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  1. Article ; Online: Aplastic anemia: Pathophysiology.

    Giudice, Valentina / Selleri, Carmine

    Seminars in hematology

    2022  Volume 59, Issue 1, Page(s) 13–20

    Abstract: Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions characterized by uni- or multi-lineage marrow and/or peripheral blood cytopenia(s), and can be classified in constitutional or acquired syndromes based on ... ...

    Abstract Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions characterized by uni- or multi-lineage marrow and/or peripheral blood cytopenia(s), and can be classified in constitutional or acquired syndromes based on pathophysiology. In inherited diseases, germline mutations occur in the hematopoietic stem and progenitor cell (HSPC) compartment causing a progressive loss of normal hematopoiesis, while in acquired syndromes, HPSC compartment disruption can be caused by an extrinsic direct damage by external cytotoxic agents on the stem cell pool or by an autoimmune attack against HSPCs. Aplastic anemia is an acquired immune-mediated BMF syndrome where marrow disruption is driven by a cytotoxic T cell-mediated autoimmune attack against HSPCs sustained by type I interferons that polarize the immune system toward T helper 1 responses in early phases and then toward T helper 17 and effector memory CD8
    MeSH term(s) Anemia, Aplastic/genetics ; Bone Marrow/pathology ; Bone Marrow Failure Disorders ; Hematopoietic Stem Cells/metabolism ; Humans ; Syndrome
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cell Viability Multiplexing: Quantification of Cellular Viability by Barcode Flow Cytometry and Computational Analysis.

    Giudice, Valentina / Fonseca, Victoria / Selleri, Carmine / Gadina, Massimo

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2644, Page(s) 99–121

    Abstract: Fluorescent cell barcoding (FCB) is a useful flow cytometric technique for high-throughput multiplexed analyses and can minimize technical variations after preliminary optimization and validation of protocols. To date, FCB is widely used for measurement ... ...

    Abstract Fluorescent cell barcoding (FCB) is a useful flow cytometric technique for high-throughput multiplexed analyses and can minimize technical variations after preliminary optimization and validation of protocols. To date, FCB is widely used for measurement of phosphorylation status of certain proteins, while it can be also employed for cellular viability assessment. In this chapter, we describe the protocol to perform FCB combined with viability assessment on lymphocytes and monocytes using manual and computational analysis. We also provide recommendations for FCB protocol optimization and validation for clinical sample analysis.
    MeSH term(s) Flow Cytometry/methods ; Cell Survival ; Lymphocytes ; Fluorescent Dyes
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3052-5_7
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  3. Article ; Online: All Roads Lead to Interferon-γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia.

    Serio, Bianca / Giudice, Valentina / Selleri, Carmine

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper( ... ...

    Abstract Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8
    MeSH term(s) Humans ; Anemia, Aplastic/etiology ; Anemia, Aplastic/pathology ; Interferon-gamma ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Bone Marrow Cells ; CD8-Positive T-Lymphocytes/metabolism
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122170
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  4. Article ; Online: Plasminogen System in the Pathophysiology of Sepsis: Upcoming Biomarkers.

    Napolitano, Filomena / Giudice, Valentina / Selleri, Carmine / Montuori, Nunzia

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Severe hemostatic disturbances and impaired fibrinolysis occur in sepsis. In the most serious cases, the dysregulation of fibrinolysis contributes to septic shock, disseminated intravascular coagulation (DIC), and death. Therefore, an analysis of ... ...

    Abstract Severe hemostatic disturbances and impaired fibrinolysis occur in sepsis. In the most serious cases, the dysregulation of fibrinolysis contributes to septic shock, disseminated intravascular coagulation (DIC), and death. Therefore, an analysis of circulating concentrations of pro- and anti-fibrinolytic mediators could be a winning strategy in both the diagnosis and the treatment of sepsis. However, the optimal cutoff value, the timing of the measurements, and their combination with coagulation indicators should be further investigated. The purpose of this review is to summarize all relevant publications regarding the role of the main components of the plasminogen activation system (PAS) in the pathophysiology of sepsis. In addition, the clinical value of PAS-associated biomarkers in the diagnosis and the outcomes of patients with septic syndrome will be explored. In particular, experimental and clinical trials performed in emergency departments highlight the validity of soluble urokinase plasminogen activator receptor (suPAR) as a predictive and prognostic biomarker in patients with sepsis. The measurements of PAI-I may also be useful, as its increase is an early manifestation of sepsis and may precede the development of thrombocytopenia. The upcoming years will undoubtedly see progress in the use of PAS-associated laboratory parameters.
    MeSH term(s) Humans ; Plasminogen ; Sepsis ; Shock, Septic ; Fibrinolysis ; Serine Proteases ; Biomarkers
    Chemical Substances Plasminogen (9001-91-6) ; Serine Proteases (EC 3.4.-) ; Biomarkers
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512376
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  5. Article ; Online: All Roads Lead to Interferon-γ

    Bianca Serio / Valentina Giudice / Carmine Selleri

    Medicina, Vol 59, Iss 12, p

    From Known to Untraveled Pathways in Acquired Aplastic Anemia

    2023  Volume 2170

    Abstract: Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper( ... ...

    Abstract Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8 + T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T cell-mediated responses and can directly induce HSPC apoptosis and differentiation block. The use of omics technologies has amplified the amount of data at the single-cell level, and knowledge on AA, and new scenarios, have been opened on “old” point of view. In this review, we summarize the current state-of-art of the pathogenic role of IFNγ in AA from initial findings to novel evidence, such as the involvement of the HIF-1α pathway, and how this knowledge can be translated in clinical practice.
    Keywords acquired aplastic anemia ; bone marrow failure syndromes ; interferon-γ ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Editorial: Endocrinological sequelae of hematopoietic stem cell transplantation.

    Giudice, Valentina / Gurnari, Carmelo / Pagliuca, Simona / Castaldi, Maria Antonietta / Selleri, Carmine

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1151213

    MeSH term(s) Endocrinology ; Hematopoietic Stem Cell Transplantation/adverse effects
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1151213
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  7. Article ; Online: Lenalidomide-induced psoriasis in a refractory multiple myeloma patient successfully treated with narrowband ultraviolet B.

    De Novellis, Danilo / Raimondo, Annunziata / Serio, Bianca / Baldi, Carlo / Giudice, Valentina / Lembo, Serena / Selleri, Carmine

    Photodermatology, photoimmunology & photomedicine

    2024  Volume 40, Issue 3, Page(s) e12965

    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/radiotherapy ; Lenalidomide/therapeutic use ; Psoriasis/drug therapy ; Psoriasis/radiotherapy ; Thalidomide/analogs & derivatives ; Thalidomide/therapeutic use ; Thalidomide/adverse effects ; Ultraviolet Therapy ; Male ; Middle Aged ; Female ; Aged
    Chemical Substances Lenalidomide (F0P408N6V4) ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Letter ; Case Reports ; Journal Article
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12965
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  8. Article: Can we turn off the "Covid-biting-tail" inflammation?

    Valentina, Giudice / Amelia, Filippelli / Carmine, Selleri

    Translational medicine @ UniSa

    2020  Volume 23, Page(s) 39–41

    Language English
    Publishing date 2020-10-01
    Publishing country Italy
    Document type Journal Article
    ISSN 2239-9747
    ISSN 2239-9747
    DOI 10.37825/2239-9747.1006
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  9. Article ; Online: Bilateral optic neuritis after COVID vaccination.

    Arnao, Valentina / Maimone, Mario Baronello / Perini, Valentina / Giudice, Gregorio Lo / Cottone, Salvatore

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 5, Page(s) 2965–2966

    MeSH term(s) COVID-19/prevention & control ; Humans ; Optic Neuritis/diagnostic imaging ; Optic Neuritis/etiology ; Vaccination/adverse effects
    Language English
    Publishing date 2022-01-31
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-021-05832-9
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  10. Article: Marked Reduction of Oxidant Species after Sulfureous Crenotherapy in Females with Joint Diseases and Psoriasis: A Retrospective Real-Life Study.

    Costantino, Maria / Conti, Valeria / Corbi, Graziamaria / Giudice, Valentina / Caro, Francesco De / Filippelli, Amelia

    Journal of clinical medicine

    2023  Volume 12, Issue 17

    Abstract: Oxidative stress, a condition induced by an excessive amount of free radicals, such as reactive oxygen species (ROS), shows several gender-related differences in basal cellular redox state and antioxidant responses. Crenotherapy with sulfureous mineral ... ...

    Abstract Oxidative stress, a condition induced by an excessive amount of free radicals, such as reactive oxygen species (ROS), shows several gender-related differences in basal cellular redox state and antioxidant responses. Crenotherapy with sulfureous mineral water can improve the cellular redox state. In this retrospective observational study, gender-related differences in the efficacy of sulfureous crenotherapy in decreasing oxidant species were investigated. Seventy-eight patients, stratified by sex, with osteoarthritis or degenerative joint disease and Vulgar psoriasis who have received a cycle of sulfureous mud-bath therapy + sulfureous hydropinotherapy were enrolled. Plasma concentration of oxidant species and clinical outcomes were measured at baseline and at the end of treatment. After 2 weeks of sulfureous crenotherapy, a significant amelioration of clinical outcomes and a significant reduction of oxidant species were observed in both sexes, more marked in females than in males (
    Language English
    Publishing date 2023-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12175731
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