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  1. Article: Long-Term

    Wu, Guangfu / Zhang, Eric T / Qiang, Yingqi / Esmonde, Colin / Chen, Xingchi / Wei, Zichao / Song, Yang / Zhang, Xincheng / Schneider, Michael J / Li, Huijie / Sun, He / Weng, Zhengyan / Santaniello, Sabato / He, Jie / Lai, Rebecca Y / Li, Yan / Bruchas, Michael R / Zhang, Yi

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Long-term, real-time molecular monitoring in complex biological environments is critical ...

    Abstract Long-term, real-time molecular monitoring in complex biological environments is critical for our ability to understand, prevent, diagnose, and manage human diseases. Aptamer-based electrochemical biosensors possess the promise due to their generalizability and a high degree of selectivity. Nevertheless, the operation of existing aptamer-based biosensors
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.18.562080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long non-coding RNA

    Zuo, You / He, Jiaqian / Zhou, Zheng / Sun, Jingjing / Ouyang, Can / Huang, Hui / Wang, Yajuan / Liu, Hairong / Reed, Simon H

    Non-coding RNA research

    2024  Volume 9, Issue 3, Page(s) 649–658

    Abstract: In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have ...

    Abstract In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (BER). Our designed DNA microarray identified dozens of functionally unknown lncRNAs, and their transcription levels significantly increased upon exposure to DNA damage inducers. One of them, named
    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2024.03.010
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  3. Article ; Online: Long-term PM

    Zhang, Yuqin / Chen, Shirui / Wei, Jing / Jiang, Jie / Lin, Xiao / Wang, Ying / Hao, Chun / Wu, Wenjing / Yuan, Zhupei / Sun, Jie / Wang, Han / Du, Zhicheng / Zhang, Wangjian / Hao, Yuantao

    Science bulletin

    2024  

    Abstract: Limited evidence exists on the effect of submicronic particulate matter ( ... ...

    Abstract Limited evidence exists on the effect of submicronic particulate matter (PM
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2024.03.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-Term

    Liu, Jing / Fang, Xiaofeng / Zhang, Zhe / Liu, Zhihe / Liu, Jie / Sun, Kai / Yuan, Zhen / Yu, Jiangbo / Chiu, Daniel T / Wu, Changfeng

    Analytical chemistry

    2022  Volume 94, Issue 4, Page(s) 2195–2203

    Abstract: ... for sensitive and long-term glucose monitoring. We use Pdot transducer in a polyacrylamide hydrogel matrix ...

    Abstract Optical sensors have attracted a great deal of interest for glucose detection. However, their practical applications for continuous glucose monitoring are still constrained by operational reliability in subcutaneous tissues. Here, we show an implantable hydrogel platform embedded with luminescent polymer dots (Pdots) for sensitive and long-term glucose monitoring. We use Pdot transducer in a polyacrylamide hydrogel matrix to construct an implantable platform. The hydrogel-Pdot transducer showed bright luminescence with ratiometric response to glucose changes. The
    MeSH term(s) Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Glucose ; Hydrogels ; Polymers ; Reproducibility of Results ; Transducers
    Chemical Substances Blood Glucose ; Hydrogels ; Polymers ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.1c04730
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Long-Term

    Davachi, Seyed Mohammad / Dogan, Belgin / Khazdooz, Leila / Zhang, Shiying / Khojastegi, Anahita / Fei, Zhangjun / Sun, Honghe / Meletharayil, Gopinathan / Kapoor, Rohit / Simpson, Kenneth W / Abbaspourrad, Alireza

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 30, Page(s) 9399–9411

    Abstract: Vegetable oils with varying saturated fat levels were inoculated ... ...

    Abstract Vegetable oils with varying saturated fat levels were inoculated with
    MeSH term(s) Inulin ; Lactobacillus rhamnosus ; Plant Oils ; Probiotics ; Temperature
    Chemical Substances Plant Oils ; Inulin (9005-80-5)
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02953
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    Zs.A 1172: Show issues Location:
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  6. Article ; Online: Long-term outcomes with HLX01 (HanliKang

    Qin, Yan / Song, Yongping / Wang, Dong / Bai, Ou / Feng, Jifeng / Sun, Xiuhua / Qiu, Lihua / Yang, Jianmin / Yang, Yu / Wang, Zhao / Hu, Jianda / Wang, Huaqing / Su, Hang / Jin, Zhengming / Qian, Wenbin / Jin, Chuan / Zhang, Mingzhi / Yu, Ding / Liu, Li /
    Chen, Guoan / Li, Yarong / Sun, Tao / Jin, Jie / Bao, Huizheng / Du, Xin / Zhou, Hui / Fu, Gan / Shi, Yuankai

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 124

    Abstract: ... HLX01 ( ... ...

    Abstract HLX01 (HanliKang
    MeSH term(s) Humans ; Biosimilar Pharmaceuticals/adverse effects ; Rituximab/adverse effects ; Follow-Up Studies ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Cyclophosphamide/adverse effects ; Doxorubicin ; Prednisone/adverse effects
    Chemical Substances Biosimilar Pharmaceuticals ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Doxorubicin (80168379AG) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-024-11876-9
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  7. Article: Long non-coding RNA

    Li, Jingzhang / Sun, Kai / Zhang, Mingming / Luo, Yusheng / Zhang, Ying / Huang, Cheng / Hong, Juanjuan / Chen, Dongmei / Liao, Wangjun

    American journal of cancer research

    2023  Volume 13, Issue 6, Page(s) 2714–2731

    Abstract: Known as long non-coding RNAs (lncRNAs), they are essential in regulating tumour metastasis ...

    Abstract Known as long non-coding RNAs (lncRNAs), they are essential in regulating tumour metastasis. In gastric carcinoma (GC), lncRNA cytoskeleton regulator (
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  8. Article ; Online: The impact of long-term PM

    Jiang, Jie / Wei, Yongyue / Wang, Ying / Wang, Xiaowen / Lin, Xiao / Guo, Tong / Sun, Xurui / Li, Zhiqiang / Zhang, Yuqin / Wu, Gonghua / Wu, Wenjing / Chen, Shirui / Sun, Huimin / Zhang, Wangjian / Hao, Yuantao

    The Science of the total environment

    2023  Volume 912, Page(s) 168997

    Abstract: ... Objectives: This study aimed to investigate the association between long-term exposure to particulate matter ...

    Abstract Background: China has a serious air pollution problem and a high prevalence of obesity. The interaction between the two and its impact on all-cause mortality is a public health issue of great concern.
    Objectives: This study aimed to investigate the association between long-term exposure to particulate matter with aerodynamic diameter ≤ 1 μm (PM
    Methods: A total of 33,087 participants from 162 counties in 25 provinces in China were included, with annual average PM
    Results: The incidence of all-cause deaths was 76.99 per 10,000 person-years over a median of 8.2 years of follow-up. After controlling for potential confounders, the PM
    Discussion: Higher PM
    MeSH term(s) Humans ; Body Mass Index ; Prospective Studies ; Thinness/chemically induced ; Particulate Matter/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; China/epidemiology ; Cohort Studies ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Environmental Exposure/analysis
    Chemical Substances Particulate Matter ; Air Pollutants
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168997
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Identification of long noncoding RNA

    Chen, Ting / Sun, Zhengxu / Cui, Yunqi / Ji, Jiamei / Li, Yating / Qu, Xiaoyan

    Hematology (Amsterdam, Netherlands)

    2023  Volume 28, Issue 1, Page(s) 2164449

    Abstract: Objective: Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and play a key role ...

    Abstract Objective: Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and play a key role in cancer progression. To determine whether lncRNAs are involved in extramedullary disease of multiple myeloma (EMD), we analyzed the expression profile of lncRNAs in EMD.
    Methods: Three pairs of EMD patients and their intramedullary MM cells were screened by microarray first. We extracted data from gene chips and made an identification of lncRNAs and mRNAs with significant differences between EMD group and non EMD group. WGCNA confirmed the EMD related gene module and drew a heat map to further determine the key gene lncRNA-NEAT1. In the meantime, bone marrow and extramedullary samples (hydrothorax and ascites) were collected from 2 MM patients and subjected to single-cell RNA-seq. Single cell Transcriptome analysis was conducted to verify the gene expression difference of malignant plasma cells derived from intramedullary and extramedullary. Then we verified high expression level of lncRNA-NEAT1 in EMD patients by using quantitative real-time PCR (qRT-PCR) and analyzed the correlation between expression patterns and survival and molecular genetics analysis of the LncRNA (NEAT1) involved in MM patients. At last, cell experiments were conducted to observe the effects of down-regulation of NEAT1on the proliferation, cell cycle and PTEN pathway related proteins of multiple myeloma cell lines U266 and RPMI8226.
    Results: We identified one of the EMD related key gene is lncRNA-NEAT1. Compared with patients without extramedullary lesions, intramedullary MM cells in EMD patients expressed NEAT1 highly. The outcome of parallel single-cell RNA sequencing (RNA-seq) revealed NEAT1 level of plasma cells came from pleural effusion /ascites increased significantly compared with myeloma-stricken bone marrow. By survival and molecular genetic analysis, NEAT1 gene expression was not associated with OS and PFS in MM patients. However, the expression of NEAT1 is related to adverse therapeutic reactions and the progression of MM. We found that the expressions of NEAT1 were negatively associated with albumin levels and were positively associated with gain of chromosome 1q, IGH-CCND1, IGH@-FGFR3/WHSC1,and IGH-MAF gene fusion, respectively. At the level of cell experiment, CCK-8, soft agar clone formation experiment and CFSE staining showed that down regulating NEAT1 could inhibit the proliferation of U266 and RPMI8226 cells; Cell cycle detection showed that down-regulation of NEAT1 would interfere with the cell cycle process, and RPMI 8226 cells were blocked in G1 phase. Western blot analysis showed that when the expression of NEAT1 was down regulated in U266 and RPMI 8226 cells, the expression of PTEN and p-PTEN (phosphorylated phosphatase and tensin homologue) was up-regulated, and the expression of PI3K, p-PI3K (human phosphorylated inositol 3 kinase), Akt, p-Akt (phosphorylated protein kinase B).
    Discuccion and conclusion: This study provides novel insights into the lncRNA-NEAT1 and reveals that NEAT1 maybe a potential lncRNA biomarkers in EMD.
    MeSH term(s) Humans ; Ascites/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Multiple Myeloma/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances MicroRNAs ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; RNA, Long Noncoding ; NEAT1 long non-coding RNA, human
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1341428-8
    ISSN 1607-8454 ; 1024-5332 ; 1024-5340
    ISSN (online) 1607-8454
    ISSN 1024-5332 ; 1024-5340
    DOI 10.1080/16078454.2022.2164449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4538: Show issues Location:
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  10. Article ; Online: Long non-coding RNA

    Yu, Qi / Cai, Benzhi / Zhang, Yong / Xu, Juan / Liu, Dongping / Zhang, Xiyang / Han, Zhenbo / Ma, Yingying / Jiao, Lei / Gong, Manyu / Yang, Xuewen / Wang, Yanying / Li, Haodong / Sun, Lihua / Bian, Yu / Yang, Fan / Xuan, Lina / Wu, Haodi / Yang, Baofeng /
    Zhang, Ying

    iScience

    2023  Volume 26, Issue 11, Page(s) 108051

    Abstract: Long non-coding RNAs (lncRNAs) play widespread roles in various processes. However, there is still ...

    Abstract Long non-coding RNAs (lncRNAs) play widespread roles in various processes. However, there is still limited understanding of the precise mechanisms through which they regulate early stage cardiomyocyte differentiation. In this study, we identified a specific lncRNA called
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108051
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