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  1. Article ; Online: Current Oncology: A Multidisciplinary Medium for Clinical Oncology.

    Gill, Sharlene

    Current oncology (Toronto, Ont.)

    2020  Volume 28, Issue 1, Page(s) 2–3

    Abstract: In recent years, the field of oncology has witnessed the unprecedented pace of genomics discovery, knowledge translation, and clinical research validation, which has led to novel systemic and locoregional therapeutics, an evolving role of immunotherapy, ... ...

    Abstract In recent years, the field of oncology has witnessed the unprecedented pace of genomics discovery, knowledge translation, and clinical research validation, which has led to novel systemic and locoregional therapeutics, an evolving role of immunotherapy, and a broader application of precision oncology [...].
    MeSH term(s) Genomics ; Humans ; Immunotherapy ; Medical Oncology ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine
    Language English
    Publishing date 2020-11-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol28010002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
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  2. Article: Controversies and management of deficient mismatch repair gastrointestinal cancers in the neoadjuvant setting.

    Boutin, Mélina / Gill, Sharlene

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231162577

    Abstract: High microsatellite instability (MSI-H)/deficient mismatch repair (dMMR) phenotype is a distinct molecular signature across gastrointestinal cancers characterized by high tumor mutational burden and high neoantigen load. Tumors harboring dMMR are highly ... ...

    Abstract High microsatellite instability (MSI-H)/deficient mismatch repair (dMMR) phenotype is a distinct molecular signature across gastrointestinal cancers characterized by high tumor mutational burden and high neoantigen load. Tumors harboring dMMR are highly immunogenic and heavily infiltrated by immune cells; consequently, they are uniquely vulnerable to therapeutic strategies enhancing immune antitumor response such as checkpoint inhibitors. The MSI-H/dMMR phenotype arose as a powerful predictor of response to immune checkpoint inhibitors with evidence supporting significantly improved outcomes in the metastatic setting. On the other hand, the genomic instability characteristic of MSI-H/dMMR tumors appears to be associated with decreased sensitivity to chemotherapy, and the benefits of standard adjuvant or neoadjuvant chemotherapy approaches in this subtype are being increasingly questioned. Here, we review the prognostic and predictive impact of MMR status in localized gastric and colorectal cancers, and highlight the emerging clinical data incorporating checkpoint inhibitors in the neoadjuvant setting.
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231162577
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  3. Article ; Online: Reply to M. Uccello et al.

    Gill, Sharlene

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2017  Volume 35, Issue 12, Page(s) 1371

    MeSH term(s) Humans ; Pancreatic Neoplasms ; Prostatic Neoplasms
    Language English
    Publishing date 2017-01-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.71.3883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Abstracts of the 2023 Canadian Association of Medical Oncologists Annual Scientific Meeting.

    Campbell, Alexi / Gill, Sharlene / Hao, Desiree / Powell, Erin / Snow, Stephanie / Veitch, Zachary / Welch, Stephen

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 8, Page(s) 7581–7607

    Abstract: On behalf of the Canadian Association of Medical Oncologists, we are pleased to present the abstracts of the 2023 Annual Scientific Meeting. The CAMO Annual Scientific Meeting (ASM) took place on 27 April 2023 in an in-person event in Toronto, ON. Thirty- ...

    Abstract On behalf of the Canadian Association of Medical Oncologists, we are pleased to present the abstracts of the 2023 Annual Scientific Meeting. The CAMO Annual Scientific Meeting (ASM) took place on 27 April 2023 in an in-person event in Toronto, ON. Thirty-two (32) abstracts were selected for presentation as oral presentations, in-person poster presentations, and virtual poster presentations. Awards for the top four (4) abstracts were presented during the ASM; they have been marked as "Award Recipient". We congratulate all presenters on their research work and contribution.
    MeSH term(s) Humans ; Canada ; Oncologists
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Congress
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30080550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Adjuvant therapy for resected high-risk colon cancer: Current standards and controversies.

    Gill, Sharlene

    Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

    2014  Volume 35, Issue 3, Page(s) 197–202

    Abstract: This evidence-based review will discuss the current standard of adjuvant chemotherapy for resected high-risk colon cancer and address existing controversies including strategies for risk-stratification, the status of targeted therapy, treatment of the ... ...

    Abstract This evidence-based review will discuss the current standard of adjuvant chemotherapy for resected high-risk colon cancer and address existing controversies including strategies for risk-stratification, the status of targeted therapy, treatment of the elderly and the optimal duration of therapy.
    Language English
    Publishing date 2014-10-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2181724-8
    ISSN 0975-2129 ; 0971-5851
    ISSN (online) 0975-2129
    ISSN 0971-5851
    DOI 10.4103/0971-5851.142032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Real-world experience supporting the role of oncologic resection and adjuvant chemotherapy in biliary tract cancers.

    Boutin, Melina / Krishnan, Tharani / Safro, Maria / Yang, Jenny / Jafari, Helia / Davies, Janine M / Gill, Sharlene

    Therapeutic advances in medical oncology

    2024  Volume 16, Page(s) 17588359241247008

    Abstract: Background: Complete resection followed by adjuvant chemotherapy is the gold standard for patients with localized cholangiocarcinoma (CC) or gallbladder cancer (GBC). However, this is not always feasible, and recurrence rates remain high.: Objectives!# ...

    Abstract Background: Complete resection followed by adjuvant chemotherapy is the gold standard for patients with localized cholangiocarcinoma (CC) or gallbladder cancer (GBC). However, this is not always feasible, and recurrence rates remain high.
    Objectives: To understand the real-world proportions and reason for treatment failure in resected biliary tract cancers.
    Design and methods: We performed a retrospective population-based review of patients with GBC or CC [intrahepatic (IHCC) or extrahepatic (EHCC)] resected between 2005 and 2019 using the BC Cancer provincial database. A chart review was conducted to characterize demographics, treatments received and outcomes.
    Results: In total, 594 patients were identified of whom 416 (70%) had disease recurrence. Most GBCs (96%) were diagnosed incidentally, and repeat oncologic resection was performed in 45%. Adjuvant chemotherapy was received in 51% of patients diagnosed after 2017 (mostly capecitabine). Patient co-morbidities, disease progression and patient preference were the commonest reasons for not proceeding with adjuvant chemotherapy. One-third of patients did not complete all planned cycles. Median overall survival was significantly higher in those with complete (R0)
    Conclusion: Complete resection, including reresection for incidentally diagnosed GBCs, and adjuvant chemotherapy were associated with improved outcomes in this retrospective cohort, yet many patients were not able to complete these treatments. Neoadjuvant strategies may improve treatment delivery and ultimately, outcomes.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359241247008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adjuvant therapy for resected high-risk colon cancer

    Sharlene Gill

    Indian Journal of Medical and Paediatric Oncology, Vol 35, Iss 3, Pp 197-

    Current standards and controversies

    2014  Volume 202

    Abstract: This evidence-based review will discuss the current standard of adjuvant chemotherapy for resected high-risk colon cancer and address existing controversies including strategies for risk-stratification, the status of targeted therapy, treatment of the ... ...

    Abstract This evidence-based review will discuss the current standard of adjuvant chemotherapy for resected high-risk colon cancer and address existing controversies including strategies for risk-stratification, the status of targeted therapy, treatment of the elderly and the optimal duration of therapy.
    Keywords Adjuvant therapy ; colon cancer ; 5-FU ; oxaliplatin ; stage II ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Current Attitudes toward Unfunded Cancer Therapies among Canadian Medical Oncologists.

    Wong, Selina K / Gondara, Lovedeep / Gill, Sharlene

    Current oncology (Toronto, Ont.)

    2021  Volume 28, Issue 6, Page(s) 4748–4755

    Abstract: Background: Despite successes in the development of innovative anticancer therapies, the fiscal and capacity restraints of the Canadian public healthcare system result in challenges with drug access. A meaningful proportion of systemic therapies ... ...

    Abstract Background: Despite successes in the development of innovative anticancer therapies, the fiscal and capacity restraints of the Canadian public healthcare system result in challenges with drug access. A meaningful proportion of systemic therapies ultimately do not receive public funding despite supporting clinical evidence. In this study, we assessed Canadian medical oncologists' current attitudes toward discussing publicly unfunded cancer treatments with patients and predictors of different practices.
    Methods: A web-based survey consisting of multiple choice and case-based scenarios was distributed to medical oncologists identified through the Royal College of Physicians and Surgeons of Canada directory.
    Results: A total of 116 responses were received. Almost all respondents reported discussing publicly unfunded treatments, including those who did so for Health Canada (HC) approved treatments (50%) and those who discussed off-label treatments (i.e., not HC approved) as guided by national guidelines (48%). Respondents in practice for over 15 years versus less than 5 years (OR 0.14, 95% CI 0.04-0.50,
    Conclusions: There is variability in medical oncologists' practices when it comes to discussing unfunded therapies. Given the limitations within Canada's publicly funded healthcare system, physicians are faced with the challenge of navigating an increasingly complex balance between patient care and available resources. Engagement of relevant stakeholders and policy makers is crucial in the continued evaluation of Canada's drug funding process.
    MeSH term(s) Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Attitude ; Attitude of Health Personnel ; Canada ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Humans ; Internet ; Neoplasms/drug therapy ; Oncologists ; Single-Payer System/economics ; Therapies, Investigational/economics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-11-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol28060400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Symptom Burden and Time from Symptom Onset to Cancer Diagnosis in Patients with Early-Onset Colorectal Cancer: A Multicenter Retrospective Analysis.

    Baronas, Victoria A / Arif, Arif A / Bhang, Eric / Ladua, Gale K / Brown, Carl J / Donnellan, Fergal / Gill, Sharlene / Stuart, Heather C / Loree, Jonathan M

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 4, Page(s) 2133–2144

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Colorectal Neoplasms/diagnosis ; Male ; Retrospective Studies ; Female ; Middle Aged ; Age of Onset ; Adult ; Aged ; Time Factors ; British Columbia/epidemiology ; Symptom Burden
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31040158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Abstracts of the 2022 Canadian Association of Medical Oncologists Annual Scientific Meeting.

    Ezeife, Doreen / Aseyev, Olexiy / Gill, Sharlene / Welch, Stephen / Colwell, Bruce / Hao, Desiree

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 6, Page(s) 3962–3982

    Abstract: On behalf of the Canadian Association of Medical Oncologists, we are pleased to present the abstracts of the 2022 Annual Meeting. The CAMO Virtual Annual Scientific Meeting (ASM) took place on 28 April 2022. Twenty-five (25) abstracts were selected for ... ...

    Abstract On behalf of the Canadian Association of Medical Oncologists, we are pleased to present the abstracts of the 2022 Annual Meeting. The CAMO Virtual Annual Scientific Meeting (ASM) took place on 28 April 2022. Twenty-five (25) abstracts were selected for presentation as oral presentations and poster presentations. Awards for the top three (3) abstracts were presented during the ASM. All of them are marked as "Award Recipient". We congratulate all the presenters on their research work and contribution.
    MeSH term(s) Canada ; Humans ; Oncologists ; Societies, Medical
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Congress
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29060317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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