosomes, which degrade the cargo (autolysosomes). The resulting macromolecules are released back and recycled in the cytosol for reuse. In the podocyte, autophagy is a homeostatic mechanism that contributes to the formation and preservation of the morphological and functional integrity of actin cytoskeleton. Podocytes, fenestrated endothelial cells and glomerular basement membrane compose the glomerular filtration barrier. Podocyte damage may cause dysfunction of the glomerular barrier, proteinuria and glomerulosclerosis in different glomerular diseases and particularly in so-called podocytopathies, namely minimal change disease and focal segmental glomerulosclerosis. Several drugs and molecules may activate autophagic function in murine models. Among them, aldosterone inhibitors, mineralocorticoid inhibitors and vitamin D3 were proven to protect podocyte from injury and reduce proteinuria in clinical studies. However, no clinical trial with autophagy regulators in podocytopathies has been conducted. Caution is needed with other autophagy activators, such as mTOR inhibitors and metformin, because of potential adverse events.
    MeSH term(s) Humans ; Animals ; Mice ; Endothelial Cells/metabolism ; Glomerulosclerosis, Focal Segmental/metabolism ; Podocytes/metabolism ; Kidney Diseases/metabolism ; Autophagy ; Proteinuria/metabolism ; Glomerular Basement Membrane/metabolism ; Mammals
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad024
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  8. Article ; Online: Late breaking clinical trials at ACC 22.

    Moroni, Francesco / Abbate, Antonio

    European heart journal. Cardiovascular pharmacotherapy

    2022  Volume 8, Issue 5, Page(s) e26

    MeSH term(s) Cardiovascular Diseases/therapy ; Clinical Trials as Topic ; Humans
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvac031
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  9. Article: Experimental Study of the Influence of the Surface Preparation on the Fatigue Behavior of Polyamide Single Lap Joints.

    Musiari, Francesco / Moroni, Fabrizio

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 4

    Abstract: The low quality of adhesion performance on polymeric surfaces has forced the development of specific pretreatments able to toughen the interface between substrate and adhesive. Among these methods, atmospheric pressure plasma treatment (APPT) appears ... ...

    Abstract The low quality of adhesion performance on polymeric surfaces has forced the development of specific pretreatments able to toughen the interface between substrate and adhesive. Among these methods, atmospheric pressure plasma treatment (APPT) appears particularly suitable for its environmental compatibility and its effectiveness in altering the chemical state of the surface. In this work, an experimental study on adhesively bonded joints realized using polyamide as substrates and polyurethane as the structural adhesive was carried out with the intent to characterize their fatigue behavior, which represents a key issue of such joints during their working life. The single lap joint (SLJ) geometry was chosen and several surface pretreatments were compared with each other: degreasing, abrasion (alone and followed by APPT) and finally APPT. The results show that the abrasion combined with APPT presents the most promising behavior, which appears consistent with the higher percentage of life spent for crack propagation found by means of DIC on this class of joints with respect to the others. APPT alone confers a good fatigue resistance with respect to the simple abrasion, especially at a low number of cycles to failure.
    Language English
    Publishing date 2021-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14041008
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  10. Article ; Online: Are We Speaking the Same "Language" Regarding Underrepresented Groups in Plastic Surgery and Increasing Diversity Within Our Field?

    Douglas, Nerone K O / Moroni, Elizabeth A / De La Cruz, Carolyn / Egro, Francesco M

    Annals of plastic surgery

    2024  Volume 92, Issue 4S Suppl 2, Page(s) S218–S222

    Abstract: Background: Plastic Surgery is one of the fields that lags behind the rest when it comes to surgeons from backgrounds underrepresented in medicine (URiM). Extensive research has shown that diversity in health care not only fosters inclusivity but also ... ...

    Abstract Background: Plastic Surgery is one of the fields that lags behind the rest when it comes to surgeons from backgrounds underrepresented in medicine (URiM). Extensive research has shown that diversity in health care not only fosters inclusivity but also saves lives. The study aim is to quantify how many integrated plastic surgery residency programs have outlined criteria defining diversity goals and/or groups of people they consider to be URiM.
    Methods: All American Council for Graduate Medical Education-accredited integrated plastic surgery program Web sites were reviewed for diversity missions/statements and explicit mentions of the racial and ethnic groups. Web sites were deemed "up-to-date" if they were last updated within 6 months before the initial data collection period. The data collection period was from November 20 to 29, 2022.
    Results: A total of 86 program were reviewed. Only 8 programs (9%) had clear URiM criteria listed on their Web sites, whereas 26 (30%) relied on institution/department-wide criteria, 1 (1%) listed that they were adhering to American Association of Medical Colleges definition of URiM, and 51 programs (60%) had no form of definition for what is considered URiM. When looking at the programs that have some form of criteria for URiM (n = 35 [40%]), all programs (100%) considered African American/Black, Native American/Alaskan Native, Hispanic/Latinx, and Pacific Islander/Native Hawaiian as groups URiM. Assessing the same subset of programs that have a form of criteria listed (n = 35 [40%]), 19 (58%) had listed other groups outside of race/ethnicity considered to be URiM for their program, and 14 (42%) programs did not. Fourteen programs (74%) considered LGBTQIA+ as a URiM group.
    Conclusion and significance: There still is a great deal of heterogeneity among residency programs when it comes to identifying which medical students are URiM. Numerous plastic surgery organizations have placed diversity and inclusive excellence at the forefront of their agendas; however, it is critical that residency programs also actively align their efforts in an equitable and intentional way. This study serves to encourage residency programs to evaluate their mission toward diversity, equity, and inclusion and to spark discussion toward creating a clearer URiM definition to be consistent among all programs.
    MeSH term(s) Humans ; Surgery, Plastic ; Plastic Surgery Procedures ; Black or African American ; Education, Medical, Graduate ; Ethnicity ; Internship and Residency
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000003876
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    Zs.A 1419: Show issues Location:
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