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  1. Article: Transcriptome analysis of the gene expression of M

    Li, Desheng / Chen, Fei / Tian, Yumin / Su, Yuhong

    Frontiers in physiology

    2023  Volume 14, Page(s) 1184651

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1184651
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  2. Article ; Online: Na

    Bi, Yongchang / Wang, Jingjun / Bian, Xingyu / Chen, Mingyue / Zhu, Guangyuan / Zhang, Yumin / Gu, Qiang

    Chemistry & biodiversity

    2024  Volume 21, Issue 4, Page(s) e202400073

    Abstract: An efficient and green method for synthesizing 3-methyl-4-(hetero) arylmethylene isoxazole-5(4H)-ones was developed using a recyclable and environmental-friendly catalyst, ... ...

    Abstract An efficient and green method for synthesizing 3-methyl-4-(hetero) arylmethylene isoxazole-5(4H)-ones was developed using a recyclable and environmental-friendly catalyst, Na
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Catalysis
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400073
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  3. Article ; Online: Community-specific diffusion characteristics determine resistance of biofilms to oxidative stress.

    Zhang, Yuzhen / Cai, Yumin / Chen, Zhaoyuan

    Science advances

    2023  Volume 9, Issue 12, Page(s) eade2610

    Abstract: Biofilms are multicellular communities with a spatial structure. Different from single-cell scale diffusion in planktonic systems, the diffusion distance becomes the dimension of multicellular clusters in a biofilm. Such differences in diffusion behavior ...

    Abstract Biofilms are multicellular communities with a spatial structure. Different from single-cell scale diffusion in planktonic systems, the diffusion distance becomes the dimension of multicellular clusters in a biofilm. Such differences in diffusion behavior affect the tolerance and response to exogenous stress. Here, we found that at the same doses of exogenous hydrogen peroxide (H
    MeSH term(s) Hydrogen Peroxide/pharmacology ; Biofilms ; Oxidative Stress ; Diffusion ; Escherichia coli/physiology ; Plankton
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.ade2610
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  4. Article ; Online: Enhancing the Enantioselectivity and Catalytic Efficiency of Esterase from

    Zhou, Jiawei / Sang, Yumin / Wang, Zhuang / Feng, Jiacheng / Zhu, Linjiang / Chen, Xiaolong

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 4, Page(s) 2277–2286

    Abstract: Enzymatic kinetic resolution is a promising way to produce l-menthol. However, the properties of the reported biocatalysts are still unsatisfactory and far from being ready for industrial application. Herein, ... ...

    Abstract Enzymatic kinetic resolution is a promising way to produce l-menthol. However, the properties of the reported biocatalysts are still unsatisfactory and far from being ready for industrial application. Herein, a
    MeSH term(s) Esterases/genetics ; Esterases/chemistry ; Menthol/chemistry ; Bacillus subtilis/genetics ; Molecular Docking Simulation ; Plant Extracts ; Acetates
    Chemical Substances Esterases (EC 3.1.-) ; Menthol (1490-04-6) ; Plant Extracts ; Acetates
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c08321
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway.

    Zhong, Wenyan / Chen, Jingjing / He, Yumin / Xiao, Li / Yuan, Chengfu

    Neuroreport

    2024  Volume 35, Issue 8, Page(s) 509–517

    Abstract: The decline of aging brain neurons is the main cause of various neurodegenerative disease. This study aimed to examine the impact of Balanophora polyandra polysaccharides (BPP) against aging related neuronal deterioration. C57BL/6 mice were fed with ... ...

    Abstract The decline of aging brain neurons is the main cause of various neurodegenerative disease. This study aimed to examine the impact of Balanophora polyandra polysaccharides (BPP) against aging related neuronal deterioration. C57BL/6 mice were fed with regular feed for 27 months to establish a natural aging mouse model. From 3 months of age, mice in the drug-treated group were respectively fed with feed containing 0.05 or 0.18% BPP until 27 months of age. The effects of BPP treatment on the pathological changes of neurons in mice brain were evaluated, as well as autophagy-related and signaling pathway proteins. BPP treatment had a notable positive impact on the pathological injury of cortical and hippocampal neurons, alleviated neuronal degeneration, and enhanced the staining of Nissl bodies in natural aging mice. Furthermore, BPP upregulated autophagy-related proteins LC3 II/I, Parkin, and PINK1 in the cortex and hippocampus of aging mice, and significantly decreased the expression of p62, PI3K, p-protein Kinase B (AKT), and p-mTOR. Immunofluorescence results showed a reduction in the brightness of LC3, which mainly coexpressed with NeuN in natural aging mice brain, and increased LC3-positive neurons were observed after BPP treatment. Collectively, BPP treatment enhanced neuronal autophagy to improve brain functional degradation through the PI3K/AKT/mTOR signaling in natural aging mice. These finding suggested that BPP has potential to mitigate or delay the neurodegeneration associated with aging and further investigation was needed to validate its efficacy in elderly populations.
    MeSH term(s) Animals ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/drug effects ; Polysaccharides/pharmacology ; Autophagy/drug effects ; Autophagy/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Aging/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Mice, Inbred C57BL ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Mice ; Male
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Polysaccharides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; mTOR protein, mouse (EC 2.7.1.1)
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000002024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: New Mechanistic Insights of Melasma.

    Liu, Wei / Chen, Qin / Xia, Yumin

    Clinical, cosmetic and investigational dermatology

    2023  Volume 16, Page(s) 429–442

    Abstract: Melasma is a common acquired disorder of pigmentation that negatively impacts quality of life. Present treatments show poor therapeutic effect with frequent recurrence. This in large part is due to the currently limited understanding of the disease's ... ...

    Abstract Melasma is a common acquired disorder of pigmentation that negatively impacts quality of life. Present treatments show poor therapeutic effect with frequent recurrence. This in large part is due to the currently limited understanding of the disease's etiology. It is urgent to elucidate the pathogenesis of melasma to further the discovery of new therapeutic strategies. Recent studies show that melasma is triggered or aggravated by a variety of factors, including genetic susceptibility, ultraviolet radiation, and sex hormone dysregulation. Ultraviolet B radiation upregulates the expression of several melanocyte-specific genes and stimulates the release of key factors that participate in the synthesis of melanin. There is a significant increase in melanin in both the epidermal and dermal layers of affected skin, possibly due to abnormalities in crosstalk between the melanocytes and other cells. Melanogenesis is regulated through various signaling networks including the Wnt/β-catenin, PI3K/Akt, cAMP/PKA, and SCF/c-kit-mediated signaling pathways. In addition, inflammatory mediators, oxidative stress, neuroactive molecules, sebocytes, etc, have also been proved to be related to the pathogenesis of melasma. This review provides a comprehensive update on the current understanding of the pathogenesis of melasma.
    Language English
    Publishing date 2023-02-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S396272
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  7. Article: Oxidative Stress Contributes to Inflammatory and Cellular Damage in Systemic Lupus Erythematosus: Cellular Markers and Molecular Mechanism.

    Yan, Zhu / Chen, Qin / Xia, Yumin

    Journal of inflammation research

    2023  Volume 16, Page(s) 453–465

    Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex pathogenesis, the treatment of which relies exclusively on the use of immunosuppressants. Increased oxidative stress is involved in causing inflammatory and cellular ... ...

    Abstract Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex pathogenesis, the treatment of which relies exclusively on the use of immunosuppressants. Increased oxidative stress is involved in causing inflammatory and cellular defects in the pathogenesis of SLE. Various inflammatory and cellular markers including oxidative modifications of proteins, lipids, and DNA contribute to immune system dysregulation and trigger an aggressive autoimmune attack through molecular mechanisms like enhanced NETosis, mTOR pathway activation, and imbalanced T-cell differentiation. Accordingly, the detection of inflammatory and cellular markers is important for providing an accurate assessment of the extent of oxidative stress. Oxidative stress also reduces DNA methylation, thus allowing the increased expression of affected genes. As a result, pharmacological approaches targeting oxidative stress yield promising results in treating patients with SLE. The purpose of this review is to examine the involvement of oxidative stress in the pathogenesis and management of SLE.
    Language English
    Publishing date 2023-02-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S399284
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  8. Article ; Online: Analysis of clinical factors impacting recurrence in myxofibrosarcoma.

    Chen, Wenlin / Ye, Ming / Sun, Ye / Wei, Yongzhong / Huang, Yumin

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3903

    Abstract: Myxofibrosarcoma (MFS) is a malignant fibroblastic/myofibroblastic neoplasm with a prominent myxoid area. It has the clinical features of frequent local recurrence (LR) and occasional distant metastasis. Robust epidemiological data on MFS in China are ... ...

    Abstract Myxofibrosarcoma (MFS) is a malignant fibroblastic/myofibroblastic neoplasm with a prominent myxoid area. It has the clinical features of frequent local recurrence (LR) and occasional distant metastasis. Robust epidemiological data on MFS in China are lacking. The aim of this retrospective analysis was to determine the natural history of MFS, identify prognostic factors for recurrence and describe the real-life outcomes of MFS. We reviewed 52 patients with primary MFS from the First Affiliated Hospital of Nanjing Medical University diagnosed between 2016 and 2020. All tumors were subjected to retrospective univariate analysis for prognostic factors of the disease, including tumor size, grade, location and sex; patient age; planned operation; surgical margin; and laboratory results. The significant factors identified by univariate analysis were subsequently analyzed via multivariate analysis. Overall survival (OS), post-treatment LR and metastatic-free survival were assessed as outcomes. The median age was 61 years (range, 13-93). Fourteen (26.92%) patients exhibited low grade disease, and 38 (73.08%) exhibited high grade disease. Among the 29 males, and 23 females, 15 (28.85%) had tumors in the trunk, 37 (71.15%) had tumors in the extremities, 26 had undergone planned surgery, and 26 had unexpected unplanned operation. The margin was negative in 39 (75%) patients and positive in 13 patients (25%). The serum creatine kinase (CK) concentration was high level in 33 (63.46%) patients and low level in 19 (36.54%) patients. The serum lactate dehydrogenase (LDH) levels were low in 23 (44.23%) patients and high in 29 (55.77%) patients. LR was observed in 25 patients (48.08%), and 4 patients developed metastasis. A worse LR rate was found for patients with a low CK level (84.21%) than for those with a high CK level (27.27%) at 5 years (p < 0.05). The LR rate of patients who underwent planned surgery was lower than that of patients who underwent unplanned surgery (p < 0.05). There were significantly more patients with positive margins than patients with negative margins (92.30%, and 33.33%, respectively; p < 0.05). Moreover, superficial tumors were also associated with greater recurrence rate (2/20 [10%]) than deep tumors, (23/32 [71.86%]) [p < 0.05]. The probability of LR in patients with MFS was significantly greater in association with unplanned operations, positive margins, low serum CK levels or superficial tumor depth. These data could help identify high-risk patients; thus, more careful follow-up should be performed for higher-risk patients. Diagnosis and treatment at qualified regular medical centers can reduce the local recurrence rate of MFS.
    MeSH term(s) Male ; Female ; Adult ; Humans ; Middle Aged ; Retrospective Studies ; Fibrosarcoma/surgery ; Fibrosarcoma/pathology ; Extremities/pathology ; Prognosis ; Histiocytoma, Malignant Fibrous/pathology ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53606-y
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  9. Article ; Online: Investigation on the spatial distribution of landslides in Sichuan Province, southwest China

    Zhuo Chen / Danqing Song / Yumin Du / Lihu Dong

    Geomatics, Natural Hazards & Risk, Vol 14, Iss

    2023  Volume 1

    Abstract: AbstractIn this study, a total of 34,893 landslides collected from the Sichuan Province of China are used to reveal their spatial distribution. Correlations between the spatial distribution of landslides and five main factors [i.e. topography, rainfall, ... ...

    Abstract AbstractIn this study, a total of 34,893 landslides collected from the Sichuan Province of China are used to reveal their spatial distribution. Correlations between the spatial distribution of landslides and five main factors [i.e. topography, rainfall, lithology, peak ground acceleration (PGA), and human activity] are analyzed based on the Geographical Information System (GIS) platform. Topographic factors exert a significant influence on landslide occurrence, and other factors also sensitive to landslides include lithology (Classes 3 and 4), PGA (≤0.15 g), rainfall (90–140 mm), and road density (≤0.6 km/km2). The geographical detector model is used to detect the relative importance of individual influencing factors and the factor interaction effects on the landslide distribution. The results show that the interacting factors between rainfall and PGA, lithology, river density, and road density are more closely related to the spatial distribution of landslides than every single factor. The results of this study can provide a foundation and insights for hazard reduction schemes in the future.
    Keywords Landslides ; spatial analysis ; geographical detector model ; Sichuan Province ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Risk in industry. Risk management ; HD61
    Subject code 910
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A novel immune-related risk-scoring system associated with the prognosis and response of cervical cancer patients treated with radiation therapy.

    Wu, Zhuna / Lin, Qiuya / Sheng, Liying / Chen, Weihong / Liang, Meili / Wu, Danni / Ke, Yumin

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1297774

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1297774
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