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Article ; Online: Fixing the anesthesia research crisis in Japan.

Saito, Junichi / Hirota, Kazuyoshi / Mazda, Yusuke / Aoyama, Kazuyoshi / Suehiro, Koichi / Amaya, Fumimasa / Morita, Kiyoshi / Takeda, Junzo

Journal of anesthesia

2024 Volume 38, Issue 2, Page(s) 254–260

Abstract: To explore the current status of anesthesia research activity in Japan, we analyzed the number of abstracts presented at the Japanese Society of Anesthesiologists (JSA) annual meetings by several factors including gender, society branches, and ... ...

Abstract	To explore the current status of anesthesia research activity in Japan, we analyzed the number of abstracts presented at the Japanese Society of Anesthesiologists (JSA) annual meetings by several factors including gender, society branches, and subspecialty categories. The number of abstracts at JSA annual meetings has declined sharply since 2016 with no gender gap. A decrease in the neurological field predated the overall decline, but other subspecialty categories showed a similar decline. Although the Tokyo, Tokai-Hokuriku, and Kyushu branches were responsible for more than half of the reduction, the trend was similar among all branches. In a survey regarding academic activities of university hospital residents and faculty, Ph.D. aspirants' rate was only 20-30%. Residents had never presented an abstract at scientific conferences and never published any papers at nearly 40% and 30% of the university hospitals, respectively. Our survey suggests that junior anesthetists are losing interest in research. Senior faculty and mentors must redouble efforts to embed and encourage research in departments and by anesthetists in training. If a revival of anesthesia research in Japan does not occur then a service only specialty awaits.
MeSH term(s)	Humans ; Japan ; Anesthesiology/education ; Anesthesia ; Hospitals, University ; Anesthesiologists
Language	English
Publishing date	2024-01-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1107821-2
ISSN	1438-8359 ; 0913-8668
ISSN (online)	1438-8359
ISSN	0913-8668
DOI	10.1007/s00540-023-03292-3
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Article ; Online: Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice.

Takeda, Kazuyoshi / Okumura, Ko

Biomedical research (Tokyo, Japan)

2021 Volume 42, Issue 5, Page(s) 173–179

Abstract: Nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide ( ... ...

Abstract	Nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Aging ; Animals ; Killer Cells, Natural ; Mice ; Mice, Inbred BALB C ; NAD ; Nicotinamide Mononucleotide
Chemical Substances	NAD (0U46U6E8UK) ; Nicotinamide Mononucleotide (1094-61-7)
Language	English
Publishing date	2021-03-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.42.173
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Zs.A 1654: Show issues

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Article ; Online: Simultaneous Inflation of Both Cuffs of an EZ-Blocker Device Facilitates Selective Endobronchial Isolation.

Goto, Marina / Aoyama, Kazuyoshi / Nishimura, Masahiro / Takeda, Takao

Journal of cardiothoracic and vascular anesthesia

2022 Volume 36, Issue 8 Pt B, Page(s) 3429–3430

MeSH term(s)	Humans ; Intubation, Intratracheal ; One-Lung Ventilation
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.03.039
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The association between emotion malleability beliefs and severe psychological distress stratified by sex, age, and presence of any psychiatric disorders.

Sasaki, Yohei / Okubo, Ryo / Takeda, Kazuyoshi / Ikezawa, Satoru / Tabuchi, Takahiro / Shirotsuki, Kentaro

Frontiers in psychology

2023 Volume 14, Page(s) 1251945

Abstract: Background: Recent studies have shown an association between psychological distress and emotion malleability beliefs, meaning mindsets about whether one's emotions are fixed or changeable. However, most studies have not examined the association between ... ...

Abstract	Background: Recent studies have shown an association between psychological distress and emotion malleability beliefs, meaning mindsets about whether one's emotions are fixed or changeable. However, most studies have not examined the association between these beliefs and sociodemographic factors. Methods: A nationwide cross-sectional Internet survey of residents of Japan aged 15-79 years was conducted using sampling weights for national estimates to investigate the association between emotion malleability beliefs and sociodemographic factors and between fixed beliefs and severe psychological distress (SPD). SPD was defined as a Kessler 6 Scale score of ≥13. Adjusted odds ratios for SPD were calculated considering potential confounders. Further analyses were stratified by sex, age and presence of any psychiatric disorder. Results: The analysis included 23,142 participants (female, 48.64%). Fixed beliefs were associated with female sex, age < 45 years, and presence of psychiatric disorders. These beliefs were associated with SPD, and additional analysis showed stronger associations with SPD among female respondents, respondents aged 45-59 years, and those aged ≥60 years. Conclusion: Results indicate that female sex, age < 45 years, and current mental disorders were associated with fixed emotion malleability beliefs. Associations between fixed emotion malleability beliefs and SPD were particularly strong among female respondents and people aged ≥45 years compared with the general population. Our study extends the association between emotion malleability beliefs and psychological health to the general population. Future studies should explore mechanisms underlying individual differences in emotion beliefs.
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1251945
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Article ; Online: IL-33 deficiency suppresses alveolar bone loss in a ligature-induced periodontitis model.

Aida, Natsuko / Takeda, Kazuyoshi / Nakae, Susumu / Saito, Hirohisa / Okumura, Ko / Azuma, Toshifumi / Ohno, Tatsukuni

Biomedical research (Tokyo, Japan)

2023 Volume 44, Issue 1, Page(s) 9–16

Abstract: Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been studied primarily in the context of type 2 immune responses. Recent reports suggest that IL-33 also enhances the func- tions of various immune cells and contributes to the ... ...

Abstract	Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been studied primarily in the context of type 2 immune responses. Recent reports suggest that IL-33 also enhances the func- tions of various immune cells and contributes to the development of different inflammatory diseas- es. Interestingly, IL-33 and its receptor ST2 axis exerted either inhibitory or promotional effects on alveolar bone loss in various periodontitis models. Using a mouse model of ligature-induced periodontitis, we found that the levels of mRNAs encoding IL-33 and other inflammatory cyto- kines (IL-1α, IL-1β, IL-6, and TNFα) were augmented in gingival tissues of wild-type (WT) mice, and that the alveolar bone loss amount was lower in IL-33-deficient than WT mice. The numbers and proportions of IFN-γ-producing CD8+ T and regulatory T cells were decreased while those of Th17 cells were increased in the draining lymph nodes of IL-33-deficient mice compared to WT mice. Additionally, the level of RNA encoding an osteoclastogenic molecule, i.e., receptor activa- tor of nuclear factor kappa-B ligand (RANKL), in ligated gingival tissue was higher in IL-33-defi- cient than WT mice. These results suggest that IL-33 is involved in alveolar bone loss in the ligature-induced periodontitis model, although IL-33 may inhibit osteoclast differentiation.
MeSH term(s)	Mice ; Animals ; Alveolar Bone Loss/etiology ; Alveolar Bone Loss/pathology ; Interleukin-33/genetics ; Periodontitis/pathology ; Cytokines ; Osteogenesis ; RANK Ligand/genetics ; RANK Ligand/pharmacology
Chemical Substances	Interleukin-33 ; Cytokines ; RANK Ligand
Language	English
Publishing date	2023-01-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.44.9
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Zs.A 1654: Show issues

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Article ; Online: Individual prefrontal neurons contribute to sensory-to-motor information transformation by rotating reference frames during spatial working memory performance.

Funahashi, Shintaro / Gao, Binbin / Takeda, Kazuyoshi / Watanabe, Yumiko / Wu, Jinglong / Yan, Tianyi

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 19, Page(s) 10258–10271

Abstract: Performing working memory tasks correctly requires not only the temporary maintenance of information but also the visual-to-motor transformation of information. Although sustained delay-period activity is known to be a mechanism for temporarily ... ...

Abstract	Performing working memory tasks correctly requires not only the temporary maintenance of information but also the visual-to-motor transformation of information. Although sustained delay-period activity is known to be a mechanism for temporarily maintaining information, the mechanism for information transformation is not well known. An analysis using a population of delay-period activities recorded from prefrontal neurons visualized a gradual change of maintained information from sensory to motor as the delay period progressed. However, the contributions of individual prefrontal neurons to this process are not known. In the present study, we used a version of the delayed-response task, in which monkeys needed to make a saccade 90o clockwise from a visual cue after a 3-s delay, and examined the temporal change in the preferred directions of delay-period activity during the delay period for individual neurons. One group of prefrontal neurons encoded the cue direction by a retinotopic reference frame and either maintained it throughout the delay period or rotated it 90o counterclockwise to adjust visual information to saccade information, whereas other groups of neurons encoded the cue direction by a saccade-based reference frame and rotated it 90o clockwise. The results indicate that visual-to-motor information transformation is achieved by manipulating the reference frame to adjust visual coordinates to motor coordinates.
MeSH term(s)	Memory, Short-Term/physiology ; Psychomotor Performance/physiology ; Prefrontal Cortex/physiology ; Neurons/physiology ; Saccades ; Reaction Time/physiology
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad280
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Zs.A 3235: Show issues

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Article ; Online: Early Reversal of Neuromuscular Block by Sugammadex for Nerve Stimulation Guidance During Peripheral Nerve Block Under General Anesthesia.

Moriwaki, Kuniaki / Aoyama, Kazuyoshi / Nishimura, Masahiro / Takeda, Takao

Asian journal of anesthesiology

2020 Volume 58, Issue 3, Page(s) 117–119

MeSH term(s)	Anesthesia, General ; Humans ; Neuromuscular Blockade ; Peripheral Nerves ; Rocuronium ; Sugammadex
Chemical Substances	Sugammadex (361LPM2T56) ; Rocuronium (WRE554RFEZ)
Language	English
Publishing date	2020-07-24
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ISSN	2468-824X
ISSN (online)	2468-824X
DOI	10.6859/aja.202009_58(3).0006
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Article ; Online: CD8

Matsumoto, Ryu / Enzhi, Yin / Takeda, Kazuyoshi / Morimoto, Kodai / Yogo, Kyoko / Harada, Masaki / Tokushige, Koji / Maehara, Yui / Hirota, Saori / Kojima, Yuko / Ito, Mamoru / Sougawa, Nagako / Miyagawa, Shigeru / Sawa, Yoshiki / Okumura, Ko / Uchida, Koichiro

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2024

Abstract: Background: Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully ... ...

Abstract	Background: Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. Methods: We transferred human peripheral blood mononuclear cells (hPBMCs) into NOD/Shi-scid IL2rg Results: The human immune cells were engrafted for more than three months in NOG-ΔMHC mice without lethal xeno-GVHD. The hiPS-CMs expressed a moderate level of human leukocyte antigen (HLA)-class I, but not HLA-class II, molecules even after interferon-gamma (IFN-γ) stimulation. Consistently, the allogenic IFN-γ-treated hiPS-CMs induced weak CD8 Conclusion: hiPS-CMs are less immunogenic in vitro but induce sufficient CD8
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2024.04.003
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Article ; Online: Anti-influenza Activity of Povidone-Iodine-Integrated Materials.

Shoji, Masaki / Ichihashi, Kenta / Sriwilaijaroen, Nongluk / Mayumi, Haruka / Morikane, Shinji / Takahashi, Etsuhisa / Kido, Hiroshi / Suzuki, Yasuo / Takeda, Kazuyoshi / Kuzuhara, Takashi

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 9, Page(s) 1231–1239

Abstract: Personal protective equipment (PPE), including medical masks, should be worn for preventing the transmission of respiratory pathogens via infective droplets and aerosols. In medical masks, the key layer is the filter layer, and the melt-blown nonwoven ... ...

Abstract	Personal protective equipment (PPE), including medical masks, should be worn for preventing the transmission of respiratory pathogens via infective droplets and aerosols. In medical masks, the key layer is the filter layer, and the melt-blown nonwoven fabric (NWF) is the most used fabric. However, the NWF filter layer cannot kill or inactivate the pathogens spread via droplets and aerosols. Povidone-iodine (PVP-I) has been used as an antiseptic solution given its potent broad-spectrum activity against pathogens. To develop PPE (e.g., medical masks) with anti-pathogenic activity, we integrated PVP-I into nylon-66 NWF. We then evaluated its antiviral activity against influenza A viruses by examining the viability of Madin-Darby canine kidney (MDCK) cells after inoculation with the virus strains exposed to the PVP-I-integrated nylon-66 NWF. The PVP-I nylon-66 NWF protected the MDCK cells from viral infection in a PVP-I concentration-dependent manner. Subsequently, we found to integrate PVP-I into nylon-66 and polyurethane materials among various materials. These PVP-I materials were also effective against influenza virus infection, and treatment with PVP-I nylon-66 NWF showed the highest cell survival among all the tested materials. PVP-I showed anti-influenza A virus activity when used in conjunction with PPE materials. Moreover, nylon-66 NWF integrated with PVP-I was found to be the best material to ensure anti-influenza activity. Therefore, PVP-I-integrated masks could have the potential to inhibit respiratory virus infection. Our results provide new information for developing multi-functional PPEs with anti-viral activity by integrating them with PVP-I to prevent the potential transmission of respiratory viruses.
MeSH term(s)	Animals ; Dogs ; Humans ; Povidone-Iodine/pharmacology ; Povidone-Iodine/therapeutic use ; Nylons ; Respiratory Aerosols and Droplets ; Influenza, Human/prevention & control ; Orthomyxoviridae
Chemical Substances	Povidone-Iodine (85H0HZU99M) ; Nylons
Language	English
Publishing date	2023-06-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b23-00161
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Zs.A 1474: Show issues

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Article ; Online: The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice.

Hanzawa, Satoshi / Sugiura, Makiko / Nakae, Susumu / Masuo, Masahiro / Morita, Hideaki / Matsumoto, Kenji / Takeda, Kazuyoshi / Okumura, Ko / Nakamura, Masataka / Ohno, Tatsukuni / Miyazaki, Yasunari

International archives of allergy and immunology

2024 , Page(s) 1–9

Abstract: Introduction: Prostaglandin D2 (PGD2), which is produced mainly by Th2 cells and mast cells, promotes a type-2 immune response by activating Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s) via its receptor, chemoattractant ... ...

Abstract	Introduction: Prostaglandin D2 (PGD2), which is produced mainly by Th2 cells and mast cells, promotes a type-2 immune response by activating Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s) via its receptor, chemoattractant receptor-homologous molecules on Th2 cells (CRTH2). However, the role of CRTH2 in models of airway inflammation induced by sensitization without adjuvants, in which both IgE and mast cells may play major roles, remain unclear. Methods: Wild-type (WT) and CRTH2-knockout (KO) mice were sensitized with ovalbumin (OVA) without an adjuvant and then challenged intranasally with OVA. Airway inflammation was assessed based on airway hyperresponsiveness (AHR), lung histology, number of leukocytes, and levels of type-2 cytokines in the bronchoalveolar lavage fluid (BALF). Results: AHR was significantly reduced after OVA challenge in CRTH2 KO mice compared to WT mice. The number of eosinophils, levels of type-2 cytokines (IL-4, IL-5, and IL-13) in BALF, and IgE concentration in serum were decreased in CRTH2 KO mice compared to WT mice. However, lung histological changes were comparable between WT and CRTH2 KO mice. Conclusion: CRTH2 is responsible for the development of asthma responses in a mouse model of airway inflammation that features prominent involvement of both IgE and mast cells.
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000537840
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