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Article ; Online: Low-cost model for pancreatojejunostomy simulation in minimally invasive pancreatoduodenectomy.

Tan, Hiang Jin / Chiow, Adrian Kah Heng / Lee, Lip Seng / Liao, Suyue / Feng, Ying / Thiruchelvam, Nita

Annals of hepato-biliary-pancreatic surgery

2023 Volume 27, Issue 4, Page(s) 428–432

Abstract: Minimally invasive pancreatoduodenectomy (MIS PD) is a well reported technique with several advantages over conventional open pancreatoduodenectomy. In comparison to distal pancreatectomy, the adoption of MIS PD has been slow due to the technical ... ...

Abstract	Minimally invasive pancreatoduodenectomy (MIS PD) is a well reported technique with several advantages over conventional open pancreatoduodenectomy. In comparison to distal pancreatectomy, the adoption of MIS PD has been slow due to the technical challenges involved, particularly in the reconstruction phase of the pancreatojejunostomy (PJ) anastomosis. Hence, we introduce a low-cost model for PJ anastomosis simulation in MIS PD. We fashioned a model of a cut pancreas and limb of jejunum using economical and easily accessible materials comprising felt fabric and the modelling compound, Play-Doh. Surgeons can practice MIS PJ suturing using this model to help mount their individual learning curve for PJ creation. Our video demonstrates that this model can be utilized in simulation practice mimicking steps during live surgery. Our model is a cost-effective and easily replicable tool for surgeons looking to simulate MIS PJ creation in preparation for MIS PD.
Language	English
Publishing date	2023-08-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.23-040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of glucagon-like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity-A systematic review.

Ng, Victoria Wen Wei / Gerard, Gheslynn / Koh, Jonathan Jin Kai / Loke, Kah Yin / Lee, Yung Seng / Ng, Nicholas Beng Hui

Clinical obesity

2024 , Page(s) e12642

Abstract: Hypothalamic obesity does not respond well to conventional interventions for obesity. GLP-1 receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. This systematic review ... ...

Abstract	Hypothalamic obesity does not respond well to conventional interventions for obesity. GLP-1 receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. This systematic review summarizes the efficacy and safety of GLP-1 receptor agonists use in hypothalamic obesity. A PRISMA-compliant systematic review was performed. Data was extracted from included studies and analysed based on change in weight, body mass index, glycaemic control, satiety, and safety profile with GLP-1 receptor agonist use. Ten studies comprising 5 case reports, 4 case series and 1 randomized-controlled trial included 54 patients (24 males, 30 females) with mean age of 25.2 (range 13-71) years with hypothalamic obesity who had received GLP-1 receptor agonists (exenatide = 48, liraglutide = 5 and dulaglutide = 1) over a mean duration of treatment of 12 (range 3-51) months. Mean weight reduction of 7.4 (SD 7.92) kg was observed in patients in whom weight was reported, with 85.7% of patients experiencing weight loss. All patients on liraglutide had weight reduction post-therapy. The sole trial had reported a non-significant reduction in BMI post-exenatide. Glycaemic control had either improved/maintained in all patients in whom this was measured. The main side effects of GLP-1 receptor agonist in individuals with hypothalamic obesity were nausea and vomiting; there were no major safety concerns. Based on limited published experience, GLP-1RA may be effective and safe for weight control in hypothalamic obesity, with the added benefit of improved glycaemic control in those with concurrent diabetes mellitus.
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12642
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Article ; Online: SARS-COV-2 as an artificial creation: scientific arguments and counterarguments.

Yee, Shermaine / Tan, Ching Siang / Khan, Abdullah / Lee, Kah Seng / Goh, Bey Hing / Ming, Long Chiau

Journal of medicine and life

2021 Volume 14, Issue 1, Page(s) 118–120

Language	English
Publishing date	2021-03-02
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3117 ; 1844-3109
ISSN (online)	1844-3117
ISSN	1844-3117 ; 1844-3109
DOI	10.25122/jml-2020-0175
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Article ; Online: Implementing dispersion measurement as part of scanning proton therapy commissioning and quality assurance.

Tan, Hong Qi / Lew, Kah Seng / Koh, Calvin Wei Yang / Wibawa, Andrew / Yeap, Ping Lin / Master, Zubin / Lee, James Cheow Lei / Beltran, Chris J / Park, Sung Yong / Furutani, Keith M

Physics in medicine and biology

2023 Volume 68, Issue 22

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Proton Therapy/methods ; Radiometry ; Protons ; Motion
Chemical Substances	Protons
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad0536
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Zs.A 199: Show issues

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Article ; Online: Repurposing DailyQA3 for an efficient and spot position sensitive daily quality assurance tool for proton therapy.

Tan, Hong Qi / Koh, Calvin Wei Yang / Lew, Kah Seng / Yeap, Ping Lin / Chua, Clifford Ghee Ann / Lee, James Kuan Huei / Wong, Yun Ming / Wibawa, Andrew / Master, Zubin / Lee, James Cheow Lei / Park, Sung Yong

Journal of applied clinical medical physics

2024 , Page(s) e14348

Abstract: Introduction: Daily quality assurance is an integral part of a radiotherapy workflow to ensure the dose is delivered safely and accurately to the patient. It is performed before the first treatment of the day and needs to be time and cost efficient for ... ...

Abstract	Introduction: Daily quality assurance is an integral part of a radiotherapy workflow to ensure the dose is delivered safely and accurately to the patient. It is performed before the first treatment of the day and needs to be time and cost efficient for a multiple gantries proton center. In this study, we introduced an efficient method to perform QA for output constancy, range verification, spot positioning accuracy and imaging and proton beam isocenter coincidence with DailyQA3. Methods: A stepped acrylic block of specific dimensions is fabricated and placed on top of the DailyQA3 device. Treatment plans comprising of two different spread-out Bragg peaks and five individual spots of 1.0 MU each are designed to be delivered to the device. A mathematical framework to measure the 2D distance between the detectors and individual spot is introduced and play an important role in realizing the spot positioning and centering QA. Lastly, a 5 months trends of the QA for two gantries are presented. Results: The outputs are monitored by two ion chambers in the DailyQA3 and a tolerance of Conclusion: With the proposed approach, we can perform four QA items in the TG224 within 10 min.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.14348
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Article ; Online: New drug law: The missing link in substance use and its control?

Ming, Long Chiau / Lee, Kah Seng

Research in social & administrative pharmacy : RSAP

2016 Volume 12, Issue 6, Page(s) 1035–1037

Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Letter
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2016.05.047
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Article ; Online: Screening for obstructive sleep apnea (OSA) in children and adolescents with obesity: A scoping review of national and international pediatric obesity and pediatric OSA management guidelines.

Ng, Nicholas Beng Hui / Lim, Carey Yun Shan / Tan, Sarah Caellainn Hui Lin / Foo, Yu Wah / Tok, Chanel Li Xuan / Lim, Yvonne Yijuan / Goh, Daniel Yam Thiam / Loke, Kah Yin / Lee, Yung Seng

Obesity reviews : an official journal of the International Association for the Study of Obesity

2024 Volume 25, Issue 5, Page(s) e13712

Abstract: Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA ... ...

Abstract	Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA are crucial in the management of children with obesity. We performed a scoping review of international and national pediatric obesity (n = 30) and pediatric OSA (n = 10) management guidelines to evaluate the recommendations on OSA screening in pediatric obesity. Sixteen (53%) of the pediatric obesity guidelines had incorporated OSA screening to varying extents, with no consistent recommendations on when and how to screen for OSA, and subsequent management of OSA in children with obesity. We provide our recommendations that are based on the strength and certainty of evidence presented. These include a clinical-based screening for OSA in all children with body mass index (BMI) ≥ 85th percentile or those with rapid BMI gain (upward crossing of 2 BMI percentiles) and the use of overnight polysomnography to confirm the diagnosis of OSA in those with high clinical suspicion. We discuss further management of OSA unique to children with obesity. An appropriate screening strategy for OSA would facilitate timely intervention that has been shown to improve cardiometabolic and neurocognitive outcomes.
MeSH term(s)	Adolescent ; Humans ; Child ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis ; Pediatric Obesity/therapy ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Sleep Apnea, Obstructive/complications ; Body Mass Index ; Polysomnography ; Cardiovascular Diseases/complications
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13712
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Zs.A 5908: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Prediction of portal dosimetry quality assurance results using log files-derived errors and machine learning techniques.

Lew, Kah Seng / Chua, Clifford Ghee Ann / Koh, Calvin Wei Yang / Lee, James Cheow Lei / Park, Sung Yong / Tan, Hong Qi

Frontiers in oncology

2023 Volume 12, Page(s) 1096838

Abstract: Objective: This work aims to use machine learning models to predict gamma passing rate of portal dosimetry quality assurance with log file derived features. This allows daily treatment monitoring for patients and reduce wear and tear on EPID detectors ... ...

Abstract	Objective: This work aims to use machine learning models to predict gamma passing rate of portal dosimetry quality assurance with log file derived features. This allows daily treatment monitoring for patients and reduce wear and tear on EPID detectors to save cost and prevent downtime. Methods: 578 VMAT trajectory log files selected from prostate, lung and spine SBRT were used in this work. Four machine learning models were explored to identify the best performing regression model for predicting gamma passing rate within each sub-site and the entire unstratified data. Predictors used in these models comprised of hand-crafted log file-derived features as well as modulation complexity score. Cross validation was used to evaluate the model performance in terms of R Result: Using gamma passing rate of 1%/1mm criteria and entire dataset, LASSO regression has a R Conclusion: Log file-derived features can predict gamma passing rate of portal dosimetry with an average error of less than 2% using the 1%/1mm criteria. This model can potentially be applied to predict the patient specific QA results for every treatment fraction.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1096838
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Article ; Online: A systematic review of pharmaceutical price mark-up practice and its implementation.

Lee, Kah Seng / Kassab, Yaman Walid / Taha, Nur Akmar / Zainal, Zainol Akbar

Exploratory research in clinical and social pharmacy

2021 Volume 2, Page(s) 100020

Abstract: Pharmaceutical products, apart from being essential for medical treatment, are of high value and heavily regulated to ensure the prices are controlled. This systematic review was conducted to identify pharmaceutical pricing mark-up control measures, ... ...

Abstract	Pharmaceutical products, apart from being essential for medical treatment, are of high value and heavily regulated to ensure the prices are controlled. This systematic review was conducted to identify pharmaceutical pricing mark-up control measures, specifically in the wholesale and retail sectors. The search method comprised the following databases: PubMed, Science Direct, Springer Link, ProQuest, and EBSCOhost and Google Scholar. The results were filtered systematically from the inception of the aforementioned databases until 23 April 2021. Eligible studies were those focusing on the implementation of pharmaceutical pricing strategies that involve a) mark-ups of medicine, and b) pharmaceutical cost control measures. A total of 13 studies were included in this review: seven covered European countries, four covered Asian countries, one covered the USA and one covered Canada. The main points of discussion in the qualitative synthesis were the implementation of medicine mark-ups, price mark-up regulatory strategies and the outcomes of these regulatory strategies. Our findings suggest that Western countries have a lower mark-up margin, around 4% to 25% of the original purchased price, compared to Asian countries, up to 50%.
Language	English
Publishing date	2021-05-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2667-2766
ISSN (online)	2667-2766
DOI	10.1016/j.rcsop.2021.100020
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Article ; Online: Effects of modern aesthetic dental fillings on proton therapy.

Wong, Yun Ming / Koh, Calvin Wei Yang / Lew, Kah Seng / Chua, Clifford Ghee Ann / Yeap, Ping Lin / Andrew, Wibawa / Zubin, Master / Poh, Sharon Shuxian / Lew, Wen Siang / Lee, James Cheow Lei / Park, Sung Yong / Tan, Hong Qi

Physics and imaging in radiation oncology

2024 Volume 29, Page(s) 100552

Abstract: Background and purpose: High-density dental fillings pose a non-negligible impact on head and neck cancer treatment. For proton therapy, stopping power ratio (SPR) prediction will be significantly impaired by the associated image artifacts. Dose ... ...

Abstract	Background and purpose: High-density dental fillings pose a non-negligible impact on head and neck cancer treatment. For proton therapy, stopping power ratio (SPR) prediction will be significantly impaired by the associated image artifacts. Dose perturbation is also inevitable, compromising the treatment plan quality. While plenty of work has been done on metal or amalgam fillings, none has touched on composite resin (CR) and glass ionomer cement (GIC) which have seen an increasing usage. Hence, this work aims to provide a detailed characterisation of SPR and dose perturbation in proton therapy caused by CR and GIC. Materials and methods: Four types of fillings were used: CR, Fuji Bulk (FB), Fuji II (FII) and Fuji IX (FIX). The latter three belong to GIC category. Measured SPR were compared with SPR predicted using single-energy computed tomography (SECT) and dual-energy computed tomography (DECT). Dose perturbation of proton beams with lower- and higher-energy levels was also quantified using Gafchromic films. Results: The measured SPR for CR, FB, FII and FIX were 1.68, 1.77, 1.77 and 1.76, respectively. Overall, DECT could predict SPR better than SECT. The lowest percentage error achieved by DECT was 19.7 %, demonstrating the challenge in estimating SPR, even for fillings with relatively lower densities. For both proton beam energies and all four fillings of about 4.5 mm thickness, the maximum dose perturbation was 3 %. Conclusion: This study showed that dose perturbation by CR and GIC was comparatively small. We have measured and recommended the SPR values for overriding the fillings in TPS.
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-6316
ISSN (online)	2405-6316
DOI	10.1016/j.phro.2024.100552
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