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  1. Book: Clinical perspectives and issues in colorectal cancer therapy 2010

    Chu, Edward

    (Clinical colorectal cancer and other gastrointestinal malignancies ; 9, Suppl. 1)

    2010  

    Author's details suppl. ed.: Edward Chu
    Series title Clinical colorectal cancer and other gastrointestinal malignancies ; 9, Suppl. 1
    Collection
    Language English
    Size S50 S. : Ill.
    Publisher CIG Media Group
    Publishing place Dallas, TX
    Publishing country United States
    Document type Book
    HBZ-ID HT016503327
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Expanding treatment options for metastatic colorectal cancer

    Chu, Edward

    (Clinical colorectal cancer ; 7, Suppl. 2)

    2008  

    Author's details suppl. ed.: Edward Chu
    Series title Clinical colorectal cancer ; 7, Suppl. 2
    Collection
    Language English
    Size S. S41 - S66 : Ill.
    Publisher Cancer Information Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT016018043
    Database Catalogue ZB MED Medicine, Health

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  3. Book: A multidisciplinary approach to the treatment of early colorectal cancer

    Chu, Edward

    including a clinical discussion on audio CD

    2007  

    Author's details ed. by Edward Chu
    Language English
    Size XII, 148 S.
    Publisher CMPMedica
    Publishing place Manhasset, NY
    Publishing country United States
    Document type Book
    Accompanying material 1 Audio-CD
    HBZ-ID HT015310741
    ISBN 978-1-891483-54-7 ; 1-891483-54-4
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: BRAF

    Gao, Chenxi / Esni, Farzad / Chu, Edward / Hu, Jing

    Biochemistry and biophysics reports

    2024  Volume 37, Page(s) 101634

    Abstract: ... ...

    Abstract BRAF
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Important advances in the management of advanced colorectal cancer

    Chu, Edward

    (Oncology ; 19,13, Suppl. 6)

    2005  

    Author's details guest ed. Edward Chu
    Series title Oncology ; 19,13, Suppl. 6
    Collection
    Language English
    Size 24 S.
    Publisher PRR
    Publishing place Melville, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014642349
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Epidermal growth factor receptor inhibition in colorectal cancer: from bench to bedside

    Chu, Edward

    (Clinical colorectal cancer ; 5, Suppl. 2)

    2005  

    Author's details suppl. ed.: Edward Chu
    Series title Clinical colorectal cancer ; 5, Suppl. 2
    Collection
    Language English
    Size S. S57 - S106 : Ill., graph. Darst.
    Publisher Cancer Information Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT014744624
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  7. Article ; Online: Treatment of Colorectal Cancer and Other GI Cancers in the COVID-19 Pandemic.

    Chu, Edward

    Clinical colorectal cancer

    2020  Volume 19, Issue 3, Page(s) 145

    MeSH term(s) COVID-19 ; Colorectal Neoplasms/therapy ; Coronavirus Infections/epidemiology ; Gastrointestinal Neoplasms/therapy ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2112638-0
    ISSN 1938-0674 ; 1533-0028
    ISSN (online) 1938-0674
    ISSN 1533-0028
    DOI 10.1016/j.clcc.2020.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: BRAFV600E mutation and DSS treatment synergize to induce cecal tumor formation in mice

    Chenxi Gao / Farzad Esni / Edward Chu / Jing Hu

    Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101634- (2024)

    2024  

    Abstract: BRAF mutation is a driver mutation in colorectal cancer (CRC), and BRAFV600E mutation is found in 10–15 % of all CRCs. BRAF mutant CRCs in patients are primarily localized in the right colon, including the cecum. However, in the Vill-Cre;BRAFV600E/+ mice, ...

    Abstract BRAF mutation is a driver mutation in colorectal cancer (CRC), and BRAFV600E mutation is found in 10–15 % of all CRCs. BRAF mutant CRCs in patients are primarily localized in the right colon, including the cecum. However, in the Vill-Cre;BRAFV600E/+ mice, adenomas mainly developed in the small intestines of the mice, and no tumor formed in the cecum. The mice model of BRAFV600E-mutant CRC with tumors in the cecum is lacking. Dextran Sulfate Sodium (DSS) treatment induces colitis in mice. Acute DSS treatment does not lead to tumor formation. We show that DSS treatment and BRAFV600E mutation synergistically induced cecal tumorigenesis, and cecal tumors formed within three months after five-day DSS treatment. The location of the adenomas supports the patient relevance of the model. Our BRAFV600E/DSS model provides a valuable in vivo model for future identification and validation of novel therapeutic approaches for treating BRAF-mutant CRC. Our results are consistent with the notion that BRAFV600E mutation is an oncogenic event that can shift controlled regeneration to unrestrained oncogenesis.
    Keywords BRAFV600E mutation ; DSS ; CRC ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Treatment of Colorectal Cancer and Other GI Cancers in the COVID-19 Pandemic

    Chu, Edward

    Clinical Colorectal Cancer

    2020  Volume 19, Issue 3, Page(s) 145

    Keywords Gastroenterology ; Oncology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2112638-0
    ISSN 1533-0028
    ISSN 1533-0028
    DOI 10.1016/j.clcc.2020.07.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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