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Article ; Online: Is aggressive intravenous fluid prescription the answer to reduce mortality in severe pancreatitis? The FLIP study: Fluid resuscitation in pancreatitis.

McGovern, Julia / Tingle, Samuel J / Robinson, Stuart / Moir, John

Annals of hepato-biliary-pancreatic surgery

2023 Volume 27, Issue 4, Page(s) 394–402

Abstract: Backgrounds/aims: Acute pancreatitis is an emergency presentation, which can range from mild to life threatening. Intravenous fluids are the cornerstone of management. Although the WATERFALL trial described the optimal fluid rate in mild/moderate ... ...

Abstract	Backgrounds/aims: Acute pancreatitis is an emergency presentation, which can range from mild to life threatening. Intravenous fluids are the cornerstone of management. Although the WATERFALL trial described the optimal fluid rate in mild/moderate pancreatitis, this trial excluded patients with moderate-severe/severe pancreatitis. The aim of this study was to establish clinical practice regarding intravenous fluid administration in acute pancreatitis and assess its effect on mortality. Methods: Prospective multi-centre audit of patients with acute pancreatitis was conducted. Data were collected regarding intravenous fluid administration within 72 hours of admission. The primary outcome was 30-day mortality. Multivariable logistic regression was used to identify predictors of 30-day mortality. Results: Those with severe pancreatitis received more fluid; median 5.7 L versus 4 L in 72 hours ( Conclusions: In severe pancreatitis, more aggressive fluid prescription was associated with decreased mortality; however, this was not the case in milder disease. Further prospective trials guiding fluid resuscitation in severe pancreatitis are needed, as the impact of fluid on this population appears to differ from that in those with milder disease.
Language	English
Publishing date	2023-10-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.23-044
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Connective Tissue Disease Associated Myocarditis on Computed Tomography Coronary Angiogram.

Tan, Sean / Moir, Stuart / Seneviratne, Sujith

Heart, lung & circulation

2021 Volume 30, Issue 12, Page(s) e121–e122

MeSH term(s)	Connective Tissue Diseases/complications ; Connective Tissue Diseases/diagnosis ; Coronary Angiography ; Coronary Artery Disease ; Humans ; Magnetic Resonance Imaging ; Myocardial Perfusion Imaging ; Myocarditis/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-07-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2021.06.526
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Zs.A 4988: Show issues

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Article ; Online: Sinkhole syncope.

Gutman, Sarah / Moir, Stuart

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2017 Volume 19, Issue 6, Page(s) 928

MeSH term(s)	Atrioventricular Block/diagnostic imaging ; Atrioventricular Block/etiology ; Atrioventricular Block/physiopathology ; Atrioventricular Block/therapy ; Cardiac Pacing, Artificial ; Computed Tomography Angiography ; Coronary Angiography/methods ; Echocardiography ; Electrocardiography ; Female ; Geological Phenomena ; Humans ; Middle Aged ; Multidetector Computed Tomography ; Pacemaker, Artificial ; Syncope/diagnostic imaging ; Syncope/etiology ; Syncope/physiopathology ; Treatment Outcome ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left
Language	English
Publishing date	2017-05-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euw183
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Zs.A 5434: Show issues

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Article: Platypnea-orthodeoxia syndrome after right lower lobectomy for lung cancer.

D'Mello, Andre C / Haji, Kawa / Moir, Stuart / Leong, Paul

Oxford medical case reports

2019 Volume 2019, Issue 1, Page(s) omy049

Abstract: Platypnea-orthodeoxia syndrome (POS) is a rare condition characterized by dyspnoea and deoxygenation in an upright position that is relieved by supine positioning. There are only five published accounts of it occurring post-lobectomy. We present the case ...

Abstract	Platypnea-orthodeoxia syndrome (POS) is a rare condition characterized by dyspnoea and deoxygenation in an upright position that is relieved by supine positioning. There are only five published accounts of it occurring post-lobectomy. We present the case of a 72-year-old male with 3 months of supposedly unexplained dyspnoea after right lower lobectomy for lung cancer who was confirmed to have POS. We highlight the importance of recognition and management as well as provide a brief summary of the pathophysiology.
Language	English
Publishing date	2019-01-01
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omy049
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Article ; Online: Echocardiographic quantification of left ventricular systolic function.

Japp, Alan G / Moir, Stuart / Mottram, Philip M

Heart, lung & circulation

2015 Volume 24, Issue 6, Page(s) 532–535

MeSH term(s)	Adult ; Disease Progression ; Early Diagnosis ; Echocardiography, Doppler, Color/methods ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Assessment ; Stroke Volume/physiology ; Systole/physiology ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2015-06
Publishing country	Australia
Document type	Comparative Study ; Editorial
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2015.01.017
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Zs.A 4988: Show issues

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Article ; Online: Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.

Boyle, Andrew J / Schultz, Carl / Selvanayagam, Joseph B / Moir, Stuart / Kovacs, Richard / Dib, Nabil / Zlotnick, David / Al-Omary, Mohammed / Sugito, Stuart / Selvarajah, Aravinda / Collins, Nicholas / McLachlan, Grant

JAMA cardiology

2021 Volume 6, Issue 7, Page(s) 762–768

Abstract: Importance: After anterior ST-segment elevation myocardial infarction (STEMI), left ventricular (LV) remodeling results in heart failure and death. Calcium/calmodulin-dependent protein kinase II delta (CaMKIId) is a key molecular mediator of adverse LV ... ...

Abstract	Importance: After anterior ST-segment elevation myocardial infarction (STEMI), left ventricular (LV) remodeling results in heart failure and death. Calcium/calmodulin-dependent protein kinase II delta (CaMKIId) is a key molecular mediator of adverse LV remodeling. Objective: To determine whether NP202, an orally active inhibitor of CaMKIId, prevents LV remodeling in patients after anterior STEMI with early residual LV dysfunction. Design, setting, and participants: A randomized, double-blind, placebo-controlled multicenter clinical trial of NP202 vs placebo in patients after primary percutaneous coronary intervention (PCI) for anterior STEMI was performed from November 19, 2015, to August 1, 2018. The study was performed at 32 sites across the US, Australia, and New Zealand. Patients presenting with anterior STEMI who underwent PCI within 12 hours of symptom onset and left ventricular ejection fraction (LVEF) less than 45% on screening echocardiogram 48 hours after primary PCI were included in the study. Baseline cardiovascular magnetic resonance (CMR) imaging was performed within 5 days of the STEMI and before administration of the study drug. Follow-up CMR was performed after 3 months. Data were analyzed from November 19, 2015, to August 1, 2018. Interventions: Patients were randomly assigned to NP202, 1000 mg, daily for 3 months vs corresponding placebo. Main outcomes and measures: The primary end point was change in LV end-systolic volume index (LVESVi) on CMR. Secondary end points were change in LV end-diastolic volume index, change in LVEF, change in infarct size, and change in diastolic function. Safety and tolerability were also assessed. Results: A total of 147 patients (mean [SD] age, 58 [11] years; 129 men [88%]; 130 White patients [88%]) who experienced anterior STEMI treated with primary PCI were randomized to receive NP202 (73 [49.7%]) or placebo (74 [50.3%]). Baseline LVEF was similar between groups. At baseline, patients randomized to NP202 had greater LVESVi (48.2 mL/m2) than that in the placebo group (41.3 mL/m2; P = .03). However, the groups were otherwise well matched. For the primary end point of change in LVESVi from baseline to 3 months, there was no significant difference between the placebo (median [interquartile range] change, -0.60 [-9.28 to 5.99] mL/m2) and NP202 groups (-3.53 [-9.24 to 4.81] mL/m2) (P = .78). There was also no difference in the secondary efficacy end points assessed by CMR. NP202 was well tolerated and demonstrated an acceptable safety profile. Major adverse cardiac and cerebrovascular event rates were similar between groups. Two deaths occurred in each group during the follow-up period. Conclusions and relevance: Three months of treatment with NP202 after primary PCI for anterior STEMI with residual LV dysfunction did not improve LV remodeling. The drug was safe and well tolerated. Trial registration: ClinicalTrials.gov Identifier: NCT02557217.
MeSH term(s)	Aged ; Aged, 80 and over ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Double-Blind Method ; Female ; Flavonols/pharmacology ; Flavonols/therapeutic use ; Humans ; Male ; Middle Aged ; ST Elevation Myocardial Infarction/drug therapy ; ST Elevation Myocardial Infarction/pathology ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Left/etiology ; Ventricular Remodeling/drug effects
Chemical Substances	CaMKIId inhibitor NP202 ; Flavonols ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
Language	English
Publishing date	2021-04-11
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2021.0676
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Article ; Online: Which test for CAD should be used in patients with left bundle branch block?

Xu, Bo / Cremer, Paul / Jaber, Wael / Moir, Stuart / Harb, Serge C / Rodriguez, L Leonardo

Cleveland Clinic journal of medicine

2018 Volume 85, Issue 3, Page(s) 224–230

Abstract: Exercise stress electrocardiography is unreliable as a test for obstructive coronary artery disease (CAD) if the patient has left bundle branch block. The authors provide an algorithm for using alternative tests: exercise stress echocardiography, ... ...

Abstract	Exercise stress electrocardiography is unreliable as a test for obstructive coronary artery disease (CAD) if the patient has left bundle branch block. The authors provide an algorithm for using alternative tests: exercise stress echocardiography, dobutamine echocardiography, computed tomographic (CT) angiography, and nuclear myocardial perfusion imaging.
MeSH term(s)	Bundle-Branch Block/complications ; Bundle-Branch Block/diagnostic imaging ; Computed Tomography Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/etiology ; Echocardiography, Stress/methods ; Humans ; Myocardial Perfusion Imaging/methods
Language	English
Publishing date	2018-04-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.85a.17051
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Ua VI Zs.212: Show issues

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Article ; Online: Is exercise stress echocardiography useful in patients with suspected obstructive coronary artery disease who have resting left bundle branch block?

Xu, Bo / Dobson, Laura / Mottram, Philip M / Nasis, Arthur / Cameron, James / Moir, Stuart

Clinical cardiology

2018 Volume 41, Issue 3, Page(s) 360–365

Abstract: Background: Current guidelines support exercise stress echocardiography (ESE) for evaluation of suspected obstructive coronary artery disease (OCAD) in ambulant patients with left bundle branch block (LBBB). Data regarding the diagnostic utility of ESE ... ...

Abstract	Background: Current guidelines support exercise stress echocardiography (ESE) for evaluation of suspected obstructive coronary artery disease (OCAD) in ambulant patients with left bundle branch block (LBBB). Data regarding the diagnostic utility of ESE in patients with LBBB are limited. Hypothesis: We hypothesized that the diagnostic performance of ESE for the assessment of suspected OCAD is reduced in the context of LBBB. Methods: We studied 191 consecutive patients with resting LBBB undergoing ESE for the investigation of suspected OCAD between 2008 and 2015 at our center. The studies were categorized as inconclusive, normal, or abnormal. Patients with an abnormal response were subcategorized as regional ischemic response or globally abnormal. Results: Eighty-two patients (43%) demonstrated a normal left ventricular contractile response (LVCR) to exercise; 92 (48%) developed an abnormal LVCR to exercise, including 70 patients with globally abnormal and 22 patients with regional ischemic responses. Of the patients with abnormal responses, 62 patients had anatomic imaging, only 29 of whom had significant OCAD, conferring an overall specificity of ESE for significant OCAD of 21% and accuracy of 52%. Of patients who developed a regionally abnormal response, 89% had significant OCAD. Conclusions: For patients with LBBB who develop a globally abnormal LVCR during ESE, the specificity of ESE for reliably excluding significant OCAD is significantly reduced. ESE appears to be a suboptimal test for the evaluation of OCAD in patients with resting LBBB, as about 50% of patients will have an abnormal response, the majority due to globally abnormal contraction where OCAD cannot be reliably diagnosed. Alternative testing should be considered for the investigation of suspected OCAD in patients with resting LBBB.
MeSH term(s)	Aged ; Bundle-Branch Block/complications ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/physiopathology ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/physiopathology ; Echocardiography, Stress/methods ; Electrocardiography ; Female ; Follow-Up Studies ; Heart Rate/physiology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Myocardial Contraction/physiology ; Reproducibility of Results ; Retrospective Studies ; Time Factors ; Ventricular Function, Left/physiology
Language	English
Publishing date	2018-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.22875
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Zs.A 1423: Show issues

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Article ; Online: Prognostic Value of Exercise Capacity in Kidney Transplant Candidates.

Tan, Sean / Thang, Yi Wen / Mulley, William R / Polkinghorne, Kevan R / Ramkumar, Satish / Cheng, Kevin / Chan, Jasmine / Galligan, John / Nolan, Mark / Brown, Adam J / Moir, Stuart / Cameron, James D / Nicholls, Stephen J / Mottram, Philip M / Nerlekar, Nitesh

Journal of the American Heart Association

2022 Volume 11, Issue 12, Page(s) e025862

Abstract: Background Exercise stress testing for cardiovascular assessment in kidney transplant candidates has been shown to be a feasible alternative to pharmacologic methods. Exercise stress testing allows the additional assessment of exercise capacity, which ... ...

Abstract	Background Exercise stress testing for cardiovascular assessment in kidney transplant candidates has been shown to be a feasible alternative to pharmacologic methods. Exercise stress testing allows the additional assessment of exercise capacity, which may have prognostic value for long-term cardiovascular outcomes in pre-transplant recipients. This study aimed to evaluate the prognostic value of exercise capacity on long-term cardiovascular outcomes in kidney transplant candidates. Methods and Results We retrospectively evaluated exercise capacity in 898 consecutive kidney transplant candidates between 2013 and 2020 who underwent symptom-limited exercise stress echocardiography for pre-transplant cardiovascular assessment. Exercise capacity was measured by age- and sex-predicted metabolic equivalents (METs). The primary outcome was incident major adverse cardiovascular events, defined as cardiac death, non-fatal myocardial infarction, and stroke. Cox proportional hazard multivariable modeling was performed to define major adverse cardiovascular events predictors with transplantation treated as a time-varying covariate. A total of 429 patients (48%) achieved predicted METs. During follow-up, 93 (10%) developed major adverse cardiovascular events and 525 (58%) underwent transplantation. Achievement of predicted METs was independently associated with reduced major adverse cardiovascular events (hazard ratio [HR] 0.49; [95% CI 0.29-0.82],
MeSH term(s)	Exercise Test ; Exercise Tolerance ; Humans ; Kidney Transplantation/adverse effects ; Myocardial Infarction/etiology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.025862
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Article: The evolving role of cardiac magnetic resonance imaging in the assessment of cardiovascular disease.

Stokes, Michael B / Nerlekar, Nitesh / Moir, Stuart / Teo, Karen S

Australian family physician

2016 Volume 45, Issue 10, Page(s) 761–764

Abstract: Background: Imaging of the heart is important in the diagnosis and follow-up of a broad range of cardiac pathology. The authors discuss the growing role of cardiac magnetic resonance imaging (CMR) in cardiology practice and its relevance to primary ... ...

Abstract	Background: Imaging of the heart is important in the diagnosis and follow-up of a broad range of cardiac pathology. The authors discuss the growing role of cardiac magnetic resonance imaging (CMR) in cardiology practice and its relevance to primary healthcare. Objective: In this article we discuss the advantages of CMR over other imaging modalities, and give a brief description of the common CMR techniques and cardiac pathologies where CMR is especially useful. Discussion: CMR provides specific advantages over other cardiac imaging modalities when evaluating pathology in congenital heart disease, cardiac masses, cardiomyopathies, and in some aspects of ischaemic and valvular heart diseases. The strength of CMR in these pathologies includes its precise ana-tomical delineation of structures, characterisation of myocardial tissue, and accurate, reproducible measurements of blood volume and flow. CMR is used in inpatient and outpatient settings, and is available primarily in major hospitals.
MeSH term(s)	Aortic Diseases/diagnosis ; Aortic Diseases/diagnostic imaging ; Cardiac Imaging Techniques/instrumentation ; Cardiac Imaging Techniques/methods ; Cardiology/methods ; Cardiology/trends ; Cardiomyopathies/diagnosis ; Cardiomyopathies/diagnostic imaging ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/diagnostic imaging ; Diagnostic Techniques, Cardiovascular/instrumentation ; Diagnostic Techniques, Cardiovascular/trends ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/diagnostic imaging ; Heart Valve Diseases/diagnosis ; Heart Valve Diseases/diagnostic imaging ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/diagnostic imaging ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/diagnostic imaging ; Myocarditis/diagnosis ; Myocarditis/diagnostic imaging ; Pericarditis/diagnosis ; Pericarditis/diagnostic imaging
Language	English
Publishing date	2016-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	423718-3
ISSN	0300-8495
ISSN	0300-8495
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