LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 52

Search options

  1. Article ; Online: Return of the (pro)renin receptor: a novel role in macula densa signaling.

    Ramkumar, Nirupama

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 4, Page(s) F913–F914

    MeSH term(s) Blood Pressure ; Juxtaglomerular Apparatus ; Receptors, Cell Surface ; Renin
    Chemical Substances Receptors, Cell Surface ; prorenin receptor ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2018-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00275.2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Physiology Is Fundamental to Patient Care and Research Advances in Nephrology.

    Ramkumar, Nirupama / Tomacruz, Isabelle Dominique V / Phachu, Deep / Sparks, Matthew A

    Advances in kidney disease and health

    2023  Volume 30, Issue 2, Page(s) 69–70

    MeSH term(s) Humans ; Nephrology ; Patient Care
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Editorial
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2023.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Acute kidney injury, necrotizing pancreatitis and nephrocalcinosis: A rare presentation of primary hyperparathyroidism.

    Sarwal, Amara / Abraham, Devaprabu / Kethineni, Rama / Ramkumar, Nirupama / Abraham, Josephine

    The American journal of the medical sciences

    2022  Volume 365, Issue 3, Page(s) 313–314

    MeSH term(s) Humans ; Nephrocalcinosis/diagnostic imaging ; Nephrocalcinosis/etiology ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Kidney Calculi ; Pancreatitis, Acute Necrotizing/diagnosis ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Hypercalcemia/complications ; Hypercalcemia/diagnosis
    Language English
    Publishing date 2022-12-18
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2022.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.2/10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Gain of 'FAOnction', Loss of Fibrosis.

    Nicholson, Rebekah J / Ramkumar, Nirupama / Summers, Scott A

    Trends in endocrinology and metabolism: TEM

    2021  Volume 32, Issue 6, Page(s) 333–334

    Abstract: Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, ... ...

    Abstract Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.
    MeSH term(s) Animals ; Disease Models, Animal ; Fibrosis ; Gain of Function Mutation ; Kidney Diseases ; Lipid Metabolism ; Mice
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2021.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: American Society of Nephrology Kidney TREKS Program.

    Rubin, Molly / Lecker, Stewart H / Ramkumar, Nirupama / Sozio, Stephen M / Hoover, Robert S / Zeidel, Mark L / Ko, Benjamin S

    Journal of the American Society of Nephrology : JASN

    2024  

    Abstract: In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney TREKS (Tutored Research and Education for Kidney Scholars) to stimulate interest in nephrology among medical ... ...

    Abstract In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney TREKS (Tutored Research and Education for Kidney Scholars) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral fellows. The program combines a one-week intensive exposure to kidney physiology with a longitudinal mentorship program at the participants' home institutions. Ten years in, an analysis was conducted to assess its effectiveness. We surveyed participants to assess their opinions regarding nephrology before and after the course and followed them longitudinally to determine their career choices. TREKS applicants who were not selected to participate were used as a comparison group. 381 people participated in the program and 242 completed the survey. After TREKS, both medical students and graduate students showed increased interest in nephrology, with rank scores of 5.6±0.2 pre- to 7.5±0.1 post-course for medical students (mean ± standard deviation, n=189, p=0.001) and 7.3±0.3 to 8.7±0.3 (n=53, p=0.001) for graduate students. In long term follow-up, TREKS medical students chose a nephrology pipeline residency at a higher rate than medical students overall (57% vs. 31%, p=0.01) and TREKS applicants who did not participate (47% vs. 31%, p=0.04). Nephrology fellowship rates for these groups exceeded the general population but did not significantly differ between TREKS participants and applicants. PhD students and postdoctoral TREKS participants had a higher rate of participating in nephrology research compared to TREKS applicants (66% vs. 30%, p=0.01). In summary, the ASN Kidney TREKS program has demonstrated that it can improve interest in nephrology in the short term and increase the number of individuals going into nephrology careers. This long-term effect is most evident in PhD students and postdoctoral participants. Further study is needed to assess the impact of TREKS on enrollment in nephrology fellowship programs.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000384
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Novel Concepts in Nephron Sodium Transport: A Physiological and Clinical Perspective.

    Van Beusecum, Justin P / Rianto, Fitra / Teakell, Jade / Kon, Valentina / Sparks, Matthew A / Hoorn, Ewout J / Kirabo, Annet / Ramkumar, Nirupama

    Advances in kidney disease and health

    2023  Volume 30, Issue 2, Page(s) 124–136

    Abstract: The kidneys play a critical role in maintaining total body sodium ( ... ...

    Abstract The kidneys play a critical role in maintaining total body sodium (Na
    MeSH term(s) Humans ; Nephrons ; Kidney ; Hypertension ; Renal Circulation ; Membrane Transport Proteins ; Sodium
    Chemical Substances Membrane Transport Proteins ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3156601-7
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.

    Ramkumar, Nirupama / Kohan, Donald E

    Kidney international

    2019  Volume 95, Issue 5, Page(s) 1041–1052

    Abstract: The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and ... ...

    Abstract The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.
    MeSH term(s) Angiotensin II/metabolism ; Animals ; Autophagy/physiology ; Blood Pressure/physiology ; Disease Models, Animal ; Glucose/metabolism ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Lipid Metabolism/physiology ; Metabolic Syndrome/etiology ; Metabolic Syndrome/physiopathology ; Proton-Translocating ATPases/metabolism ; Receptors, Cell Surface/metabolism ; Renin/metabolism ; Renin-Angiotensin System/physiology ; Vacuolar Proton-Translocating ATPases/metabolism ; Wnt Signaling Pathway/physiology
    Chemical Substances ATP6AP2 protein, human ; ATP6AP2 protein, mouse ; Receptors, Cell Surface ; Angiotensin II (11128-99-7) ; Renin (EC 3.4.23.15) ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Proton-Translocating ATPases (EC 3.6.3.14) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.10.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Collecting duct renin regulates potassium homeostasis in mice.

    Xu, Chuanming / Chen, Yanting / Ramkumar, Nirupama / Zou, Chang-Jiang / Sigmund, Curt D / Yang, Tianxin

    Acta physiologica (Oxford, England)

    2022  Volume 237, Issue 1, Page(s) e13899

    Abstract: Aim: The kaliuretic action of the renin-angiotensin-aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the ... ...

    Abstract Aim: The kaliuretic action of the renin-angiotensin-aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the involvement of intrarenal RAAS in K
    Methods: Wild-type (Floxed) and CD-specific deletion of renin (CD renin KO) mice were treated for 7 days with a high K
    Results: In floxed mice, renin levels were elevated in the renal medulla and urine following a 1-week HK diet, indicating activation of the intrarenal renin. CD renin KO mice had blunted HK-induced intrarenal renin response and developed impaired kaliuresis and elevated plasma K
    Conclusion: Taken together, these results support a kaliuretic action of CD renin during HK intake.
    MeSH term(s) Mice ; Animals ; Renin/metabolism ; Aldosterone/metabolism ; Cytochrome P-450 CYP11B2/metabolism ; Water-Electrolyte Imbalance ; Potassium/metabolism ; Homeostasis ; Epithelial Sodium Channels/metabolism ; Mice, Knockout
    Chemical Substances Renin (EC 3.4.23.15) ; Aldosterone (4964P6T9RB) ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Potassium (RWP5GA015D) ; Epithelial Sodium Channels
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13899
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: ClC-K2 Cl

    Pyrshev, Kyrylo / Khayyat, Naghmeh Hassanzadeh / Stavniichuk, Anna / Tomilin, Viktor N / Zaika, Oleg / Ramkumar, Nirupama / Pochynyuk, Oleh

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2022  Volume 36, Issue 5, Page(s) e22275

    Abstract: The collecting duct is a highly adaptive terminal part of the nephron, which is essential for maintaining systemic homeostasis. Principal and intercalated cells perform different physiological tasks and exhibit distinctive morphology. However, acid- ... ...

    Abstract The collecting duct is a highly adaptive terminal part of the nephron, which is essential for maintaining systemic homeostasis. Principal and intercalated cells perform different physiological tasks and exhibit distinctive morphology. However, acid-secreting A- and base secreting B-type of intercalated cells cannot be easily separated in functional studies. We used BCECF-sensitive intracellular pH (pH
    MeSH term(s) Acidosis/metabolism ; Animals ; Anion Transport Proteins/genetics ; Anion Transport Proteins/metabolism ; Kidney Tubules, Collecting/metabolism ; Mice ; Nephrons/metabolism ; Sulfate Transporters/metabolism
    Chemical Substances Anion Transport Proteins ; Sulfate Transporters
    Language English
    Publishing date 2022-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202200160R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The nephron (pro)renin receptor: function and significance.

    Ramkumar, Nirupama / Kohan, Donald E

    American journal of physiology. Renal physiology

    2016  Volume 311, Issue 6, Page(s) F1145–F1148

    Abstract: The (pro)renin receptor (PRR) is a multifunctional protein that is part of the renin-angiotensin system and is an important accessory molecule for the vacuolar ... ...

    Abstract The (pro)renin receptor (PRR) is a multifunctional protein that is part of the renin-angiotensin system and is an important accessory molecule for the vacuolar H
    MeSH term(s) Angiotensin II/metabolism ; Animals ; Humans ; Mice ; Mice, Knockout ; Nephrons/metabolism ; Receptors, Cell Surface/metabolism ; Renin/metabolism ; Renin-Angiotensin System/physiology ; Signal Transduction/physiology
    Chemical Substances Receptors, Cell Surface ; prorenin receptor ; Angiotensin II (11128-99-7) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2016-12-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00476.2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top